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LifePoint Health partners with virtual clinic Midi to support women approaching menopause

The collaboration will focus on addressing specific health needs of women experiencing symptoms of perimenopause and menopause

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The US healthcare provider Lifepoint Health has announced a partnership with the virtual clinic Midi Health to improve care for women as they age.

The two companies seek to fill a significant gap in care for women experiencing symptoms of perimenopause and menopause by providing virtual care to thousands of women in the US.

Midi, a virtual care platform for women navigating midlife hormonal transition, says it will work closely with Lifepoint’s hospitals to “enhance” care for patients experiencing perimenopause and menopause with tech-enabled telehealth services.

According to Lifepoint Health, this collaboration will not only improve care for patients, but it will also help alleviate the burden placed on primary care providers and other women’s health providers who may lack this specialty or time to adequately address a patient’s unique needs at this stage of her life.

“Lifepoint serves a wide range of diverse communities from coast to coast, including those located outside of major urban areas,” said Joanna Strober, Midi co-founder and CEO.

“Midi connects women ages 40-65 who may live farther away from larger cities with convenient and specialised virtual care for the specific health concerns they may face as they age.

“This collaboration with Lifepoint represents a huge leap forward in our mission to put high-quality care within reach for all women.”

Hormonal changes through the menopause transition is estimated to cause life-altering symptoms for approximately 57 million American women, yet the vast majority do not receive treatment.

“Our collaboration with Midi is part of Lifepoint’s efforts to ensure inclusive care for those we serve and demonstrates our commitment to meeting patients where they are on their health journey,” explained Cherie Sibley, acute care service line president of Lifepoint Health.

“Women face a number of unique health concerns as they age, and Midi helps virtually connect them with skilled providers who can deliver the specialised care they need to navigate the post-childbearing years.

“We are excited about this new relationship and look forward to how our collaboration will further advance our mission of making communities healthier.”

Jessie Beegle, senior vice president and chief innovation officer of Lifepoint Health, said: “We are committed to bringing cutting-edge technologies and innovative solutions that are traditionally only found in Silicon Valley or at large academic medical centres to our community-based facilities across the country.

“Lifepoint is pleased to support this important segment of women’s health, and we look forward to expanding specialty care offerings through Midi to better care for women as they age.”

As part of this hybrid model, Lifepoint providers will be educated on the services offered by Midi and may decide to refer their patients for clinically appropriate services.

Midi may direct patients back to their Lifepoint providers for necessary in-person care, including mammograms, colonoscopies, PAP smears, surgeries, biopsies and ultrasounds.

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Topical HRT protects bone density in women with period loss – study

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Transdermal HRT best protects bone density in women with functional hypothalamic amenorrhoea, a condition that stops periods, a review of trials has found.

The meta-analysis pooled randomised clinical trials involving 692 participants and found transdermal hormone replacement therapy and teriparatide increased bone mineral density by between 2 and 13 per cent.

Functional hypothalamic amenorrhoea can follow anorexia or intense exercise. Bone mineral density measures bone strength and the amount of mineral in bone.

Around half of women with the condition have low bone mineral density, compared with about 1 per cent of healthy women, and their fracture risk is up to seven times higher.

The research was conducted by scientists at Imperial College London and Imperial College Healthcare NHS Trust.

Professor Alexander Comninos, senior author of the study and consultant endocrinologist at the trust, said: “Bone density is lost very rapidly in FHA and so addressing bone health early is very important to reduce the lifelong risk of fractures.

“Our study provides much needed comparisons of all the available treatments from all available studies.

“Clearly the best treatment is to restore normal menstrual cycles and therefore oestrogen levels through various psychological, nutritional or exercise interventions – but that is not always possible.

“The foundation for bone health is good calcium and vitamin D intake (through diet and/or supplements) but we have additional treatments that are more effective.”

When FHA is diagnosed, clinicians first try to restore periods through lifestyle measures, including psychological and dietary support, but these can fail. Guidelines then recommend giving oestrogen, though the best form was unclear.

The team reviewed all prior randomised trials comparing therapies, including oral and transdermal oestrogen, and also assessed teriparatide, a prescription bone-building drug used for severe osteoporosis.

