News
Fertility technology start-up opens cryostorage facility in Colorado
TMRW Life Sciences has expanded its network of cryostorage facilities for frozen sperm, eggs and embryos
The US fertility technology company TMRW Life Sciences has opened a new cryostorage facility for frozen sperm, eggs and embryos in Colorado.
The biorepository in Boulder is TMRW’s second location alongside one in New York City in a growing network of offsite cryostorage offerings that use automated platforms for the management and storage of frozen specimens.
More than five million frozen eggs and embryos are now stored at fertility clinics around the US in biorepositories using “antiquated” systems prone to human error, according to TMRW.
The traditional offsite storage model, the company claims, no longer works for modern fertility clinics.
The start-up argues that instead fertility clinics need a digital platform that can reduce paperwork, improve operational efficiencies, provide specimen visibility, and support the “clinic-patient” relationship.
“TMRW’s embryology teams, including those onsite at our biorepositories and onsite in clinics digitising legacy inventories, have 180+ years of combined embryology, andrology and/or lab experience,” explained Lori Batta, chief operating officer at TMRW.
“They work in lock-step with our fertility clinic partners as an extension of their labs managing short- and long-term storage needs with a logistics operation built to meet the dynamic nature of IVF cycles.”
The Boulder facility, Batta said, has around-the-clock monitoring, which aims to provide daily checks with remote monitoring that alerts TMRW’s team before any problems might arise.
“TMRW selected Boulder for its low risk of earthquakes, fires, tornadoes, hurricanes, and natural disasters. It is also an easy transportation hub in a state with strong legislative and judicial support for reproductive rights,” she added.
Michael Collins, executive director, scientific affairs and clinical development at TMRW, said: “Shipping eggs, sperm and embryos to offsite storage facilities is a routine and remarkably safe aspect of fertility care.
“The addition of continuous telemetry with TMRW improves specimen safety by proactively identifying and mitigating any environmental excursion that may damage or harm specimens.”
Louis Villaba, chief executive officer at TMRW, added: “With more than 250,000 specimens under management and growth expected to continue doubling every year, TMRW’s expansion into Colorado and beyond is fuelled by high demand from patients and clinics alike.”
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Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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