Fertility
Fairtility unveils CHLOE OQ™ expanding its offering into fertility preservation
CHLOE OQ™ secures CE, empowering embryologists and patients with oocyte quality insights for egg freezing, egg donation and IVF applications

Fairtility, the transparent AI innovator powering reproductive care for improved outcomes, has announced the launch of CHLOE OQ™, bringing Oocyte Quality Insights to CHLOE’s core technology suite of capabilities and expanding the applicability of its AI-driven decision support tool to fertility preservation.
The solution will be unveiled at the 39th Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) being held in Copenhagen, Denmark from June 25 to 28, 2023.
With CE declared for CHLOE OQ™, the new Oocyte Quality Insights capability offers IVF professionals comprehensive information to support decision making as patients undergo fertility preservation or assisted reproductive journeys.
The tool delivers predictions of an oocyte’s potential to reach the blastocyst stage post-fertilisation.
“Assessing fertility potential involves understanding three factors: sperm, oocytes and embryos. We can evaluate the viability of embryos and understand sperm quality. However, assessing oocyte quality has remained a statistical gamble,” said Dr Cristina Hickman, chief clinical officer of Fairtility.
“When looking at a seemingly ‘good’ oocyte, we can’t really identify which one will become a blast after fertilisation. CHLOE OQ helps us fill the critical gap, providing evidence-based viability predictions for the evaluation of oocytes.
“This will help clinicians to provide transparency to patients while discussing a failed IVF cycle in fertility preservation, or when assessing and allocating donor eggs.”
Oocyte quality assessment commonly relies on statistical methods based on a woman’s age. Embryologists analyse oocyte quality based on oocyte maturity and characteristics including size, texture, shape, discoloration and fragmentation.
However, these factors have proven to be subjective and lack correlation with the actual quality of the egg.
CHLOE OQ brings the power of AI to oocyte assessment, replacing generalised decision-making with personalised, data-driven AI analysis that reveals the potential of each oocyte backed by biological data.
CHLOE OQ offers personalised data to support decision making for three key applications:
- Egg freezing: In the process of fertility preservation, IVF professionals may recommend an additional oocyte retrieval based on the raw number of oocytes retrieved. While CHLOE OQ cannot change the biology of the egg, it can assist in providing a personalised assessment and managing expectations for family planning early on. CHLOE OQ helps IVF professionals and patients make informed decisions on whether to undergo an additional oocyte retrieval cycle. The tool is designed to optimise the chances of successful IVF in the future and gives women greater control of their reproductive opportunities later in life.
- Egg donation: CHLOE OQ helps fertility clinics and egg banks to further assess the quality of donor eggs, ensuring equitable distribution to recipients. By leveraging data-driven insights, donor-egg providers may match recipients with the most suitable donor eggs, increasing the chances of successful IVF outcomes, maximising limited donor egg resources and enhancing the donor-recipient experience.
- IVF treatment: During IVF, older patients are often guided to utilise donor eggs based on age rather than the true quality of their eggs. At 40-years of age, approximately 10 per cent of patients utilise their own eggs, and by 44-years old, this number drops to one per cent. CHLOE OQ is expected to help IVF professionals consider if a patient’s own eggs have sufficient quality for a successful IVF treatment, or if an egg donor may be a more suitable option. This reduces costs for patients undergoing IVF and maximises egg donor resources. A better understanding of oocyte quality also provides IVF professionals insight on an oocyte’s role in a failed IVF cycle, enabling better treatment decisions for future IVF cycles.
“Adding oocyte analysis broadens CHLOE’s core technology capabilities, extending beyond embryo assessment for IVF. CHLOE OQ now provides decision support for fertility preservation, egg donation, and female-factor infertility in IVF treatment. This expansion allows us to assist a larger population seeking to secure their reproductive futures,” stated Eran Eshed, CEO and co-Founder of Fairtility.
“While we can’t halt the passage of time and the consequent decline in oocyte quality, we can effectively freeze it. With CHLOE OQ, patients, through their fertility care team, can gain transparency into their oocytes’ viability, enabling proactive management of their reproductive health and facilitating well-informed decisions based on biological data.”
CHLOE’s core technology is the first and only decision support tool that combines AI-driven analysis of embryos and oocytes with explainable biological insights in terms that IVF professionals understand and can trust.
This supports data-driven and consistent decision-making in the IVF lab, with a goal of optimising outcomes, making fertility care more efficient and creating new family-building possibilities.

Insight
Working from home linked to higher fertility, research finds
Fertility
UPFs linked to fertility issues in men, study suggests

