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Freezing treatment effective for breast cancer patients with large tumours- study

Cryoablation could dissipate tumours in breast cancer patients who are not eligible for surgery

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A technique that uses ice to freeze and destroy cancerous tumours has been proven effective for breast cancer patients with large tumours, providing a new treatment path for those who are not candidates for surgery.

Cryoablation is a minimally invasive treatment that uses imaging guidance such as ultrasound or a computed tomography (CT) scan to locate tumours.

An interventional radiologist will then insert small, needle-like probes into the breast to create an ice ball that surrounds the tumour, killing the cancer cells. When combined with hormonal therapy and radiation, patients can have nearly 100 per cent of their tumours destroyed.

If the tumours do grow, patients can be treated with cryoablation multiple times to control growth. The treatment has been successfully used to treat tumours smaller than 1.5 cm, but its effectiveness on larger tumours was not extensively demonstrated until now.

A new retrospective study assessed outcomes for 60 patients who underwent cryoablation because they were not candidates for surgery or refused surgery after consultation with a breast surgeon due to age, cardiac issues, hypertension, or currently undergoing chemotherapy for another cancer.

Their tumour sizes ranged from 0.3 – 9 cm with an average size of 2.5cm. Patients with tumours larger than 1.4 cm were treated with multiple probes. In a follow-up after 16 months, the recurrence rate was just 10 per cent.

“For patients who have larger tumours but can’t undergo surgery, this approach could be more effective than the current standard of care for patients who are not surgical candidates,” Dr Yolanda Bryce, an interventional radiologist at Memorial Sloan Kettering Cancer Center, explained.

“When treated with only radiation and hormonal therapy, tumours will eventually return. So, the fact that we saw only a 10 per cent recurrence rate in our study is incredibly promising.”

Bryce said surgery is still the best option for tumour removal, but there are women who, for various reasons, can’t have surgery.

“We are optimistic that this can give more women hope on their treatment journeys,” she added.

The researchers will continue to follow the patient cohort to collect data on long-term effectiveness and to better understand the impact that adjuvant therapies combined with cryoablation can have on this patient population.

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Female-led antimicrobial resistance startup secures €24 million

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ShanX Medtech, a female-led AMR diagnostics startup, has secured €24m to scale its rapid antimicrobial susceptibility testing (AST) technology.

The Eindhoven-based company has closed a €15m seed round and been awarded an €8.85m European Commission contract developed by the Health Emergency Preparedness and Response Authority in collaboration with the European Health and Digital Executive Agency.

Founded in 2019, ShanX Medtech develops in-vitro diagnostic solutions for antimicrobial susceptibility testing, which determines which antibiotics will work against a specific infection.

The company says its technology can deliver results within an hour, compared to current methods which take longer.

The platform uses proprietary chemistry called FLORA to monitor pathogen metabolism in real time. According to the company, this requires limited user involvement and offers an improvement over approaches that need trained expertise.

Dr Sophia E. Shanko, founder and chief executive of ShanX Medtech, said: “We founded ShanX Medtech because of a single patient story, one that revealed how much is at stake when diagnostic results arrive too late.”

“Our vision is to equip every clinician with the ability to act decisively, guided by diagnostic evidence in real-time.

“This funding brings us significantly closer to delivering ultra-rapid AST directly to both laboratory and point-of-care environments; faster, simpler, and more accessible than ever before.”

The company’s initial market focus is on urinary tract infections, a common women’s health application, though the underlying platform has potential across wider clinical uses.

The oversubscribed seed round includes equity, grants and the Innovatiekrediet. The equity investment was led by Borski Fund, NextGen Ventures, CbusineZ, Brabantse Ontwikkelings Maatschappij, Invest-NL and a strategic angel fund.

Simone Brummelhuis, partner at Borski Fund, said: “Following an extensive market analysis of innovations addressing antimicrobial resistance, ShanX’s technology clearly emerged as best-in-class.

