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Clue launches initiative to close diagnosis gap for female health conditions

The project is supported by top researchers and aims to leverage Clue’s data for new insights

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Audrey Tsang, CEO of Clue

The period tracking app Clue has announced a new initiative to leverage its collective, anonymised health data to help close the diagnosis gap for the most common yet under-researched and underdiagnosed female health conditions.

With the new My Health Record feature within the Clue app, users will be able to input confirmed diagnoses for 21 different health conditions including endometriosis, polycystic ovary syndrome (PCOS), premenstrual dysphoric disorder (PMDD), uterine fibroids, bleeding disorders and anxiety disorders.

Clue is engaging with researchers from top institutions, such as the University of California, Berkeley, and the University of Exeter, and collaborating with the Menarche Menstruation Menopause and Mental Health (4M) consortium on the ways in which this unique dataset can be leveraged to help close the diagnosis gap in areas that have previously lacked large-scale data for research.

Launched in 2021, 4M facilitates collaborative interdisciplinary research into how menstruation and menopause interact with mental health.

Research projects planned for Clue’s Health Record data in 2024 include improving diagnostics for endometriosis and PMDD, exploring the impact of the menstrual cycle on ADHD, anxiety, and depression and shedding light on under-researched symptom patterns in early perimenopause.

“Together with our global user community, we are creating what will be the world’s largest data set that can match the menstrual and wider health symptom patterns of people with confirmed diagnoses with those who have the same patterns, but who don’t yet have a diagnosis,” said Audrey Tsang, Clue CEO.

“By working with top researchers from around the world to leverage this data, we believe we will be able to make significant progress to accelerate and improve diagnostics and support for people with these conditions.”

Gemma Sharp, associate professor in epidemiology in the School of Psychology at the University of Exeter, and founder and director of the 4M consortium, said: “I started the global 4M research consortium because I was astounded by the social stigma, lack of understanding and paucity of research in the field of women’s menstrual health, which is a big contributor to gender inequality. Half the world menstruates, and related health issues can have a major impact on quality of life, health and wellbeing.

 “Now, this new partnership between our global research consortium and Clue is a really exciting opportunity to conduct research at the intersection of two crucial areas: menstrual and mental health.

“This collaboration will allow us to gather and analyse data on a massive scale, enabling us to generate answers which will improve understanding of women’s health, and ultimately improve lives.”

Professor Kim Harley, associate professor at the University of California, Berkeley, said: “The impacts of perimenopause symptoms, including loss of sleep, hot flashes, mood and mental health changes, are coming to the fore as a major factor in economic and health equality.

“However, there is still a lot we don’t know about the very earliest stages of perimenopause, the frequency and severity of symptoms, and individual factors that increase symptoms. This is tied to the lack of real-time data on large populations of people experiencing this highly individual and often gradual process.

“Working with Clue and its new ‘perimenopause mode’ provides the opportunity to study and understand the perimenopausal process. Clue’s data is unique in that it covers poorly understood periods of people’s reproductive lives, including the transition from fertility to menopause, early onset menopause and the experiences of people at the beginning stages of this process before they would otherwise be clinically identified.

“Many people experience symptoms without understanding them as part of the perimenopause process and few people successfully receive clinical support for their symptoms. We hope that our research with Clue will help individual users understand more about this universal life stage.”

Currently, only one per cent of traditional biopharma R&D funding goes into female health conditions, despite women spending nearly twice as much on healthcare as men.

Conditions that disproportionately affect women, such as endometriosis, migraine and anxiety disorders, all attract much less funding relative to the disease burden, which considers the impact on the population in terms of quality of life, cost of care, and loss of productivity.

“What is politely called ‘the research gap’ is more of a research ‘canyon’ when it comes to female health, with the direct consequence that millions of women and people with cycles people are living with symptoms that could benefit from medical support, but too often it takes far too long for them to access that support and treatment,” explained Tsang, Clue CEO.

“We believe through this initiative we’ll be able to uncover insights and patterns that can be used to develop personalised insights to help people engage with their healthcare providers and accelerate the diagnosis process.”

She added: “We know data is power and agency when it comes to health and that it can play a critical role in making what is otherwise invisible, both visible and quantifiable.

“We’re excited to take the scale of Clue data and put it to work to specifically address the diagnosis gaps that cause so much frustration, confusion and pain. Having a diagnosis can mean validation, relief and most importantly, the opportunity to get the help and treatment one needs.”

