Connect with us

Fertility

Genetic testing of IVF embryos helps women over 35 conceive faster

Published

on

Genetic testing of IVF-created embryos could help more women over 35 have a baby in less time, a clinical trial has found.

This is the first randomised controlled trial worldwide to focus exclusively on women aged 35–42, a group at higher risk of producing embryos with chromosomal abnormalities.

The trial looked at the use of Preimplantation genetic testing for aneuploidy (PGT-A) to check embryos for chromosomal abnormalities before transfer.

Older women are more likely to produce embryos with the wrong number of chromosomes, which can lead to difficulties conceiving, and increases the risk of miscarriage.

Current NICE guidance does not currently recommend routine use of PGT-A, driving women to pursue this test privately or skip it altogether.

This guidance is based on previous evidence from studies which had a young average age of participants where the rate of aneuploidy, abnormal number of chromosomes in a cell, is lower.

The study also broke new ground by including mosaic embryos, those containing both normal and abnormal cells, which are frequently encountered in IVF but rarely included in research.

Dr Yusuf Beebeejaun, first author of the paper at King’s College London and King’s Fertility, said: “The number of women starting their family above the age of 35 is increasing and women in this age group are more likely to create embryos with the wrong number of chromosomes.

“This increases the risk of unsuccessful implantation and miscarriages.

“Our findings suggest that targeted use of PGT-A in this age group could help more women have a baby sooner, while also reducing the emotional toll of repeated unsuccessful cycles.”

The pilot study of 100 women undergoing fertility treatment at King’s Fertility was aimed to fill the evidence gap by focusing on older patients, and assessing the feasibility of conducting a multi-centre randomised controlled trial that explores the test’s impact on pregnancy and live birth rates in women aged 35-42.

Both the clinical treatment and embryology procedures for the study were carried out at King’s Fertility.

The unblinded trial was conducted from June 2021 to June 2023. There were 50 patients in the PGT-A group and 50 patients in the control group.

The study showed that the PGT-A test showed a higher cumulative live birth rate after up to three embryo transfers with 72 per cent in the PGT-A group versus 52 per cent in the control group.

Women in the PGT-A group achieved pregnancy in fewer transfers, reducing the time to conception, an important factor for women of advanced reproductive age.

Whilst this is a pilot study and the difference did not reach statistical significance due to the small sample size, the trend suggests a potential benefit that warrants investigation in a larger, multi-centre trial.

Lead author Dr Sesh Sunkara from King’s College London and King’s Fertility said: “By focusing exclusively on women aged 35–42 and including mosaic embryos, we have addressed questions that previous studies have not adequately explored.

“While larger multi-centre trials are needed to confirm these findings, improving treatment efficiency with a shorter time to achieving pregnancy and live birth could reduce the physical and emotional burden of IVF for women of advanced reproductive age.”

Dr Ippokratis Sarris, Director of King’s Fertility and co-author of the study, added: “This research is a testament to the dedication and expertise of the team at King’s Fertility.

“Not only were all patients recruited and treated here, but the embryology work was also carried out by our laboratory staff.

“We are proud to have led this pioneering trial, which addresses one of the most important questions in IVF treatment for women over 35, and we look forward to building on these findings in larger, multi-centre studies.”

Fertility

Fertility clinic named London finalist in UK StartUp Awards

Published

on

A London-based fertility clinic has been shortlisted for a startup award.

Plan Your Baby was shortlisted as a London finalist for Innovative Startup of the Year at the UK StartUp Awards.

Plan Your Baby is a new generation fertility and pregnancy telehealth clinic that provides fertility treatment and and-to-end pregnancy clinical monitoring and psychological support.

The company said on LinkedIn: “Being recognised in a city as competitive as London is meaningful for our team. 

“The award is judged by industry experts and reflects the growing need for fertility care that is structured, transparent, and centred around the patient.

“Many people come to us looking for clarity in what can often feel like a complex process. 

“Our focus has been to make each step easier to understand and easier to access.”

Plan Your Baby founder Marija Skujina was inspired to launch the company after working at the highest level in private fertility clinics and realising the impact that the traditional approach to fertility treatment was having on clients.

She told Femtech World in a 2023 interview: ““Fertility support is not just a medical procedure, it’s physical, mental, and emotional too.

“That’s why I launched Plan Your Baby: to help parents conceive in a fully supported and holistic manner.”

The UK StartUp Awards aim to ‘recognise the achievements of amazing individuals who have had a great idea, spotted the opportunity and taken the risks to launch a new product or service.’

If selected as the regional winner, Plan Your Baby will go on to the national final at Ideas Fest this September.

Previous winners include Magic AI, makers of a wall-mounted AI fitness mirror that acts as a personal trainer, and EnsiliTech, a medtech startup developing innovative health technology solutions at the intersection of engineering and healthcare.

