Fertility
Fertility treatment not tied to cancer risk, research finds

Fertility treatment was not linked to a higher overall risk of invasive cancer in women, a large Australian study has found.
The study, published today in JAMA Network Open, analysed health records of more than 417,000 women and found some specific cancers were slightly more common, while others were less common.
The researchers said the findings need to be interpreted with caution, and in the context of the many factors that influence cancer risk.
Adrian Walker, joint lead author from UNSW’s Centre for Big Data Research in Health, said the overall findings were reassuring, with women who receive fertility treatment not having a higher total incidence of cancer than other women.
“Women who’ve had assisted fertility should continue to participate in routine cancer screening programs they’re eligible for,” he said.
“And they should discuss their cancer risk with their doctor, to understand how else they can reduce their risk.”
The study analysed national health and cancer records from 417,984 Australian women who underwent medically assisted reproduction between 1991 and 2018.
This included IVF, intrauterine insemination and treatment with the fertility drug clomiphene. Cancer outcomes were examined over an average of 10 years.
The researchers compared how often cancer occurred in these women with how often it occurred in Australian women of the same age and in the same calendar years.
While the overall cancer rate was not higher, some specific cancers were slightly more common in women who had fertility treatment, while others were less common.
Uterine and ovarian cancer were slightly more common, as was melanoma. A non-invasive form of breast cancer was also more common in women who had IVF, but invasive breast cancer was not increased.
At the same time, some cancers, including cervical and lung cancer, were less common.
“It is very normal for a specific group of people to have a slightly different cancer profile from the general population,” Walker said.
“But as we see here, that doesn’t mean that their overall risk is increased.”
Claire Vajdic, professor at UNSW’s Kirby Institute and study lead, said the findings need to be interpreted carefully.
“This study focused on comparing rates of cancer in different populations, not whether fertility treatments themselves cause cancer.
“As such, we must consider the pre-existing risks of cancer in these populations when interpreting the findings.
“Women with infertility who are having or have had treatment, like all women, should ensure that they have regular check-ups, and seek further evaluation if they have concerns about unusual symptoms.”
Of the cancers that occurred at a higher rate than in the general population, uterine cancer was between 23 per cent and 83 per cent more common, depending on the type of fertility treatment.
Ovarian cancer was around 18 per cent to 23 per cent more common in women who had IVF or related treatments, while melanoma was about 7 per cent to 15 per cent more common.
On the other hand, some cancers were less common. Cervical cancer rates were about 40 per cent lower than in the general population, and lung cancer rates were about 30 per cent lower.
However, when the researchers looked at the actual number of additional cases, the difference was small. Across the cancers that were more common, the largest increase amounted to three to seven extra cases per 100,000 women per year.
So even where a relative increase was observed, the overall chance of developing cancer remained low.
Very few medical treatments are without risk, but the elevated cancer incidence here is low,” Vajdic said.
The researchers said there could be many reasons why certain cancers were more common in women who had fertility treatment.
“Women who need fertility treatment may differ from other women in ways that affect cancer risk,” Vajdic said.
Certain underlying causes of infertility, such as endometriosis and polycystic ovary syndrome, are known to increase the risk of uterine and ovarian cancers.
The researchers showed Australian women who underwent fertility treatment were more likely to live in major cities and be socioeconomically advantaged.
Although not examined in this study, women having fertility treatment are also more likely to have fair skin and be less likely to smoke. Additionally, before starting fertility treatment, doctors must check that women are up to date with any recommended routine cancer screening.
All these factors will contribute to the cancer patterns observed in this study, including reduced lung cancer rates and reduced cervical cancer rates.
“What this study does is describe cancer patterns we’re seeing at a population level,” Walker said.
“It doesn’t tell us the risk of receiving treatment, or the risk for individual women who undergo treatment.”
Because many women in the study were still relatively young at the end of follow-up, the researchers said longer follow-up would provide additional insights.
“Continued cancer awareness is important as this population ages,” Vajdic said.
The researchers concluded that cancer risk after fertility treatment was not higher overall, and that further research to better understand differences in incidence for individual cancers will help women and their doctors make informed decisions.
Fertility
Weight loss surgery improves menstrual health and PMOS symptoms, study finds

