News
Researcher supports creation of database to improve maternal care in Nigeria

A university researcher has been part of a new project to establish an electronic healthcare database to improve maternity care in low and middle-income countries.
The Maternal and Perinatal Database for Quality, Equity and Dignity (MPD-4-QED) Programme in Nigeria has been established by the World Health Organisation, in collaboration with the Nigerian Federal Ministry of Health (FMOH), and was funded by the global initiative MSD for Mothers.
Dr Abiodun Adanikin, an assistant professor of maternal and perinatal epidemiology at Coventry University’s research centre for healthcare and communities, worked with colleagues to create the database.
The database serves as a monitoring tool for maternal and early neonatal care and outcomes and is the first of its kind in low and middle-income countries (LMICs).
“The challenge of quality data often plagues LMICs, preventing performance tracking and progress monitoring in maternity care,” said Dr Adanikin.
“While this database hasn’t been easy to accomplish, now we have a system which collects quality data.
“With periodic analysis, we can monitor the quality of maternity care and outcomes for women and babies and learn about what works and what can be improved. In addition, the data can be used for research purposes.”
What’s great about this database, Adanikin said, is that it can be replicated in other low- and middle-income countries that face the similar challenges of inequalities in maternity care outcomes as Nigeria.
“Many thanks to the outstanding teams and colleagues who collaborated on this project.
“Overall, the MPD-4-QED programme demonstrates substantial potential for tracking essential maternal, newborn and child health metrics in Nigeria – and potentially in other LMICs – rather than relying solely on estimates.”
Dr Adanikin recently shared the team’s experience and lessons learned in establishing the database in a publication in the British Journal of Obstetrics and Gynaecology.
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Entrepreneur
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Diagnosis
Women with osteoporosis face increased Alzheimer’s risk, study suggests

Women with osteoporosis may be more likely to carry a gene linked to Alzheimer’s, according to new research.
Scientists found that APOE4, the most common genetic risk factor for Alzheimer’s, can weaken bone quality in women, even when standard scans appear normal.
The study, carried out by researchers at the Buck Institute for Research on Ageing in California, US, and UC San Francisco, suggests the gene may damage bone at a microscopic level long before any visible signs.
These changes can emerge as early as midlife and remain invisible to routine imaging tests used to assess bone strength.
The findings suggest a link between Alzheimer’s risk and skeletal health and could help pave the way for earlier detection of both conditions.
Professor Birgit Schilling, a senior author of the study, said: “What makes this finding so striking is that bone quality is being compromised at a molecular level that a standard bone scan simply will not catch.
“APOE4 is quietly disrupting the very cells responsible for keeping bone strong – and it is doing this specifically in females, which mirrors what we see with Alzheimer’s disease risk.”
Doctors have long observed that people with Alzheimer’s suffer higher rates of bone fractures, while osteoporosis in women is known to be one of the earliest predictors of the disease.
Now scientists believe they may have uncovered why.
Researchers led by Dr Charles Schurman carried out a detailed analysis of proteins in aged mouse bone and found that tissue was unusually rich in molecules linked to neurological disease, including those associated with Alzheimer’s.
In particular, long-lived bone cells known as osteocytes showed elevated levels of APOE, with levels twice as high in older female mice compared with younger or male animals.
Further experiments using genetically modified mice revealed that APOE4 had a strong and sex-specific impact on both bone and brain tissue.
The disruption at the protein level was even greater in bone than in the brain.
However, the bone structure itself appeared completely normal under scans.
Instead, the gene interfered with a key maintenance process inside bone cells, preventing them from repairing microscopic channels that keep bones strong and resilient.
When this process breaks down, bones become more fragile even if they look healthy on standard imaging.
These results suggest bone cells could potentially act as early biological warning signs of cognitive decline in women carrying APOE4.
Professor Lisa Ellerby, another senior author, said: “We think targeting these cells may open a new front in preserving bone quality in this population.”
Experts say the findings highlight the need to view the body as an interconnected system rather than treating diseases in isolation.
Dementia, of which Alzheimer’s is the most common form, remains one of the UK’s biggest health challenges.
Around 900,000 people are currently living with the condition, a figure expected to rise to 1.6 million by 2040.
It is already the leading cause of death, responsible for more than 74,000 deaths each year.
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