Continue Reading

Fertility

Future Fertility partners with Japan’s leading IVF provider, Kato Ladies Clinic

Published

on

Future Fertility, a Toronto-based health technology company specialising in AI-powered fertility insights, has entered the Japanese market through a new commercial partnership with Kato Ladies Clinic — a globally recognised leader in IVF research and advancing clinical fertility care.

The collaboration marks Future Fertility’s first partnership in Japan and reflects growing global demand for technologies that bring greater objectivity and personalisation to fertility care.

Kato Ladies Clinic will integrate the company’s AI-powered oocyte (egg) quality assessment tools into its clinical workflows, with the aim of supporting more informed treatment planning and patient counselling across IVF and egg freezing cycles.

“At Kato Ladies Clinic, we are committed to advancing fertility care through innovation while maintaining a strong focus on individualised, patient-centred treatment,” said Keiichi Kato, chief executive officer.

“Partnering with Future Fertility enables us to integrate objective, data-driven insights into our clinical approach and better support our patients in making informed decisions.”

Future Fertility’s platform analyses images of oocytes using artificial intelligence trained and validated on a dataset of more than 650,000 unique oocyte images.

The technology is already in use at more than 300 clinics across more than 35 countries, helping clinicians better understand the developmental potential of individual eggs and provide patients with more personalised insight earlier in their treatment journey.

From Research Collaboration to Clinical Adoption

The partnership between Future Fertility and Kato Ladies Clinic began as a scientific research collaboration in 2024, marking the first use of AI-powered oocyte quality assessment in Japan.

The collaboration not only validated the technology in a new patient population and across diverse clinical protocols — including minimal stimulation cycles —but also resulted in a peer-reviewed publication in Reproductive BioMedicine Online (RBMO) and a poster abstract presentation at ESHRE 2025.

The joint research explored how AI-derived oocyte quality scores relate to early embryonic development and overall treatment outcomes. In a retrospective study conducted at Kato Ladies Clinic, researchers analysed nearly 2,800 mature oocytes across more than 1,300 ICSI cycles, linking image-based assessments of egg quality to key developmental milestones.

The study demonstrated that lower AI scores were associated with reduced fertilization rates, delays, and abnormalities in early embryo development, increased developmental errors, and lower-quality blastocyst formation.

Notably, the researchers also found that cumulative oocyte scores were a stronger predictor of live birth outcomes than the number of eggs retrieved — underscoring the importance of assessing egg quality alongside quantity.

“Our collaboration with Future Fertility has demonstrated how artificial intelligence can uncover meaningful biological differences between oocytes that were previously difficult to quantify,” said Kenji Ezoe, senior scientist.

“Bringing this technology into routine clinical use is an important step toward translating research into improved patient outcomes.”

Future Fertility’s VP of clinical embryology & scientific operations, Jullin Fjeldstad, noted that the findings provide important clinical validation.

“Our joint research with Kato Ladies Clinic has shown how AI-based oocyte assessment can be directly linked to numerous embryo development outcomes, from fertilization through early developmental milestones and blastocyst formation,” she said.

“We are excited to see this work translated into clinical practice.”

Growing Demand for Fertility Care in Japan

The partnership comes at a time when demand for fertility treatment in Japan continues to rise.

The country performs over 450,000 fertility treatment cycles annually, making it one of the largest markets globally. Delayed childbearing and evolving societal trends have also contributed to increasing interest in egg freezing.

As patients seek more clarity and personalization in their care, tools that provide earlier insight into reproductive potential are gaining traction.

“Entering the Japanese market with a partner like Kato Ladies Clinic is a significant step forward for our global commercial strategy,” said Rafael Gonzalez, Future Fertility’s VP of global sales & strategy.

“It reflects the growing demand for technologies that support more transparent, data-driven fertility care across diverse healthcare systems.”

Expanding a Global Footprint

Founded in 1993, Kato Ladies Clinic is known for its pioneering work in natural and minimal stimulation IVF and has long been a leader in clinical innovation in Japan.

For Future Fertility, the partnership represents both a geographic expansion and a continuation of its broader mission to bring AI-driven insights into routine fertility care.

“We are proud to partner with Kato Ladies Clinic, a globally respected leader in IVF and a pioneer in reproductive medicine in Japan,” said Future Fertility’s CEO, Christy Prada.

“This partnership represents an important milestone as we expand into Asia and continue our mission to bring objective, personalised insights into fertility care worldwide.”

Future Fertility develops AI-powered tools designed to generate personalised insights across the fertility journey.

Its flagship oocyte assessment technologies analyse egg images to provide objective, individualised measures of egg quality, supporting treatment planning, patient counselling, and clinical decision-making in egg freezing and IVF, while also enabling more data-driven approaches to donor egg distribution and quality assurance.

