News
Aspira Women’s Health teams up with BioReference to fight ovarian cancer
Ovarian cancer is the second most common gynaecologic cancer in the US
Two US biotech companies have announced a co-marketing and distribution collaboration to address ovarian cancer.
Aspira Women’s Health has collaborated with BioReference, one of the largest full service specialty laboratories in the US, to co-market and distribute Ova1Plus, Aspira’s FDA-cleared blood tests that detect the risk of ovarian malignancy in women diagnosed with a pelvic mass.
Under terms of the agreement, the sales teams of the two companies will collaborate to sell Ova1Plus to gynaecologists and other women’s healthcare providers nationwide.
The collaboration is hoped to lead to more women being appropriately triaged for surgery and improve patient outcomes.
“We are excited to formally launch our collaboration with BioReference,” said Nicole Sandford, CEO of Aspira Women’s Health.
“Providing more physicians and their patients with access to our ovarian cancer risk assessment products is a top priority for Aspira, and this strategic alliance with BioReference is a significant accelerator.
“Our two organisations are well aligned with similar goals of improving care for women. We have complementary relationships and offerings that will most certainly benefit healthcare providers and the women that they serve.
“I believe this is the start of a long-term relationship that will accelerate the adoption of Ova1Plus and provide incremental revenues at attractive margins for each company,” Sandford added.
Greg Richard, head of strategy and business development at Aspira Women’s Health, said sales professionals from each company will work collaboratively to ensure physicians understand the power of our ovarian cancer risk assessment products to expand market access and provider adoption.
Craig Allen, president and BioReference CEO, said: “We are pleased to offer Ova1Plus to physicians across the country as part of our focus on women’s health and look forward to a successful collaboration with Aspira.
“As women’s health test offerings advance, it becomes more and more imperative to offer women access to information about their health.”
Aspira Women’s Health aims to transform women’s gynaecological health with the discovery, development, and commercialisation of testing options for women of all races and ethnicities.
The company says the blood tests could reduce the falsely elevated rate by up to 50 per cent, maintain the high rate of detection for ovarian cancer risk, continue to provide confidence in low-risk results with a high negative predictive value, and increased specificity by up to 20 per cent.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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