Diagnosis
Home urine tests could detect breast cancer, endometriosis and PCOS

“Game-changing” home urine tests to detect early stage breast cancer are being developed in Wales, alongside similar work on endometriosis and polycystic ovary syndrome.
Researchers said they hope to have a prototype kit within the next year to detect early stage breast cancer using a lateral flow urine sample. Lateral flow tests are simple strip-based devices used during the Covid-19 pandemic.
A similar test is now also being explored for endometriosis and polycystic ovary syndrome, or PCOS, which in the long term could help reduce diagnostic waiting times.
The developments form part of wider work on women’s health in Wales, with women’s health hubs being rolled out across all parts of the country.
The research is being led by Prof Luis Mur at Aberystwyth University, who said key changes could be identified in urine to detect breast cancer “with a high degree of accuracy” and that new at-home tests were being developed to complement existing diagnostic tools.
“We’ve found very important changes in urine to tell you’ve got breast cancer, and even [which] stage of breast cancer,” he said.
“We’re building little kits that are based on urine that actually allow you to go to your GP and have it done, or even do it at home.”
Mur said it could take about 18 months to develop the lateral flow prototypes, followed by a further three to five years of testing to confirm accuracy.
“We need to have 90 per cent accuracy or greater, at the moment we’ve got it, but we need to make sure we get that with the kit itself,” he said.
He added that researchers were now applying the same approach to detect endometriosis and PCOS, where “diagnoses are very poor and also very delayed”.
The breast cancer testing kits are among projects funded by the Welsh government’s £75m investment in women’s health research, as part of the women’s health plan.
Dr Helen Munro, clinical lead for women’s health in Wales, said one of the goals of the Women’s Health Research Centre was to bring research findings, such as the work at Aberystwyth University, into clinical practice “in a timely way”.
“Currently there’s evidence to suggest it takes 17 years for evidence to get into practice, Munro said.
“But what we’re doing in Wales is working really closely with our academic universities and health boards to shorten that gap.”
The 10-year women’s health plan in Wales, published in December 2024, also set out ambitions for women’s health hubs in each health board.
By the end of this month each health board will have at least one hub serving part of their community, though Munro said “each will look different”.
In west and mid Wales, Hywel Dda health board has split the region into seven GP clusters, each of which will have a women’s health service.
GPs in each cluster have been trained to provide menopause and contraceptive care and can take referrals from other surgeries, bringing specialist care closer to home.
“We’re aiming to see a reduction in referrals into secondary care, with women referred into the hub in a timelier fashion,” said Dana Scott, who is leading the women’s health plan for Hywel Dda.
Dr Lauren Thomas, a sexual health doctor who has been training GPs in more remote areas to fit coils and contraceptive implants, said ultrasound biopsies would also be available in each county.
“As a GP I see women wait months and months and months to see gynae [specialists] because obviously the secondary care service has to prioritise suspected cancer cases,” she said.
“Women are left with pelvic pain or [with] endometriosis waiting a long time for discussions, investigations and treatments that they could access in a community-based clinic, and hopefully we’ll be able to bring that to women moving forward.”
Munro said all hubs had been asked to deliver on three priority areas: menopause care, contraception and pelvic health.
Sarah Murphy MS, minister with responsibility for women’s health, said each health board was “starting from different places”.
She said: “They’re trying to fill in the gaps, breaking down the barriers for each of those locations and communities.
“But as we go forward there’ll be an evaluation and we’ll spread that good practice across Wales.”
Diagnosis
Trust to decide how far back to review unnecessary breast cancer surgeries

A health trust will decide how far back to review breast cancer cases after more than 30 women were found to have undergone unnecessary surgery.
It has already been established that hundreds of patients came to harm during treatment at the breast unit at County Durham and Darlington Foundation Trust (CDDFT).
The trust has apologised and is using specialists from other hospitals to review cases to see if other women underwent unnecessary operations or received otherwise poor care.
An extraordinary trust board meeting in Durham will consider the scope of its Look Back Exercise.
Board papers recommend reviewing cases as far back as 2015, working backwards one year at a time.
Documents estimate that this could take five years and involve reviewing the care of approximately 4,500 patients.
Members of the Pink Justice Network, an online support group for women who have received breast cancer treatment from the trust, will attend the meeting.
Nadeen Lister, who runs the group of around 150 women with Amelia Green, said members were calling for a public inquiry into what went wrong.
Lister told the Press Association: “When we started the group, nobody was talking about compensation, they just wanted justice for what has been done.
“The Look Back Exercise has cost the trust more than £500,000 this year, with staff checking back over records, medical experts reviewing cases and psychological help offered to patients affected.”
Green said the trust could avoid the expense of the exercise “by backing our call for a public inquiry”.
Hayley Collinson, of Hudgell Solicitors, which represents many affected patients, said: “Given the scale of harm revealed so far, we can’t see how the Trust board can come to any other decision than to extend this lookback investigation given the findings of the first batch of cases to have been reviewed, and the high percentage of harm being identified.
“The reality is that any woman who had breast cancer treatment at this Trust from 2015 onwards is now going to be questioning whether their treatment was appropriate and if they were actually harmed.”
Diagnosis
Breast cancer patients face ‘postcode lottery’ for new drug

