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Evvy teams up with MicroGenDX to relaunch metagenomics-based vaginal health test

Results and insights will be delivered through Evvy’s platform



The female-founded startup Evvy has announced a partnership with the MicroGenDX laboratory to relaunch vaginal health test.

Evvy and MicroGenDX have partnered to relaunch the Evvy vaginal health test as the world’s first and only CLIA-validated mNGS vaginal microbiome test.

The Clinical Laboratory Improvement Amendments (CLIA) regulate laboratory testing and require clinical laboratories to be certified by the Center for Medicare and Medicaid Services (CMS) before they can accept human samples for diagnostic testing

The Evvy vaginal health test, developed and validated at MicroGenDX, uses mNGS to screen for every microbe isolated from the vaginal and urinary tract.

The company aims to help consumers understand their own vaginal health and enable them to get a better picture of their vaginal microbiome.

The results for the test are delivered through Evvy’s platform, alongside personalised education and actionable insights.

Vaginal discomfort is one of the leading reasons women seek healthcare advice with over 90 per cent of these cases being attributed to imbalances in the vaginal microbiome.

Despite the high prevalence of vaginitis and the rapid adoption of DNA testing into many other branches of medicine, vaginitis testing remains limited.

Most clinicians diagnose based on the Amsel score criteria, which is oftentimes unreliable and subjective.

Without a comprehensive, objective picture of the vaginal microbiome, Evvy says, it is unsurprising that both physicians and patients often misdiagnose vaginal complaints.

In a study of 220 physician-diagnosed patients with vaginal symptoms, the diagnoses for 61 per cent of bacterial vaginosis and 77 per cent of yeast infection cases were incorrect.

Dealing with vaginal infections can significantly impact both a patients’ quality of life and long term health outcomes, leading to higher anxiety rates and reduced self-esteem.

Additionally, in terms of long term health outcomes, research suggests that imbalances in the vaginal microbiome, such as bacterial vaginosis, can be associated with increased risk of a variety of adverse health outcomes, such as STI acquisition, pelvic inflammatory disease, preterm birth and infertility.

“I’m thrilled that Evvy’s groundbreaking test and educational platform is supported by CLIA validation,” said Dr Rebecca Nelken, OB/GYN and Evvy’s founding physician.

“Patients can get direct access to personalised, scientifically sound education on their bodies, enabling them to participate in shared decision making about their health. Clinicians see a patient’s entire vaginal microbiome composition from one swab that can be collected in the comfort of a patient’s home.

“Vaginal healthcare has been hugely overlooked for decades, and I’m so excited that Evvy is continuing to pioneer a new standard of care.”

Priyanka Jain, co-founder and CEO of Evvy, said: “We’re committed to leveraging the best technology to provide anyone with a vagina with the most comprehensive, scientifically validated, and personalised information on their vaginal health.

“We’re extremely excited about partnering with MicroGenDX to advance the available tools for overlooked, yet highly important women’s health issues.”

Rick Martin, CEO of MicroGenDX, added: “We’ve been committed to bringing NGS testing to improve healthcare outcomes for over a decade, and we’re very excited to partner with Evvy to bring advancements to vaginal health — a field that has been overlooked for too long.

“We’re proud to partner with Evvy to bring their vaginal health test to market, providing answers and hope to the millions of women suffering from vaginitis.”


‘Groundbreaking’ endometriosis study identifies patient priorities



A “groundbreaking” study into endometriosis has identified three areas for future research that can help improve the outcomes for women with the condition.

The study, commissioned by Endometriosis New Zealand, attracted 1,262 participants, including 1,024 people with confirmed endometriosis, making it the largest ever study involving endometriosis patients and supporters in New Zealand.

Study participants identified the management and treatment of endometriosis, the need for a better understanding of its cause and improvements to diagnostic capability as the three main priorities for further research.

While these findings provide a clear pathway for future work, Endometriosis New Zealand chief executive, Tanya Cooke, said endometriosis research had historically been underfunded.

“With an estimated 120,000 New Zealanders living with endometriosis, much more needs to be invested into finding solutions,” Cooke explained.

“The reality is the outcomes for many endometriosis patients are pretty poor, with diagnosis often taking many years and treatment patchy across the country.”

Estimates based on Australian data suggest that endometriosis is likely to be costing New Zealand somewhere in the range of $1.3-1.5bn annually through increased healthcare costs and lost workforce productivity.

