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Understanding inflammaging and how preventative health data could help lessen its impact

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By Dominique Kent, CEO, Bluecrest

As women, we spend much of our lives juggling, I know this from my own experience.

Running a business, raising a family, caring for parents as they get older, the list is endless. Somewhere in the mix, our own health slips down the priority list.

That is why the idea of inflammaging resonates so strongly with me.

It is a quiet, creeping process in the body: low-level inflammation that builds up over time and accelerates ageing.

Unlike a sprained ankle or a winter flu, you cannot feel it happening.

Yet it’s there, silently increasing the risk of conditions that affect so many women in later life such as heart disease, osteoporosis and dementia.

My background before Bluecrest was in the care sector where I saw first-hand what happens when people live longer but not necessarily well.

Too many spent their final years dealing with pain, frailty and loss of independence.

It shaped my belief that the goal for us all should not just be about lifespan but healthspan: the years we live in good health, able to do the things we enjoy and remain independent.

Inflammaging is a direct and silent threat to this, so it’s something that needs to be addressed.

We as women face some particular challenges here. Hormonal changes during menopause remove a natural buffer against inflammation. Autoimmune conditions, which are often inflammatory, are far more common in women.

There are pressures outside of our biologies too, which often fall more heavily on women: stress, trauma, poor sleep, carrying the invisible load of family responsibilities.

All of these add to the inflammatory burden.

The danger is that inflammaging is invisible, you don’t wake up one day and feel it.

Instead it builds, and its impact often only shows when something serious has developed. This is what makes it so risky.

We already know that women’s health issues are often picked up late, misdiagnosed or brushed aside. Add a hidden process like inflammaging into the mix and you see why prevention is so important.

That focus on prevention is what drew me to Bluecrest.

        Dominique Kent

The NHS has made prevention a key part of its long-term plan, and rightly so. If we can spot risks earlier, through small and regular interventions, we can act earlier. That is good for individuals and for the health system.

Inflammaging links directly to so many of the chronic conditions that we see in the headlines, the ones that put the heaviest strain on the NHS, so tackling it at source makes sense.

At Bluecrest, I see how empowering it can be when women come for a health check.

Often it is the first time in years they have put themselves at the top of the list, rather than convincing their husbands or parents to get checked out.

The results are not always perfect, but even when they show areas of concern, women tell me they feel in control.

They leave with a plan, and with knowledge which can be a huge turning point.

I also think about this in the context of business.

Midlife is often when women are at the peak of their careers, yet it is also when health issues start to appear. If hidden risks like inflammaging go unaddressed, we lose women from the workforce at a time when their skills and leadership are most needed.

For me, that’s why prevention is not just a personal issue, it is an economic one.

The good news is that there are things we can do.

A balanced diet, regular exercise, proper sleep and managing stress all help reduce inflammation. Stopping smoking and cutting back on alcohol make a difference too.

But it is unrealistic to leave it all to the individual – and we’ll fail if we add this to an already never-ending list of responsibilities that women take on.

This is where femtech has such a vital role to play.

For too long, women have lacked access to the kind of information that would allow them to make confident and informed health decisions. Now we are seeing new technologies emerge that can change that.

From wearable devices that track sleep and stress, to apps that monitor cycle changes, to biomarker tests that give an early picture of cardiovascular or metabolic risk, women can increasingly access the data they need to understand their own bodies and act sooner.

At Bluecrest, we see how powerful it is when women are given personalised health information alongside the expertise and support to understand it. It shifts prevention from being a vague idea into something tangible.

When data is made accessible, women are more likely to act, whether that is adjusting lifestyle choices, speaking to a GP, or booking follow-up tests.

For femtech to really deliver, though, it has to be part of a bigger ecosystem.

Women need healthcare services that take their concerns seriously, workplaces that respect their health needs, and innovations that are affordable and fit in with their lives.

You’re not going to go and get your inflammation levels checked if you have to take a day off work or caring responsibilities and travel 50 miles to get there.

