News
UK couples exploiting legal loophole to rank embryos based on IQ, height and health
UK couples undergoing IVF are exploiting a legal loophole to rank embryos based on genetic predictions of IQ, height and health, a Guardian investigation has revealed.
The screening method, which scores embryos from their DNA, is not permitted at UK fertility clinics and critics have raised scientific and ethical objections, saying the approach is unproven.
But under data protection laws, patients can request their embryos’ raw genetic data and send it abroad for analysis to influence selection for traits linked to intelligence, height and health.
Dr Cristina Hickman, a senior embryologist and founder of Avenues fertility clinic in London, said rapid advances in embryo screening techniques and the recent launch of several US companies offering polygenic screening, which analyses multiple genes to predict traits, had left clinics facing “legal and ethical confusion.
“This opens a whole can of worms,” said Hickman, who raised the issue in a letter last month to the Human Fertilisation and Embryology Authority (HFEA).
One US company, Herasight, which charges couples US$50,000 (£37,000) to assess an unlimited number of embryos, confirmed it had already worked with couples undergoing IVF at clinics in the UK. There is no suggestion Herasight is in breach of any regulations.
In the UK, tests performed on embryos are legally restricted to a list of serious health conditions, such as Huntington’s, sickle cell disease or cystic fibrosis.
Clinics cannot perform polygenic screening for the purpose of embryo selection.
Peter Thompson, chief executive of the HFEA, said polygenic testing was unlawful for use in the UK.
“Licensed clinics in the UK are responsible for selecting embryos based on what is permitted in the HFE Act and therefore should not offer such testing and subsequent treatment,” he said.
“However, there is nothing to stop a UK-based couple seeking such testing, and indeed treatment, overseas, but a UK licensed clinic should not then make decisions on what embryo to put back using that information.”
Some have questioned whether the HFEA’s position is enforceable.
Hickman said the clinic would not generally block a couple’s request that a particular embryo is transferred, provided there was no conflict with medical safety.
“I would rather have polygenic testing allowed here and have the HFEA control how to do it ethically,” she said.
The European Society of Genetics has condemned the technique as “unproven and unethical”, and there are broader concerns about the potential for a stratified society where wealthier people pay to select preferred embryos.
Prof Angus Clarke, a clinical geneticist at Cardiff University, said: “These companies are dealing in murky science in an emotionally fraught context.”
Cancer
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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