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Preeclampsia may be linked to cellular stress in the placenta, study suggests
Although many cases are mild, preeclampsia can lead to serious complications for both mother and baby
Preeclampsia, a condition that affects up to 10 per cent of pregnancies worldwide, could be linked to cellular stress in the placenta, new research has shown.
The study, conducted by researchers from the Medical College of Wisconsin (MCW) and published in the Science Advances journal, investigated the hypothesis that an abnormal amount of cellular and molecular stresses to a particular layer of cells of the placenta is associated with preeclampsia.
Preeclampsia is a condition that occurs in about one of 10 pregnancies. After 20 weeks or more of normal blood pressure during the pregnancy, patients with preeclampsia will begin to experience elevated blood pressure and may also have increased levels of protein in their urine due to hypertension reducing the filtering power of the kidneys.
Although many cases are mild, the condition can lead to serious complications for both mother and baby if it is not monitored and treated. Prolonged hypertension due to preeclampsia can lead to organ damage and life-threatening complications for mothers and foetuses.
“For some patients who can make it to full term, a preeclampsia diagnosis is scary at first but ultimately a bump in the road,” said Jennifer McIntosh, associate professor of obstetrics and gynaecology at the MCW.
“For those who get it earlier on, it can be terrifying and life-changing, potentially including a long hospital stay before delivery and significant supportive care for the infant in the NICU afterwards.
“It is a condition that has existed for as long as women have been giving birth, and yet the only cure for it is delivering the baby.”
MCW scientists aimed to better understand the cause of preeclampsia by focusing on a particular layer of cells of the placenta called the syncytiotrophoblast (STB), a key part of the barrier between the mother and developing foetus.
The authors investigated the hypothesis that abnormal levels of cellular and molecular stresses to the STB can damage the placenta and lead to preeclampsia.
“There is considerable evidence that these stresses accumulate, however, how and why it happens continues to be an open question,” explained Justin Grobe, MCW professor of physiology and biomedical engineering.
“We felt it was important to continue to validate the STB stress findings before advancing work on our hypothesis that elevated hormones of pregnancy contribute to the accumulation of stress by overstimulating the STB.”
The research team studied placentas donated for research purposes. By comparing “normal” placentas with placentas from pregnancies where patients suffered from preeclampsia, investigators demonstrated that preeclampsia was associated with higher levels of cellular stresses in the STB layer on the placenta.
Additionally, the researchers found a hyperactive level of activity of the Gαq protein known to play a role in transmitting signals related to the levels of several hormones present in excessive amounts during preeclampsia.
Megan Opichka, research and development scientist at BioSpyder Technologies and first author on the publication, said: “The donated human placenta samples were critical to identifying potential mechanisms of STB stress.
“Because these samples are collected upon delivery, we then needed to develop an animal model to determine if these sources of stress may actually be causative.”
Based on the findings of hyperactive signalling through G-protein-coupled receptors (GPCRs) in samples from patients with preeclampsia, the scientists developed a new mouse model genetically engineered to enable the precise manipulation of GPCR signals within specific cell types. This allowed them to activate the signalling pathways associated with preeclampsia within the STB layer of the mouse’s placenta.
The team demonstrated that even a very brief activation of the identified signalling cascades during the early or middle portions of gestation led to significant consequences during the mouse pregnancy. The mice developed all the signature signs of preeclampsia, including high blood pressure, kidney damage and other anatomical and cellular changes.
In some mice exposed to the preeclampsia inducing signals, the scientists also tested the effects of a medicine that reduces stress on the mitochondria that generate energy within each cell. The drug provided substantial protection against developing the signs and symptoms of preeclampsia.
“With our unique model, we can study the effects of contributing factors to preeclampsia throughout pregnancy,” Dr Grobe explained.
“We can test specific signalling cascades in specific cells and tissues at specific times to observe their effects. We have only scratched the surface on what we can learn.”
