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Hormonal health

Researchers to develop portable hormone monitoring device

The device is hoped to help women identify symptoms that could be signs of common female health conditions

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Scientists from Edinburgh’s Heriot-Watt University are working on a new portable device that could help women track and monitor their health and hormones.

The gadget will be smaller than an iPhone and will keep track of the full picture of women’s health, from period symptoms to hormone fluctuations, mood and sleep.

The device is hoped to help women identify symptoms that could be signs of common health conditions, such as polycystic ovary syndrome (PCOS), and alert them when they would need to see a doctor.

The researchers hope it will capture data on a variety of fertility-related hormones, like luteinising hormone, which stimulates ovulation, and others like thyroid-stimulating hormone.

The project, led by Dr Sadeque Reza Khan, a specialist in biomedical devices and sensing in Heriot-Watt’s Institute of Sensors, Signals and Systems, is funded by the Scottish Government.

Improving women’s healthcare

According to the Royal College of Obstetricians and Gynaecologists (RCOG), the waiting list for gynaecology appointments, diagnosis and treatment has soared up to 60 per cent recently, affecting more than half a million female patients.

A study conducted by the RCOG in 2022 shows such delays can significantly affect women’s physical and mental health, as well as their quality of life.

“We’re working on building a device that will be about half the size of an iPhone and completely portable. Women will be able to take it everywhere,” explained Dr Khan.

“Women will be able to test both blood and urine, as well as record symptoms, which will provide the most accurate and real-time picture of their health. The device will transfer key data wirelessly to an app, and share it with a gynaecologist.

“At Heriot-Watt we are working on the hardware development and miniaturisation aspect of the device, which is critical as we envision a portable female health monitoring device which women can carry anywhere and reliably use without any hassle.”

Dr Khan is working with viO HealthTech, whose OvuSense device provides continuous general monitoring of the reproductive cycle, and Dr Ruchi Gupta from the University of Birmingham, an expert in developing biosensors.

Rob Milnes, CEO of viO HealthTech, said: “Our users tell us they want access to personalised health information and insights that can help them make informed decisions about their health not only when issues occur, but to avoid those issues in the first place.

“This project offers the exciting prospect of targeted diagnostics added to our existing monitoring system”

Dr Ruchi Gupta from the University of Birmingham, added: “We have been developing our leaky waveguide (LW) biosensor to measure different types of biomarkers; proteins, DNA, hormones, and even cells.

“Our LW biosensor will be at the heart of the gadget for women’s health monitoring. Our partnership with Dr Khan and viO HealthTech will be a key step in the translation of our LW biosensor from bench to bedside. ”

Concept to commercialisation

The team have already started working on the project and, once they have proof of concept, they want to start focusing on making the device commercially available.

“As well as making sure we meet all regulatory requirements, we need to ensure that women can afford the device,” said Khan.

“We’re focused on making sure we are using affordable, sustainable materials that will make this available to a greater number of women.”

Professor Steve McLaughlin, deputy principal of research and impact at Heriot-Watt University, said: “The development of this device demonstrates how our new centre of excellence will support the creation of ground-breaking technologies that have the potential to revolutionise patient care.

“Bringing together academics and industry experts, we want to accelerate the process of bringing these vital developments to market.

“We already have several research projects underway and the next 12 months are going to be a really exciting time as we showcase our developments on the global stage.”

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Hormonal health

Man City launch female athlete health education platform

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Manchester City has launched a female athlete health platform covering menstrual, pelvic and breast health, as well as nutrition.

The Her City website is designed for the club’s women’s first-team players, coaches, support staff, academy players and parents.

Manchester City says the platform is the first of its kind in the Women’s Super League and was developed over two years.

The project was led by director of performance services Emma Deakin, physical performance scientist Rosie Anderson and PhD student and first-team nutritionist Sarah Malone.

It grew out of PhD research into menstrual, pelvic and breast health and nutrition, with the team seeking to turn that work into an online educational resource.

The website divides the four areas into separate sections and provides peer-reviewed information that the club says has been critically analysed by experts.

Content will continue to be reviewed and updated as further evidence emerges.

Resources include posters, visual explainers, audio materials and downloadable educational content, with information tailored to different groups including players and parents.

The platform aims to improve knowledge, develop critical analysis skills and strengthen communication within football and at home.

