News
US health provider Labcorp introduces menopause testing
While it can’t diagnose menopause, the test could help women address their symptoms sooner
The US health provider Labcorp has started offering menopause testing through its digital platform in a bid to help women treat symptoms earlier.
More than one million women in the US enter menopause each year. While menopause officially marks the end of a woman’s menstrual cycles, most women begin experiencing symptoms much earlier, during perimenopause, which typically begins about eight to 10 years before menopause.
Recent studies show more than 60 per cent of women do not feel informed about menopause or the associated symptoms and only 38 per cent of women who are approaching menopause age have discussed it with their providers.
Labcorp argues its menopause test could help women understand hormonal factors related to menopause and take proactive steps to address their symptoms.
The blood test, recommended for women over 45, measures four key hormones, estradiol, follicle-stimulating hormone, luteinising hormone and progesterone.
While it can’t diagnose menopause, it may help women better understand their symptoms and have “more informed” conversations with their providers.
“As individuals look to take an increasingly more proactive role in their health and healthcare, it’s critical they have easy access to trusted testing options,” said Amy Summy, Labcorp’s executive vice president and chief marketing officer, and consumer business lead.
“Our new menopause test is just one more example of how Labcorp is listening to the needs of consumers, empowering them to understand their symptoms, and enabling them to have more informed conversations with their doctors.”
With the addition of Ovia Health by Labcorp’s menopause support programme, the company says it aims to help women navigate this life transition through diagnostic testing, resources and education.
The menopause test is part of a suite of Labcorp blood tests available to consumers.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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