To paint a picture of the current diagnosis gaps and delays for women and people with cycles:

  • In 72 per cent of cases, women will wait longer than men to get a diagnosis for the same health conditions.
  • One in 10 will have endometriosis, but only 40 per cent will be diagnosed, with seven to 12 years between the first onset of symptoms to the actual diagnosis.
  • 90 per cent of women with PMDD are undiagnosed, with an average delay of 20 years before it is correctly identified.
  • 70 per cent of women with PCOS are undiagnosed and for a third of those with the condition, it will take two years to diagnose. Almost half of people with this condition had to see more than three healthcare providers to get a diagnosis.
  • One in three women with perimenopausal symptoms go undiagnosed  and middle-aged women are more likely to have their symptoms brushed off as mental health related.

As a Germany-based company, Clue says it adheres to the world’s strictest data privacy laws. Data tracked within the app, the company says, has long contributed to important scientific research helping to close the gender-data gap, to improve societal understanding of menstrual and reproductive health.

According to Clue, data is only used for research with the express consent of users – and research partners only work with anonymous data that cannot be traced back to any individual.

In a recent survey, 85 per cent of Clue users indicated that they wanted their anonymised data to be used for health research.

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Why cardiovascular health deserves a spotlight in femtech

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When we think about women’s health innovation, certain categories immediately come to mind: fertility tracking, pregnancy care, menopause management.

These are vital areas that have long been neglected, and the femtech revolution has brought much-needed attention and resources to them.

But there’s another area of women’s health that remains dangerously overlooked, despite being the leading cause of death for women worldwide: cardiovascular disease.

Heart disease kills more women than all forms of cancer combined, yet most women don’t know this.

For decades, cardiovascular research has been designed around male bodies, male symptoms, and male experiences.

The result is a healthcare system that often fails to recognise when women are having heart attacks, misdiagnoses their symptoms and prescribes treatments that were never tested on female patients.

Women are more likely to die from their first heart attack or stroke than men, and they’re less likely to receive life-saving interventions in time.

This is precisely why the Femtech World Awards have teamed up with Women As One to create a dedicated category for cardiovascular health innovation.

With this award, we want to shine a light on the entrepreneurs, researchers, clinicians and advocates who are working to close not just a gap in care but a gap in innovation, research and recognition.

The cardiovascular health innovation award is an opportunity to celebrate this work and to call for more of it.

If you know of a company, researcher, or organisation doing groundbreaking work in cardiovascular health for women, now is the time to nominate them.

Perhaps it’s a startup developing wearable technology that predicts cardiac events in pregnant women. Maybe it’s a research team uncovering the links between hormonal health and heart disease.

It could be a community health initiative bringing cardiovascular screening to underserved populations of women.

Whoever they, or you are, submit your nomination here.

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WHO hosts parliamentary dialogue on women’s health

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The World Health Organization (WHO) welcomed a delegation of parliamentarians to its Geneva headquarters for a high-level dialogue on women’s health and sexual and reproductive health and rights.

The meeting on 20 January 2026 focused on women’s health, sexual and reproductive health and rights, noncommunicable diseases (long-term conditions such as cancer and diabetes) and global health cooperation.

The exchange was convened by the Konrad-Adenauer-Stiftung and the UNITE Parliamentarians Network for Global Health, bringing together parliamentarians from Albania, Germany, Georgia, Mexico, Slovakia, South Africa, Sri Lanka, Sweden and Zimbabwe.

A central theme was the need to move beyond fragmented approaches to women’s health.

Dr Alia El-Yassir, WHO director for gender, equity and diversity, highlighted that outcomes are shaped by gender inequalities, social norms and structural barriers across the life course, requiring coordinated action across health systems.

Thirty years after the Beijing Declaration and Platform for Action, a landmark framework adopted in 1995 to advance gender equality and women’s rights, Dr Anna Coates, WHO gender equality technical lead, noted that progress on women’s health remains uneven.

She called for health systems that are more gender-responsive and able to address women’s health holistically across the life course.

Parliamentarians stressed that health is inseparable from wider social and economic policies, and called for stronger links between evidence, legislation and measurable impact at country level.

The meeting also focused on sexual and reproductive health and rights, where parliamentarians expressed interest in engaging on issues that directly affect their constituents.

