News
UK government to invest £10m in new breast cancer screening units
The government has pledged £10m to speed up breast cancer diagnosis and treatment
The UK government has announced a £10m investment to develop 29 new breast cancer screening units.
The units will be directed to areas where they are most needed to increase capacity and speed up diagnosis and treatment.
The announcement follows concerns voiced by the charity Breast Cancer Now over a decline in breast cancer early-stage diagnosis as a result of the pandemic.
The data has shown a dip in the rate of early, stage one and two, breast cancer diagnosis – a sharp contrast to the years leading up to the pandemic when early diagnosis rates were rising.
The government’s latest investment is hoped to reverse the trend, allowing more women to be screened earlier and access care closer to home.
“Last year 100,000 people were diagnosed with cancer at stages one and two. This is the highest proportion on record but we want to do better still,” said Minister of State for Health, Helen Whately.
“These breast cancer screening units will mean more people can get checked for cancer, closer to home.
“Most people will get the reassurance of an all-clear but for those who are diagnosed, catching their cancer early is the best thing we can do.”
As part of the investment, the government will provide 16 new mobile breast screening units, 13 static units, 58 live remote access upgrades for existing units and 10 software upgrades in areas with existing units to carry out ultrasounds and X-rays.
The funding is now in place for NHS trusts to spend within the 2022 to 2023 financial year and the timing for delivery of units will be individual to each trust.
Steve Russell, NHS national director for screening and vaccinations, said: “Screening is vital in detecting breast cancer early and getting better outcomes for patients, and this further investment is great news for improving access to breast screening services for women across England.
“This funding will help increase screening rates among women from communities and regions where uptake is lowest by improving facilities in both fixed and mobile locations, making it easier for more women to get checked, and we encourage anyone invited for a screening to take up their appointment without delay and help us catch cancers earlier when they are easier to treat.”
Ciarán Norris, head of campaigns and public affairs at Macmillan Cancer Support, said: “We welcome any intervention that helps to speed up diagnosis and improve access to cancer screening services, particularly in areas where they are most needed, as we know the earlier someone is diagnosed the better their outcome is likely to be.
“Alongside this, we also look forward to working with the government on steps to grow and sustain the cancer workforce, to ensure our cancer services can provide timely treatment and care for everyone living with cancer, both now and in the future.”
Breast screening is one of the best ways to spot a cancer that is too small to feel or see. Each year more than two million women have breast cancer screening in the UK through the NHS Breast Screening Programme.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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