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Females have a 31% higher risk of developing Long Covid

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Females have a 31 per cent higher associated risk of developing Long Covid, with women aged 40 to 55 years having the highest propensity, according to a new study.

The study followed 12,276 participants over time to identify the risk of developing Long Covid, and found females with a “risk ratio” of 1.31 compared with males, equating to 31 per cent higher associated risk.

This was even when considering factors like race, ethnicity, Covid variant, severity of Covid infection and other non-medical social factors that affect health.

The risk among females for developing long Covid was dependent on age, pregnancy and menopausal status.

“These findings show that patients and health care teams should consider the differences in long COVID risk as it relates to sex assigned at birth,” said Dimpy Shah,  assistant professor of population health sciences at UT Health San Antonio.

“Understanding these differences can help us recognise and treat patients with Long Covid more effectively.”

“This important study from the RECOVER cohort identifies risk factors for long COVID that are critical in providing insights for prevention and treatment of this often debilitating disease,” said Thomas Patterson, professor of medicine at UT Health San Antonio.

Largest cohort study for Long Covid

Worldwide, SARS-CoV-2, a strain of coronavirus that causes Covid-19, has infected more than 700 million people, with an estimated seven million deaths, the study notes. Although many individuals recover from acute Covid-19, a substantial portion experience long-term effects, called Long Covid, or post-Covid condition.

Other post-viral and autoimmune conditions have a female predominance, but whether the same is true for Long Covid, especially within different subgroups, has been uncertain.

Numerous studies had shown that males have more severe acute Covid-19 cases and higher mortality than females. However, emerging literature suggested that females may be at greater risk for new and persisting symptoms following initial infection.

Studies had yet to fully account for factors that may distort the true estimate of biological sex-related risk – like age, menstrual status, comorbidities, vaccination status, variants of concern, severity of acute illness and differential engagement in health care. Some studies relied upon relatively small sample sizes or those lacking ethnic or racial diversity.

The RECOVER researchers set out to evaluate sex differences in the risk of developing Long Covid among adults with SARS-CoV-2 infections, accounting for distorting factors and representing the largest cohort to date followed up in a natural history study of Long Covid.

Data was examined from participants who had a qualifying study visit six months or more after their initial Covid-19 infection. Gender was defined as self-reported sex assigned at birth.

The scientists measured development of Long Covid using a self-reported symptom-based questionnaire and scoring guideline at the first study visit. They used propensity score matching to estimate risk ratios and risk differences.

The full model included demographic and clinical characteristics, and social determinants of health, with a reduced model including only age, race and ethnicity.

The full model found the 31 per cent higher risk for females, with a mean age of infection at 46 years. Among participants aged 40 to 54 years, the risk was even higher – at 42 per cent higher in menopausal participants and 45 per cent higher in non-menopausal female participants, compared with male participants.

“This study gives us new knowledge and builds on other studies that also looked at sex assigned at birth and Long Covid,” Shah said.

“Because of the size of the RECOVER study and the diversity of participants, we had a special opportunity to look at sex assigned at birth while also considering things like vaccination status, autoimmune disease, diabetes, BMI and Covid variant.

“We hope this encourages other researchers to explore why there are differences in the risk of developing Long Covid based on your assigned sex at birth,” she said.

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Wellness

Elimination of cervical cancer in EU an ‘achievable goal’, report finds

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Cervical cancer elimination in the EU is becoming achievable as HPV vaccination coverage rises, a new report says.

As Europe marks European Immunisation Week 2026, the European Centre for Disease Prevention and Control said progress in human papillomavirus vaccination is continuing across the EU and European Economic Area.

All EU and European Economic Area countries now recommend HPV vaccination for adolescent girls and boys as part of their immunisation programmes, marking a major step forward in Europe’s cancer prevention efforts.

Bruno Ciancio, head of unit, directly transmitted diseases and vaccine preventable diseases at the European Centre for Disease Prevention and Control, said: “The elimination of cervical cancer in the EU/EEA is becoming an achievable goal, thanks to the HPV vaccination programmes.

“The progress we are seeing across Europe demonstrates what can be accomplished when countries invest consistently in effective immunisation strategies.

“We are closely monitoring this progress and actively supporting countries to accelerate uptake and move faster towards cervical cancer elimination.”

According to the report, three EU and European Economic Area countries, Iceland, Portugal and Norway, have reached the 2024 EU Council Recommendation target of 90 per cent HPV vaccination coverage among girls by the age of 15.

Fifteen years after HPV vaccination programmes were introduced in Europe, a growing body of evidence confirms the vaccine is highly effective in preventing cervical cancer.

Large-scale studies from Sweden, the Netherlands and Denmark, as well as other parts of the world, have shown significant reductions in HPV infections and precancerous lesions, which are abnormal cell changes that can develop into cancer if left untreated, alongside falling cervical cancer rates among vaccinated women.

Since 2020, European countries have reported a decreased incidence of cervical cancer among vaccinated women.

Studies from Sweden, Denmark and the UK show that early administration of the vaccine increases its full protective potential.

A Swedish study suggested that vaccinating girls before their 17th birthday reduced the incidence of cervical cancer by 88 per cent.

An additional six-year follow-up found a sustained reduction in cervical cancer risk and a population-level decline in invasive cervical cancer incidence after HPV vaccination.

