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Researchers achieve first pregnancy using AI to recover sperm in infertile men

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Researchers have reported the first successful pregnancy using an AI-guided sperm recovery method in infertile men with azoospermia, a condition where ejaculate contains little or no sperm.

The case involved a man who had spent nearly 20 years trying to start a family, undergoing multiple IVF cycles, manual sperm searches and two surgical procedures.

Male factors account for around 40 per cent of infertility in couples, and 10–15 per cent of infertile men have azoospermia.

Researchers at Columbia University Fertility Center developed the technique, detailed in a research letter published online on 31 October 2025.

Zev Williams is senior author and director of the Columbia University Fertility Center.

Williams said: “A semen sample can appear totally normal, but when you look under the microscope you discover just a sea of cellular debris, with no sperm visible.”

Many couples with male-factor infertility are told they have little chance of having a biological child.

Men with azoospermia may undergo a procedure to have sperm surgically extracted from the testes, but the procedure is often unsuccessful and can cause vascular problems, inflammation or a temporary drop in testosterone.

Currently, a few specialist labs manually inspect semen samples — a slow and expensive process — often after centrifugation or other treatments that can damage sperm.

“The field has really been challenged to find a better way to identify and retrieve viable sperm cells in men with exceedingly low sperm counts,” Williams said.

The new approach, called STAR (Sperm Tracking and Recovery), combines imaging, microfluidics and AI to identify and recover rare sperm cells from men with azoospermia.

The method uses high-powered imaging to scan semen samples, taking more than eight million images in under an hour.

AI then pinpoints sperm cells, and a microfluidic chip – a device with tiny, hair-like channels – isolates the portion containing sperm.

Within milliseconds, a robot gently removes the sperm so it can be used to create an embryo or frozen for later use.

Hemant Suryawanshi is assistant professor of reproductive sciences at Columbia University Vagelos College of Physicians and Surgeons and project leader.

Suryawanshi said: “Our team included experts in advanced imaging techniques, microfluidics, and reproductive endocrinology to tackle each step required to find and isolate rare sperm.”

STAR was tested in a patient who provided a 3.5 mL semen sample.

Within about two hours, it scanned 2.5 million images and identified two viable sperm cells, which were used to create two embryos and start a pregnancy.

“You only need one healthy sperm to create an embryo,” Williams said.

Although based on a single case, the findings demonstrate the feasibility of using this technology to help men with azoospermia overcome long-standing barriers to biological parenthood.

Larger clinical studies are now under way to assess STAR’s efficacy in broader patient populations.

The research team first unveiled the STAR method earlier this year, combining advanced imaging and microfluidic technologies to detect and extract rare sperm cells.

Once identified, the system can remove sperm within milliseconds for immediate use or freezing.

Opinion

The science behind the scar: What’s really in our period products

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By Ruby Raut, founder and CEO, WUKA

Over the past year, headlines about “toxic period products” have been hard to ignore. Stories about PFAS, heavy metals, and hormone disruptors in pads, tampons, and underwear have sparked global concern, and for good reason. But behind the fear, there’s a scientific story worth understanding.

At the recent House of Lords event, “Have We Reached the Tipping Point for Toxic Period Products?”, researchers and policymakers came together to separate fact from panic. The truth is more nuanced: yes, chemicals and metals are present in some menstrual products, but understanding how much, where they come from, and what that means for our health is key to driving change that’s informed, not sensational.

What Scientists Have Found So Far

Dr Kathrin Schilling, an environmental health scientist at Columbia University, shared new research that tested 16 metals in menstrual products, including arsenic, cadmium, lead, and antimony, all known toxic substances linked to long-term health effects such as cardiovascular disease, kidney problems, and hormonal disruption.

The findings were striking:

  • Non-organic products showed higher levels of lead and cadmium than organic ones.
  • Some reusable and single-use products exceeded 30,000 nanograms per gram (ng/g) of antimony, a toxic metal commonly used in plastics manufacturing.
  • Lead levels varied dramatically, some products contained 100× more than others.

