Insight
Female-led antimicrobial resistance startup secures €24 million
ShanX Medtech, a female-led AMR diagnostics startup, has secured €24m to scale its rapid antimicrobial susceptibility testing (AST) technology.
The Eindhoven-based company has closed a €15m seed round and been awarded an €8.85m European Commission contract developed by the Health Emergency Preparedness and Response Authority in collaboration with the European Health and Digital Executive Agency.
Founded in 2019, ShanX Medtech develops in-vitro diagnostic solutions for antimicrobial susceptibility testing, which determines which antibiotics will work against a specific infection.
The company says its technology can deliver results within an hour, compared to current methods which take longer.
The platform uses proprietary chemistry called FLORA to monitor pathogen metabolism in real time. According to the company, this requires limited user involvement and offers an improvement over approaches that need trained expertise.
Dr Sophia E. Shanko, founder and chief executive of ShanX Medtech, said: “We founded ShanX Medtech because of a single patient story, one that revealed how much is at stake when diagnostic results arrive too late.”
“Our vision is to equip every clinician with the ability to act decisively, guided by diagnostic evidence in real-time.
“This funding brings us significantly closer to delivering ultra-rapid AST directly to both laboratory and point-of-care environments; faster, simpler, and more accessible than ever before.”
The company’s initial market focus is on urinary tract infections, a common women’s health application, though the underlying platform has potential across wider clinical uses.
The oversubscribed seed round includes equity, grants and the Innovatiekrediet. The equity investment was led by Borski Fund, NextGen Ventures, CbusineZ, Brabantse Ontwikkelings Maatschappij, Invest-NL and a strategic angel fund.
Simone Brummelhuis, partner at Borski Fund, said: “Following an extensive market analysis of innovations addressing antimicrobial resistance, ShanX’s technology clearly emerged as best-in-class.
“While the company’s initial go-to-market strategy focuses on a well-defined women’s health application in urinary tract infections, the underlying platform offers substantial potential across a wide range of clinical indications.
“We are proud to support Sophia and her exceptional team in realising their ambitious vision.
“The oversubscribed financing round, together with multiple multi-million-euro commercial contracts, underscores both the strength of the technology and the founder’s proven commercial execution.”
Insight
75% of new mothers struggle with body image, study finds
Up to 75 per cent of Australian women report concerns about their body image after giving birth, with many feeling pressure to “bounce back” to pre-pregnancy shape.
A review of 36 studies found these struggles are shaped by partners, families and cultural expectations, and that social pressure can even trigger eating disorders for the first time.
The analysis showed that social and interpersonal factors can either protect against or worsen body dissatisfaction and disordered eating during pregnancy and the first year after birth.
Researchers at Flinders University in Australia found that supportive partners and strong social networks help women feel more positive about their bodies, while unrealistic media portrayals and appearance-focused comments can cause harm.
Lead author Madeleine Rhodes, a PhD candidate at Flinders, said: “We wanted to understand how new and expecting mums are affected by the people and environment close to them when it comes to their bodies and eating habits.
“Whilst support from partners, family, friends, and healthcare professionals can help women feel better about their bodies, negative comments and social pressure to ‘bounce back’ make things worse.”
Protective factors included emotional and practical support from loved ones and clear, non-judgemental guidance from healthcare providers.
Risk factors included appearance-related comments, interpersonal abuse and pressure to conform to thin ideals. Some women reported that weight-related advice triggered distress, especially those with a history of eating disorders.
Healthcare professionals were identified as vital sources of reassurance, yet many women said conversations about body changes were absent or overly focused on weight.
Professor Ivanka Prichard, senior author, said: “The cultural obsession with ‘getting your body back’ is harmful and unrealistic.
“This is a public health issue with real consequences for mothers, babies, and families.
“By shifting the focus from individual responsibility to shared support, we can create healthier outcomes for everyone.”
Insight
NICE recommends new age-based thresholds for ovarian cancer screening
The National Institute for Health and Care Excellence (NICE) has proposed age-based thresholds for ovarian cancer screening to help identify women at higher risk earlier.
Previously, testing has used a blood test for cancer antigen 125 (CA125), a protein marker linked to ovarian cancer, with women showing 35 IU/mL or above referred for checks regardless of age.
Experts say this fixed threshold can miss cancers in older women while prompting unnecessary investigations in younger women.
In a draft update to guidelines, the NICE proposes more personalised criteria to reflect changing risk with age.
It adds that CA125 alone is not accurate enough to guide decisions for women under 40 and recommends ultrasound for those with persistent symptoms.
Eric Power, deputy director of the centre for guidelines at NICE, said: “The committee’s proposed recommendations will ensure more personalised, targeted testing, so women at greatest risk of ovarian cancer are identified and referred sooner.
“This tailored approach will mean GPs can make more informed decisions about which patients need urgent investigation, while reducing unnecessary ultrasound scans, freeing up NHS resources.
“These updates will ensure that our guideline reflects the latest evidence and will help improve the detection of cancer and ensure those who need it get swift treatment.”
The draft also proposes that people aged 60 and over with unexplained weight loss of more than five per cent over six months receive further investigation or suspected cancer pathway referral.
Amid rising hormone replacement therapy use in England, NICE also calls for more research into when unexpected bleeding while on HRT should trigger checks for endometrial cancer, which affects the womb lining.
There are an estimated 7,000 new ovarian cancer cases and nearly 4,000 deaths in the UK each year.
Only one in five patients are diagnosed early, when treatment is more likely to succeed.
Of those diagnosed early, 93 per cent survive more than five years, compared with 13 per cent diagnosed later.
Insight
Research aims to shed light on chronic UTIs
A new database on chronic urinary tract infections aims to help explain why millions of women and girls worldwide develop persistent infections that can defy treatment.
A growing body of research suggests persistent, antibiotic-resistant UTIs may be caused by bacteria that embed deep within the bladder wall, potentially evading both the immune system and conventional treatments.
This phenomenon, known as intracellular bacterial colonisation, means bacteria live inside cells rather than on their surface.
While it is not new, a medical case study of a child with chronic infections, led by University of Sydney researchers, suggests its long-term impact may be underestimated.
The case study found no antibiotic regimen, including aggressive long-term courses, could eliminate the infection because bacteria were embedded in the epithelium, the bladder’s inner lining.
Samples showed no improvement despite years of treatment, raising concerns about current approaches, which remain limited to antibiotic therapy and diathermy, a surgical technique using heat from an electrical current to cut or coagulate the bladder lining, and which carries an increased risk of cancer development if performed repeatedly.
Lead researcher Dr Arthika Manoharan, from the Charles Perkins Centre and the School of Medical Sciences, said some girls as young as five are treated with antibiotics for years, often relapsing as soon as treatment stops.
As a result of the published case study, children under 15 will be the focus of the new database built by Dr Manoharan, which aims to understand why some people develop chronic UTIs.
She said she hopes it will help remove the long-held assumption that UTIs are linked to sexual activity.
She said: “Often people think of UTIs only affecting adult women who are sexually active, which is not the case.
“There are many cases where this issue starts in childhood, with no clear cause.
“This can have a huge impact to their quality of life at a time when they should be enjoying school, playing sports and simply being kids.
“The longer consequences of persistent UTIs can be severe.
“Some women see their employment affected due to chronic incontinence; others are unable to maintain a sexual relationship.
“Many echo the same sentiment: One minute you’re fine, the next you’re in agony and can’t leave the house.”
The research team said it hopes the database will help explore whether immune system evasion or genetic predisposition could explain why some children develop chronic UTIs while others do not.
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