Data is only empowering when it is clear, trusted and connected to practical next steps.

That is the opportunity now: to combine the science of inflammaging with the growing power of technology, so that women can extend not only lifespan but healthspan, with more years lived in good health and independence.

As a female CEO, I feel a responsibility to use my voice on issues like this.

Women’s health has too often been overlooked, underfunded and under-researched.

Inflammaging may be silent, but it does not have to remain invisible.

By naming it, understanding it, and taking action early, we can give women more years of healthy, independent life.

Wellness

Elimination of cervical cancer in EU an ‘achievable goal’, report finds

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Cervical cancer elimination in the EU is becoming achievable as HPV vaccination coverage rises, a new report says.

As Europe marks European Immunisation Week 2026, the European Centre for Disease Prevention and Control said progress in human papillomavirus vaccination is continuing across the EU and European Economic Area.

All EU and European Economic Area countries now recommend HPV vaccination for adolescent girls and boys as part of their immunisation programmes, marking a major step forward in Europe’s cancer prevention efforts.

Bruno Ciancio, head of unit, directly transmitted diseases and vaccine preventable diseases at the European Centre for Disease Prevention and Control, said: “The elimination of cervical cancer in the EU/EEA is becoming an achievable goal, thanks to the HPV vaccination programmes.

“The progress we are seeing across Europe demonstrates what can be accomplished when countries invest consistently in effective immunisation strategies.

“We are closely monitoring this progress and actively supporting countries to accelerate uptake and move faster towards cervical cancer elimination.”

According to the report, three EU and European Economic Area countries, Iceland, Portugal and Norway, have reached the 2024 EU Council Recommendation target of 90 per cent HPV vaccination coverage among girls by the age of 15.

Fifteen years after HPV vaccination programmes were introduced in Europe, a growing body of evidence confirms the vaccine is highly effective in preventing cervical cancer.

Large-scale studies from Sweden, the Netherlands and Denmark, as well as other parts of the world, have shown significant reductions in HPV infections and precancerous lesions, which are abnormal cell changes that can develop into cancer if left untreated, alongside falling cervical cancer rates among vaccinated women.

Since 2020, European countries have reported a decreased incidence of cervical cancer among vaccinated women.

Studies from Sweden, Denmark and the UK show that early administration of the vaccine increases its full protective potential.

A Swedish study suggested that vaccinating girls before their 17th birthday reduced the incidence of cervical cancer by 88 per cent.

An additional six-year follow-up found a sustained reduction in cervical cancer risk and a population-level decline in invasive cervical cancer incidence after HPV vaccination.

The report showed that vaccination programmes and health system design are critical factors in reaching high levels of HPV vaccination coverage.

Evidence from across Europe showed that school-based vaccination programmes are particularly effective and tend to reach higher levels of coverage among both girls and boys.

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Wellness

Poor mental health, poverty and pollution significantly raise women’s heart failure risk – study

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Poor mental health, poverty and pollution can raise women’s heart failure risk, with up to one in four cases potentially preventable, a study has found.

UK Biobank data from more than 230,000 women suggest that depression, socioeconomic hardship and exposure to polluted environments are linked to a significantly higher risk of heart failure in women.

Heart failure happens when the heart becomes too weak or too stiff to pump blood effectively around the body.

High blood pressure, high cholesterol, smoking and diabetes are among the better-known risk factors often targeted in public health campaigns.

Peige Song from China’s Zhejiang University and her team found that living in polluted areas, having poor mental wellbeing, facing socioeconomic deprivation and experiencing chronic inflammatory conditions such as lupus, in which the immune system attacks the body’s own tissues, make women more prone to heart failure.

These risks, however, are often overlooked.

The researchers found that mental wellbeing, environmental exposures, socioeconomic circumstances and reproductive history together contributed almost as much risk for heart failure as all well-known risk factors combined.

