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AI model could predict breast cancer risk without racial bias, study finds
The deep learning model has been shown to outperform traditional risk models in predicting a woman’s risk of developing breast cancer
A new AI model developed using mammogram image biomarkers could accurately predict both invasive and non-invasive forms of breast cancer without racial bias, new research has shown.
The findings, presented at the annual meeting of the Radiological Society of North America (RSNA), have suggested the model showed no bias across multiple races.
Traditional breast cancer risk assessment models use information obtained from patient questionnaires, such as medical and reproductive history, to calculate a patient’s future risk of developing breast cancer.
Data shows old models are more likely to demonstrate poor performance across different patient races, most likely due to the data used to develop the model.
“In the domain of precision medicine, risk-based screening has been elusive because we have not been able to accurately evaluate a woman’s risk of developing breast cancer,” said study lead author Leslie R. Lamb, a breast radiologist at Massachusetts General Hospital (MGH) in Boston.
“Even the best existing traditional risk models do not perform well on the individual level.
“Traditional models likely have racial biases due to the populations on which they were developed. Several of the commonly used models were developed on predominantly European Caucasian populations.”
According to the American Cancer Society, Black women demonstrate the lowest five-year relative survival rate for breast cancer among all racial and ethnic groups. This translates to a six per cent to eight per cent disparity in five-year survival rates between Black and white women across all breast cancer types.
The new deep learning AI risk assessment model developed using mammographic images has been shown to outperform traditional risk assessment models in future breast cancer development while also mitigating the racial biases seen in traditional models.
In the first study of its kind, Dr Lamb and colleagues assessed the performance of the image-based deep learning risk assessment model in predicting both future invasive breast cancer and non-invasive breast cancer across multiple races.
The study included 129,340 routine screening mammograms performed in 71,479 women between 2009 to 2018 with five-year follow-up data. Patient demographics were obtained from electronic medical records and instances of cancer were identified from the regional tumour registry.
The racial makeup of the study group included white, Black, Asian, self-reported and other races. The mean age of the women was 59 years old.
The deep learning model was shown to outperform traditional risk models in predicting a woman’s risk of developing early-stage, non-invasive breast cancer, also known as ductal carcinoma in situ (DCIS), as well as invasive breast cancer, known as invasive carcinoma.
“The model is able to translate the full diversity of subtle imaging biomarkers in the mammogram, beyond what the naked eye can see, that can predict a woman’s future risk of both DCIS and invasive breast cancer,” explained Lamb.
“The deep learning image-only risk model can provide increased access to more accurate, equitable and less costly risk assessment.”
Constance D. Lehman, senior author and breast radiologist at MGH, said: “This is a particularly exciting domain for AI, as it demonstrates the opportunity to apply ‘AI for good’—to reduce well-known racial disparities in risk assessment.
“We are now poised to translate these findings into improved clinical care for our patients.”
Women with ADHD are nearly twice as likely to experience perimenopause symptoms compared with women without ADHD, new research has revealed.
The study reported 54 per cent of women with attention deficit hyperactivity disorder had perimenopausal symptoms, compared with 30 per cent without the condition.
Among perimenopausal women with ADHD, 59 per cent reported psychological symptoms such as anxiety, low mood, irritability and fatigue.
Physical symptoms, including hot flushes, headaches or palpitations (a rapid or irregular heartbeat), occurred in 30 per cent with ADHD versus 14 per cent without.
Published in 2025, the research also found symptoms tended to start earlier for women with ADHD, peaking around ages 35 to 39, while those without ADHD reported their most severe symptoms around age 45.
The study suggests two explanations for the increased burden among women with ADHD.
Firstly, anxiety and lower socio-economic status are known risk factors for perimenopausal symptoms; both are more common among women with ADHD and chronic stress may amplify risk.
Secondly, oestrogen helps modulate ADHD symptoms.
Women with ADHD are at higher risk of premenstrual dysphoric disorder (PMDD) and other cycle-related issues because ADHD symptoms can intensify when oestrogen levels fall.
During perimenopause, oestrogen naturally declines, so women with ADHD may experience both typical perimenopausal symptoms and a worsening of ADHD symptoms at the same time.
The research also found a higher prevalence of lifetime post-traumatic stress disorder (PTSD) symptoms among women with ADHD.
When this factor was accounted for, women with ADHD who did not have PTSD still faced increased risks, though both risk and symptom intensity were reduced.
These findings suggest that interventions which reduce chronic stress and inflammatory responses could help women with ADHD navigate perimenopause more effectively.
Stanford graduates’ startup Clair is building a wearable hormone tracker for women, offering continuous, non-invasive monitoring.
The company, Clair, founded by Jenny Duan and Abhinav Agarwal, aims to build what its founders describe as a research-led, privacy-focused tool to help women see how hormone levels affect daily life.
Duan and Agarwal met in spring 2025 and began working on Clair shortly after. Over the past six months, they have been developing the technology and refining the company’s mission.
The device is designed to address gaps in women’s healthcare. Women remain underrepresented in medical research and clinical trials, leading to limited data and slower progress in understanding women’s health conditions.
