News
Women’s Health Strategy risks becoming “PR sticking plaster”, warn campaigners
Experts and women’s health campaigners fear that the government could be using the strategy as a “short-term vote-winner”
England’s Women’s Health Strategy risks becoming a “PR sticking plaster” unless more government funding is made available, campaigners have said.
The Women’s Health Strategy, published for the first time in July 2022, has bold ambitions to tackle inequalities within the health and care system.
As of this year, the initiative seeks to provide better care for menstrual and gynaecological conditions, expand women’s health hubs, improve maternity care and accelerate research.
However, with the UK general election looming, experts and women’s health campaigners have warned that the government could be using the strategy as a “short-term vote-winner” rather than a sustainable, long-term plan.
Kate Muir, women’s health campaigner and author of Everything You Need to Know About the Pill, said: “Until the Women’s Health Strategy is properly funded, it will just be a public-relations sticking plaster covering up ongoing chaos, misery, and year-long waiting lists.
“While Dame Professor Lesley Regan is doing an innovative job, the £25m over two years to fund one-stop-shop women’s health hubs across the country works out at roughly £1 per woman.
“Meanwhile, the government has spent £240m on its failed Rwanda deportation scheme. It is clear women’s health is not a priority.”
Hannah Wrathall, director at the London-based consulting firm Wrapp Consulting, said: “My concern is that the government is using the strategy as a short-term vote-winner.
“The promised funding is not enough. We need to keep reinforcing that addressing women’s health is not only a health issue but one that impacts our productivity and economic growth too.”
Last month, as part of the Women’s Health Strategy, the health secretary Victoria Atkins announced £50m in funding to tackle maternal disparities and support research into other aspects of women’s health. How that will play out, however, remains unclear.
“They specifically talk about research, but we don’t know how they are going to fund that research,” said Karli Büchling, women’s health advocate and founder of Yoni Health.
“What are the actions that they are going to take to prioritise menstrual and gynaecological conditions and women’s health research?
“With regards to research into menstrual and gynaecological conditions, it is solely focussed on how to improve care. We don’t know though what type of research they are going to focus on and how long this budget will be allocated for.”
Currently, the UK has the largest gender health gap in the G20. According to Public Health England, the average woman spends nearly a quarter of her life in poor health compared with a fifth for men.
Despite the fact that one in three women in the UK will suffer from a reproductive or gynaecological problem, less than 2.5 per cent of publicly funded research is dedicated solely to reproductive health.
Dr Bella Smith, GP and co-founder of The Well HQ, said: “For too long women’s health has been medicalised and shrouded in shame and stigma. Women want to talk openly about their symptoms and their experience and be able to understand their bodies at every life stage.
“Too many women suffer with menstrual issues, such as endometriosis, that need more understanding, quicker easier diagnosis and better treatment.
“As a doctor, I want to be able to help my patients to diagnosed and treated quickly, efficiently and effectively. Women need to be heard more, listened to and believed.”
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Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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