The study also found that risk rises with socioeconomic hardship and chronic inflammatory conditions such as lupus or rheumatoid arthritis, approaching the impact of conventional risk factors.

Song said: “[The study] is a call to redefine prevention in women’s cardiovascular health, integrating biological, psychosocial and structural determinants into a unified, equitable approach.

“One in four heart-failure cases in women could be prevented if all under-recognised risk factors were eliminated, assuming causal relationships.”

While completely eliminating all risks is not realistic, Song said “even partial reductions through better mental health services, social equity policies and environmental regulations could yield significant public health benefits”.

Catherine Pirkle, a women’s health specialist at the University of Hawaiʻi at Mānoa in the US, who was not involved in the study, said: “These calculations show convincingly that under-recognised and female-specific risk factors contribute significantly to heart failure in women, independently of the well-established ones.”

Song said: “It’s important to understand that heart health is influenced by more than just blood pressure or cholesterol.

“Factors like mental wellbeing, reproductive milestones and socioeconomic conditions all matter. Awareness and advocacy for comprehensive, gender-sensitive care are key.”

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Resistance training has preventative effects in menopause, study finds

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Resistance training improves hip strength, balance and flexibility during menopause and may also improve lean body mass, research suggests.

A study of 72 active women aged 46 to 57 found those who completed a 12-week supervised programme saw greater gains than those who kept to their usual exercise routines.

None of the participants were taking hormone replacement therapy.

The supervised, low-impact resistance exercise programme focused on strength at the hip and shoulder, dynamic balance and flexibility.

Participants used Pvolve equipment, including resistance bands and weights around the hips, wrists and ankles, and also lifted dumbbells of varying loads.

Women in the resistance training group showed a 19 per cent increase in hip function and lower-body strength, a 21 per cent increase in full-body flexibility and a 10 per cent increase in dynamic balance, meaning the ability to stay stable while moving.

Those in the usual activity group did not show any significant improvements.

Previous studies have assessed the decline in lower limb strength and flexibility during menopause, but this is said to be the first study to compare the effect of resistance training on muscle strength and mass before, during and after menopause.

This was done by including participants in different phases of menopause rather than following the same participants over a long timeframe.

Francis Stephens, a researcher at the University of Exeter Medical School in the UK, said: “These results are important because women appear to be more susceptible to loss of leg strength as they age, particularly after menopause, which can lead to increased risk of falls and hip fractures.

“This is the first study to demonstrate that a low-impact bodyweight and resistance band exercise training programme with a focus on the lower limbs, can increase hip strength, balance, and flexibility.

“Importantly, these improvements were the same in peri- and post-menopausal females when compared to pre-menopausal females, suggesting that changes associated with menopause do not mitigate the benefits of exercise.”

Although one of the researchers sits on Pvolve’s clinical advisory board, the researchers said the company did not sponsor the study or influence its results.

Stephens added that any progressive resistance exercise training focused on lower-body strength is likely to yield the same results.

He said: “The important point is for an individual to find a type of exercise, modality, location, time of day etc., that is enjoyable, sustainable, and improves everyday life.

“The participants in the present study reported an improvement in ‘enjoyment of exercise,’ and some are still using the programme since the study finished.”

Kylie Larson, a women’s health and fitness coach and founder of Elemental Coaching, who was not involved in the study, said the results were compelling.

She said: “This is particularly exciting for those that tend to think of menopause as ‘the end’. The study proves that if you incorporate strength training you can still make improvements to your muscle mass and strength, which will also have a positive ripple effect to your ability to manage your body composition.

“In addition, staying flexible and being able to balance are both keys to a healthy and functional second half of life.”

Participants in the study did four classes a week for 30 minutes each session, but Larson said even half that amount of strength training can go a long way, particularly if you emphasise progressive overload, which means gradually increasing muscle challenge through more weight.

Larson said: “Gradually increasing the challenge is what drives real change.

“Lifting heavier over time is what builds strength, protects your bones, and keeps your body resilient through menopause and beyond.”

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