“Because the drug we tested is generally known to be safe, we’re working on plans for a clinical pilot study to test appropriate dosage and efficacy in advance of pursuing larger clinical studies of preeclampsia in the future,” added Dr McIntosh.
“What drives my research is my frustration about the lack of understanding of what causes preeclampsia. We need to continue linking the bench and the bedside together so that we can understand the causes and use them to bring a cure to the bedside.”
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Why cardiovascular health deserves a spotlight in femtech
When we think about women’s health innovation, certain categories immediately come to mind: fertility tracking, pregnancy care, menopause management.
These are vital areas that have long been neglected, and the femtech revolution has brought much-needed attention and resources to them.
But there’s another area of women’s health that remains dangerously overlooked, despite being the leading cause of death for women worldwide: cardiovascular disease.
Heart disease kills more women than all forms of cancer combined, yet most women don’t know this.
For decades, cardiovascular research has been designed around male bodies, male symptoms, and male experiences.
The result is a healthcare system that often fails to recognise when women are having heart attacks, misdiagnoses their symptoms and prescribes treatments that were never tested on female patients.
Women are more likely to die from their first heart attack or stroke than men, and they’re less likely to receive life-saving interventions in time.
This is precisely why the Femtech World Awards have teamed up with Women As One to create a dedicated category for cardiovascular health innovation.
With this award, we want to shine a light on the entrepreneurs, researchers, clinicians and advocates who are working to close not just a gap in care but a gap in innovation, research and recognition.
The cardiovascular health innovation award is an opportunity to celebrate this work and to call for more of it.
If you know of a company, researcher, or organisation doing groundbreaking work in cardiovascular health for women, now is the time to nominate them.
Perhaps it’s a startup developing wearable technology that predicts cardiac events in pregnant women. Maybe it’s a research team uncovering the links between hormonal health and heart disease.
It could be a community health initiative bringing cardiovascular screening to underserved populations of women.
Whoever they, or you are, submit your nomination here.
News
WHO hosts parliamentary dialogue on women’s health
The World Health Organization (WHO) welcomed a delegation of parliamentarians to its Geneva headquarters for a high-level dialogue on women’s health and sexual and reproductive health and rights.
The meeting on 20 January 2026 focused on women’s health, sexual and reproductive health and rights, noncommunicable diseases (long-term conditions such as cancer and diabetes) and global health cooperation.
The exchange was convened by the Konrad-Adenauer-Stiftung and the UNITE Parliamentarians Network for Global Health, bringing together parliamentarians from Albania, Germany, Georgia, Mexico, Slovakia, South Africa, Sri Lanka, Sweden and Zimbabwe.
A central theme was the need to move beyond fragmented approaches to women’s health.
Dr Alia El-Yassir, WHO director for gender, equity and diversity, highlighted that outcomes are shaped by gender inequalities, social norms and structural barriers across the life course, requiring coordinated action across health systems.
Thirty years after the Beijing Declaration and Platform for Action, a landmark framework adopted in 1995 to advance gender equality and women’s rights, Dr Anna Coates, WHO gender equality technical lead, noted that progress on women’s health remains uneven.
She called for health systems that are more gender-responsive and able to address women’s health holistically across the life course.
Parliamentarians stressed that health is inseparable from wider social and economic policies, and called for stronger links between evidence, legislation and measurable impact at country level.
The meeting also focused on sexual and reproductive health and rights, where parliamentarians expressed interest in engaging on issues that directly affect their constituents.
Dr Pascale Allotey, director of WHO’s Department of Sexual, Reproductive, Maternal, Child, Adolescent Health and Ageing, outlined WHO’s life-course approach to sexual and reproductive health and rights.
She highlighted how needs evolve from birth to older age and how these are shaped by social determinants, humanitarian crises and demographic trends.
Dr Allotey underscored the role of parliamentarians in advancing sexual and reproductive health and rights and the importance of continued engagement with WHO to support evidence-based policy-making.
