Pregnancy
What is NIPT and why are more women choosing it?
Non-Invasive Prenatal Testing (NIPT) is becoming a common part of antenatal care across the UK.
Offering a safe, highly accurate way to screen for certain genetic and chromosomal conditions in early pregnancy, NIPT is increasingly chosen by expectant parents who want clearer, earlier insight into their baby’s health.
As of June 2021, NIPT has been added to the NHS screening pathway for pregnant women with a higher chance result from standard first- or second-trimester screening.
But while the NHS offer is focused on three core conditions, a growing number of private providers now offer more comprehensive screening options—and many women are choosing to go further.
Understanding How NIPT Works
NIPT works by analysing cell-free DNA found in maternal blood. From as early as 9 weeks, small fragments of fetal DNA originating from the placenta can be detected in the bloodstream. By sequencing and examining this DNA, NIPT can estimate the chance of conditions such as Down’s syndrome, Edwards’ syndrome, and Patau’s syndrome.
It’s important to note that NIPT is a screening test, not a diagnostic one. A high-chance result does not confirm the condition, and follow-up diagnostic testing—such as amniocentesis or CVS—is required. Likewise, a low-chance result cannot guarantee the baby is unaffected.
Watch on on YouTube a breakdown of how NIPT works:
NIPT on the NHS: What’s Included
Since 1 June 2021, the NHS has integrated NIPT into its Fetal Anomaly Screening Programme (FASP) for those identified as higher chance through standard screening.
Currently, the NHS NIPT screens for only three chromosomal conditions: Down’s syndrome (Trisomy 21), Edwards’ syndrome (Trisomy 18), and Patau’s syndrome (Trisomy 13). Eligibility is based on a risk result between 1 in 2 and 1 in 150 following the combined or quadruple test.
NHS guidance is clear that NIPT cannot be performed in specific cases, such as recent blood transfusion, certain cancer treatments, or the presence of a vanished twin. The NHS test does not report on fetal sex, other chromosomal abnormalities, or single-gene disorders.
According to data, around 1 in every 671 pregnancies in the UK is affected by one of these three conditions, making early, safe testing an important step for many.
This increased detection reflects the broader scope of conditions being screened—many of which now have potential treatment options either before or immediately after birth. In fact, researchers have recently identified nearly 300 genetic disorders considered treatable foetal findings, meaning they can be managed through prenatal or early postnatal interventions.
These conditions include heart defects, metabolic imbalances, and gastrointestinal disorders that can be stabilised or treated immediately after birth—sometimes even during pregnancy. With the help of genomic sequencing and family history analysis, these findings open the door to earlier, more proactive care.
Private NIPT: Basic vs Advanced Screening
Outside the NHS, private providers offer NIPT to anyone looking for earlier reassurance or broader screening.
Basic NIPT in private settings mirrors the NHS offer, screening only for the three most common trisomies. It’s a popular option for parents who want earlier access or more control over their care.
While basic NIPT focuses on Down’s syndrome, Edwards’ syndrome and Patau’s syndrome—which together affect approximately 1 in 671 pregnancies in the UK—advanced NIPT screens for additional conditions that, collectively, are more prevalent than many parents realise.
When these are included, the likelihood of detecting a potential genetic finding rises significantly, with some studies estimating that advanced panels identify actionable findings in as many as 1 in 126 pregnancies.
This increased detection is not due to a higher false positive rate, but reflects the broader scope of conditions being screened—many of which have established management plans or clinical relevance during pregnancy and early childhood.
Learn more about NIPT statistics: https://www.jeen.health/nipt/nipt-statistics
Why More Parents Are Choosing NIPT
There are several reasons why NIPT is gaining popularity. First and foremost, it is non-invasive and safe, involving only a simple blood draw from the mother. This makes it far less risky than procedures like amniocentesis or CVS, which carry a small risk of miscarriage.
It’s also highly accurate, with tests such as Panorama™ showing over 99 percent sensitivity for Down’s syndrome. These technologies also maintain strong specificity, reducing false positives and the emotional toll of uncertain results.
NIPT can be done early in pregnancy, typically from 9 or 10 weeks, offering information well ahead of the 20-week anomaly scan. This can be crucial for parents wanting time to plan or seek further support.
And unlike traditional screening, modern advanced NIPT panels cover a broader range of genetic and chromosomal conditions—including some that may not present at birth, but have long-term health implications.
Leading Providers in the UK
Several well-known clinics now offer NIPT across the UK. The London Pregnancy Clinic offers the SMART Test and PrenatalSafe, combining US and UK lab capabilities.
