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Menopause

HRT patches prevent prostate cancer spread, study finds

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HRT patches used for menopause may be as effective as injections at preventing prostate cancer spread, a study suggests.

Patches that lower testosterone by delivering oestradiol, a form of oestrogen, through the skin were found to be as effective as injections at stopping the cancer from spreading.

Researchers at University College London investigated whether the patches could match the effectiveness of current injection-based hormone therapies.

These injections are routinely given to men with locally advanced prostate cancer, where the disease has spread just beyond the gland.

The main aim of this hormone therapy is to suppress testosterone levels, a hormone that is crucial for the cancer’s growth.

The study, published in the New England Journal of Medicine, involved 1,360 men with an average age of 72, recruited from cancer centres across the UK.

Participants were either given patches to wear or received injections designed to block testosterone production, allowing researchers to compare the effectiveness of the two methods.

The patches used in the trial are the same as those used in hormone replacement therapy, or HRT, to treat menopause symptoms in women.

Researchers found the patches were just as effective as injections at preventing the cancer from spreading.

The patches also led to fewer side effects than injections, which can include hot flushes, bone density problems and risk factors for heart disease such as higher cholesterol, higher blood sugar and higher blood pressure.

However, the patches were linked to more breast tissue swelling.

Experts said patients who are given injections of LHRH agonists, a type of hormone therapy, need multiple hospital or GP visits, while oestradiol patches can be applied by patients at home.

Ruth Langley, from the MRC Clinical Trials Unit at UCL and lead author of the study, said: “We believe our findings should lead to men with locally advanced prostate cancer being able to choose which hormone therapy suits them best.

“For some men, for instance, hot flushes can be very debilitating, and so the patches could greatly increase their quality of life.”

Commenting on the study, Caroline Geraghty, senior specialist nurse manager at Cancer Research UK, said: “Thanks to research, over eight in 10 men diagnosed with prostate cancer will now survive for 10 years or more, as well as finding more effective treatments, we need to find ways to make them kinder too.

“This trial has done exactly that, it shows that hormone patches are just as effective as traditional injections at controlling locally advanced prostate cancer, while being much easier and gentler to administer.

“This should give men greater choice over their treatment in the future, allowing them to live not just longer lives, but better lives.”

The results were published as the UK national screening committee, which advises the Government, prepared to meet to decide the future of screening men for prostate cancer.

In a draft recommendation last year, it rejected population-wide screening using the prostate specific antigen, or PSA, test, saying it ‘is likely to cause more harm than good’.

The committee recommended only screening men with BRCA1 and BRCA2 genetic mutations, who are at much higher risk of prostate cancer, every two years between the ages of 45 and 61.

Health secretary Wes Streeting said he was surprised by the move but that any final decision needs to be ‘based on science and evidence, not on politics’.

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Menopause

‘Limited scientific evidence’ for most menopause supplements, expert says

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Many menopause supplements contain ingredients with limited evidence for symptom relief, while formulations and prices vary widely, a study has found.

Researchers analysed 201 products sold by nine major UK retailers, comparing their ingredients, doses and monthly costs.

Prices ranged from £1.50 to £95 a month, while no single ingredient or category of ingredient was common across all products.

The study, carried out by University College London, found that 80 per cent of products contained herbs, 77 per cent contained vitamins and 74 per cent contained phytoestrogens, naturally occurring plant compounds found in foods including soy and flaxseed.

Vitamin B6 was the most common vitamin, while red clover and sage were the most frequently identified plant ingredients.

Researchers said more evidence was needed on the effectiveness and safety of supplements marketed for menopause symptoms.

Professor Joyce Harper, senior author of the study and professor of reproductive science at University College London, said: “The menopause supplement market is growing rapidly, despite limited scientific evidence that many of these products improve menopause symptoms.

“Some social media influencers promote these products as effective solutions, despite many claims not being supported by scientific evidence.

“This can contribute to the spread of misinformation and help drive a rapidly growing menopause supplement market, leading some women to spend substantial amounts of money on supplements in the hope of improving their symptoms and overall wellbeing.”

Half of the supplements did not contain vitamin D, while less than 24 per cent contained calcium.

The British Menopause Society and International Menopause Society have highlighted vitamin D and calcium as important for maintaining bone health and preventing osteoporosis after menopause.