Breast cancer patients in Scotland face a postcode lottery that could limit access to two newly approved NHS treatments.
The Scottish Medicines Consortium has approved Elacestrant and Capivasertib, which could be life-extending for some people with metastatic breast cancer.
Eligibility depends on genetic testing to confirm gene mutations before treatment can be prescribed, but the necessary testing is not yet available through the NHS in Scotland.
The testing is available to patients in England and to those able to pay for it privately.
Claire O’Donnell, who was diagnosed with metastatic breast cancer at 37, has raised concerns about the difference in access.
Ten years after her diagnosis, O’Donnell is receiving a treatment that works for her but does not know when it may stop being effective.
She said: “I know how lucky I am. It’s certainly not been easy but I’m incredibly lucky and incredibly privileged to be in that position.
“I’ve watched a lot of my friends die, and a lot of the circumstances has been about not being able to access a drug or getting the drug too late or being too poorly by the time the drug becomes available to them. It makes me angry, and it makes me sad.”
O’Donnell, who has been supported by secondary breast cancer charity Make 2nds Count, is frustrated by the gap in care for patients in Scotland.
She said: “These drug are a lifeline to people. It makes all the difference, and it only takes one drug to be your drug that you know can give you six months a year, two years, five years. It’s almost like they’ve given you a bit of good news, but they’ve also put a little bit of a criteria on it that you know they dangle the carrot in front of you.”
David Cameron, professor of oncology at Edinburgh University and chair of trustees for Make 2nds Count, said the system needed improving to better support patients.
He said: “It’s a frustration for many of us in the clinic because for a long time we’ve been saying as we move into an era of medicines, not just cancer medicines, but medicines that are increasingly driven by special tests, we need a system which absolutely locks the two things together.
“There has been progress in that direction, but they’re not locked together. this comes down to the way the NHS is in a sense fragmented internally.”
Health secretary Angela Constance said: “I welcome the acceptance of Elacestrant, known as Korserdu, for treatment of post-menopausal women, and men, with a certain type of advanced breast cancer.
“We work closely with the independent SMC and the NHS in Scotland to improve access to new medicines, helping to expand the range of treatment options available.
“We are aware that a genomic test is needed in order to access this therapy, and we are working in collaboration with the NHS and industry partners to secure access to this as soon as possible.”
Diagnosis
New test could cut need for invasive womb cancer checks

A urine and vaginal fluid test could help rule out womb cancer in women with postmenopausal bleeding, potentially reducing invasive checks.
In a study of 1,864 women with postmenopausal bleeding, the test identified 80 of 99 womb cancers and correctly gave a negative result for 93 per cent of women without the disease.
Researchers said the test was not accurate enough to rule out cancer on its own, but could help fast-track women at the highest risk for urgent investigation while reducing immediate invasive testing for those at lower risk.
Professor Emma Davidson, of the University of Manchester and Manchester University NHS Foundation Trust, said: “Bleeding after the menopause is understandably alarming for women because it can be a sign of cancer, but the vast majority of those investigated will not have the disease.
“At the moment, many women face invasive, uncomfortable tests that can be stressful as well as costly for health services before cancer can be ruled out.
“Our study shows that a simple test using urine and vaginal samples could help identify the women most likely to have cancer while safely reassuring many others much earlier in the diagnostic pathway.
“If further studies confirm these findings in routine practice, this approach has the potential to transform care for thousands of women every year.”
Developed at the University of Manchester and Manchester University NHS Foundation Trust, the test examines cells collected from urine and vaginal fluid samples.
Postmenopausal bleeding currently triggers an urgent cancer referral, although only about 5 to 10 per cent of women who report it have an underlying cancer.
Current investigations include an internal ultrasound scan, a biopsy of the womb lining and hysteroscopy, in which a camera is passed into the womb.
Women taking part in the study attended seven hospitals in north-west England and provided urine and vaginal fluid samples before undergoing their routine tests.
Five per cent of participants, 99 of 1,864 women, were diagnosed with womb cancer through biopsy or surgery.
Cytologists assessed the samples without knowing the women’s diagnoses.
Researchers said the test could be used to triage women suspected of having womb cancer, with lower-risk patients monitored through repeat sampling or given a full assessment if symptoms continued.
They cautioned that the samples were assessed by highly trained specialist cytologists, so it is not yet known whether the same accuracy could be achieved in other settings.
The test has also not been studied in women without symptoms.
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