Entrepreneur
Lab-grown human eggs and sperm ‘about seven years away’
Scientists say lab-grown human sex cells could be less than a decade from reality, with major implications for fertility and reproduction.
The technology could, in theory, allow anyone to have biological children, regardless of sex, fertility or age.
Researchers are making rapid progress towards turning adult skin or blood cells into eggs and sperm through a process known as in-vitro gametogenesis (IVG) – a method that reprogrammes cells genetically to become gametes.
The technique typically starts by converting adult cells into stem cells, which are then guided into becoming primordial germ cells – the precursors to eggs and sperm.
These are placed inside a lab-grown organoid (a miniature version of an organ), which provides the biological signals needed to develop them further.
Prof Katsuhiko Hayashi, a developmental geneticist at the University of Osaka, told a meeting of the European Society of Human Reproduction and Embryology in Paris this week that his lab is about seven years away from creating viable human sperm.
Other frontrunners include a team at the University of Kyoto and California-based startup Conception Biosciences, whose Silicon Valley backers include OpenAI founder Sam Altman.
Conception’s chief executive told the Guardian the company is focused on producing clinical-grade human eggs and believes the technology could reverse population decline and open the door to human gene editing.
Hayashi said: “I feel a bit of pressure. It feels like being in a race.
“On the other hand, I always try to persuade myself to keep to a scientific sense of value.”
Hayashi’s lab has already produced baby mice with two biological fathers, suggesting the technique could one day be used by same-sex couples.
He said the lab receives emails from prospective fertility patients about once a week.
He said: “We get emails from [fertility] patients, maybe once a week.
“Some people say: ‘I can come to Japan.’ So I feel the demand from people.”
Matt Krisiloff, chief executive of Conception Biosciences, said: “Just the aspect alone of pushing the fertility clock … to potentially allow women to have children at a much older age would be huge.
“Outside of social policy, in the long term this technology might be the best tool we have to reverse population decline dynamics due to its potential to significantly expand that family planning window.”
Hayashi presented his team’s latest progress at the event, including the creation of primitive mouse sperm inside a lab-grown testicle organoid measuring about 1mm across, and the development of a human ovary organoid – a step towards growing human eggs in the lab.
Inside the artificial testes, Hayashi’s team managed to grow spermatocytes – the precursors of sperm cells – before the cells died.
He said an updated version of the organoid with a better oxygen supply could allow the cells to reach maturity.
Hayashi estimated that viable lab-grown human sperm could be about seven years away.
Creating sperm from female cells, he said, would be “technically challenging, but I don’t say it is impossible.”
He also suggested that his former colleague Prof Mitinori Saitou, based at Kyoto University, or Conception Biosciences could be ahead in the race.
“But they [Conception] are really, really secretive,” he added.
Others agreed with Hayashi’s timescale.
“People might not realise how quickly the science is moving,” said Prof Rod Mitchell, research lead for male fertility preservation in children with cancer at the University of Edinburgh.
“It’s now realistic that we will be looking at eggs or sperm generated from immature cells in the testicle or ovary in five or 10 years’ time.
“I think that is a realistic estimate rather than the standard answer to questions about timescale.”
Prof Allan Pacey, professor of andrology and deputy vice-president at the University of Manchester, said: “I think somebody will crack it. I’m ready for it. Whether society has realised, I don’t know.”
While several labs have successfully produced baby mice from lab-grown eggs, producing viable human eggs has been far more technically difficult.
A recent breakthrough in understanding how eggs stay dormant in the ovary for years could prove key.
Krisiloff declined to share detailed updates but said the company is “making really good progress on getting to a full protocol”.
In the best case, he said, the technology could reach the clinic within five years – though it may take longer.
Most researchers believe years of testing would be required to ensure that lab-grown cells do not carry genetic mutations that could be passed to embryos and future generations.
Some mice created using lab-grown cells have lived normal lifespans and been fertile.
Hayashi said: “We really need to prove that this kind of technology is safe.
“This is a big obligation.”
In the UK, using lab-grown eggs or sperm in fertility treatment is currently illegal.
The Human Fertilisation and Embryology Authority is already considering how safety could be ensured and what testing would be needed before clinical use could be approved.
