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What does ‘non-invasive’ mean in women’s health?

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By Gloria Kolb, Co-Founder & CEO – Elitone

When it comes to women’s health, “non-invasive” is often associated with medical procedures that avoid surgery.

While accurate, the term encompasses much more — technically, it means not entering the body, but it’s also about “non-intrusiveness,” which encompasses comfort, accessibility, and the ability to integrate care into daily life without disruption.

From menopause management to fertility tracking, innovations in non-invasive healthcare are reshaping how women approach their well-being. 

For example, stress urinary incontinence — a condition in which leaks occur during activities like sneezing, coughing, or jumping — affects one in three women.

These leaks can significantly disrupt daily life, yet the idea of invasive procedures, even through natural orifices, often deters women from seeking care.

Additionally, invasive methods for prenatal testing and diagnosis during pregnancy, such as Amniocentesis to remove and test amniotic fluid from the uterus, can sometimes cause amniotic fluid to “leak through the vagina” and comes with a risk of miscarriage in 0.1-0.3 per cent of cases. 

Similarly, more invasive methods to track women’s fertility, including laparoscopies and hysteroscopies, may be linked to post-operative risks like bleeding, pain, discomfort, infection, or damage to the cervix, bowel, uterus, or bladder — all of which could prevent women from seeking the care they need 

These potential complications underscore the worry that many women have regarding invasive treatment options.

This is where non-invasive solutions shine, offering not only a surgical alternative but also options that prioritise ease, discretion, and the ability to maintain a busy schedule.

Non-invasive advances across women’s health

Fertility tracking without invasive procedures

Fertility assessments often involve many blood tests and ultrasounds, which can be inconvenient and stressful.

Non-intrusive devices that analyze hormone levels in saliva or urine provide real-time fertility insights, reducing the need for many clinic visits.

These necessary tools give women deeply detailed knowledge of their reproductive health to help prevent the discomfort that naturally comes with invasive testing. 

Menopause and vaginal health solutions

Menopause brings several significant changes, including a noticeable degree of vaginal dryness and large hormone fluctuations.

To address this, there are new inventions that use novel and non-invasive technology, such as an ultrasound device that treats vaginal dryness without hormones and vaginal devices or procedures.

While some of these inventions are not yet available, continued improvements in non-invasive technology will provide more options that offer relief while respecting women’s comfort and autonomy. 

Period health monitoring

While menstrual blood contains many important health indicators, customary testing methods frequently ignore this vital resource.

Advanced menstrual blood analysis devices, however, provide several key insights into hormonal health, degrees of inflammation, and multiple reproductive conditions by directly testing blood samples obtained from sanitary pads or menstrual cups.

This method is unobtrusive and enables the tracking of health trends over time. 

Non-invasive genetic testing for pregnancy

Amniocentesis, an invasive procedure with several risks, has been used for prenatal testing and diagnostics, but this invasive procedure has historically been unnecessary.

Genetic analysis of amniotic fluid is now achievable through the mother’s blood, thanks to non-invasive prenatal testing tests (NIPT).

This improvement makes prenatal screening safer because it only requires providers to take a standard blood sample rather than conduct an invasive procedure that could harm the mother or fetus, thereby reducing stress for expectant mothers while offering important health information. 

Weight management and metabolic health

Hormonal balance, metabolic rate, and genetic predisposition are meaningful factors in many women’s weight loss adventures.

Today, many wearable metabolic health devices are available to help women track essential indicators such as glucose and ketone levels.

These devices eliminate the need for more invasive blood tests and allow women to make more easily educated choices about diet and exercise. 

Comfort matters: Why non-invasive solutions succeed

One of the most significant barriers to consistent healthcare treatment is discomfort — whether physical, emotional, or logistical.

Many women discontinue treatments that are excessively invasive, remarkably time-consuming, or incredibly inconvenient.

Easy-to-use options make it more likely that women will use them consistently, and minimally intrusive options have the same effect.

Clinicians know that compliance in treatment is one of the largest hurdles in any care.

For instance, many pelvic floor therapy and electrical stimulation devices involve vaginal inserting these devices vaginally to strengthen the pelvic floor.

However, these treatments may produce significant discomfort, which can lead to a decline in use.

On the other hand, external pelvic floor stimulation devices are convenient and comfortable and provide an at-home option for strengthening the pelvic floor that minimally disrupts a woman’s daily routine. 

Conversely, alternative menopause treatments exist that acknowledge that hormone therapy, along with vaginal suppositories, is not universally suitable for women.

Wearable cooling devices, acupressure bands, and hormone-monitoring patches offer symptom relief, and they do so with no need for medical intervention. 

