Menopause
Perimenopausal depression: the symptoms to look out for and how to help employees
By Dr Haleema Sheikh, specialist in integrative women’s health and bioidentical hormone balancing, Marion Gluck Clinic

When the orchestra of hormones is not balanced, mood can be severely impacted. Dr Haleema Sheikh goes through everything you need to know about perimenopause.
Perimenopause is the lead up to menopause when the effects of hormonal changes start to become evident.
It refers to the menopausal transition phase when the levels of reproductive hormones become more variable, and the effects of these fluctuations are felt throughout the body including the brain.
Interestingly, perimenopause can last for 10 years or more, ending one year after the last menstrual cycle – which is the official date of menopause.
Thus, it is useful for women to know what to expect and equip themselves with knowledge and tools to empower themselves to navigate a path through.
Hormones are chemicals produced by your body’s glands, which signal the body to initiate certain physical processes like ovulation as well as mental functions such as mood regulation.
We have receptors in the brain for reproductive hormones and thus fluctuations and hormonal imbalances can have a profound impact on our mood and also through their impact on neurotransmitters
There are four main hormones that have a significant effect on mood: oestrogen, progesterone, testosterone and cortisol.
- Oestrogen can improve mood by supporting serotonin – the happy neurotransmitter – and noradrenaline levels in the brain.
- Progesterone is our soothing calming and sleep-inducing hormone which can alleviate mood swings, irritability, and depression.
- Testosterone is an uplifting hormone and helps with a sense of wellbeing, focus and confidence.
- Cortisol is a released as a stress response from the adrenal glands and when stress is chronic remains elevated at the expense of sex hormones, which in turn creates further imbalances. It can cause irritability, anxiety, and low moods when over or under produced – adrenal dysfunction.
When the orchestra of hormones is not balanced with glands producing too much or not enough of a particular hormone, mood can be severely impacted and, in some cases, lead to depression.
Women during perimenopause can be vulnerable to such mood issues with the fluctuations and dropping hormones.

Symptoms of depression may include fatigue and lack of energy, feeling restless or slowed down, struggles with focus and remembering things, apathy and lack of interest in activities previously enjoyed as well as feelings of helplessness, hopelessness or worthlessness.
Reduced levels of female hormones during perimenopause may also cause additional depressive symptoms such as mood swings, sleep problems, hot flashes, irritability and feeling profound despair and tearful.
Premenopausal depression may present somewhat differently than classical depression with more irritability and more frequent mood changes, while feeling sad and tearful are less often experienced.
There are additional risk factors associated with perimenopausal depression which include family history of depression, prior history of sexual abuse or violence, having a sedentary lifestyle, smoking, being socially isolated, struggling with self-esteem, having negative feelings about ageing and feeling disappointed about not being able to have children.
Awareness of these can be helpful to identify those women who are more vulnerable and may have difficulty adapting to the fluctuating levels of oestrogen and progesterone during the menopause transition.
A significant percentage of women going through perimenopause and menopause are prescribed medication such as antidepressants by their GP or a mental health specialist.
However, low mood around the time of menopause is very likely to have hormonal imbalance as a root cause and in women where there is no prior history of depression antidepressants may not be the most effective treatment.
A lot of women going through perimenopause are misdiagnosed with depression and can feel a lot better with lifestyle changes and bioidentical progesterone treatment especially early on in perimenopause.

Antidepressants regulate certain neurotransmitters like serotonin and noradrenaline that can affect mood but they do not address the underlying hormones imbalances associated with perimenopause or menopause which are often the important root causes.
There are a number of lifestyle factors that can help improve hormone balance and thus improve mood during perimenopause. And it would be ideal to work on these before accessing pharmaceutical medication.
Working on lifestyle to optimise hormonal balance and brain health will in turn help improve mood and emotional health:
- ‘When the body moves the brain grooves.’ Movement and exercise help the body release natural endorphins and BDNF (brain derived neurotrophic factor) that lifts our mood.
- B vitamins can be important to the mental and emotional well-being of perimenopausal women as they improve hormonal balance and support progesterone production
- Mindful breathing can help reduce anxiety. A common technique involves paying attention to your body’s response to natural relaxation as you slowly breathe in — from the abdomen — and then exhale. Doing this for 10-15 minutes a day will help bring down stress and cortisol levels which in turn improves reproductive hormone production
- Proper sleep-adopting good sleep habits such as going to bed at the same time every night in a quiet, dark, cool room and avoiding using electronics in bed.
- Valerian is an herb which has been shown to help perimenopausal depresstion and contains a number of compounds that may help promote calmness by increasing GABA (neurotransmitter) availability in the body and interacting with certain receptors involved in mood and sleep.
It is important for employers to understand the impact of hormonal fluctuations during perimenopause on mood, as it can have a profound effect.
Building awareness in the workplace and a having a framework to support women is essential to ensure the expertise and wisdom of this demographic is retained.

