Cancer
Study confirms link between breast density and higher breast cancer risk

Breast density plays a significant role in both the risk of breast cancer diagnosis and the sensitivity of mammography, which may affect screening practices, new research has shown
The study showed that women with dense breasts had a 1.8 times higher likelihood of being diagnosed with breast cancer compared with women with less dense breasts.
Additionally, when accounting for screening sensitivity, the relative risk of developing breast cancer was 1.7 times higher for women with dense breasts.
The study’s lead author, Jane Lange, Ph.D. is a staff scientist at the Oregon Health & Science University Knight Cancer Institute’s Cancer Early Detection Advanced Research Center.
She said: “Breast density has been known to be associated with an increased risk of breast cancer diagnosis.
“What we wanted to do was go beyond that and determine the actual underlying risk of developing breast cancer, separate from the biases in screening.”
The study analysed data from more than 33,000 women in the Breast Cancer Surveillance Consortium from 2000 to 2018.
Researchers found that women with dense breasts were about 1.7 times more likely to develop breast cancer than those with less dense breast tissue.
Mammography is less sensitive in detecting cancer in dense breasts, leading to potential false negatives.
This issue, known as “masking,” may result in missed diagnoses and more interval cancers, where breast cancer is diagnosed between screenings.
The study found that the sensitivity of digital mammography is 73 per cent for women with extremely dense breasts, compared with 93 per cent for women with mostly fatty breasts.
Lange said: “Mammograms are less sensitive for women with dense breasts.
“That means tumors can be missed, leading to delayed detection.
“But on the other hand, women with dense breasts are often advised to get screened more frequently, which can increase the chances of finding cancer earlier.”
To account for these competing factors, the researchers used a novel statistical modeling approach to separate the actual risk of developing cancer from the likelihood of detection.
Their findings support recent updates to U.S. regulations requiring mammography centres to inform patients about their breast density and its implications for cancer risk.
The Food and Drug Administration has mandated that, starting in September 2024, all women undergoing mammograms must be notified if they have dense breasts and be advised of the potential risks.
Lange said: “Our study really reinforces the importance of these requirements.
“Even after accounting for differences in screening sensitivity, we found that breast density is strongly linked to cancer risk.”
While the study does not change current screening recommendations, Lange emphasised that women with dense breasts should be aware of their higher risk and discuss additional screening options, such as MRIs or ultrasounds, with their doctors.
The researcher said: “We’re not making specific recommendations,.
Our study shores up the evidence that breast density is directly linked to breast cancer diagnosis and onset.”
Diagnosis
Women unaware of gynaecological cancers

Only one per cent of women can name all five gynaecological cancers, new research suggests, as 21 women in the UK die every day of the diseases.
The report also found that 31 per cent of women have put off or avoided seeking medical advice for gynaecological symptoms.
It also found that 43 per cent of women invited for cervical screening said barriers had put them off attending, while 18 per cent of respondents aged 25 to 34 who had been invited had never attended.
The five main gynaecological cancers are womb, also called uterine, ovarian, cervical, vulval and vaginal cancer.
The Lady Garden Foundation said that, while progress has been made since the UK government’s 2022 Women’s Health Strategy aimed to improve gynaecological cancer care, significant challenges remain.
John Butler, medical director and trustee at the Lady Garden Foundation, said: “The fact that only one per cent of the population can name the diseases that directly affect half of us underscores a significant awareness gap, impacting individuals’ ability to recognise vital signs and symptoms or seek timely medical help.
“Addressing this isn’t just about awareness; it’s a critical public health priority. Our collective efforts are essential to ensure the latest commitments announced by this government translate into tangible change that saves lives.”
The report said key reasons for delaying medical advice included difficulty making appointments, embarrassment and, for cervical screening, fear of pain or previous bad experiences.
Women also reported challenges within healthcare interactions, including feeling “not taken seriously”, “dismissed” or “not believed” when seeking gynaecological advice.
Jenny Halpern Prince, chief executive and charity co-founder, said: “We frequently hear reports of women feeling ‘not taken seriously,’ ‘dismissed,’ or ‘not believed’ when seeking gynaecological advice.
“These experiences highlight crucial areas where we can improve patient support and trust within our healthcare system, ensuring women receive the empathetic and effective care they need.”
The Lady Garden Foundation said it aims to increase awareness of both the charity and the five gynaecological cancers.
It also aims to serve as a primary entry point for reliable, stigma-free information, helping people understand their bodies, recognise symptoms and overcome barriers to accessing care.
Its Silent No More Garden was unveiled at the RHS Chelsea Flower Show 2026. Designed by Darren Hawkes, the garden serves as a national call to action, using five sculptures to spark conversations, break long-standing taboos and encourage open dialogue about symptoms and preventative care.
Butler said: “Continued focus and collaborative action are essential to progress.
“The ongoing commitment from the government, alongside societal efforts to break down taboos surrounding gynaecological health, are crucial.
“The Lady Garden Foundation is dedicated to being a beacon of information and support, empowering women with the knowledge they need. We urge everyone to learn the signs, speak up, and help us save lives.”
Fertility
AI could transform ovarian care through personalisation, study finds