“While the company’s initial go-to-market strategy focuses on a well-defined women’s health application in urinary tract infections, the underlying platform offers substantial potential across a wide range of clinical indications.

“We are proud to support Sophia and her exceptional team in realising their ambitious vision.

“The oversubscribed financing round, together with multiple multi-million-euro commercial contracts, underscores both the strength of the technology and the founder’s proven commercial execution.”

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Femtech World Awards to celebrate innovators closing heart health gender gap

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Heart disease is the leading cause of death for women worldwide, yet women’s cardiovascular health has historically been underfunded and underrepresented in research and policy.

This year’s Femtech World Awards will shine a light on the innovations and innovators working to close this gender health gap and transform care for women everywhere.

The Cardiovascular Health Innovation award recognises groundbreaking advances that are transforming women’s heart health and improving patient outcomes.

The award honours innovators at the forefront of progress in areas such as wearable monitoring, AI-driven diagnostics, breakthrough therapies, telehealth, and community-based care.

The award is sponsored by Women As One.

Women As One was founded in 2019 by Dr Roxana Mehran and Dr Marie-Claude Morice, two internationally recognised physicians in cardiovascular care and research.

The mission of the organisation is to promote talent in medicine by providing unique professional opportunities to women cardiologists.

These opportunities range from clinical education to research funding to mentorship and network building.

Women As One also maintaina a Talent Directory database, which includes comprehensive qualification data on nearly 3,000 women cardiologists across 15 cardiovascular subspecialties and over 100 countries worldwide.

Dr Mehran said: “We are delighted to sponsor the new ‘Cardiovascular Health Innovation of the Year’ award at the 2026 Femtech World Awards.

“Cardiovascular disease is the leading cause of death for women, yet too often women’s symptoms, needs, and outcomes are overlooked.

“By recognising innovation in this field, we hope to accelerate progress toward equity in cardiovascular health and ensure that women everywhere benefit from groundbreaking advances in care.”

The Femtech World Awards are free to enter.

Winners and shortlisted entries will receive extensive coverage on all Femtech World platforms.

Winners will also receive a trophy and an interview with a Femtech World journalist.

Find out more about the awards and enter for free here.

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Sexual guilt and anxiety linked to worse sexual functioning

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Women with stronger sexual guilt and anxiety report poorer sexual functioning, a study of sexually active women in Indonesia finds.

Sexual functioning is the ability to experience healthy, satisfying sexual activity, including desire, arousal, lubrication, orgasm and satisfaction, and the absence of pain during sex.

The study authors note that traditional values in Indonesian society discourage discussion of sexual issues, with sex remaining largely taboo.

They suggest young people face conflicting social and cultural views that foster sexual guilt and anxiety.

Sex guilt is a generalised expectation of punishment for violating standards of appropriate sexual behaviour.

Individuals with strong sex guilt may avoid sex, lack sexual initiative and struggle to process sexual stimuli. Sex anxiety concerns others’ opinions and possible breaches of social norms.

Participants were 169 women aged 19 to 40 from Greater Jakarta, recruited via an online survey shared on social media and WhatsApp.

Of those surveyed, 59 per cent were married, 44 per cent had children and 56 per cent held a bachelor’s or master’s degree.

They completed assessments of sexual functioning (Female Sexual Function Index), sex guilt (Brief Mosher Sex Guilt Inventory) and sex anxiety (Sex Anxiety Inventory).

Results showed higher sex guilt and sex anxiety were linked to worse sexual functioning.

There were no differences in sex guilt, sexual functioning or sex anxiety between participants with and without children. Single women tended to report worse sexual functioning than other groups.

Study authors Mia Audina Olivia and Ahmad Naufalul Umam concluded: “Our main finding confirmed the global dynamics on how sexual guilt and anxiety may hinder one’s sexual functioning, while the demographic data showed that sexual functioning in Indonesian women’s context is tied with normative relationship of marriage.”

The researchers noted that the study design does not allow causal conclusions to be drawn from the results.

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