Men who eat more ultra-processed food may be more likely to face fertility issues, a study suggests.
Ultra-processed foods, or UPFs, include bread, cakes, pastries, fried foods and salty snacks.
They contain artificial ingredients and high levels of fat, sugar and salt. Previous studies have linked UPFs to at least 32 serious health conditions, including heart disease, cancer and dementia.
Romy Gaillard, an epidemiologist at Erasmus University Rotterdam and lead researcher of the study, said: “Our findings suggest that a diet low in UPFs would be best for both partners, not only for their own health, but also for their chances of pregnancy and the health of their unborn child.
“We should move away from the idea that only the health and lifestyle of mothers-to-be is important for pregnancy and offspring outcomes, and recognise that the health and lifestyle of both the mother- and father-to-be play an important role.
“Our results highlight the need to pay more attention to male health in the preconception period, which has traditionally been overlooked.”
The Dutch study tracked health data from 831 women and 651 men who were trying for a baby.
On average, women said about a fifth of their diet consisted of UPFs, while men said roughly a quarter did. More than one in ten couples said more than a third of their diet was made up of UPFs.
Researchers at Erasmus University Rotterdam found that men with the highest UPF intake were at a 75 per cent greater risk of subfertility, where it takes longer for a partner to become pregnant, than those with an average diet.
Just under 40 per cent of the men surveyed experienced subfertility overall, but among those consuming the most UPFs this rose to nearly 70 per cent.
The study also found that the unborn children of women with UPF-heavy diets were slightly more likely to experience developmental issues.
These unborn children had slightly smaller yolk sacs, one of the earliest structures to form in pregnancy during the first six weeks.
They also took marginally longer to develop from a fertilised egg into an embryo, a process known as embryonic growth that generally happens in the first two months of pregnancy.
Previous studies have suggested slower embryonic growth can sometimes be linked to premature birth, miscarriage and an increased risk of heart and blood problems in childhood.
The authors said further research was needed, particularly because the study was observational, meaning it cannot prove that UPF consumption directly led to these fertility issues.
However, the researchers said the findings suggest couples, but particularly men, trying for a baby should avoid UPFs where possible.
Experts welcomed the findings but urged caution over the study’s limitations on such a sensitive subject.
Channa Jayasena, a professor of reproductive endocrinology at Imperial College London, said the results were ‘interesting, but there are several reasons to be cautious interpreting them’.
He said: “First, we have no way of knowing whether it is UPF itself, or some other behaviour that is linked with the things they observed.
“Secondly, the differences observed are tiny, and hardly significant compared with measures such as weight loss.
“This means that even if UPF are causing reproductive problems, their impact on individuals appears very small indeed.
“We know from previous research that in general all couples should prioritise a healthy diet, exercise, and smoking cessation when trying to get pregnant.
“Whether avoiding UPF will offer additional benefits remains unresolved.”
Gunter Kuhnle, a professor of nutrition and food science at the University of Reading, said ‘fertility is an important but very sensitive topic and should therefore be handled accordingly’.
He raised concerns about the questionnaire used in the study, which he said ‘does not appear to have been developed or validated for ultra-processed food’.
Kuhnle added: ‘Given that the assessment of ultra-processed food intake has severe limitations, the conclusions of the study, and the recommendations, need to be interpreted carefully.”
Fertility
Peers push to pardon women criminalised under abortion laws

Peers are set to debate abortion law changes that would pardon women in England and Wales already criminalised and halt active police investigations.
Last summer, MPs voted to end the criminalisation of women who terminate pregnancies outside the legal framework through a new clause in the crime and policing bill.
The House of Lords will consider its own series of amendments to the legislation on Wednesday, including two that would end active police investigations into suspected illegal abortions and pardon women who have already been criminalised.
Liberal Democrat peer Elizabeth Barker, who has put forward one of the amendments, said: “When I heard how the system has treated these women and girls when they are at their most vulnerable, and how they may have to explain this every time their [disclosure and barring service] check gets renewed, it was clear this cruelty had to be stopped.”
“Although there are far fewer who have been convicted, that conviction is a life sentence, it prevents them getting jobs, and even when renewing their car insurance every year they’ll have to explain they have a lifelong criminal record.”
Becca was 19 and working as a healthcare assistant in a hospital in the north of England when she realised she was pregnant.
She had had no signs of pregnancy over the prior months and assumed she had only just conceived.
She went to a clinic and saw a doctor who gave her abortion pills, but when she did not experience the bleeding she had been warned to expect, she called NHS 111 and was advised to go to A&E.
A scan then showed she was six months pregnant, and Becca gave birth to her son Harry within an hour.
Because Harry was born at 28 weeks, meaning very prematurely, he was moved to a hospital better equipped to care for premature babies, and then to a third hospital.
“And that is the hospital that ended up calling the police on us,” Becca said.
A few weeks after Harry was born, police arrived at Becca’s home and arrested her for attempted child destruction. Her partner was arrested at the hospital where he had been visiting their son.
Their electronic devices were confiscated. Social services told the couple they were not allowed any unsupervised contact with their son for several months, and it was not until 15 months later that the police investigation was dropped.
Because abortion offences are classed as violent crimes, the fact of an arrest can still be disclosed on a disclosure and barring service check even without a conviction. A disclosure and barring service check is a background check often used by employers.
Becca, now 21, said: “You don’t want to have to tell such a traumatic event to a random stranger who’s going to be your boss.”
If the law was changed so that her arrest records could be erased, she said: “I think it would just be almost like a release from it.
“We could just be able to live a normal life, because it’s having an impact on job applications and plans for the future.”
Her mother, Anne, said: “She’s thinking of training to be a nurse or a midwife, and all of that, I mean it’s possible now, but it’s going to be awkward because she’s going to have to declare it. If that’s gone, she can just carry on just like any 21-year-old making plans.”
Nikki Packer, who was last year cleared of carrying out an illegal abortion, said: “The lasting effects on myself and other women placed under investigation aren’t something I can simply ‘get over’. The current law is ancient, it’s time it reflects modern society.”
Dr Alison Wright, president of the Royal College of Obstetricians and Gynaecologists, said the college was calling on peers to follow the House of Commons and support clause 208, “ensuring that women are no longer at risk of investigation or prosecution for decisions about their own healthcare”.
She added: “It is also vital that the harm already caused is addressed.
“That is why we are also urging peers to support amendment 426B, which would pardon women previously prosecuted under outdated and unjust abortion laws.
“Women who have faced investigation or conviction should not have to continue living with the consequences of this archaic legislation.”
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