The future of non-invasive care: Meeting women where they are

Women’s healthcare is rapidly advancing, providing more personalised, convenient, and patient-centred care.

Because women’s health experiences vary from patient to patient, treatment should be tailored to their unique experiences. 

Many non-invasive treatments are available to address this diversity, offering a variety of options for personalised management of fertility, menopause, weight loss, and postpartum recovery.

Their appeal lies in effortlessly delivering considerable results. 

Today, women can use a number of non-intrusive options to manage their health, including hormone tracking, improved pelvic health, menopause symptom relief, and other aspects of their health.

As technology advances, improving women’s quality of care and life, it will continue to broaden the definition of non-intrusive treatments. 

— Gloria Kolb is the CEO and co-founder of Elitone, the first non-invasive, FDA-cleared, wearable treatment for women with urinary incontinence. 

Elitone’s accolades include winning Best New Product by My Face My Body, Sling Shot, finalist in Women Startup Challenge, and CES’ Innovation Award. As an inventor with 30+ patents and advocate for women’s health, Gloria has been featured in Forbes as a Top Scientist Driving Innovation in Women’s Health, TechRound’s Top Women in Tech, Boston’s “40 Under 40” and MIT Review’s “World’s Top Innovators under 35.”

She has engineering degrees from MIT and Stanford, and an Entrepreneurship MBA from Babson College.

Insight

Working from home linked to higher fertility, research finds

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Working from home is linked to 0.32 more children per woman when both partners do it at least once a week, research across 38 countries suggests.

The study found that among working adults aged 20 to 45, estimated lifetime fertility, meaning children already born or fathered plus plans for future children, rises when one or both partners work remotely.

In the US, the increase was even higher at 0.45 children per woman.

On average, women whose partners did not work from home had 2.26 children.

When the woman worked from home at least one day a week, this rose to 2.48. When both partners did so, it increased to 2.58.

If the man worked from home at least one day a week, the increase was more limited at 2.36 children.

The research, by Steven J. Davis and colleagues and published as a working paper by the National Bureau of Economic Research, points to three possible explanations.

Remote working may make it easier to balance childcare with paid work, leading some couples to have more children.

Families with children may also be more likely to look for remote roles. Or the growing availability of those roles may lift fertility by opening up more parent-friendly jobs.

“All three stories align with the idea that WFH jobs make it easier for parents to combine child rearing and employment,” the report suggests.

The pattern held both after the pandemic, between 2023 and 2025, and before it, between 2017 and 2019.

The implications for national fertility rates vary mainly because working-from-home rates differ widely between countries.

Among workers aged 20 to 45, the share working from home at least one day a week ranges from 21 per cent in Japan to 60 per cent in Vietnam. The UK ranks third globally and leads Europe at 54 per cent.

The report estimates that, if “interpreted causally”, remote working accounts for 8.1 per cent of US fertility, equal to about 291,000 births a year as of 2024.

The researchers note that while this may sound modest, it is larger than the effect of government spending on early childhood care and education in the US.

“Bringing WFH rates to the levels that currently prevail in the United States, United Kingdom, and Canada has the potential to materially boost fertility in many other countries,” the report suggests.

However, the research cautions against broad policy approaches, saying the desire for remote work varies widely between individuals, and that it is not practical in every job or organisation.

“Thus, policy interventions that push for a one-size-fits-all approach to working arrangements are likely to yield unhappier workers and lower productivity,” it warns.

A UK Parliament report has also found that remote and hybrid work can boost employment, with parents, carers and people with disabilities likely to benefit most from more flexible working options.

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Cancer

Radiotherapy may cut lymphoedema risk

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Radiotherapy to the armpit instead of surgery may cut lymphoedema risk in some breast cancer patients, early trial results suggest.

Lymphoedema is swelling of the arm or armpit that can happen after surgery to remove lymph nodes.

New findings suggest axillary radiotherapy may be as effective at killing any remaining cancer cells while being less likely to trigger this complication.

The results come from the pilot phase of a phase III randomised international clinical trial looking at whether axillary radiotherapy has a lower risk of lymphoedema than axillary lymph node dissection in breast cancer patients who have had chemotherapy or hormone therapy before surgery, and whose cancer has spread to only one or two lymph nodes.

The trial will also assess overall survival and disease-free survival.

The researchers stressed that these are preliminary results from two years of follow-up in the pilot study, and that clinicians should wait for results from the ongoing phase III trial before considering changes to clinical practice.

Amparo Garcia-Tejedor, from the Functional Breast Unit at Bellvitge University Hospital in Spain and the Institut Català d’Oncologia, is leading the trial.