Dr Pascale Allotey, director of WHO’s Department of Sexual, Reproductive, Maternal, Child, Adolescent Health and Ageing, outlined WHO’s life-course approach to sexual and reproductive health and rights.

She highlighted how needs evolve from birth to older age and how these are shaped by social determinants, humanitarian crises and demographic trends.

Dr Allotey underscored the role of parliamentarians in advancing sexual and reproductive health and rights and the importance of continued engagement with WHO to support evidence-based policy-making.

The agenda highlighted cancer as a growing priority for women’s health and for health system sustainability. Dr Prebo Barango, lead for the Cervical Cancer Elimination Initiative, Dr Meghan Doherty, consultant for palliative care, and Santiago Milan, lead for the WHO Global Platform for Access to Childhood Cancer Medicine, presented WHO’s integrated approach to cancer control.

Palliative care is treatment and support that aims to improve quality of life for people with serious illness by managing pain and other symptoms.

The discussion underlined the need for sustained political commitment and domestic investment to address noncommunicable diseases.

Parliamentarians shared national experiences showing the social and economic impacts of cancer on families and caregivers, reinforcing the importance of improving health literacy, reducing stigma and delivering people-centred care.

The meeting also addressed the state of global multilateralism.

Dr Jeremy Farrar, assistant director-general for health promotion, disease prevention and care, outlined how WHO has restructured to enhance efficiency, impact and capacity to support countries.

He reaffirmed WHO’s commitment to more systematic engagement with parliaments, recognising their role in shaping health policy, legislation and budgets.

The exchange concluded with a call for continued collaboration, including through partnerships with the Konrad-Adenauer-Stiftung and the UNITE Parliamentarians Network for Global Health, ahead of the UNITE Global Summit 2026 on 6–7 March in Manila, the Philippines.

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Women’s health firms face banking barriers after being tagged as ‘adult services’

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Financial services providers across Europe and the UK are incorrectly classifying female-focused healthcare ventures as high risk enterprises, placing them in the same category as weapons dealers and tobacco companies.

As reported by The Banker, research by advocacy organisation CensHERship found that many women’s wellness technology companies are being denied standard banking services and payment processing facilities because of flawed classification protocols.

The investigation found significant inconsistencies in how financial institutions assess these businesses. 

SheSpot, a British company specialising in female intimate wellness, received conflicting decisions from different divisions within the same bank.

Co-founder Kalila Bolton, who took part in the study, explained that one department initially classified their venture as “higher risk” alongside firearms and tobacco, while another branch of the same bank later said they were “fine with it”.

Similarly, HANX, a manufacturer of condoms designed to support vaginal microbiome health, faced payment processing rejection after being incorrectly labelled as an “adult services business”.

Published this week, the CensHERship analysis links these barriers to “outdated classification systems, over-compliance and cultural discomfort” that together prevent legitimate healthcare enterprises from accessing essential financial infrastructure.

The findings suggest that women’s wellness ventures are “routinely flagged, delayed, rejected or deplatformed”, outcomes that stem not from actual regulations but from financial and ecommerce systems that “default to caution” when dealing with women’s health topics that remain poorly understood or culturally sensitive.

CensHERship co founder Anna O’Sullivan said these results usually arise from unfamiliarity rather than deliberate discrimination.

“In most cases, this isn’t malicious or intentional — it’s what happens when people and systems meet something unfamiliar,” O’Sullivan said in a statement. 

“But this unconscious bias can materially affect a founder’s ability to start, grow and scale a business.”

Investment platform The Case for Her, which partnered with CensHERship on the report, described the issue through co founders Wendy Anderson and Cristina Ljungberg as a clear “market failure” when founders cannot secure basic banking relationships.

“Fixing this issue is essential if we want to unlock one of the most promising growth markets in global health,” they said.

Risk consultant Aoife Mansfield, managing director at Athrú Group and a contributor to the report, said that terms such as “vagina” or “menstrual” trigger automated alerts within financial systems because they appear on the same watchlists as adult entertainment or pornography, raising a “red flag” in the systems used by banks and payment service providers.

O’Sullivan urged financial service providers to update their internal procedures, review their risk tolerance settings and explicitly include women’s healthcare within their approved client categories.

“They could remove this friction almost overnight,” she said.

The CensHERship analysis includes findings from across the UK and Europe, based on survey responses from more than 30 women’s health enterprises and interviews with founders, insurance underwriters, and compliance and risk professionals.

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