It also includes material to help users assess misinformation they encounter on social media or elsewhere.

A confidential contact form allows users to raise concerns or ask questions directly of experts at Manchester City.

Parents of academy players can also access the platform, with resources intended to help them support their children during a key phase of their development.

Manchester City said its longer-term aim is to make the platform available to all women working across City Football Group.

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Menopause

NIH awards multi-university team over US$4 million to improve women’s health

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Michigan State University researchers are launching a novel project to transform how medications are developed and prescribed for women.

A US$4.6m award will fund computer models designed to predict how hormonal changes affect the way medicines move through and act in women’s bodies.

The funding is the first instalment of an award worth up to US$12.8m over three years, supporting work intended to account for hormonal changes throughout women’s lives.

Researchers plan to examine factors including menstrual cycles, pregnancy, contraceptive use, menopause and hormone replacement therapy, which can affect responses to medicines.

Teresa K. Woodruff, lead investigator on the project, said: “Because female hormone levels are constantly shifting, precision medicine allows us to map out these complex interactions.

“This NIH-backed initiative will create the first computationally driven clinical tool designed to guide medical care across every stage of a woman’s life.”

The project is led by researchers at Michigan State University and funded by the National Institutes of Health, with collaborators from Rutgers, Emory, Tulane, the University of Colorado Anschutz, the University of Michigan and the University of Utah.

Thirteen researchers will develop computational models to predict how changes in female hormones influence the way medicines move through and act within the body.

The work is part of the NIH Computational Modeling of Hormone Homeostasis Initiative, which is awarding US$21m nationally to support research into sex-specific hormonal biology.

The team plans to use artificial intelligence to digitise and organise more than 40 years of hormone research data in a publicly accessible database.

Researchers will also develop a standard computer model of a 28-day menstrual cycle, alongside models of how hormones regulate organs and tissues involved in processing nutrients, including the liver, muscle and fat.

Real-world patient data will then be used to expand the models to represent groups including women going through menopause or taking birth control, as well as women with conditions such as diabetes and obesity.

The project will also use three-dimensional human tissue models and lab-grown organoids, including liver, muscle and ovarian tissue, to test and refine the computer predictions.

Researchers plan to examine medicines including metformin, insulin and GLP-1 drugs, with the aim of developing tools that could help clinicians tailor doses and avoid harmful side effects.

Qiang Zhang, associate professor at Emory University, said: “Empowered by AI, novel assays and legacy human data, we will develop mechanistically based computational models of female physiology that can make translational, quantitative predictions for women’s responses to metabolic therapies.”

The researchers said the work could help address differences in how women respond to treatments for metabolic conditions including obesity, type 2 diabetes, cholesterol imbalances and thyroid disorders.

Nanette Santoro, professor at the University of Colorado Anschutz and president of the Endocrine Society, said: “Women experience large shifts in reproductive hormones at several points in their lifespan: puberty, pregnancy and menopause.

“During reproductive years, women also undergo profound day-to-day changes in reproductive hormone levels, giving them a markedly different endocrine backdrop than men.

“Using state-of-the-art computational technology to examine how these changes interact with commonly used medications is a critical pathway toward supporting life-course women’s health.”

The project team said its computer models and data will be made freely available to researchers and healthcare professionals when the work is completed.

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Menopause

High street bakery chain Gail’s reveals menopause plan

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Gail’s has unveiled a menopause action plan offering new workplace support to thousands of staff ahead of legal reforms due in 2027.

The high street bakery chain will offer new benefits including 24/7 digital GP access and a new employee assistance programme, according to The Times.

It will also explore new online training for staff, including specific training for management.

Gail’s people director Miranda Burgum told The Times: “All we’re trying to do is talk freely and for it not to be a forbidden subject. It’s helping our managers and teams understand that this isn’t a taboo.”

“We’re going to develop the education with our managers, so it will be threaded through all our policies

“It will look at induction training, it will look at the types of people we need to make sure that we make reasonable adjustments for.

“And if somebody needs some sort of risk assessment, we’re going to be looking at [that].”

The move comes ahead of reforms due to be introduced in spring 2027 under the Employment Rights Act.

UK employers with 250 or more employees will be legally required to publish and update official menopause action plans.

The plans are intended to support employers to take effective action to improve workplace gender equality and support employees experiencing menopause.

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