Researchers also identified botanical ingredients that may carry risks, including black cohosh.

Poppy Sullivan, first author of the study, said: “Certain botanical ingredients in some menopause supplements may also have risks.

“Black cohosh, in particular, is known to carry a potential risk of liver toxicity.”

The amounts of vitamins and minerals included in different products also varied widely.

Sullivan said: “Some nutrients can have adverse effects when consumed in excess over time.

“For example, excessive vitamin D intake can theoretically lead to high calcium levels, which could cause adverse effects such as vomiting and confusion.”

The study found little empirical evidence supporting the effectiveness of even the most expensive products.

Researchers called for more high-quality research, including clinical trials, to determine whether menopause supplement ingredients are effective and safe.

They said the findings could also help healthcare professionals understand the wide variation in supplement formulations.

The researchers acknowledged that the analysis may not have included every menopause supplement available in the UK.

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Menopause

High street bakery chain Gail’s reveals menopause plan

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Gail’s has unveiled a menopause action plan offering new workplace support to thousands of staff ahead of legal reforms due in 2027.

The high street bakery chain will offer new benefits including 24/7 digital GP access and a new employee assistance programme, according to The Times.

It will also explore new online training for staff, including specific training for management.

Gail’s people director Miranda Burgum told The Times: “All we’re trying to do is talk freely and for it not to be a forbidden subject. It’s helping our managers and teams understand that this isn’t a taboo.”

“We’re going to develop the education with our managers, so it will be threaded through all our policies

“It will look at induction training, it will look at the types of people we need to make sure that we make reasonable adjustments for.

“And if somebody needs some sort of risk assessment, we’re going to be looking at [that].”

The move comes ahead of reforms due to be introduced in spring 2027 under the Employment Rights Act.

UK employers with 250 or more employees will be legally required to publish and update official menopause action plans.

The plans are intended to support employers to take effective action to improve workplace gender equality and support employees experiencing menopause.

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Menopause

Menopause frequently missing from electronic health records – study

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Menopause is often absent from women’s electronic health records, a study of nearly 396,000 women has found.

Researchers found menopause appeared almost seven times more often in participant surveys than in electronic health records (EHRs).

The findings suggest important reproductive health information, including age at menopause, may often be missing from health records used for research.

Audrey Hendricks, associate professor of bioinformatics at CU Anschutz and the study’s principal investigator, said: “Ultimately, we cannot study what we do not measure. We cannot treat what we do not know.

“Menopause has enormous implications for women’s health, but if we don’t consistently capture when menopause occurs and other important reproductive health information, we limit our ability to understand how this transition affects disease risk and health outcomes.”

Researchers at the University of Colorado Anschutz analysed data from women taking part in the National Institutes of Health’s All of Us Research Program.

They compared menopause information reported by participants in surveys with menopause diagnoses recorded in their electronic health records.

Around 193,000 menopause observations were identified in survey data, compared with approximately 28,000 diagnoses in EHR data.

Menopause was documented in electronic health records for only about 7 per cent of women in the dataset.

Nearly all participants with a menopause diagnosis recorded in their EHR also reported menopause in survey data. However, substantially fewer women had menopause documented in their health records.

Other important information was also frequently unavailable, including age at menopause, which researchers may use when examining links between menopause and chronic disease risk.

Menopause is a physiological transition that can affect cardiometabolic health and many other aspects of women’s health.

Researchers said relatively little is known about how factors including the timing and type of menopause influence health outcomes across diverse populations.

Large-scale programmes such as All of Us combine participant surveys, electronic health records and genomic data, but menopause-related research depends on relevant reproductive health information being available.

Missing menopause information can make it harder to investigate how the transition relates to health and disease.

The findings may also help researchers using All of Us data define menopause-related study populations, design studies and estimate how many participants are needed.

Hendricks said: “We have an enormous opportunity to use large-scale datasets to understand women’s health across the menopause transition and to identify who may be at greater risk for disease.

“But we need to make sure that the information researchers need is actually being collected.

“We must do a better job of capturing women’s health information, including reproductive health and measures related to menopause.”

Researchers said more complete and consistent collection of menopause and reproductive health information could help future studies examine factors such as age at menopause and their relationship with disease risk and health outcomes.

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