A new partnership aims to advance AI-enabled digital pathology for end-to-end breast tumour profiling
PathPresenter, a digital pathology platform and 4D Path, a Boston company producing computer-aided cancer diagnostic products, are announcing a global partnership to distribute 4D Q-plasia OncoReader Breast within the new clinical workflow platform, ClinPx.
The 4D Q-plasia OncoReader Breast uses digitised pathology slides of breast cancer tissue to diagnose disease with improved accuracy, effectively acting as an aid for clinical histopathology experts.
“We believe that the integration of these two technologies will redefine how AI can be adopted by everyday pathologists,” says Rajendra Singh, M.D., founder of PathPresenter.
The primary purpose of integrating 4D’s proprietary algorithms within ClinPx is to potentially improve the throughput, reliability and quality of consultations provided by physicians. Additionally, users from pharmaceutical organisations could also benefit from the enablement of the standardised central pathology review of certain biomarkers within the context of clinical trials leveraging the ClinPx platform.
“This unique partnership is very much needed to make the most of the increasing investment in digital pathology,” says Tathagata Dasgupta, founder and president of 4D Path.
“While PathPresenter offers a software platform made by pathologists to serve pathologists in their digital workflow, it will have at its heart the 4D Path-driven end-to-end tumour profiling white-box solution that can produce synoptic reports to potentially assist clinical reporting.”
To advance the adoption of digital pathology worldwide, 4D Path and PathPresenter have also created educational content to teach current and future pathologists about how evaluation of breast cancer features prior to downstream genomic and molecular testing can potentially improve patient care.
Fairtility’s AI decision-support tool granted CE mark under new MDR
CHLOE EQ™ is the first AI-powered tool for embryo classification and selection to achieve CE MDR approval
Fairtility’s AI decision-support tool CHLOE EQ™ has earned the CE Mark under the European Medical Devices Regulation (MDR) regulatory requirements and is now commercially available to fertility clinics across Europe.
CHLOE EQ™ is an AI decision-support tool that was developed to provide embryo viability assessment which supports the prediction of blastulation, the prediction of implantation and ploidy and ranks embryos in order of priority.
It provides automatic annotations for morphokinetic and PN count which support fertilisation assessment.
According to Dr. Cristina Hickman, Fairtility VP of Clinical Affairs and leading embryology expert, embryo evaluation and selection has traditionally been a manual process, limiting patient access to treatment while also opening the door for human error.
“One of the key advantages that CHLOE EQ™ was designed to offer is accuracy and consistency in assessment,” she adds. “CHLOE’s proprietary AI-based algorithms become more accurate the more data it gathers, leading to uniform and accurate embryo assessment.”
The information provided by CHLOE EQ™ can then assist embryologists and IVF professionals in the decision of prioritising the most viable embryo for treatment, especially when there are multiple embryos deemed suitable.
The tool is designed to add efficiency to embryologists’ workflow, automating manual steps, including annotation of each embryo and written daily observations into each patient’s electronic medical record (EMR).
Embryologists verify the system’s automatic annotations that are then immediately integrated from the Time Lapse Incubator (TLI) directly into the EMR.
Eran Eshed, CEO and Co-Founder of Fairtility, says that: “Having gained regulatory acknowledgement in Europe, under the more stringent directive that the CE MDR provides, we are now commercially launching CHLOE EQ™ in clinics across the EU while continuing to uphold the highest standard of this classification.
“With the EU IVF market size estimated to reach over $2 billion by 2027, we see tremendous opportunities to demonstrate the clinical efficacy and impact of CHLOE EQ™ ahead of US market entry.”
The European MDR came into effect in May 2021 and serves as the new European legal framework for medical devices. MDR has more stringent requirements for demonstrated compliance, vis a vis the obsolete Medical Device Directive (MDD), the previous industry standard.
Fairtility is showcasing CHLOE EQ™ at the 38th Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE), taking place in Milan Italy from July 3-6, 2022 with five oral presentations and seven posters supporting the clinical impact of the product.
In vitro fertilisation (IVF) is the most effective form of assisted reproductive technology. Due to the complexity of the procedure, however, prediction of embryonic implantation prior to IVF is key in decision-making.
The Israeli software company Fairtility aims to maximise IVF outcomes by using AI and computer vision algorithms to provide early, data-driven embryo quality.
For more info, visit fairtility.com.
True Wealth Ventures raises US$35m to back its gender-diversity strategy
The Austin-based venture capital firm invests in companies improving human and environmental health
True Wealth Ventures has announced the close a US$35m Fund II, focusing on investing in women-led companies.
True Wealth Ventures’ investment thesis is that women-led companies perform better financially, yet remain an untapped market.
Just 2.3 per cent of total capital invested in U.S. venture-backed start-ups in 2021 went to companies solely founded by women, and only 14.8 per cent of that capital went to companies co-founded by women, according to a May PitchBook report.
“While our primary mission continues to be getting early-stage capital to female founders whose core value proposition is improving environmental or human health, our secondary mission has been to facilitate more women investing into this asset class as LPs – limited partners,” says Sara T. Brand, True Wealth Ventures founding general partner.
“We not only believe this is the fastest way to change the gender inequality in the VC ecosystem, we also believe it is critical for our country’s innovation economy with the wealth shifting to women.”