The report showed that vaccination programmes and health system design are critical factors in reaching high levels of HPV vaccination coverage.

Evidence from across Europe showed that school-based vaccination programmes are particularly effective and tend to reach higher levels of coverage among both girls and boys.

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Mental health

Poor mental health, poverty and pollution significantly raise women’s heart failure risk – study

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Poor mental health, poverty and pollution can raise women’s heart failure risk, with up to one in four cases potentially preventable, a study has found.

UK Biobank data from more than 230,000 women suggest that depression, socioeconomic hardship and exposure to polluted environments are linked to a significantly higher risk of heart failure in women.

Heart failure happens when the heart becomes too weak or too stiff to pump blood effectively around the body.

High blood pressure, high cholesterol, smoking and diabetes are among the better-known risk factors often targeted in public health campaigns.

Peige Song from China’s Zhejiang University and her team found that living in polluted areas, having poor mental wellbeing, facing socioeconomic deprivation and experiencing chronic inflammatory conditions such as lupus, in which the immune system attacks the body’s own tissues, make women more prone to heart failure.

These risks, however, are often overlooked.

The researchers found that mental wellbeing, environmental exposures, socioeconomic circumstances and reproductive history together contributed almost as much risk for heart failure as all well-known risk factors combined.

The study also found that risk rises with socioeconomic hardship and chronic inflammatory conditions such as lupus or rheumatoid arthritis, approaching the impact of conventional risk factors.

Song said: “[The study] is a call to redefine prevention in women’s cardiovascular health, integrating biological, psychosocial and structural determinants into a unified, equitable approach.

“One in four heart-failure cases in women could be prevented if all under-recognised risk factors were eliminated, assuming causal relationships.”

While completely eliminating all risks is not realistic, Song said “even partial reductions through better mental health services, social equity policies and environmental regulations could yield significant public health benefits”.

Catherine Pirkle, a women’s health specialist at the University of Hawaiʻi at Mānoa in the US, who was not involved in the study, said: “These calculations show convincingly that under-recognised and female-specific risk factors contribute significantly to heart failure in women, independently of the well-established ones.”

Song said: “It’s important to understand that heart health is influenced by more than just blood pressure or cholesterol.

“Factors like mental wellbeing, reproductive milestones and socioeconomic conditions all matter. Awareness and advocacy for comprehensive, gender-sensitive care are key.”

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Resistance training has preventative effects in menopause, study finds

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Resistance training improves hip strength, balance and flexibility during menopause and may also improve lean body mass, research suggests.

A study of 72 active women aged 46 to 57 found those who completed a 12-week supervised programme saw greater gains than those who kept to their usual exercise routines.

None of the participants were taking hormone replacement therapy.

The supervised, low-impact resistance exercise programme focused on strength at the hip and shoulder, dynamic balance and flexibility.

Participants used Pvolve equipment, including resistance bands and weights around the hips, wrists and ankles, and also lifted dumbbells of varying loads.

Women in the resistance training group showed a 19 per cent increase in hip function and lower-body strength, a 21 per cent increase in full-body flexibility and a 10 per cent increase in dynamic balance, meaning the ability to stay stable while moving.

Those in the usual activity group did not show any significant improvements.

Previous studies have assessed the decline in lower limb strength and flexibility during menopause, but this is said to be the first study to compare the effect of resistance training on muscle strength and mass before, during and after menopause.

This was done by including participants in different phases of menopause rather than following the same participants over a long timeframe.

Francis Stephens, a researcher at the University of Exeter Medical School in the UK, said: “These results are important because women appear to be more susceptible to loss of leg strength as they age, particularly after menopause, which can lead to increased risk of falls and hip fractures.

“This is the first study to demonstrate that a low-impact bodyweight and resistance band exercise training programme with a focus on the lower limbs, can increase hip strength, balance, and flexibility.

“Importantly, these improvements were the same in peri- and post-menopausal females when compared to pre-menopausal females, suggesting that changes associated with menopause do not mitigate the benefits of exercise.”

Although one of the researchers sits on Pvolve’s clinical advisory board, the researchers said the company did not sponsor the study or influence its results.

Stephens added that any progressive resistance exercise training focused on lower-body strength is likely to yield the same results.

He said: “The important point is for an individual to find a type of exercise, modality, location, time of day etc., that is enjoyable, sustainable, and improves everyday life.

“The participants in the present study reported an improvement in ‘enjoyment of exercise,’ and some are still using the programme since the study finished.”

Kylie Larson, a women’s health and fitness coach and founder of Elemental Coaching, who was not involved in the study, said the results were compelling.

She said: “This is particularly exciting for those that tend to think of menopause as ‘the end’. The study proves that if you incorporate strength training you can still make improvements to your muscle mass and strength, which will also have a positive ripple effect to your ability to manage your body composition.

“In addition, staying flexible and being able to balance are both keys to a healthy and functional second half of life.”

Participants in the study did four classes a week for 30 minutes each session, but Larson said even half that amount of strength training can go a long way, particularly if you emphasise progressive overload, which means gradually increasing muscle challenge through more weight.

Larson said: “Gradually increasing the challenge is what drives real change.

“Lifting heavier over time is what builds strength, protects your bones, and keeps your body resilient through menopause and beyond.”

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