Concepto Diagnostics runs the Concepto-NIPT test with a strong focus on accuracy and fast turnaround.
CRGH offers the Neo5® platform, and The Medical Chambers Kensington provides testing using Illumina’s high-precision technology.
Each provider differs slightly in terms of lab location, result timing, and which conditions are screened—but all aim to provide peace of mind and clarity early in pregnancy.
Jeen’s New At-Home NIPT: Accessible and Clinically Guided
One of the most recent entries into the space is Jeen, a UK digital health provider specialising in genetic testing. Jeen now offers NIPT with at-home nurse visits or in-clinic testing at Spital Clinic, its partner GP practice in Shoreditch.
What makes Jeen’s service stand out is its emphasis on clinical oversight and accessibility. Every parent speaks with a genetic counsellor before testing to understand what NIPT can and cannot do.
Jeen’s obstetric team reviews scan reports to confirm eligibility and appropriateness for testing.
Once blood is drawn—either at home or in the clinic—results are returned within 2 to 10 days, with the option for post-test counselling.
Jeen also offers advanced NIPT panels, including screening for microdeletions and sex chromosome abnormalities, giving parents broader insight than what the NHS currently provides.
The experience is designed to be supportive, flexible and clinically robust—ideal for those who want clear guidance and expert support without needing to attend multiple hospital appointments.
The Future of NIPT in the UK
NIPT reflects a wider trend in maternity care: personalised, preventive medicine, made accessible through genomic technology.
While the NHS has made an important step in expanding access to NIPT for high-risk pregnancies, private services are offering more people a chance to act earlier and understand more.
Whether through the NHS or private providers, the goal is the same—to empower parents with knowledge and give them time to make informed decisions.
Fertility
Most NHS regions in England limit IVF to single cycle, research finds
Nearly 70 per cent of NHS regions in England fund only one IVF cycle for women under 40, breaking national guidelines, new research has found.
Twenty-nine of the 42 integrated care boards, which control local NHS budgets, now offer only one round of treatment, after four reduced access in the past year.
National Institute for Health and Care Excellence (Nice) guidelines recommend three full cycles for women under 40 who have been unable to conceive for two years.
Only two of England’s 42 integrated care boards have policies consistent with these guidelines, which they are not legally obliged to follow.
The research was conducted by the Progress Educational Trust, a fertility charity.
Sarah Norcross, the director of PET, said the impact was “devastating” for couples struggling with infertility.
She said: “Infertility is already incredibly stressful for people, and it puts them under even more pressure, because there is so much riding on whether that one NHS-funded cycle is going to work.
“And for some people, that will be their only chance, because private fertility treatment is so expensive.”
The data showed regional variations, with the whole of the north-west offering just one cycle.
“It’s a postcode lottery, and we’re seeing a race to the bottom,” said Norcross.
Of the 29 integrated care boards that offer a single cycle, 19 provide only a partial cycle, where not all viable embryos created are transferred.
There was just one recent example of improved services, from NHS South East London, which in July 2024 went from one partial to two full cycles.
The NHS estimates that about one in seven couples may have difficulty achieving a pregnancy. One cycle of IVF can cost from £5,000 at a private clinic.
Fertility rates in England and Wales have fallen since 2010 to 1.41 children per woman in 2024, the lowest on record and below the replacement level of 2.1 at which a population is stable without immigration.
Health minister Karin Smyth said in a written parliamentary answer last month that it was “unacceptable” that access to NHS-funded fertility services varied across the country.
Revised Nice fertility guidelines are due this spring, but Norcross said changing them seemed pointless.
She said: “Fertility treatment has always been a Cinderella service. It’s always been the one they’ve chosen to cut or to ignore.
“Nice has recommended three full NHS-funded cycles, for women under 40, for more than 20 years. This has never been implemented across England, unlike in Scotland.”
Norcross advocated centralised commissioning and replicating Scotland’s approach, which included financial modelling and a phased implementation starting with two cycles to avoid long waits, moving up to three once capacity was achieved.
“It is a tried and tested plan that England could follow,” Norcross added.
A Department of Health and Social Care spokesperson said: “We recognise access to fertility treatment varies across the country and we are working with the NHS to improve consistency.
“Nice provides clear clinical guidelines, and we expect integrated care boards to commission treatment in line with these.
“Updated Nice fertility guidelines are expected this spring and we will continue to support NHS England to make sure the guidance is fully considered in local commissioning decisions.”
An NHS England spokesperson said: “These clinical services are commissioned by integrated care boards for their area based on the needs of the local population and prioritisation of resources available.