Cooke said: “The good news is that our findings align closely with those in Australia and provide three clear priorities for future research – improved treatment options, causation and better diagnostic capability.

“What New Zealand now requires is proper funding for a future research programme that can investigate these priorities more closely and improve the outcomes for individuals living with endometriosis.”

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Virtual care platform secures US$46m to address US maternal health crisis

Pomelo Care will use the funding to scale its care model and improve maternal and infant outcomes



Marta Bralic Kerns, founder and CEO of Pomelo Care

The US virtual maternity care platform Pomelo Care has secured US$46m in funding to address the US maternal health crisis.

One in 10 babies born in the US today start their life in a neonatal intensive care unit.

Healthcare access continues to worsen, with one in eight births occurring in US counties with limited-to-no access to maternal care. Due to significant gaps in postpartum care, about half of pregnancy-related deaths in the US occur after hospital discharge.

The evidence exists for how to identify people at highest risk for complications and which interventions are most effective, but existing data gaps and provider capacity challenges make it difficult to apply these interventions at scale.

Pomelo has developed a care model that aims to address these challenges by analysing claims and health record data to identify individual risk factors and providing virtual pregnancy, postpartum, and infant care to patients to reduce those risks.

“We’ve long known what works to reduce maternal and infant complications,” said Marta Bralic Kerns, founder and CEO of Pomelo Care.

“The questions have always been: can you identify the patients who are at highest risk, can you deeply engage them in care to drive uptake of the prevention strategies we know work, and can you do it in the highest risk populations with the most limited access to care?”

“This data demonstrates that we absolutely can. And with this additional funding, we’ll have the opportunity to scale our care model to more pregnant people across the country.”

The funding, led by existing investors First Round Capital and Andreessen Horowitz (a16z) Bio + Health, is hoped to help Pomelo accelerate its partnerships with payors across the US and increase access to “evidence-based” care.

Josh Kopelman, partner at First Round Capital and Pomelo board member, said: “It’s rare to come across an opportunity where the incentives between patient, provider and payor are all aligned.

“Marta and the Pomelo team have found an incredible opportunity to dramatically improve outcomes for the highest risk populations, while helping payors reduce their avoidable costs.”

Vineeta Agarwala, general partner at a16z Bio + Health and Pomelo board member, added: “Pomelo is one among a small set of health tech companies that have earned true scale.

“This scale is evident in our partnerships with major Medicaid and commercial plans covering over three million lives, which create the opportunity to collaborate with OB providers, labour and delivery wards, and NICUs nationwide, while serving hundreds of thousands of expecting mothers and newborns with high quality, technology-enabled care.”

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One in three UK fertility patients seek treatment abroad due to high costs

Expensive fertility treatments prompt UK patients to seek help abroad



One in three fertility patients in the UK seek treatment abroad due to high costs, a new survey has shown.

Fertility Family has gathered insights from 429 UK participants who have experienced difficulties with infertility.

The Infertility Awareness Report found that the high cost of fertility treatment in the UK has driven over one in four people to spend over £10,000 on both treatments and investigative procedures.

The research showed around 35 per cent of people struggling with infertility have considered seeking fertility treatment abroad due to the prospect of lower costs.

Of those seeking fertility treatment in a foreign country, however, only 14 per cent believed that clinics abroad have a higher success rate.

Of those actively trying to conceive almost one in five have used their life savings in the pursuit of having a child, whilst 25 per cent have paid for their fertility treatments using a credit card.

Dr Gill Lockwood, consultant at Fertility Family, said: “While we tend to cast our gaze on women when it comes to infertility, case studies have shown that infertility can impact both women and men in similar ways. However, women have been observed to seek help more than men.

“Although the psychological struggles of infertility can be overwhelming, many patients ultimately reach some type of resolution. Some of the alternatives include becoming parents to a relative’s children, adopting children, or deciding to adopt a child-free lifestyle.

“Needless to say, this resolution is usually psychologically demanding, and patients may feel forever impacted by the experience of infertility.”

A combination of fertility struggles and accessible healthcare have impacted people across the UK significantly, with one in two admitting to feeling “ashamed” due to their difficulties trying to conceive.

A further 31 per cent reported feeling that other people think “less” of them due to their fertility struggles, showcasing the need for better mental health support.

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