To put this in perspective, even very small doses of lead can cause harm. The World Health Organization confirms there is no safe level of lead exposure. Chronic, low-level contact can gradually affect the nervous system and fertility. The same applies to arsenic, where countries have tightened drinking water limits from 10 µg/L to as low as 1 µg/L after learning that long-term exposure causes disease.

So while the numbers in menstrual products might sound tiny, what matters most is frequency and route of exposure. Menstrual products are used regularly and in contact with one of the body’s most absorbent tissues — the vaginal wall — where absorption is estimated to be 10–80× higher than through skin. Over decades of use, even low concentrations can add up.

Understanding PFAS — The “Forever Chemicals”

Alongside metals, PFAS (per- and polyfluoroalkyl substances) have become another major concern. These synthetic compounds are used for absorbency and stain resistance — but they don’t break down easily, earning the name “forever chemicals.”

They accumulate in soil, water, and the human body, and have been linked to reproductive issues, thyroid disease, and immune dysfunction. California recently became the first state to ban PFAS in menstrual products, while New York is pushing for broader restrictions that include heavy metals and hormone disruptors.

These international shifts signal a clear message: the world is moving towards stricter, transparency-first regulation — something the UK could soon follow.

Why It Matters for Our Bodies

It’s important to remember that our world is already filled with background exposure, from air pollution, processed food, and household plastics. We all live in a chemically complex environment. The key isn’t to fear every product but to understand which exposures matter most and how to minimise them.

Menstrual products are unique because of their intimate and repeated contact with the body. Even trace chemicals can bypass the body’s natural detox systems when absorbed vaginally. This doesn’t mean every product is dangerous, but it underscores why regular, independent testing and clear ingredient disclosure are essential.

Internal vs. External Exposure:  Why It Makes a Difference

One of the least understood parts of this debate is the difference between internal and external products. A pad or period underwear sits on the skin; it can only transfer chemicals through surface contact. But products like tampons or menstrual cups are inserted directly into the vagina, an environment that absorbs substances 10–80 times more efficiently than normal skin.

That’s because the vaginal wall is highly vascular, full of small blood vessels, and it bypasses the liver, the organ that usually filters and detoxifies harmful substances. So when a chemical is absorbed vaginally, it goes straight into the bloodstream.

Yet, most testing and regulation still treat all menstrual products as if exposure happens through skin contact. There’s very little research separating the risk profiles of internal (tampons, cups, discs) versus external (pads, underwear) products. That’s why scientists like Dr Schilling emphasised the need for new safety standards that actually reflect how the body interacts with these materials, not just how a fabric performs in a laboratory test.

How Responsible Brands Are Responding

Some brands are already ahead of regulation.

At WUKA, we take this responsibility seriously. We are one of the very few period underwear brands with no PFAS detected in our products. Every batch is tested rigorously, both at source (in China) and again in the UK by Eurofins laboratories, an independent global testing agency.

We also screen for toxic chemicals, metals, and harmful finishes, ensuring that what touches your body is as safe as it is sustainable. As a founder, I always remind our team: I use our products myself. If I wouldn’t wear it, I wouldn’t make it for anyone else.

Our philosophy is simple,  transparency builds trust. Consumers shouldn’t need a chemistry degree to choose a safe period product.

The Path Ahead

The science is clear: menstrual product safety deserves the same rigour as drinking water, cosmetics, or food. But we can also take heart, awareness is growing, data is expanding, and governments are beginning to act.

As policymakers push for international standards (through bodies like the ISO TC338 on menstrual products), and as responsible brands lead by example, the future of menstrual care looks safer, smarter, and far more transparent than the past.

This isn’t just about fear of toxins, it’s about empowering everyone who menstruates with knowledge and choice. Because understanding the science is the first step toward changing it.

Find out more about WUKA at wuka.co.uk

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Ageing

Women face worse stroke recovery than men in first year, study finds

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Women experience slightly worse recovery than men in the first year after stroke, with more difficulty with daily tasks such as eating, dressing and driving.

The differences persisted after adjusting for age, race and ethnicity, education and insurance status, according to the study.