AI could transform ovarian care by personalising cancer and fertility treatment, but more clinical validation is needed before routine use.
A systematic review and meta-analysis found AI models showed high diagnostic accuracy for ovarian cancer when combining data such as ultrasound scans and blood test results.
Across 81 studies, AI models correctly identified ovarian cancer in around nine out of 10 cases, with pooled rates of 89 to 94 per cent.
They were also highly accurate at ruling out ovarian cancer when it was not present, with specificity of 85 to 91 per cent.
The analysis also found that explainable AI tools could predict complete surgical cytoreduction in advanced ovarian cancer.
Complete surgical cytoreduction means removing all visible cancer during surgery, which can be an important goal in treatment planning.
The tools achieved a pooled AUC of 0.87. AUC is a measure of how well a model distinguishes between different outcomes, with higher scores showing stronger performance.
In reproductive medicine, AI algorithms helped physicians optimise ovarian stimulation protocols and predict follicular growth during IVF.
Ovarian stimulation is the use of hormones to encourage the ovaries to produce eggs, while follicles are the small sacs in the ovaries where eggs develop.
The review found AI could reliably model ovarian response in IVF with a pooled AUC of 0.81.
However, researchers said challenges remain in translating promising research findings into routine clinical practice.
They identified substantial variation across studies, driven by retrospective study designs, variable AI systems and a lack of standardised validation.
Only 22 per cent of analysed studies reported prospective, multicentre external validation, where models are tested forward in time across multiple healthcare settings.
The authors called for rigorous validation to help close the gap between research and routine clinical practice, alongside standardised methodological and reporting frameworks, smooth integration with clinical workflow and robust governance to support responsible and ethical AI use.
They concluded: “Artificial intelligence is a transformative force in the management of ovarian conditions.
“In gynaecologic oncology, AI enhances every phase of care, from early detection and accurate diagnosis to prognostic stratification and surgical planning.”
In reproductive medicine, AI personalises ovarian stimulation and refines the diagnosis of heterogenous endocrine disorders such as PCOS.
PCOS, or polycystic ovary syndrome, is a hormonal condition that can affect periods, skin, weight and fertility.
Cancer
Three cancer innovators shortlisted for Femtech World Award

Femtech World is delighted to reveal the shortlist for this year’s Women’s Cancer Innovation award.
The award, sponsored by Endomag, will honour a groundbreaking innovation dedicated to the prevention, early detection treatment or ongoing care of cancers that uniquely or disproportionately affect women.
Endomag is a medical technology company devoted to improving the global standard of cancer care.
Its Sentimag system, Magseed marker and Magtrace lymphatic tracer are used by thousands of the world’s leading physicians and cancer centres.
After careful review of this year’s submissions, we are delighted to announce the three shortlisted entries for the Women’s Cancer Innovation Award 2026.

Auria is tackling one of the most stubborn problems in breast cancer screening: the 66 per cent of women who simply don’t participate.
Rather than improving existing imaging pathways, Auria is creating an entirely new access layer: a non-invasive, at-home test that detects protein biomarkers for breast cancer in tears.
Auria’s test, a CLIA-certified Lab Developed Test, has been validated across more than 2,000 patients in multiple clinical studies with collaborators including MD Anderson Cancer Center and Stanford University.
It reports a sensitivity of 93 per cent and a negative predictive value of 98 per cent.

Founded on six years of combined research at the University of Barcelona and UC Irvine, The Blue Box has developed a non-invasive, urine-based test that detects breast cancer by analysing volatile organic compound (VOC) signatures – no radiation, no compression, no imaging facility required.
The test achieves a sensitivity of 88.42 per cent, outperforming mammography by 15 per cent overall, and by 30 per cent specifically in women with dense breasts.
The technology could function as a first-line screening tool in primary care settings, as a complement to mammography for high-density patients, or as an accessible alternative in healthcare systems where imaging infrastructure is limited.

Celbrea is a disposable and affordable thermal screening device that empowers women of all ages to stay on top of monitoring their breast health.
The device aims to add to doctors’ existing standard evaluation protocols with a quick, painless examination. Celbrea does not replace a mammogram but simply provides an additional way to screen for breast disease, including breast cancer.
The device consisting of two disposable pads with photochromic sensors. The pads are self-applied to each breast for 15 minutes.
1188 nano-sensors are embedded within a biocompatible multilayer pad, accurately measuring any temperature differences on the surface of the breast using liquid crystal thermographic technology.
What happens next
The shortlisted entries will now be judge by an Endomag representative who will reveal the winner at a virtual awards event on June 19.
Winners will receive a trophy and will be interviewed by a Femtech World journalist.
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