News
Research round up: Overlooked changes in menopause, routine breast cancer screening for better outcomes and more

Femtech World explores the latest research developments in women’s health.
Global study underscores overlooked health changes during menopause
A new study has highlighted critical and often overlooked changes in women’s health during menopause.
Drawing from anonymised data from 1.12 million females across the globe, the analysis reveals significant transformations in sleep quality, body composition, and cardiovascular health that begin in perimenopause and persist through postmenopause.
This large-scale research – carried out by from Withings and analysed by Withings Observatory for Health and Longevity – provides some of the most comprehensive physiological insights to date on the impact of menopause, underscoring the importance of better awareness, monitoring, and support for women navigating this natural yet complex life stage.
The study found shifts in sleep patterns, showing that women may experience up to a 33 per cent increase in nighttime awakenings, averaging between three and four wake-ups per night, and that sleep disorders, including insomnia and sleep apnoea, increase by 374 per cent
Furthermore, the study found changes to body composition, showing that abdominal and visceral fat naturally increase by 43 per cent, and changes to cardiovascular health, showing that blood pressure rises by +3.384 mmHg, and the risk of cardiovascular diseases, like atrial fibrillation, increases by 293 per cent.
Routine breast cancer screening brings better outcomes for patients
Compared to breast cancer that is symptom-detected, patients with breast cancer detected via routine screening mammography are more likely to have improved clinical outcomes, according to a new study.
While it is commonly understood that early detection of breast cancer results in better patient outcomes, national cancer registries in the US and Canada don’t track the method of cancer detection.
Since improvements in patient outcomes may be incorrectly attributed solely to treatment advances, identifying the association between the method of breast cancer detection and clinical outcomes may have a direct impact on health care policy.
In a retrospective observational analysis, researchers collected data of patients aged 40 years or older who were diagnosed with breast cancer in 2016.
Of the 821 patients included in the study, just over 50 per cent had breast cancer diagnosed as the result of a symptom, rather than as the result of a screening mammogram.
Compared to patients with symptom-detected breast cancer, patients with screening-detected breast cancer had significantly lower odds of an advanced stage of breast cancer, lower odds of undergoing a mastectomy and a lower hazard ratio of death.
Breast cancers detected from symptoms were more frequent in women aged 40 to 49 years and over 75 years of age, 72.9 per cent and 70.4 per cent, respectively. All-cause deaths were also higher among patients who were not undergoing regular screening.
Most surprising was how many patients died shortly after their breast cancer was detected, the researchers noted, showing that within only 6.7 years of follow-up, almost 20 per cent of the 821 breast cancer patients had died, half of them from breast cancer.
The researchers concluded that reducing the barriers to breast cancer screening in women aged 40 to 74 will improve patient outcomes and reduce the number of patient deaths from cancer.
Women over age 75 might also benefit from screening, as these patients were more likely to be diagnosed due to symptoms and required more intensive treatment.
Longer reproductive years linked to healthier brain ageing in women
The number of years a woman spends in her reproductive phase between her first period and menopause may be linked to how well her brain ages later in life, a new study has shown.
For the study, brain scans from over 1,000 postmenopausal women were analysed, finding that women who had their first period earlier, experienced menopause later, or had a longer reproductive span showed signs of slower brain ageing.
According to lead researcher, associate professor Eileen Lueders, of the University of Auckland’s School of Psychology, the findings support the idea that estradiol – the most potent and prevalent form of estrogen during a woman’s reproductive years – may help protect the brain as it ages.
The research may point toward the potential for health interventions such as hormone treatment in the years leading up to menopause and immediately afterward to combat an increased risk of Alzheimer’s for some women.
While this new study adds to the growing evidence that estradiol may play a protective role in brain health, Luders cautions that the effects were small, and estradiol levels were not directly measured.
Other factors like genetics, lifestyle, and overall health also influence brain ageing.
Research to observe effects of fentanyl during pregnancy
Wayne State University researchers have been provided a National Institutes of Health (NIH) two-year grant that will aid in measuring the effects of fentanyl during pregnancy on maternal behaviours and offspring at birth through early development.
The principal investigators are Shane Perrine, associate professor of psychiatry and behavioural neurosciences in Wayne State’s School of Medicine, and Susanne Brummelte, professor of psychology in Wayne State’s College of Liberal Arts and Sciences.
Both researchers credited a news report and a previous NIH grant received by Brummelte to examine the effects of opioids during pregnancy as what inspired them to explore this area.
The study will determine the impact of gestational fentanyl exposure on morbidity and mortality, developmental milestones, external morphology, blood cholesterol, brain morphogen signaling, and neonatal opioid withdrawal and related behavioural measures in offspring.