The research, led by Chen Chen at the University of Michigan, examined recovery from ischaemic stroke, the most common type, which happens when blood flow to part of the brain is blocked.

“Stroke is a leading cause of disability in the US and with the ageing population, the number of stroke survivors is growing,” said Chen. “Since many people live with physical, cognitive and emotional challenges after stroke, it is important to find ways to improve recovery. Our study provides a better understanding of sex differences during stroke recovery.”

Researchers identified 1,046 people who experienced their first ischaemic stroke, average age 66. Recovery was tracked through records and interviews at three, six and 12 months, with neurological assessments, cognitive tests and quality-of-life questionnaires.

Participants were assessed on their ability to complete daily tasks, both simple and more complex, such as walking, bathing, cooking and doing housework.

Female participants had higher average scores than male participants, indicating poorer recovery, at three, six and 12 months. Female participants had an average score of 2.39 compared to 2.04 for male participants at three months. Scores for female participants decreased from three to 12 months, indicating some improvement, while male participants’ scores remained stable.

Chen noted the effect size was small. While there were no sex differences in other areas of recovery, both sexes improved in neurological function, which includes communicating and performing simple movements.

“Our results suggest that early and repeated assessments of a person’s ability to do daily tasks after stroke are needed, and particularly for female individuals, in order to reduce these differences in recovery,” said Chen. “When developing new interventions, these recovery patterns should be considered. Since the differences were mainly in activities such as doing heavy housework, shopping and carrying heavy weights, new interventions could include muscle-strengthening activities.”

A limitation was the lack of data on participants’ use of rehabilitation services.

The study was supported by the US National Institutes of Health.

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Wellness

AI-driven digital tool delivers sustained blood pressure reductions, study finds

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A large real-world study has found that an AI-powered digital tool developed by Megi Health can significantly reduce blood pressure over time while maintaining high long-term patient engagement –  a combination that has remained a major challenge in hypertension care.

The peer-reviewed research, published in JMIR mHealth and uHealth, analysed real-world data from more than 5,000 adults using Megi’s digital blood pressure management platform as part of their everyday lives.

The results showed meaningful reductions in systolic blood pressure, with the greatest improvements seen in people who started with higher readings.

Crucially, the study found that outcomes improved the longer people stayed engaged with the platform.

Dr Petroula Laiou, chief scientific officer at Megi and senior author of the study, said: “High blood pressure can’t be managed through occasional GP visits alone.

“This study shows that ongoing, easy-to-use digital support can help people control their blood pressure in the real world –  particularly those at highest risk.

“It also demonstrates how combining digital tools with routine clinical care creates a more effective ‘phygital’ model for managing long-term conditions.”

Around half of users were still active after one year, while patient feedback showed high satisfaction, greater confidence in self-managing blood pressure, and reduced anxiety around monitoring.

Rather than relying on a tightly controlled clinical trial, the study examined how people actually use digital health tools in real life.

Users interacted with Megi through WhatsApp, receiving reminders to measure their blood pressure and take medication, and entering readings directly into the chat.

This approach enabled continuous tracking of blood pressure, engagement and outcomes over time.

The research was led by a multidisciplinary team from King’s College London, King’s College Hospital NHS Foundation Trust, Megi Health, the Magdalena Clinic for Cardiovascular Diseases in Zagreb, and the University of Zagreb.

The cohort included both women and men aged 17 to 95, with more than 90 per cent of participants regularly submitting blood pressure readings.

The findings add to growing evidence that home-based digital monitoring can overcome many of the limitations of clinic-based blood pressure checks, which are often affected by white-coat or masked hypertension.

By combining regular home readings with behavioural support, digital tools such as Megi could play an increasingly important role in long-term cardiovascular care.

Dr Nina Šesto, CEO of Megi Health, said: “What’s striking is not just the blood pressure reductions, but how long people stayed engaged.

“That level of sustained use is exactly what hypertension care has been missing.

“As health systems move towards prevention, home monitoring and long-term condition management, this approach aligns closely with the direction set out in the NHS 10-Year Health Plan.”

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