She said studies had already shown that axillary radiotherapy was a good alternative to axillary lymph node dissection in patients whose first line of treatment was surgery.

She said: “In situations where patients have received chemotherapy or hormone therapy before surgery, it is expected that results could be similar. However, robust prospective data are not yet fully established or published.

“Many patients treated with neoadjuvant therapy experience a significant reduction in axillary disease burden and ultimately present with only one or two lymph nodes that are positive for cancer metastases, which often correspond to the sentinel lymph node, while the remaining axillary nodes are negative.

“This observation strongly suggested that further axillary surgery might be unnecessary in a substantial proportion of patients and that a strategy of de-escalation should be explored.”

From June 2021 to April 2023, the ADARNAT trial recruited 272 breast cancer patients whose disease might have spread to one or more lymph nodes.

The patients had received neoadjuvant therapy and, at the time of surgery, had metastatic cancer in one or two sentinel lymph nodes, the lymph nodes where cancer typically spreads first.

Patients were randomised to receive either axillary radiotherapy or axillary lymph node dissection, and patients in both groups also received radiotherapy to areas of the breast and chest. Results were available for 46 patients in the radiotherapy group and 56 in the surgery group, with a median follow-up of two years.

No cancer recurred in the axillary area in the radiotherapy group, compared with one recurrence in the surgery group, or 1.8 per cent.

Cancer spread to other parts of the body in 4.4 per cent of radiotherapy patients and 5.5 per cent of surgery patients, and there were two deaths in the surgery group, or 4.3 per cent.

Lymphoedema was more common after surgery, at 26.7 per cent, than after radiotherapy, at 18.9 per cent, although the researchers said this difference was not statistically significant. Disease-free and overall survival rates were similar after two years.

Garcia-Tejedor said: “These results indicate that ART instead of ALND is feasible and has good cancer outcomes at two years.

“While some specialists have already begun to substitute axillary lymph node dissection with axillary radiotherapy without waiting for definitive results, the only way to determine with certainty whether this strategy is truly safe and effective is through participation in a well-designed clinical trial such as the one we are now conducting.

“This is particularly important given that the study population includes patients with residual axillary disease and, therefore, a potentially worse prognosis.

“In this context, treatment decisions should not be made without robust evidence.

“Our trial is designed to provide the necessary data to definitively answer this question and to ensure that any future change in standard practice is safe in terms of cancer outcomes and is also beneficial for patients.”

Maria Laplana-Torres, a radiation oncologist at the Hospital Clínic de Barcelona, presented pilot-phase results showing that although axillary radiotherapy was linked to more skin damage from radiation, this was usually temporary and easily treated.

Acute skin damage of grade 2 or above occurred in 27.8 per cent of radiotherapy patients compared with 13.3 per cent after surgery.

It mainly involved skin redness, pigment changes or, in some cases, skin peeling. There were no significant differences in later skin damage between the two groups.

She said: “Some patients experienced mild, temporary difficulty raising the arm above the shoulder or lifting it to the side. These limitations were usually short-lived and did not affect everyday activities.

“We found that treating the axilla with radiotherapy instead of extensive surgery can avoid a more aggressive operation without compromising treatment safety in patients with sentinel lymph node involvement.

“One and two years after treatment, there were no meaningful differences in arm mobility or quality of life between the two groups, although there was a more favourable trend in the ART patients.

“These results show that axillary radiotherapy may be a safe and less invasive option for some women treated with chemotherapy or hormone therapy before surgery.’

“This kind of research is essential to continue improving patient outcomes and to define safer, equally effective therapeutic approaches.”

More than 500 patients have now joined the main phase III trial. The researchers estimate that about three more years will be needed to complete recruitment, followed by five years of follow-up to fully assess cancer outcomes.

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Insight

Report makes the case for an incentive change in health data

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In a new report, “The Case for Incentive Change in Healthcare Data,” WHIS Lead Producer Poppy Howard-Wall explores why healthcare’s biggest data challenge may not be technical but economic.

Integrating learnings from Poppy’s conversations with senior leaders at the ViVE Summit, the report highlights how fragmented data and misaligned incentives continue to limit the industry’s ability to deliver truly longitudinal care.

Howard-Wall writes: “For the women’s health industry, where many conditions have historically been under-researched and longitudinal datasets remain incomplete, the consequences of fragmented data infrastructure are even more pronounced.

“Artificial intelligence promises to accelerate discovery, improve diagnosis and enable more proactive care. But its potential is inseparable from the data ecosystems that support it.

“In the absence of strong economic incentives for deeper integration, the question becomes how the industry is beginning to navigate this constraint and what signals are emerging about the future of healthcare data and AI in women’s health.”

Read the report here.

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