To receive the Femtech World newsletter, sign up here.
News
Contraception app raises US$55m to ‘fill gaps’ in women’s health
Natural Cycles is the only digital form of birth control on the market cleared by regulators around the world
The contraception app Natural Cycles has secured US$55m in funding to “fill the gaps” in underserved areas of women’s health.
Natural Cycles is the first direct-to-consumer contraceptive app that aims to help women plan or prevent a pregnancy “naturally” through an algorithm that analyses daily hormone-driven temperature changes to confirm if the user is fertile.
The app remains the only digital form of birth control on the market cleared by regulators in the US, Europe, Canada, Australia, Singapore and South Korea.
The US$55m funding round, led by Lauxera Capital Partners with participation from Point72 Private Investments and a revolving debt facility from J.P. Morgan, is hoped to help the Stockholm-based company invest in commercial acceleration, product development and healthcare reimbursement automation.
“We’ve experienced profitable growth over the last few years as women actively seek more birth control options and we’re excited to welcome the next phase of Natural Cycles journey together with Lauxera Capital Partners and Point72 Private Investments,” said Dr Raoul Scherwitzl, co-founder and CEO of Natural Cycles.
“We look forward to leveraging their expertise to fulfil Natural Cycles’ mission of making hormone-free birth control more accessible and combining technology and science to fill the gaps in underserved areas of women’s health.”
Samuel Levy, founding partner of Lauxera Capital Partners, added: “Our mission at Lauxera is to partner with ambitious entrepreneurs transforming the future of medicine with unique technology.
“The visionary Natural Cycles team has built an exceptional company delivering profitable growth supported by unique clinical and regulatory business moats.
“We are delighted to partner with Elina, Raoul and their team to offer women an alternative to traditional approaches without the side effects and compromises.”
As part of the investment, Levy will join Natural Cycles’ board of directors.
Lauxera Capital Partners and Point72 Private Investments join Natural Cycles’ current investors, including EQT Ventures, Samsung Ventures, Heartcore Capital, Headline and Bonnier Ventures.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
Insight
Higher nighttime temps linked to increased risk of autism diagnosis in children – study
Entrepreneur
Kindbody unveils next-gen fertility platform
-
Insight2 weeks agoParents sue IVF clinic after delivering someone else’s baby
-
Wellness3 weeks agoWomen’s health could unlock US$100bn by 2030
-
Insight4 weeks agoChina’s birth rate hits record low despite government fertility efforts
-
Menopause3 weeks agoHRT linked to greater weight loss on tirzepatide
-
Entrepreneur7 days agoUS startup builds wearable hormone tracker
-
Menopause2 weeks agoFlo Health and Mayo Clinic publish global perimenopause awareness study
-
Menopause2 weeks agoStudy reveals gap between perimenopause expectations and experience
-
Pregnancy6 days agoFrance urges 29-year-olds to start families now







7 Comments