They found no significant benefit for oral contraceptive pills or oral hormone therapy.

A recent UK audit reported that about a quarter of women with anorexia-related FHA are prescribed the oral contraceptive pill for bone loss; the study suggests using transdermal therapy instead.

Comninos said: “Our goal is simple: to help women receive the right treatment sooner and to protect their bone health in the long-term.

“We hope this study provides clinicians with better evidence to choose transdermal oestrogen when prescribing oestrogen and so inform future practice guidelines.

“Right now, millions of women with FHA may not be receiving the best treatments for their bone health.”

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AI cuts interval breast cancers in Swedish trial

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An AI tool cut interval breast cancers by 12 per cent in a Swedish screening trial of more than 105,000 women.

The study also found 27 per cent fewer aggressive breast cancers detected at screening when AI was used.

Interval cancers are cancers found between routine screening appointments because they were missed at the original scan. They are often more dangerous and linked to higher death rates than cancers found at screening.

The MASAI trial is described as the first large randomised study to test whether AI can improve mammography screening, which uses low-dose X-rays to examine breast tissue for signs of cancer.

The AI tool, called Transpara Detection and developed by ScreenPoint Medical, supported radiologists in analysing mammography images.

Earlier results from the same trial showed that Transpara Detection increased cancers found by 29 per cent and reduced radiologist workload by 44 per cent compared with standard double-reading, where two radiologists independently review each scan.

The latest findings indicate higher accuracy with AI support. Sensitivity, the ability to detect cancer, was 6.7 percentage points higher in the AI group while specificity, the ability to rule out healthy cases, was maintained. Results were similar across age groups and breast density levels.

Women screened with AI had 16 per cent fewer invasive interval cancers and 21 per cent fewer large interval cancers than those in the standard screening group.

The system also helps doctors assess risk more precisely by subdividing suspicious findings into BI-RADS 4 categories A, B and C. BI-RADS (Breast Imaging Reporting and Data System) is a standardised scale that guides whether a patient needs closer monitoring, further tests or treatment.

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Mental health

Fear of ageing may age women faster, study suggests

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Ageing anxiety may accelerate biological ageing in women, with fears about worsening health linked to faster epigenetic ageing, according to new research.

The study found that greater anxiety about growing old was associated with accelerated epigenetic ageing, as measured by the DunedinPACE clock, based on biological markers in blood samples.

Epigenetic changes are shifts in how genes are switched on or off without altering DNA itself, which can influence how the body ages and functions.

“Our research suggests that subjective experiences may be driving objective measures of ageing,” said Mariana Rodrigues, a PhD student and the first author of the study.

“Ageing-related anxiety is not merely a psychological concern, but may leave a mark on the body with real health consequences.”

Researchers analysed data from 726 women in the Midlife in the US study.

Participants were asked how much they worried about becoming less attractive with age, having more health issues and being too old to have children.

Blood samples were used to assess ageing with two epigenetic clocks: DunedinPACE, which estimates the pace of biological ageing, and GrimAge2, which estimates cumulative biological damage.

The study was conducted by researchers at NYU School of Global Public Health.

Worrying about declining health showed the strongest links with epigenetic ageing, while anxiety about attractiveness and fertility was not significantly associated with biological markers.

The authors suggest health worries are more common and persist over time, whereas concerns about appearance and reproduction may fade with age.

“Women in midlife may also be multiple in roles, including caring for their ageing parents,” Rodrigues said.

“As they see older family members grow older and become sick, they may worry about whether the same thing will happen to them.”

The authors caution that the study offers a snapshot in time and other factors may influence these biological changes.

When analyses were adjusted for health behaviours such as smoking and alcohol use, the link between ageing anxiety and epigenetic ageing decreased and was no longer significant.

“Our research identifies ageing anxiety as a measurable and modifiable psychological determinant that seems to be shaping ageing biology,” said Adolfo Cuevas, associate professor of social and behavioural sciences and the study’s senior author.

They call for more research to clarify how this anxiety influences ageing over time, to guide support for those experiencing ageing anxiety.

“Ageing is a universal experience.” Rodrigues said.

“We need to start a discourse about how we as a society, through our norms, structural factors and interpersonal relationships, address the challenges of ageing.”

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