According to Clair advisor and Stanford Medicine professor Brindha Bavan, hormone tracking in reproductive healthcare “improves our understanding of the function of and communication between the brain’s pituitary gland and ovaries or testes.
The pituitary gland is a small organ at the base of the brain that produces hormones regulating many bodily functions. The ovaries and testes are the primary reproductive organs that also produce sex hormones.
Hormonal health affects not only fertility and reproduction but also mental health, metabolism, energy levels and overall wellbeing.
Bavan said hormone tracking can “provide insight into menstrual cycle patterns and can aid with both diagnosing and assessing treatment for [various] conditions.”
“[Clair enables] patients [to] gain insight into their personal hormone fluctuations over different time periods,” Bavan said, “and share this information at healthcare visits to better understand and correlate any medical issues they are facing and avoid repeat blood draws.”
The device, which resembles a bracelet worn on the wrist, will connect to a mobile app, allowing all data processing to occur directly on the user’s phone rather than in external data centres.
“The device connects with an app so all of the processing happens on the app itself, not in a data centre like other devices. This is especially important given the current political climate around data privacy,” Agarwal said.
Clair also plans to pursue FDA approval and position itself as a medically credible device rather than solely a lifestyle product. The company is planning to launch a clinical trial at Stanford Medicine this spring.
Duan’s interest in women’s health and technology began as a Stanford undergraduate. At TreeHacks in 2024, she built apps focused on endometriosis, a condition where tissue similar to the lining of the womb grows outside of it.
She said a course on Philanthropy for Sustainable Development was particularly influential. “It was this class that sparked my interest in building a solution in [the women’s healthcare] space,” Duan said.
WUKA has announced a groundbreaking partnership with the Royal Yachting Association (RYA), including RYA Scotland and RYA Northern Ireland, supporting women and girls in sailing.
Building on WUKA’s growing #TackleAnything campaign – which has already reached thousands of girls across sports in the UK – this collaboration brings practical period solutions into sailing.
Together, WUKA and the RYA are committed to breaking down barriers so periods never limit confidence, participation, or performance on the water.
Ruby Raut, WUKA founder & CEO, said: “Partnering with the RYA has been incredibly important for us at WUKA.
“Sailing is an amazing way for women and girls to build confidence, and periods shouldn’t hold anyone back from enjoying the water or reaching their full potential.
“Through this partnership and our #TackleAnything campaign, we’re proud to provide practical solutions and innovative products that help female sailors feel comfortable, confident, and free to focus on learning, performing, and having fun.
“Breaking down barriers and supporting women to tackle anything — on land, at sea, and everywhere in between – has never felt more meaningful.”
WUKA, which stands for Wake-Up Kick Ass, shares the RYA’s commitment to inclusivity and empowerment.
In 2023, WUKA launched #TackleAnything, a campaign supporting women, girls and sportspeople with periods. Since its launch, the initiative has reached 3,576 girls across 46 clubs and partnered with a range of sports across the UK – from Scottish Gymnastics to Titans wheelchair basketball – helping young athletes play without limits and stay confident, comfortable, and in the game.
The brand offers period-friendly aquatic apparel and practical solutions that help women train and compete with freedom of movement and total assurance.
Through this partnership, WUKA will provide innovative period swimwear for young sailors across key RYA programmes, including the NI Sailing Team, the RYA Scotland Performance Pathway Programme, and the British Sailing Pathways Talent Academies.
By combining WUKA’s mission to challenge stigma with the RYA’s commitment to inclusion, the partnership ensures young sailors can focus on what matters most – learning, performing, and enjoying their time on the water – with confidence and comfort. RYA members will also receive a 10 per cent discount on WUKA products.
Sailing offers incredible benefits for women and girls, but time on the water can present unique challenges -particularly during menstruation.
Together, WUKA and the RYA are providing practical solutions that remove these barriers, helping young sailors participate fully and confidently in the sport.
Sara Sutcliffe, RYA CEO, said: “At the RYA, we have been making strides to break down barriers for women of all ages to help ensure they can experience the water in a supportive and positive environment.
“From education workshops and practical sessions, we want to make sure our female sailors are empowered and this partnership is another great example of how we can demonstrate possible tools to equip them to succeed”.
This partnership is part of the RYA’s wider commitment to making sailing a sport where women and girls can thrive. Alongside initiatives such as the Female Futures Group, the Women’s Race Officials Programme and all new Talent Academy Female Future’s Camps; it demonstrates a continued focus on removing barriers and creating meaningful opportunities across every stage of the sailing.
WUKA’s involvement ensures that practical solutions are available on the water, from innovative period swimwear to support resources, helping young sailors feel fully equipped and confident during training and competition.
By integrating these tools into RYA programmes, WUKA brings a new level of comfort and assurance to female athletes, allowing them to focus entirely on performance, enjoyment, and growth in the sport.
For any women and girls looking to learn more about sailing, visit www.rya.org.uk.
For more information on WUKA visit www.wuka.co.uk.
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