News
Most midlife women with menopause symptoms don’t seek care, research finds
More than 80 per cent of women with menopause symptoms do not seek medical help, despite the impact on daily life, according to new research.
The study surveyed nearly 5,000 women aged 45 to 60 across four Mayo Clinic primary care sites, finding that more than three-quarters had experienced symptoms affecting work productivity and overall wellbeing.
Conducted by the Mayo Clinic, the research found that menopause symptoms remain underrecognised, undertreated and inadequately addressed within the healthcare system, despite the availability of effective treatments.
Lead author Ekta Kapoor is an endocrinologist and menopause specialist at the Mayo Clinic in Rochester.
The researcher said: “Menopause is universal for women at midlife, the symptoms are common and disruptive, and yet, few women are receiving care that could help them.
“This gap has real consequences for women’s health and quality of life, and it’s time we address it more proactively.”
More than one-third (34 per cent) the survey respondents reported moderate to very severe symptoms.
Sleep disturbances and weight gain were among the most common issues, affecting more than half of participants.
Only about one in four women were receiving treatment at the time of the survey.
While some preferred to manage symptoms independently, others said they were too busy or unaware that effective treatments exist.
Without proper treatment, menopause symptoms can negatively affect sleep, mood and cognition, as well as productivity at work and home.
The study noted that women often do not raise menopause-related concerns during medical appointments.
Researchers emphasised the need for strategies to destigmatise menopause care and make it more visible and accessible.
Work is underway to develop questionnaires, digital tools and smartphone apps that help women identify symptoms, learn about treatment options and have more productive discussions with their healthcare professionals.
Dr Kapoor said: “Our goal is to educate women and healthcare professionals about menopause.
“By making it easier to recognise and understand symptoms, we can close the gap between need and care – and help midlife women live healthier, more fulfilling lives.”
Cancer
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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