News
Partnership to expand the clinical development of breast cancer drug candidate
ER+ breast cancers are estimated to account for 75-80 per cent of all breast cancer cases

The biotech company Lantern Pharma has announced a collaboration with TTC Oncology to expand the development of its breast cancer drug candidate.
Lantern Pharma has previously developed an artificial intelligence and machine learning platform to transform the cost, pace, and timeline of oncology drug discovery and development.
Now, through this latest collaboration, the company aims to use the insights from its AI platform to advance TTC Oncology’s first- and “best-in-class” drug candidate TTC-352 for recurrent ER+ breast cancer patients.
In US women, breast cancer remains the most commonly diagnosed cancer and second leading cause of cancer related deaths.
ER+ breast cancers are estimated to account for 75-80 per cent of all breast cancer cases and can have a recurrence rate between 13 per cent and 41 per cent.
Globally, the treatment of ER+ breast cancer is estimated to have a US$44bn market potential by 2027.
”It is of the utmost importance for cancer drug development to understand targeted tumour biology and mechanisms of resistance in order to select the patient population that will benefit the most from novel therapy,” said Dr Arkadiusz Dudek, TTC Oncology chief medical officer.
“We expect that by using Lantern’s RADR AI platform it can save us time and costs in the further successful clinical development of TTC-352 while providing important information for precision patient selection.”
The companies say the collaboration will be powered by the platform’s oncology-focused data points, algorithms and drug discovery and development modules and will be aimed at identifying biomarker or gene signatures to power potential patient selection for an upcoming clinical trial, characterising TTC-352’s mechanism of action and discovering additional treatment indications.
Panna Sharma, Lantern Pharma’s CEO and president, said: “Using AI insights generated by RADR, we are able to both sharpen existing clinical programmes and uncover additional unrealised clinical potential of Lantern’s and our collaborators’ drug candidates.
“We believe our AI-powered collaboration with TTC Oncology will accelerate the clinical development of TTC-352 for patients with metastatic ER+ breast cancer and will also identify new potential patient populations that can benefit from TTC-352 treatment.
Under the terms of the collaboration, Lantern Pharma is receiving an exclusive right to license TTC-352, including any collaboration intellectual property (IP), during an exclusive option period.
Additionally, Lantern and TTC will each participate in upfront, milestone, and royalty payments in the event a third party licenses IP resulting from the collaboration. No further financial details were disclosed.
Fertility
Chelsea FC Women to launch first-of-its-kind player fertility fund

Chelsea FC Women is to launch a fertility fund giving players access to assessments, treatments, counselling and workshops.
The initiative is part of a new partnership with London fertility clinic Fertility Plus, which has been named the club’s official fertility partner.
Chelsea said the fund will be available to every player in its women’s team, with support tailored to individual needs.
Giulia Mazzia, commercial director for Chelsea FC Women, said: “At Chelsea FC Women we are never done pushing for progress for our players and our community.
“This first-of-its-kind partnership with Fertility Plus will open up the conversation about fertility, help to raise awareness for our incredible fanbase and beyond, and give practical support to our players off the field as well as on it.”
Support through Fertility Plus will include fertility assessments and treatments, as well as counselling and workshops.
The partnership will also provide evidence-based information about reproductive health and address misconceptions around fertility.
Chelsea cited previous research on fertility knowledge which found that 41 per cent of respondents actively trying to conceive did not know when their fertile window was.
The club and Fertility Plus plan to provide educational content, resources comparing fertility myths with medical evidence and insights from Chelsea FC Women ambassadors.
Dr Amit Shah and Dr Anil Gudi, co-founders of Fertility Plus, said: “Elite sport asks a lot of women during the very years when fertility matters most, yet it’s a conversation the game has rarely had.
“Partnering with Chelsea FC Women allows us to help change that by giving players, staff and supporters access to trusted fertility expertise and compassionate, consultant-led care.
“We’re proud to work alongside a club that’s setting a new standard for supporting women’s health, both on and off the pitch.
Pregnancy
Climbing during pregnancy may be safer than long assumed, study finds

Climbing during the third trimester was not linked to higher rates of self-reported pregnancy complications in a global study.
The findings provide direct evidence on an activity pregnant women have traditionally been advised to avoid because of concerns about falls.
Researchers surveyed 692 people about climbing during pregnancy, falls, maternal and baby health outcomes and their return to the activity after giving birth.
The study recorded almost 64,000 hours of climbing among participants.
During that time, participants reported 155 “hard falls”, defined as falls or catches forceful enough to be remembered or cause concern.
The rate of adverse clinical events, meaning negative medical outcomes affecting the pregnancy or baby, was 0.03 per 1,000 hours of climbing exposure. All babies in the study were born live.
Researchers found no significant difference in pregnancy or foetal health outcomes between participants who stopped climbing at or before 27 weeks and those who continued beyond that point.
The findings suggest continuing the activity into the third trimester was not associated with increased self-reported complications among those surveyed.
The survey also found 96 per cent of participants said that, despite concerns about climbing while pregnant, they felt “happy” or “very happy” that they had continued.
Margie Davenport, professor in the Faculty of Kinesiology, Sport, and Recreation and lead author of the study, said the preliminary findings challenge an assumption about maternal exercise that had been based on opinion rather than research.
She said: “For decades we have restricted pregnant women from activities like climbing due to concern for their health and the health of the baby, but our evidence suggests it’s beneficial for both mental and physical health.”
Pregnancy
Peripear wins Innovate UK Women in Innovation Award

Medtech startup Peripear has won an Innovate UK award for developing a wearable designed to prevent perineal trauma during childbirth.
The Oxford-based company is developing a hands-free warm compress device for use on the perineum during the second stage of labour.
Peripear describes its product as the world’s first automated perineal thermotherapy wearable, designed to prevent perineal trauma during childbirth.
The device is intended to reduce severe tearing and episiotomies while improving maternal comfort.
Peripear has secured an Innovate UK Women in Innovation Award and a £74,974 grant.
The funding will support further product development ahead of the company’s planned first-in-human study.
Nina van Schaick, co-founder and chief operating officer of Peripear and midwife, said: “I’m sure I wasn’t the only one to see this gap.
“I was incredibly lucky to meet my co-founder, Eviatar Natan, right as my frustration about the lack of translation of evidence into practice had peaked.
“There was a proven mechanism that could reduce injuries occurring in up to 90 per cent of vaginal births, and it was being left out of clinical pathways simply because no standardised tool existed to deliver it.
“I’m a farmer’s granddaughter, and when I started practising over 14 years ago, I asked: where is the tool I need to implement this evidence? I looked around and realised we were still asking clinicians to improvise.
“Peripear is what happens when the person who has lived the problem, both personally and professionally, meets the person who can help her build the solution.”
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