Fund II will invest across the spectrum of software, hardware and consumer packaged goods start-ups. First checks typically range between US$500,000 and US$1m. True Wealth Ventures LPs often co-invest an additional 50 per cent on top of the Fund’s investment, with total rounds most often ranging up to US$3.5 to US$4m.
True Wealth already has already made investments from Fund II since its first close in May 2021, including Flourish, a start-up headquartered in Austin, Texas, which educates women how to build sustainable habits in nutrition, hydration, sleep, stress, relationships and movement.
The firm intends to invest in 15 companies from Fund II. Those start-ups must be women-led, meaning at least one woman with significant decision-making power must be on the founding or executive team.
About 80 per cent of U.S. assets will be controlled by women by 2030, but women largely are not active in investing in VC funds today.
“Investing in women-led companies personally resonates with women who know their peers have potential and should be backed much more than a mere 2.3 per cent,” says Kerry Rupp, True Wealth Ventures general partner.
“There’s a feeling of, ‘If not us, then who?’ Women are twice as likely to invest in companies that will have a positive social impact, and 10 times as likely to invest in companies with diverse teams.”
Brand and Rupp posit bringing more women to invest as LPs likely will pave the way for more women general partners to join the investment-decision-making VC table to ultimately fund more women entrepreneurs.
About 2.4 per cent of investment decision-making partners at VC funds are women. True Wealth Ventures emphasises that women accredited investors should have the opportunity to benefit from financial gains yielded by investing in venture capital. However, most are not invited to invest.
A majority of True Wealth Ventures Fund I women LPs, including the general partners themselves, previously had never had been invited to invest in a VC fund, according to a survey conducted by the firm.
The venture capital firm also believes that women are more likely to back femtech and silvertech companies than their male counterparts, presumably because the latter have less first-hand experience with the problems and opportunities in those sectors.
True Wealth Ventures Fund I has invested in 12 companies, all of which remain active.
For more info, visit truewalthvc.com.
The Irish start-up on a mission to help women navigate menopause
identifyHer’s medical device will be able to monitor menopausal symptoms and help clinicians give a better diagnostic
Disease prevention means data. Heidi Davis, co-founder of the Irish start-up identifyHer, tells FemTech World why a medical wearable device is essential in understanding menopause and predicting future disease.
The effect of menopausal symptoms on women’s future health is rarely talked about.
In the UK and Ireland, 3.7 million women are experiencing symptoms that negatively affect their lives during perimenopause and menopause and untreated, such symptoms can lead to chronic diseases.
“Understanding menopause is extremely important to assess the future risks of disease,” says Heidi Davis, co-founder of identifyHer. The Irish digital health company focuses on predictive health services for women going through menopause, guiding personalised management of menopausal symptoms.
“When we started, we realised that nobody knew anything about menopause and that there was no real objective data to understand this life stage,” the co-founder explains. “So, we looked at a range of symptoms that we believed we could capture with a wearable sensor that could identify those physiological changes.
“We collected data from women who were going through menopausal symptoms and we understood that they are the ones who are looking for this information, who need this information and who are desperate to understand what’s going on.”
Along with the American manufacturing company, Analog Devices, the identifyHer team is developing a medical device that uses AI-enabled technology to capture physiological signals and personalise the management of menopausal symptoms to reduce the risk of disease in the future.
“The symptoms women experience [during perimenopause and menopause] can overlap with other symptoms that happen in daily life,” Davis points out.
“For that reason, clinicians find it hard to diagnose and give treatment because they don’t have diagnostic tests that can give a clear image. So, our mission is to help them differentiate those symptoms and provide objective data.”
The identifyHer tracker, which can be used from perimenopause onwards, sits under the breast and is activated by an app. The wearer goes about their business as normal and they will get daily, weekly, and monthly reports on their menopausal symptoms and lifestyle data.
The woman will wear the sensor for three months to track her symptoms and the data collected during that time will be used to initiate or evaluate the treatment she is already on.
The device will not only save clinicians time, but it will also offer them a better diagnostic tool and help them improve and change the treatment accordingly.
“Managing those symptoms correctly can actually set women up for a better future post-menopause because the severity and the frequency of the symptoms themselves are indicators of future risk of disease,” Davis adds.
“Women who seek medical help will be offered our solution and get remote monitoring of their symptoms while clinicians can use it for diagnosis and treatment.”
The device will be regulated both for cybersecurity and data protection and it will first launch in the UK and Ireland, followed by the EU and the US. The company will be working with health insurance companies on a paying claim policy and hopes that with time, the tracker will be integrated into the national healthcare systems.
“It’s been great to be working in women’s health,” the entrepreneur tells me. “It has been challenging, but the overall experience was good.
“We are hoping to close a round of €2.2 million by the end of this year and our aim is to become the gold standard in clinics to diagnose and help women get the right treatment. So far, we’ve had some good conversations and we are moving forward.”
Before we wrap up our Zoom call, I ask Heidi what is her biggest achievement since establishing identifyHer.
“Building the team. We wouldn’t be where we are now, if it wasn’t for the people that have helped us along the journey. It took us a long time to find them, but we knew they were the right people straight away.
“I hope we can continue growing it with as good people as we have now.”
For more info, visit identifyher.ai.
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