As fertility care continues to evolve, collaborations like this one are helping shape a new standard — one that emphasises earlier insight, greater transparency, and more personalised decision-making for patients navigating increasingly complex reproductive journeys.

Continue Reading

Fertility

The 0th trimester: Reshaping the start of your pregnancy

Published

on

Article produced in association with London Pregnancy Clinic and Jeen Health

For many years, formal clinical involvement in a pregnancy began at the point of confirmation, typically around eight to ten weeks.

The concept of the ‘0th trimester’ represents a shift in thinking: that the period before conception is itself a clinically significant window, during which health optimisation, risk identification and informed planning can meaningfully improve pregnancy outcomes.

Guidance from Tommy’s and the NHS both recommend pre-conception care as part of responsible reproductive health management.

What Pre-Conception Care Involves

Pre-conception care is not a single test or appointment. It is a structured approach to assessing and optimising a woman’s health before she attempts to conceive.

The NHS guidance on planning a pregnancy recommends a range of measures including taking folic acid, reviewing medications for safety in pregnancy, ensuring immunity to rubella and chickenpox, and addressing pre-existing conditions such as thyroid disorders, diabetes or high blood pressure before conception occurs.

General pre-conception assessments typically include blood pressure and BMI review, full blood count and iron levels, thyroid function, immunity screening (rubella, varicella), vitamin D status and cervical screening if overdue.

For women with existing conditions, specialist review before pregnancy is often more valuable than specialist referral during it.

Fertility Investigations as Part of the 0th Trimester

For women who are planning a pregnancy but have concerns about fertility, pre-conception investigations provide information that informs planning rather than leaving uncertainty unaddressed.

Clinics offering 0th trimester services, including London Pregnancy Clinic, provide investigations including hysterosalpingo-contrast-sonography (HyCoSy) to assess tubal patency, follicle tracking scans, anti-Mullerian hormone (AMH) testing to estimate ovarian reserve, and endometrial assessment.

These tests do not guarantee conception but they provide a clinical foundation from which fertility decisions can be made with better information.

Genetic Assessment in Pre-Conception Care

The genetic dimension of pre-conception care is increasingly central to a thorough 0th trimester assessment.

Genetic carrier screening before pregnancy allows couples to identify their carrier status for conditions such as cystic fibrosis, SMA and a range of other inherited disorders before conception, giving them time to consider their options with appropriate clinical support.

At-home carrier testing offered by Jeen Health provides access to comprehensive carrier screening without the need for a clinical referral.

Couples collect their sample at home and receive results within a defined timeframe.

When both partners carry a variant in the same gene, the result can be followed up with genetic counselling via clinics such as London Pregnancy Clinic, where clinical specialists can contextualise the findings and explain the available options.

Lifestyle and Nutritional Factors

Pre-conception health is not limited to clinical testing.

Lifestyle factors including physical activity levels, nutritional status, alcohol consumption and smoking all influence fertility and early fetal development.

Pre-conception care provides an opportunity to address these factors proactively rather than as an afterthought following a positive test.

Folic acid supplementation, recommended at 400 micrograms per day in the pre-conception period and the first trimester, is one of the most evidence-supported interventions available.

Why Timing Matters

Many of the interventions that benefit pregnancy are most effective when started before conception rather than after.

Addressing thyroid dysfunction, normalising blood pressure, treating iron deficiency anaemia, and identifying genetic risks all have a higher potential impact when managed from the outset rather than detected at the first antenatal appointment.

The 0th trimester framework provides a way of thinking about pre-conception care as a structured medical period with its own clinical agenda, rather than simply a waiting room for the first trimester.

What a Pre-Conception Appointment Might Look Like

A comprehensive pre-conception assessment with a specialist provider would typically cover a clinical consultation reviewing medical and family history, a pelvic ultrasound scan, blood tests for general health markers and fertility hormones, cervical health review if indicated, and a discussion of genetic risk including a recommendation for carrier screening if appropriate.

For couples with specific concerns about fertility or genetic history, specialist investigations can be added to this baseline assessment.

Disclaimer: This article is produced for informational purposes only and does not constitute medical advice, diagnosis or treatment.

Clinical guidance referenced reflects published NHS, NICE and RCOG standards as at March 2026. Individual circumstances vary; readers are advised to consult a qualified healthcare professional before acting on any information in this article.

This piece was produced in association with London Pregnancy Clinic and Jeen Health, which provided background clinical information for editorial purposes.

Hyperlinks to external sources are included for reference only and do not represent an endorsement of any product, service or organisation.

Continue Reading

Trending

Copyright © 2025 Aspect Health Media Ltd. All Rights Reserved.