Mental health
PMS linked to increased risk of heart disease

Women diagnosed with premenstrual symptoms may face a higher risk of cardiovascular disease later in life, new research suggests.
A long-term study tracked more than 99,000 women with premenstrual symptoms for up to 22 years, comparing their outcomes with women who did not have such symptoms.
Researchers found that those affected had around a 10 per cent higher overall risk of developing cardiovascular disease, with particularly strong associations with stroke and heart rhythm disorders.
The study, led by researchers at Karolinska Institutet in Sweden, focused on women diagnosed with premenstrual syndrome (PMS) and the more severe premenstrual dysphoric disorder (PMDD). These conditions cause psychological and physical symptoms that typically begin a few days before menstruation and ease shortly after.
To account for genetic and environmental influences, the researchers compared affected women both with unrelated women and with their own sisters.
The analysis showed that women with premenstrual symptoms had a 31 per cent higher risk of developing heart rhythm disorders, known as arrhythmias, and a 27 per cent higher risk of stroke caused by a blood clot. These elevated risks remained even after adjusting for factors such as smoking, body mass index and mental health conditions.
“The increased risk was particularly clear in women who were diagnosed before the age of 25 and in those who had also experienced postnatal depression, a condition that can also be caused by hormonal fluctuations,” said Yihui Yang, PhD student at the Institute of Environmental Medicine at Karolinska Institutet and first author of the study.
The researchers suggested several possible reasons for the link. One is that women with premenstrual symptoms may have disrupted regulation of the renin-angiotensin-aldosterone system (RAAS), which helps control blood pressure and fluid balance. Another is that they may have higher levels of inflammation, a known contributor to atherosclerosis – hardening of the arteries – and other cardiovascular diseases. A third is the presence of metabolic abnormalities that increase the risk of stroke and heart attack.
“We hope that our findings will contribute to greater awareness that premenstrual disorders not only affect daily life but can also have consequences for long-term health,” said Donghao Lu, associate professor at the same department and last author of the study.
The findings suggest that women diagnosed with premenstrual disorders, particularly at a young age or those with a history of postnatal depression, may benefit from closer monitoring of their cardiovascular health.
Mental health
Dr-Julian helps deliver breakthrough mental health support for Black and ethnically minoritised mothers

A groundbreaking digital perinatal mental health pilot for Black and ethnically minoritised women has helped women access support faster, complete therapy at higher rates, and recover more successfully than national averages.
The partnership between digital tech company Dr-Julian and The Essential Baby Company Ltd within a new model of mental health care named haPPIE SHE Cares – who offer personalised support for women sharing their healthcare experiences, showed results well above NHS benchmarks for Black and ethnically minoritised women.
The pilot was created to help women who are less likely to use traditional mental health services during pregnancy and in the first year after giving birth.
By combining trusted community referrals, culturally aware support, and fast access to therapy through Dr-Julian’s online and virtual care platform, the programme delivered standout results.
Every woman who joined the pilot started therapy, 90 per cent completed treatment, and 74 per cent recovered; well above the NHS benchmark of around 52 per cent.
Women referred through community organisations accessed support in just one day on average, compared with around 21 days through many standard services.
Even the programme’s regular referral route reduced waits to 13 days.
The findings come as NHS leaders continue to focus on maternity inequalities and unequal access to mental health care.
Black and ethnically minoritised women can face barriers including stigma, language needs, lack of trust in services, childcare pressures, and difficulty navigating complex systems.
The haPPIE SHE Cares model was designed to break down those barriers by working with trusted community groups, offering culturally informed support, and where possible matching women with therapists who understood their background or language.
Gemma Poole for The Essential Baby Company said: “Too many women who need help feel unseen, unheard or unable to get support when they need it most.
“This project shows that when services are built around trust, culture and community, women engage, recover and thrive.
“This early success could provide a blueprint for reducing inequalities in maternal mental health care across the UK. Behind every statistic is a mother who felt supported, a family that benefited and a woman who found her voice.
“Mental healthcare must work for every community. This partnership shows that when high-quality therapy is combined with culturally responsive support, outcomes improve and women get help faster.
We are proud to have provided the therapists, virtual care systems and digital pathways behind this programme. We believe this model could help NHS organisations nationwide cut waiting times and improve recovery rates.”
Women who took part described the programme as life-changing, saying it reduced isolation, gave them confidence speaking with healthcare professionals, and made them more willing to seek help.
With growing pressure on maternity and mental health services, leaders behind the project say the pilot offers a practical solution that improves care while helping cut long waiting lists.
Plans are now being explored to expand the model through training, regional partnerships, and future funding.
Mental health
Poor sleep linked to Alzheimer’s risk in older women – study

Poor sleep may signal higher Alzheimer’s risk in older women with greater genetic risk, a study suggests.
Older women who reported poorer sleep also showed greater memory difficulties and more Alzheimer’s-related brain changes, the study found.
That pattern appeared only in women with higher genetic risk, suggesting sleep complaints may be a stronger warning sign for some women than for others.
Researchers examined 69 women aged 65 years and older taking part in the Women Inflammation Tau Study, an ongoing project focused on ageing and Alzheimer’s disease risk.
Participants completed questionnaires about their sleep quality, underwent memory testing and received brain scans measuring tau. Tau is a protein that accumulates abnormally in Alzheimer’s disease.
The study found that poorer self-reported sleep was associated with worse visual memory performance and greater tau accumulation in brain regions affected early in Alzheimer’s disease, but only among women with higher genetic risk.
Women with lower genetic risk did not show the same relationship between sleep complaints, memory and tau build-up. The finding was specific to visual memory and was not observed for verbal memory.
Researchers said the results add to growing evidence that sleep disturbances and Alzheimer’s disease may reinforce one another over time.
Previous studies have suggested that disrupted sleep can contribute to the build-up of abnormal tau proteins, while Alzheimer’s-related brain changes may also interfere with healthy sleep patterns.
Because women account for nearly two thirds of Alzheimer’s cases and frequently report poorer sleep quality than men, the researchers said sleep may represent an important and potentially modifiable risk factor in older women.
The authors noted that self-reported sleep assessments are inexpensive and easy to administer, raising the possibility that sleep complaints could help identify people who may benefit from closer monitoring or early intervention.
They also suggested that improving sleep could become a target for future Alzheimer’s prevention strategies, particularly for women at elevated genetic risk.
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