The team will also measure brain volume, morphology and the neurochemistry of offspring using magnetic resonance imaging and spectroscopy in vivo.
Antibiotics taken during pregnancy may reduce preterm births
According to a new study, a daily dose of a safe antibiotic may reduce the risk of preterm births.
Maternal infections and inflammation during pregnancy are linked to adverse birth outcomes, particularly for babies born to mothers living with HIV, who have a greater risk of being born too small or too soon.
For this study, an international group of researchers looked at almost 1000 pregnant women in Zimbabwe, finding that a daily dose of trimethoprim–sulfamethoxazole may have led to fewer babies being born early.
Among women living with HIV, those who received the antibiotic had larger babies who were less likely to be preterm.
The participants received regular antenatal care during their pregnancies and data regarding their birth outcomes were recorded.
Although birthweight did not differ significantly between the two groups, the trimethoprim–sulfamethoxazole group showed a 40 per cent reduction in the proportion of preterm births, compared to the placebo group.
Overall, 6.9 per cent of mothers receiving the drug had babies born preterm, compared to 11.5 per cent of mothers receiving the placebo, and no women receiving antibiotics had babies born prior to 28 weeks.
For babies born to a small group of 131 women with HIV, the reduction in premature births was especially marked, with only 2 per cent of births in the trimethoprim–sulfamethoxazole group preterm, as compared with 14 per cent in the placebo group.
Babies exposed to antibiotics during pregnancy also showed a 177 gram increase in their birth weight.
pain conditions
Endometriosis documentary profiles stars including Marilyn Monroe and Amy Schumer

A non-profit has launched an endometriosis documentary featuring Amy Schumer and Marilyn Monroe as it pushes for changes in how the condition is treated and understood.
The Endometriosis Collective has launched to change how endometriosis is researched, treated and understood, starting with a documentary featuring stories from people including Amy Schumer and Marilyn Monroe.
The feature-length documentary, “End of the Cycle”, will premiere in New York on Tuesday, and The Endometriosis Collective is making the film free to stream online.
Schumer, a comedian, writer and actor, has previously spoken of how endometriosis left her “on the floor in pain, vomiting from the pain, the pain that nobody can see.”
Schumer is one of several celebrities featured in the documentary. Other contributors include dancer Julianne Hough, Olympic medallist Brittany Brown and actors Janel Parrish and Folake Olowofoyeku.
The Endometriosis Collective timed the documentary premiere to coincide with the 100th anniversary of Marilyn Monroe’s birth.
Monroe, who died in 1962, starred in films such as “Some Like It Hot” and “Gentlemen Prefer Blondes.”
According to a biography published in 1985, Monroe’s endometriosis was so severe that it destroyed her marriages, her wish for children, her career and ultimately her life.
The Endometriosis Collective said the documentary shares newly uncovered information about Monroe’s experience with endometriosis.
The non-profit said the information connects Monroe’s story to the experiences of women across generations, highlighting how far awareness, research and care still have to go.
A representative of the Marilyn Monroe Estate said: “By sharing this part of her story through ‘End of the Cycle,’ we hope to honour her legacy in a way that brings visibility to endometriosis, encourages more open dialogue and helps inspire the research needed to create change.”
As part of the premiere, The Endometriosis Collective is holding a panel discussion.
Schumer, Brown and Olowofoyeku, the documentary’s co-directors Sammy Jaye and Soraya Simi, and medical experts are due to be part of the premiere.
AbbVie’s Orilissa and Sumitomo Pharma’s Myfembree are among the approved drugs for endometriosis pain.
Hough, one of the participants in the documentary, starred in an Orilissa campaign in 2017.
News
Bridging the metabolic wealth gap: The telehealth platform bypassing insurance to democratise care

As weight-loss treatments remain locked behind prohibitive paywalls, a new direct-pay initiative is cutting costs in half for low-income patients, and it could provide a new blueprint for health equity.
It is one of the most persistent, frustrating paradoxes in modern healthcare: the medical innovations most capable of addressing widespread chronic conditions are overwhelmingly priced out of reach for the populations most vulnerable to them.
Nowhere is this more evident than in the current landscape of metabolic health and weight management.
As state governments and insurance providers increasingly restrict coverage for advanced weight-loss medications due to skyrocketing costs, a stark dividing line has emerged. Clinical need is no longer the primary factor in who receives treatment. Affordability is.
This financial barrier disproportionately impacts women, who not only face high rates of metabolic conditions but also frequently serve as the primary caregivers in their households.