Open communication with sensitivity empathy and active listening as well as careful consideration of how employees can have access to high quality information and education about perimenopause/menopause are key.
This will encourage women to talk with honesty and engender self-compassion and agency.
It would be worth considering hosting an organisational campaign on the perimenopause to break taboos and to raise awareness.
This could be as simple as putting up posters or hosting a talk which could fit into a wider organizational well-being week.
Developing a healthy lifestyle culture within the workplace will mitigate a lot of the troublesome mood issues during perimenopause/ menopause.
It is important to lead by example and consider how to incentivise employees to look after themselves which will in turn lead to improved productivity.
Ensuring a balanced timetable for staff with breaks for movement and access to healthy protein-based snacks to balance blood glucose is helpful. A simple 10-minute walk can alleviate anxiety and improve mood
Hormone replacement therapy can certainly help alleviate the hormone fluctuations and help women rebalance their mood especially if there is significant flux.
HRT will work better with a good foundational lifestyle, and this is an important message to share.
Bioidentical hormone prescribing allows for a personalised approach to check hormone levels and ensure a balanced prescription is issued for each woman according to where they are in their perimenopausal journey.
Dr Haleema Sheikh is certified in functional medicine and uses her knowledge to complement hormone balancing. She has joined the Marion Gluck Clinic last year and is particularly well versed in women’s health issues including PCOS, PMS, perimenopause and menopause.
News
Resistance training has preventative effects in menopause, study finds

Resistance training improves hip strength, balance and flexibility during menopause and may also improve lean body mass, research suggests.
A study of 72 active women aged 46 to 57 found those who completed a 12-week supervised programme saw greater gains than those who kept to their usual exercise routines.
None of the participants were taking hormone replacement therapy.
The supervised, low-impact resistance exercise programme focused on strength at the hip and shoulder, dynamic balance and flexibility.
Participants used Pvolve equipment, including resistance bands and weights around the hips, wrists and ankles, and also lifted dumbbells of varying loads.
Women in the resistance training group showed a 19 per cent increase in hip function and lower-body strength, a 21 per cent increase in full-body flexibility and a 10 per cent increase in dynamic balance, meaning the ability to stay stable while moving.
Those in the usual activity group did not show any significant improvements.
Previous studies have assessed the decline in lower limb strength and flexibility during menopause, but this is said to be the first study to compare the effect of resistance training on muscle strength and mass before, during and after menopause.
This was done by including participants in different phases of menopause rather than following the same participants over a long timeframe.
Francis Stephens, a researcher at the University of Exeter Medical School in the UK, said: “These results are important because women appear to be more susceptible to loss of leg strength as they age, particularly after menopause, which can lead to increased risk of falls and hip fractures.
“This is the first study to demonstrate that a low-impact bodyweight and resistance band exercise training programme with a focus on the lower limbs, can increase hip strength, balance, and flexibility.
“Importantly, these improvements were the same in peri- and post-menopausal females when compared to pre-menopausal females, suggesting that changes associated with menopause do not mitigate the benefits of exercise.”
Although one of the researchers sits on Pvolve’s clinical advisory board, the researchers said the company did not sponsor the study or influence its results.
Stephens added that any progressive resistance exercise training focused on lower-body strength is likely to yield the same results.
He said: “The important point is for an individual to find a type of exercise, modality, location, time of day etc., that is enjoyable, sustainable, and improves everyday life.
“The participants in the present study reported an improvement in ‘enjoyment of exercise,’ and some are still using the programme since the study finished.”
Kylie Larson, a women’s health and fitness coach and founder of Elemental Coaching, who was not involved in the study, said the results were compelling.
She said: “This is particularly exciting for those that tend to think of menopause as ‘the end’. The study proves that if you incorporate strength training you can still make improvements to your muscle mass and strength, which will also have a positive ripple effect to your ability to manage your body composition.
“In addition, staying flexible and being able to balance are both keys to a healthy and functional second half of life.”
Participants in the study did four classes a week for 30 minutes each session, but Larson said even half that amount of strength training can go a long way, particularly if you emphasise progressive overload, which means gradually increasing muscle challenge through more weight.
Larson said: “Gradually increasing the challenge is what drives real change.
“Lifting heavier over time is what builds strength, protects your bones, and keeps your body resilient through menopause and beyond.”
Menopause
More research needed to understand link between brain fog and menopause, expert says