Weight loss surgery was linked to more regular periods and fewer polyendocrine metabolic ovarian syndrome (PMOS) symptoms in women aged 18 to 45 living with obesity in a recent study.
The researchers recommend that women undergoing the procedure have access to preconception care and reproductive counselling to support their reproductive health.
Researchers at the University of Surrey analysed data over 24 months from 84 women who underwent bariatric surgery and 18 women living with obesity who did not have surgery.
Of those who underwent surgery, 49 had gastric bypass procedures and 35 had gastric sleeve surgery.
Women who underwent metabolic bariatric surgery lost more than 30kg on average at 12 and 24 months after the procedure.
Among women with polycystic ovaries, the condition persisted in only 10 per cent after 24 months.
Women also reported a resolution of clinical hirsutism, or excess body hair, by 12 months.
Women who had previously experienced irregular periods reported more regular menstrual cycles after surgery.
Professor Martin Whyte, co-author of the study and professor of metabolic medicine at the University of Surrey, said: “A large proportion of those undergoing bariatric surgery are women of reproductive age, who may be planning a pregnancy in the coming years.
“So much remains unknown about the impact of this type of surgery on women who are planning to have children.
“This raises the question of when the ideal time after surgery is to conceive.”
Women have a higher prevalence of obesity than men, with 57 per cent of women in the UK classified as overweight and 27 per cent living with obesity, which can affect fertility and the health of an unborn baby.
The researchers said 17 women had healthy pregnancies following surgery.
Although this was not specifically examined in the study, no difference in birth weight was observed between babies conceived within or after the first year.
Dr Kathryn Hart, co-author of the study and associate professor in nutrition and dietetics at the University of Surrey, said: “What we have found is that bariatric surgery positively affects the reproductive health of women living with obesity and can improve the likelihood of them having a healthy pregnancy after surgery.
“Dysregulated hormone levels, irregular periods and conditions such as polycystic ovaries are affected by obesity.
“By reducing this, what we have seen is that it can lead to improvements without the need for medication.
“We would suggest that clinicians consider medical intervention for obesity to treat irregularities in the menstrual cycle and issues with fertility.”
Fertility
Scottish gov to consider IVF for single women

The Scottish government has launched a national review into whether NHS IVF access should be extended to single women.
The review will also consider whether wider access should be offered to couples who have children from previous relationships.
Health secretary Angela Constance said: “Access to NHS IVF treatment should be fair, timely and reflect the way people’s lives and families look today.”
Most single women are not currently eligible for NHS IVF treatment in Scotland.
Campaigners have welcomed the review.
Katie Rollings of Fertility Action said: “It’s an essential and long-awaited decision that will impact a huge number of people who are struggling to grow their families.
She said there is “no evidence” that having two parents rather than one determines whether a child will thrive.
She added: “What matters is whether a child is loved, safe, supported and has stable, positive relationships around them.”
Figures from the Human Fertilisation and Embryology Authority show Scotland is the only UK nation where NHS-funded IVF cycles outnumber privately funded cycles.
In 2024, more than 6,000 cycles of fertility treatment were carried out among more than 4,000 patients in Scotland. Both figures were slightly lower than the record highs recorded in 2022.
The past 20 years have also seen a rise in the number of same-sex female couples and single women receiving fertility treatment.
In 2024, 625 IVF cycles were carried out for women in same-sex couples in Scotland, with more than one third funded by the NHS.
There were 330 cycles involving single women, of which 50 were NHS-funded.
In England, single women can access IVF through the NHS, although eligibility varies according to the local health trust’s policy.
Current Scottish rules state that couples are eligible if they have been living in a stable relationship for two years and neither partner has been sterilised.
Couples where one partner already has a child can be eligible, but those where both partners have children from previous relationships are not.
Eligibility rules also require a body mass index above 18.5 and below 30, and state that couples must not smoke, drink alcohol or take drugs during treatment. The mother must be under 42.
The Scottish government said the review would also examine consistency of access to fertility preservation, including during cancer treatment, as well as reducing waiting times for donor eggs and sperm.
Same-sex female couples already have access to NHS IVF, but they can face long waits for donor eggs or sperm, as can heterosexual couples who require donor treatment.
The National Fertility Group will lead the review and make “costed, demand-modelled recommendations”, which are due to be published by early summer 2027.
The group will include fertility experts from Scotland’s four NHS-assisted conception units in Glasgow, Edinburgh, Aberdeen and Dundee.
Prof Sarah Martins Da Silva, an NHS consultant and chair of fertility medicine at Dundee University, said there were questions to be answered in a resource-stretched NHS.
“As a fertility specialist I’m never going to be disappointed if the criteria is widened,” she said.
“But with single people, as an NHS clinician looking at the competing demands we have, I’d ask the question about whether being single is a health condition that needs to be funded.”
Da Silva said NHS waiting lists were full of couples who require donated eggs or sperm because of medical conditions including cancer and could face longer waits.
“It’s slightly a disservice to them,” she said.
“There would need to be a real investment and resource without making everybody wait an extraordinary long time.
“With the current financial environment we work in, if you’re talking about new money, where would that come from?”
She said she would welcome changes that encouraged more people to donate eggs or sperm and questioned whether arguments about children needing two parents were necessarily relevant to the debate.
“On the one hand bringing up a child is quite an expensive process, and if you don’t have that support, it can be very difficult.
“But on the other hand, many people start off as a couple and divorce.”
Da Silva also welcomed plans for the review to consider eligibility for couples who already have children, describing the move as “fantastic”.
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