For a single mother managing childcare, grueling work hours, and the relentlessly rising cost of living, personal well-being is often the first casualty of a tight budget.
These patients are forced into a holding pattern, watching their conditions progress year after year while highly effective, life-changing treatments remain separated from them by a paywall.
Now, a telehealth platform called Amble Health is attempting to dismantle that wall by bypassing the traditional insurance apparatus entirely.
A Structural Shift for Access
Today, Amble Health announced the launch of the Amble Cares Program, a national initiative designed to cut the cost of medical weight-loss treatments in half for low-income Americans.
The programme arrives at a critical inflection point.
Today, roughly one in eight U.S. adults have utilized advanced metabolic medications, according to a recent KFF Health Tracking Poll.
This surge in adoption has driven a fundamental shift in preventative care, but the distribution of that care has been deeply uneven.
Through the Amble Cares Program, eligible patients can access comprehensive medical weight-loss programmes, which may include prescription medications if clinically appropriate, at up to 50 per cent below standard rates.
To ensure the discounts reach the intended demographic, eligibility is determined by an independent, third-party verification partner, based on verified financial need.
The programme explicitly prioritises individuals and families with limited disposable income, including parents and guardians whose financial flexibility is tied up in providing for dependents.
Once verified, patients are connected directly to licensed clinicians to begin treatment immediately, stripping away the friction of waiting periods.
“Healthcare should not be a luxury item,” said Joey Stiver, CEO of Amble Health. At Amble, we believe that a patient’s zip code or income shouldn’t dictate their metabolic health outcomes.
“The Amble Cares Program is our direct response to the cost of living crisis, moving beyond talk of ‘affordability’ to actually delivering it to the people the traditional system has left behind.”
The Direct-Pay Trade-Off
However, this rapid, lower-cost access comes with a significant structural trade-off.
To achieve these price reductions and eliminate the administrative delays, denials, and red tape associated with traditional healthcare, Amble Health operates strictly as a direct-pay platform.
This means participants cannot use outside coverage. The programme does not accept Medicaid, Medicare, commercial insurance, or even HSA/FSA funds.
For some patients, being entirely locked out of utilizing their existing health benefits may present a new kind of hurdle.
But for those who have already found themselves abandoned by traditional coverage networks, facing outright denials, unnavigable prior authorisations, or insurmountable deductibles, the direct-pay model offers a predictable, transparent alternative to a broken system.
Ultimately, the Amble Cares Program is making a bold bet: that the most efficient way to deliver equitable healthcare to disenfranchised populations isn’t to fix the traditional insurance system, but to innovate entirely around it.
Motherhood
Natural birth pressure harming new mothers’ mental health, research finds

Pressure to have a natural birth can cause lasting psychological harm when labour does not go to plan, new research shows.
The study found that the messages women receive during pregnancy are directly linked to the shame and self-blame many feel when those expectations are not met.
For the first time, the research provides an explanation for why unmet birth expectations contribute to psychological harm.
Several women involved in the research said they felt they had not given birth “properly”, even when medical intervention had saved their lives.
Rebecca Matthews, lead author and PhD researcher at the University of Reading, said: “These women were not failed by their bodies, they were failed by the messages they were given.
“Birth trauma does not begin with birth. It begins in the ideology sold to women throughout pregnancy.
“For the first time we can explain precisely how, by showing how birth culture creates a moral standard for women that defines what a good mother does and then leaves them to blame themselves when birth does not match that.
“Until we reform the way we prepare women for birth, we will keep seeing the same devastating consequences for mothers and their babies.”
The researchers interviewed 21 first-time mothers in the UK whose births did not go as planned.
From NCT and hypnobirthing classes, to social media to midwives, the researchers heard how women are surrounded by messaging that frames natural, unmedicated vaginal birth as the “gold standard”, not just medically preferable, but as a mark of being a good mother and the first test of maternal worth.
Research shows around half of women report their birth differed significantly from their expectations, and for the women in this study, all of whom experienced exactly that, the psychological consequences were profound.
Women judged themselves against the internalised moral standard that this ideology had created.
The researchers are calling for antenatal education to stop treating one kind of birth as the goal and to present all birth outcomes as equally valid routes to motherhood.
They also call for better postnatal screening for women whose births did not go as expected, specifically targeting the shame, self-blame and identity disruption that this research identifies as mechanisms underlying birth trauma.
The findings align with and extend the conclusions of the Kirkup, Ockenden and Birth Trauma Inquiry reports, all of which documented how the institutional pursuit of “normal birth” contributed to preventable harm.
This research provides the first theoretical explanation of how that ideology generates individual psychological harm and points to antenatal messaging as the primary site of such preventable harm.
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