Brain fog in menopause is common but still poorly understood, with researchers calling for more work to explain the link and how best to support women.
For a new perspective article published in The Lancet Obstetrics, Gynaecology, & Women’s Health, researchers based in the UK and Australia reviewed the evidence on menopause-related cognitive symptoms. They found that symptoms such as forgetfulness, reduced concentration and brain fog are common during the menopause transition, but are still poorly recognised and under-researched.
More than two-thirds of women report difficulties with memory or concentration over the menopause transition. Multiple factors may contribute to these cognitive symptoms, including hormonal changes, sleep disturbances and psychological and psychosocial stress. Yet, because cognitive symptoms are not widely discussed, they can cause considerable worry, with some fearing they are signs of dementia or undiagnosed neurodevelopmental conditions.
The review paper emphasises that overall cognitive performance for women experiencing menopause-related brain fog typically remains within expected ranges and, importantly, that cognitive symptoms are not linked to an increased risk of dementia.
Professor Aimee Spector of UCL Division of Psychology and Language Sciences, co-author on the paper, said: “Cognitive symptoms such as forgetfulness and ‘brain fog’ are incredibly common during menopause, yet they are often overlooked. Our findings highlight just how complex menopause-related cognitive symptoms are, and how much we still don’t know about what drives them. More targeted research is essential if we are to identify which biological, psychological or lifestyle factors contribute most, and what types of support or treatment are likely to be effective.”
The authors argue that clinicians can play a key role in understanding and validating women’s experiences by asking about the duration of cognitive symptoms, impacts on day-to-day functioning and any other medical or psychosocial factors that could be contributing to cognitive symptoms.
The review also discusses a range of approaches that may ease cognitive symptoms, such as improving sleep quality, engaging in regular aerobic exercise and eating a balanced diet. There is also little but promising research into the impact of psychological therapies targeting cognitive symptoms, with a recent meta-analysis of three cognitive behavioural therapy-based studies showing significant improvements in memory and concentration. The evidence is more mixed for the benefits of hormone therapy on cognitive symptoms during menopause.
The authors identify cognitive symptoms as a major area of unmet need in menopause research. They call for a unified definition of menopause-related cognitive changes and for prospective, longitudinal studies that can track women from pre- to post-menopause. Better understanding of the biological, psychological and social factors that contribute to cognitive symptoms will be crucial for developing effective treatments.
Lead researcher Dr Caroline Gurvich of Monash University said: “There’s a lot of pressure to use objective measures of cognitive decline, like a memory test, for example, in a clinical trial, but the key symptom of brain fog is a subjective experience. So having a definition that acknowledges the key cognitive symptom is critical.”
This is not without precedent – we already use subjective or self-report measures for depression, anxiety and other mental health conditions with great success.
Dr Gurvich said the proposed definition would also validate women’s individual experiences while empowering them through the reassurance that any objective decline in their cognitive ability is subtle.
She added: “This is a decrease in cognitive or learning efficiency, not functionality or capacity. For many women, the perception they are losing capacity is what drives them to stop work or lose the confidence to live fulfilling lives during and after menopause. I hear all the time from women who have gone through menopause that validation would have made a significant difference to their resilience and the approach they took to living with menopause.”
Co-author Professor Martha Hickey of the University of Melbourne and Royal Women’s Hospital said: “Our analysis of the best available research shows that many women experience some degree of cognitive symptoms, such as brain fog, during the menopause transition.”
“But there’s a lack of long-term data, which means that there’s a gap in our knowledge about how the brain fog symptom develops and changes from peri-menopause to after menopause ends. It’s a real gap in our understanding.”
Professor Spector added: “We increasingly see women, typically at the peak of their careers, losing confidence in the workplace, often translating to leaving work or reducing work hours. Having simple strategies to support and retain them at work is also a broader economic issue.”
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