News
Fairtility to give presentations at the ESHRE 2022 meeting in Milan
The company will share clinical data on the effectiveness of its AI-powered embryo quality assessment assistant
Fairtility, the Israeli AI innovator powering in vitro fertilisation (IVF), will present five abstracts and seven posters at the Annual European Society of Human Reproduction and Embryology (ESHRE) Meeting in Milan.
The company’s research presents qualitative and quantitative data showcased in the 12 total presentations at ESHRE.
Fairtility’s proprietary AI-powered embryo quality assessment assistant, CHLOE EQ™ (Cultivating Human Life through Optimal Embryos), provides embryologists with previously unachievable data supporting embryo selection, creating an opportunity to clearly explain analysis results based on quantifiable biological parameters.
“Embryologists are longing for a solution that will bring standardisation, accuracy, and greater efficiency to their emotional and impactful work,” says Dr. Cristina Hickman, VP of clinical affairs with Fairtility. In the embryology lab, we must carefully maintain and protect the potential of life at its earliest stages. We feel a strong sense of responsibility to patients as they work to fulfil their dream of becoming parents.
“Fairtility is the only solution I know of that provides the level of transparency that embryologists really expect from an AI system,” she adds. “Having this information available on the ‘WHY’ behind our recommendations positions CHLOE to reshape the conversation between IVF professionals and their patients.”
Along with other fertility clinic partners, the Israeli company will give five oral presentations at ESHRE. Registrations for the meeting, taking place in Milan, Italy between July 3-6, 2022, can be found here.
“We are investing heavily in clinical validation for CHLOE EQ™, as we believe we must hold ourselves accountable to the industry’s highest standards of clinical evidence and validation,” says Eran Eshed, CEO and co-founder of Fairtility.
“Just as any medical device must go through rigorous assessment to achieve regulatory clearance, we are continuously testing, analysing and improving CHLOE EQ™’s accuracy and usability. It has the potential to help fertility clinics improve their clinical outcomes, reduce the number of cycles to live birth and improve workflow efficiency. Crucially, it is designed to earn physicians and embryologists’ trust by introducing visibility into the IVF process.”
For more information, visit fairtility.com.
Cancer
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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