“All ICBs have a responsibility to ensure services are provided fairly and are accessible by different population groups.”
Fertility
France urges 29-year-olds to start families now
France is urging 29-year-olds to have children as part of a 16-point plan to boost fertility and raise birth rates.
Health officials say the aim is to prevent men and women facing fertility problems later in life and thinking “if only I had known”.
The strategy comes as the country, like many western nations including the UK, faces tumbling birth rates.
The trend is creating concerns about how governments can fund pensions and healthcare for ageing populations with fewer younger working people paying taxes.
But policies to raise fertility rates globally have produced limited results, and critics of the scheme suggest better housing and maternity provision could be more effective.
The government will send out “targeted, balanced, and scientifically sound information” to young people on issues including sexual health and contraception.
The material “will also reiterate that fertility is a shared responsibility between women and men,” the country’s health ministry said.
The plan includes efforts to increase the number of egg-freezing centres from 40 to 70. The process involves extracting and storing a woman’s eggs for potential future use.
The country’s health system already provides free egg-freezing for people aged 29 to 37, a service that costs about £5,000 per round in the UK.
The country’s fertility rate of 1.56 children per woman is below the 2.1 needed to maintain a stable population.
However, it is higher than rates in China, Japan and South Korea, and the UK, where the latest figures show it dropped to a record low of 1.41 in England and Wales by 2024.
Professor François Gemenne, who specialises in sustainability and migration at HEC Paris Business School, told Sky News: “This is something that demographers had known for a long time, but the fact that there were more deaths than births in France last year created a shock effect.”
He said the country’s “demographic worry” is exacerbated by the design of its pensions system and its “obsession with immigration and the fear of being ‘replaced'”.
The plan also includes a new national communication campaign, a “My Fertility” website advising on the effects of smoking, weight and lifestyle, and school lessons for children about reproductive health.
The health ministry has acknowledged its maternal and infant mortality rates are higher than neighbouring countries and is beginning a review of perinatal care to address the “concerning” situation.
Channa Jayasena, professor in reproductive endocrinology at Imperial College London, told Sky News: “On the female side, societal changes leading to older age of motherhood are certainly important.
He said obesity was also a problem as it increased women’s risk of polycystic ovary syndrome and endometriosis.
Allan Pacey, professor of andrology (male reproductive health) at Manchester University, said for most people globally, deciding to have children was “down to [non-medical] factors such as better access to education, career opportunities, taxation, housing, mortgages, finance, etc.”
“Medicine can’t help with those things,” Pacey added.
Insight
Pregnancy and breastfeeding linked to higher cognitive ability in postmenopausal women
Pregnancy and breastfeeding are linked to stronger cognition in postmenopausal women, a long-term study suggests.
Greater cumulative time spent pregnant and time spent breastfeeding correlated with higher overall scores in the study, including verbal and visual memory, in later life.
Researchers analysed annual assessments of more than 7,000 women aged about 70 for up to 13 years using data from the Women’s Health Initiative Memory Study and the Women’s Health Initiative Study of Cognitive Aging.
On average, those who were pregnant for around 30.5 months were expected to have a 0.31 per cent higher global cognition score than those who had never been pregnant.
A lifetime average of 11.6 months of breastfeeding was linked to a 0.12 per cent higher global score.
Each additional month spent pregnant was associated with a 0.01-point rise in overall ability.
Each extra month of breastfeeding showed the same increase, and a 0.02-point gain in verbal and visual memory. Although small, these effects are similar to known protective factors such as not smoking and high physical activity.
The work was led by Molly Fox, an anthropology professor at the University of California, Los Angeles.
Fox said: “Any ways in which we can focus public health outreach or clinical interventions towards higher-risk populations leads to more effective and efficient efforts.”
Participants who had ever been pregnant scored, on average, 0.60 points higher than those who had never been pregnant.
Those who had breastfed scored 0.19 points higher overall and 0.27 points higher for verbal memory than those who had never breastfed.
Women are disproportionately affected by Alzheimer’s disease, a progressive condition that impairs memory and thinking skills, and this is not fully explained by life expectancy differences.
The authors say biology and social factors may both play roles.
They noted that more adult children could contribute to cognitive health by buffering stress, supporting wellbeing or encouraging healthy behaviour.
“If we can figure out, as a next step, why those reproductive patterns lead to better cognitive outcomes in old age, then we can work towards figuring out how to craft therapies, for example, new drugs, repurposed drugs or social programmes, that mimic the naturally occurring effect we observed,” said Fox.
The study team is now working to identify the mechanisms that link reproductive histories to cognitive resilience.
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