News
Maven Clinic secures US$90m to advance reproductive health platform
The round will bring Maven’s total funding to US$300m
The US virtual clinic Maven has raised US$90m in funding to invest in personalisation across its reproductive health platform.
The end-to-end reproductive health and family care platform offers support and virtual care, including fertility, family building, maternity, parenting, pediatrics and menopause support.
The clinic partners with employers and health plans to deliver family benefit design in an effort to reduce costs of care and improve clinical outcomes.
The new funding round, led by General Catalyst, with participation from CVS Health Ventures, La Famiglia and Intermountain Ventures, will bring Maven’s total funding to US$300m, highlighting the growing demand for women’s and family health services globally.
“At Maven, we have reimagined the care model to address the complex needs of women and families in a global system that was not designed for them,” said Kate Ryder, founder and CEO of Maven Clinic.
“Whether it’s a pregnant woman faced with access issues in rural America, working parents in India needing financial support and navigation for infertility treatment, a same-sex couple facing bias in the opaque surrogacy industry, or a senior executive unable to get support for menopause, our platform shows up reliably, affordably, and relentlessly focused on patient outcomes.”
The clinic says it will use the capital to invest in personalisation across its platform to drive meaningful outcomes in both commercial and Medicaid populations, enhance localisation of resources to meet the cultural and country-specific needs of its members, and increase depth of support across all family and reproductive health life stages.
With almost one third of US women of reproductive age living in states with restrictions on access to abortion, 15 per cent of reproductive-age couples globally experiencing infertility, and nearly one in three women saying they have taken sick days for their menopause symptoms, the need for greater access to quality care has become even more urgent.
Dr Jeff Tzeng, AT&T senior vice president of health and wellbeing, said: “At AT&T, we’re passionate about providing world-class, family-focused benefits to support the total wellbeing of our employees.
“Maven is a wonderful complement to the generous reproductive health benefits, paid parental leave and family planning resources we offer, helping AT&T mums and dads access care providers, educational materials and parental support at every stage of their experience.
Holly Maloney, managing director at General Catalyst, added: “Maven’s technology-driven platform is purpose-built to create a personalised care experience for all women and families regardless of geography, income level, or pathway to parenthood, which aligns with our health assurance mission to create a proactive and equitable system of care.
“Maven has already demonstrated incredible outcomes driving commercial traction and a breadth of coverage that we have not seen in a women’s and family care platform.
“The GC health assurance team and community is excited to join Maven in this exciting new phase of growth.”
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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