Mitchell said:“The idea that you can take a cell that was never supposed to be a sperm or an egg and make it into a sperm or an egg is incredible.
“But it does bring the problem of safety. We need to be confident that it’s safe before we could ever use those cells to make a baby.”
Events
Kate Ryder headlines Women’s Health Week USA 2026 as full agenda goes live
Women’s Health Week USA 2026 has unveiled its first populated agenda, anchored by an opening keynote from Kate Ryder, Founder and CEO of Maven Clinic, and featuring a cross-sector lineup shaping the next phase of scale in women’s health.
You can view the full agenda here.
Taking place May 13–14, 2026, at the New York Academy of Medicine, Women’s Health Week USA brings together the full women’s health ecosystem to focus on one central question: what does it take to move women’s health from innovation to institutional scale?
Kate Ryder will open Day 1 with a keynote drawing on her experience building Maven Clinic into the world’s largest virtual clinic for women’s and family health.
Under her leadership, Maven has partnered with employers and health plans to deliver care across fertility, maternity, postpartum, paediatrics, and menopause at scale.
Her perspective sets the tone for a program centered on commercialisation, partnership, and sustainable growth.
Beyond the opening keynote, the newly released agenda reflects the sector’s growing maturity.
Across two days, the program features 70+ speakers, with representation from leading organizations including the FDA, Planned Parenthood, CVS Health Ventures, Samsung Next, NIH, WHO, and Maven Clinic.
Sessions span investment and deal flow, clinical innovation, regulation, data and technology, and market expansion, alongside dedicated pitch sessions and curated 1:1 matchmaking designed to turn insight into action.
The agenda has been built to facilitate meaningful connections across the ecosystem, with partnerships positioned as the primary driver of scale.
As women’s health continues to attract institutional capital and global attention, Women’s Health Week USA 2026 offers a clear snapshot of where the market is heading, and who is shaping it.
The full agenda is now live, with additional speakers and partners to be announced in the coming months.
View the full programme here.
Entrepreneur
Merck partners on intravaginal drug delivery device
Calla Lily Clinical Care has partnered with Merck to support the intravaginal drug delivery platform Callavid in an effort to improve how vaginal medicines are given.
The collaboration will continue development of Callavid, described as a leak-resistant device that addresses challenges with self-administered vaginal therapies.
Callavid uses a small, tampon-shaped device with an integrated absorbent liner. It is inserted, remains in place during drug absorption, then is removed.
The platform is intended for use with medicines in fertility treatment, oncology and hormone therapy. Administration via the vaginal route can prompt patient anxiety about positioning, dosing accuracy and leakage.
The partnership is the first industry collaboration for the Callavid technology, which was developed by Calla Lily Clinical Care.
Thang Vo-Ta, co-founder and chief executive of Calla Lily Clinical Care, said: “This collaboration with Merck marks an important milestone in the development of Callavid, our novel vaginal drug delivery platform.
“Merck’s scientific heritage and forward-looking approach to innovation make them an ideal partner as we work to address long-standing unmet needs in women’s health.
“By improving how vaginal therapeutics are delivered and experienced, Callavid has the potential to enhance both patient outcomes and quality of life.
“We see this collaboration as a meaningful step towards translating our technology into real-world clinical and patient impact.”
Calla Lily Clinical Care is seeking to develop what it describes as the world’s first drug-device combination product to prevent threatened miscarriage and for IVF luteal phase support, the phase after ovulation when the body produces progesterone to support early pregnancy.
The device is also being developed to deliver therapeutics for oncology, menopause, infectious diseases and live biotherapeutics to reduce repeated antibiotic use.
Dr Lara Zibners, co-founder and chairman of Calla Lily Clinical Care, said: “Our initial engagement with Merck through the Merck Innovation Challenge in October 2024 was an important moment of alignment around the need for more patient-centric innovation in women’s health.
“As both a clinician and a patient, I have seen how profoundly drug delivery can shape treatment experience.
“This collaboration builds on that early dialogue and reflects a shared interest in rigorously exploring new approaches that may improve how therapies are delivered and experienced by patients.”
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