The agenda highlighted cancer as a growing priority for women’s health and for health system sustainability. Dr Prebo Barango, lead for the Cervical Cancer Elimination Initiative, Dr Meghan Doherty, consultant for palliative care, and Santiago Milan, lead for the WHO Global Platform for Access to Childhood Cancer Medicine, presented WHO’s integrated approach to cancer control.
Palliative care is treatment and support that aims to improve quality of life for people with serious illness by managing pain and other symptoms.
The discussion underlined the need for sustained political commitment and domestic investment to address noncommunicable diseases.
Parliamentarians shared national experiences showing the social and economic impacts of cancer on families and caregivers, reinforcing the importance of improving health literacy, reducing stigma and delivering people-centred care.
The meeting also addressed the state of global multilateralism.
Dr Jeremy Farrar, assistant director-general for health promotion, disease prevention and care, outlined how WHO has restructured to enhance efficiency, impact and capacity to support countries.
He reaffirmed WHO’s commitment to more systematic engagement with parliaments, recognising their role in shaping health policy, legislation and budgets.
The exchange concluded with a call for continued collaboration, including through partnerships with the Konrad-Adenauer-Stiftung and the UNITE Parliamentarians Network for Global Health, ahead of the UNITE Global Summit 2026 on 6–7 March in Manila, the Philippines.
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Women’s health firms face banking barriers after being tagged as ‘adult services’
Financial services providers across Europe and the UK are incorrectly classifying female-focused healthcare ventures as high risk enterprises, placing them in the same category as weapons dealers and tobacco companies.
As reported by The Banker, research by advocacy organisation CensHERship found that many women’s wellness technology companies are being denied standard banking services and payment processing facilities because of flawed classification protocols.
The investigation found significant inconsistencies in how financial institutions assess these businesses.
SheSpot, a British company specialising in female intimate wellness, received conflicting decisions from different divisions within the same bank.
Co-founder Kalila Bolton, who took part in the study, explained that one department initially classified their venture as “higher risk” alongside firearms and tobacco, while another branch of the same bank later said they were “fine with it”.
Similarly, HANX, a manufacturer of condoms designed to support vaginal microbiome health, faced payment processing rejection after being incorrectly labelled as an “adult services business”.
Published this week, the CensHERship analysis links these barriers to “outdated classification systems, over-compliance and cultural discomfort” that together prevent legitimate healthcare enterprises from accessing essential financial infrastructure.
The findings suggest that women’s wellness ventures are “routinely flagged, delayed, rejected or deplatformed”, outcomes that stem not from actual regulations but from financial and ecommerce systems that “default to caution” when dealing with women’s health topics that remain poorly understood or culturally sensitive.
CensHERship co founder Anna O’Sullivan said these results usually arise from unfamiliarity rather than deliberate discrimination.
“In most cases, this isn’t malicious or intentional — it’s what happens when people and systems meet something unfamiliar,” O’Sullivan said in a statement.
“But this unconscious bias can materially affect a founder’s ability to start, grow and scale a business.”
Investment platform The Case for Her, which partnered with CensHERship on the report, described the issue through co founders Wendy Anderson and Cristina Ljungberg as a clear “market failure” when founders cannot secure basic banking relationships.
“Fixing this issue is essential if we want to unlock one of the most promising growth markets in global health,” they said.
Risk consultant Aoife Mansfield, managing director at Athrú Group and a contributor to the report, said that terms such as “vagina” or “menstrual” trigger automated alerts within financial systems because they appear on the same watchlists as adult entertainment or pornography, raising a “red flag” in the systems used by banks and payment service providers.
O’Sullivan urged financial service providers to update their internal procedures, review their risk tolerance settings and explicitly include women’s healthcare within their approved client categories.
“They could remove this friction almost overnight,” she said.
The CensHERship analysis includes findings from across the UK and Europe, based on survey responses from more than 30 women’s health enterprises and interviews with founders, insurance underwriters, and compliance and risk professionals.
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