Pregnancy
Research to treat placenta could improve human pregnancies

A gene therapy approach to boosting the placenta is safe in monkeys, according to a new, short-term study, bringing the potential treatment closer to improving birthweights of human babies and sparing them the complications of an early birth and developmental difficulties later in life.
In humans, placental insufficiency restricts the growth of developing foetuses and typically leads to premature delivery and extended stays in the neonatal intensive care unit.
“The placenta, although transient and typically discarded after pregnancy, is an organ that is so critical to ensuring healthy babies,” says Jenna Schmidt at the University of Wisconsin–Madison.
“Placental insufficiency contributes to poor nutrient and oxygen transport to the foetus and low birth weight, but there is currently no way to treat the placenta.”
A poor environment in the womb can also lead to problems in adult life, such as cardiovascular disease and neurocognitive developmental conditions, according to Schmidt. Risk factors for placental insufficiency can include high blood pressure, preeclampsia, diabetes and smoking, but in many cases placental insufficiency has no identifiable cause.
“If we can improve placental function to better support growth and development, could we extend those pregnancies to term with the outcome of healthier babies at birth and throughout their lives?” Schmidt asks.
University of Florida placenta research expert Helen Jones and her lab — with the help of AI platforms to identify targets for treatment — developed a nanoparticle loaded with a small strand of DNA that encodes for a human protein called IGF-1.
IGF-1 signalling is important for normal placental development. In pregnancies complicated by foetal growth restriction there are lower levels of this protein, contributing to smaller birthweights and the increased risk of adult diseases.
The researchers injected the nanoparticles into the placentas of pregnant monkeys and found that the DNA strands were successfully taken up and expressed in the animals’ placentas within 24 hours without harm to the animals or their developing foetuses and without signs of off-target effects.
“Our studies so far in mice and guinea pig models of placental insufficiency are very encouraging,” says Jones, whose work is supported by the National Institutes of Health’s Eunice Kennedy Shriver National Institute for Child Health and Development.
“And now, with this pilot study demonstrating no detrimental impact in normal non-human primate pregnancies, we are excited to continue to optimise and further target this therapy.”
Jones knew that to move the research toward clinical impact, safety studies were necessary in the rhesus macaque model of human pregnancy.
“This was the first study to test this treatment in macaques and it worked,” Schmidt says.
“The transgene was indeed expressed and there was no immune reaction from mom. We saw a signal of the transgene’s expression as far as 10 days after treatment, which was really encouraging. Maybe that could translate into a nanotherapy infusion every two weeks in humans after mid-pregnancy.
“That is usually when doctors see that the foetus is smaller than normal through ultrasound diagnoses. But there is a lot more work to do before we can move this into human trials.”
The researchers’ next step in rhesus macaques is to extend the therapy through the third trimester of pregnancy, and ultimately to measure the impact on mother and foetus through birth.
“Our goal is to improve placental function, extend pregnancies, and see more healthy babies and adults,” Schmidt said.
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More than half of women with gestational diabetes face harmful stigma, research reveals

More than half of women with gestational diabetes report stigma from healthcare staff, family, friends and wider society, new research shows.
A survey of 1,800 UK women found widespread emotional distress at diagnosis of the condition, a form of high blood sugar that develops during pregnancy, with effects lasting beyond birth.
Gestational diabetes affects around one in 20 pregnancies in the UK, and the findings highlight the wider toll on women diagnosed with the condition.
The study was funded by Diabetes UK and led by researchers at King’s College London and University College Cork.
Dr Elizabeth Robertson, director of research and clinical at Diabetes UK, said: “Stigma can have a dangerous and devastating impact on pregnant women diagnosed with gestational diabetes, particularly at a time when emotions and anxieties may already be heightened.
“We know that stigma can lead to shame, isolation and poorer mental health, and may discourage people from attending healthcare appointments, potentially increasing the risk of serious complications.
“This research highlights the urgent need for better support systems, based on understanding and empathy to ensure no one feels blamed or judged during their pregnancy.”
More than two-thirds of women, 68 per cent, reported anxiety at diagnosis, while 58 per cent felt upset and 48 per cent experienced fear.
The psychological impact continued beyond birth, with 61 per cent saying the condition negatively affected their feelings about future pregnancies.
Nearly half of women, 49 per cent, felt judged for having gestational diabetes, while 47 per cent felt judged because of their body size.
More than 80 per cent felt other people did not understand gestational diabetes, and more than a third, 36 per cent, concealed their diagnosis from others.
Gestational diabetes stigma was also common in healthcare settings, with 48 per cent reporting that professionals made assumptions about their diet and exercise, and more than half, 52 per cent, feeling judged based on their blood glucose results.
Many women described a loss of control and a sense of disruption during pregnancy.
Nearly two-thirds, 64 per cent, felt they were denied a normal pregnancy, while 76 per cent reported a lack of control over their pregnancy.
More than a third, 36 per cent, felt abandoned by healthcare services after giving birth, and one in four, 25 per cent, continued to experience depression or anxiety postpartum.
Focus group participants described harmful stereotypes, including assumptions that they were ‘lazy’, had ‘poor eating habits’ or ‘lacked willpower’.
Comments from family and friends included remarks such as “should you be eating that?” and “you must have eaten too much, that’s why you have gestational diabetes.”
The researchers are calling for targeted interventions alongside structured emotional support for women during and after pregnancies affected by gestational diabetes, to improve both mental and physical health outcomes.
Professor Angus Forbes, lead researcher from King’s College London, said: “Stigma and emotional distress are far more common in women diagnosed with gestational diabetes than many realise.
“Everyday interactions, even with those who mean well, can deepen this harm, shaping women’s emotional wellbeing and the choices they feel able to make.
“It’s clear that meaningful action is needed to protect women’s mental and physical health.”
Risk factors for gestational diabetes include living with overweight or obesity, having a family history of type 2 diabetes, and being from a South Asian, Black or African Caribbean or Middle Eastern background.
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