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Outpost Bio raises €2.9m for microbiology platform
Outpost Bio has raised €2.9m (US$3.5m) in pre-seed funding to develop a platform aimed at making human microbiology computable.
The London and Boston-based startup, founded in 2025 by Dr Jenny Yang and Alex Merwin, says it is working to decode interactions between microbes and human biology that it believes are often overlooked by existing biological models.
The company says most frontier biological models focus on elements encoded in human DNA. However, many biological processes arise from interactions between multiple biological systems.
Outpost Bio’s platform aims to address this by modelling what it calls the “interaction layer”, focusing on human microbiology, the study of micro-organisms that live in and on the human body.
Its Lab-in-the-Loop platform combines automated laboratory experiments with machine learning, a form of artificial intelligence that enables computer systems to improve as they process data. The platform creates a feedback loop in which models learn from experiments and guide what should be tested next.
The company says this approach generates proprietary human-derived functional data at scale, which it claims could help pharmaceutical partners reduce risk in clinical development, design safer formulations and support regulatory evidence. It also says food and consumer companies could use the system to test how prebiotics, botanicals and other ingredients affect microbial communities.
The startup says its platform could help partners developing molecules intended for use in or on the human body predict microbe-mediated metabolism, toxicity and response.
Dr Yang, co-founder and chief executive, holds a PhD from the University of Oxford and is a former Marie Curie Fellow with a background in clinical machine learning.
Co-founder and chief operating officer Alex Merwin previously served as head of growth for health and bio startups at AWS.
The pre-seed funding round was co-led by Merantix Capital and Seedcamp, with participation from OpenSeed VC, Defined and strategic family offices and angel investors.
Dr Yang said: “We’re building what we believe to be the most comprehensive dataset in human microbiology.
“Microbial communities can dramatically alter drugs and other interventions, yet this layer has been largely ignored because the data hasn’t existed at scale.
“For the first time, we can move beyond correlations to reveal causal pathways.”
Adrian Locher, co-founder and general partner at Merantix Capital, added: “What took decades to build for earlier biological models can now be achieved in years.
“Faster wet-lab data generation, lower sequencing costs, and more powerful machine learning make this the right moment to build predictive models of the microbes that live within and on us.”
With the new funding, Outpost Bio plans to expand its experimental and modelling platforms as it seeks to develop new approaches to designing drugs, ingredients and consumer health products.
Pregnancy complications may leave women more vulnerable to the long-term heart effects of stress, a recent study suggests.
A study of more than 3,000 women in their first pregnancy found persistently higher stress levels were associated with higher blood pressure after pregnancy, specifically in women who had adverse pregnancy outcomes including preeclampsia, preterm birth, having a baby that was small for gestational age, meaning smaller than expected for that stage of pregnancy, or stillbirth.
Among women who experienced these complications, higher stress levels over time were associated with blood pressure that was 2 mm Hg higher than that of the low-stress group during the years two to seven after delivery.
This was not the case among women who did not experience adverse pregnancy outcomes.
Virginia Nuckols, lead author of the study and a postdoctoral fellow in the University of Delaware’s department of kinesiology and applied physiology, said: “For women who were having babies for the first time and had complications, referred to as adverse pregnancy outcomes, we found that higher stress levels over time were associated with higher blood pressure levels 2-to-7 years after delivery.
“This suggests that women who had pregnancy complications may be more susceptible to the negative effects of stress on their heart health, and taking steps to manage and reduce stress could be important for protecting long-term heart health.”
The researchers analysed records of 3,322 first-time mothers aged 15 to 44 who did not have high blood pressure before pregnancy.
The women were enrolled at 17 medical centres in eight US states, were pregnant with one baby and were having their first child. According to the authors, 66 per cent of participants self-identified as white, 14 per cent as Hispanic and 11 per cent as Black.
Blood pressure and stress levels were measured during the first and third trimesters, and again two to seven years after delivery.
Stress was assessed using the Perceived Stress Scale, a standard questionnaire that asks how often people feel situations are uncontrollable, unpredictable or overwhelming.
Those who experienced moderate to high stress levels were often younger, between 25 and 27 years of age, had higher body mass index, a measure based on height and weight, and lower educational attainment.
The authors said it is not yet clear exactly how higher stress leads to higher blood pressure in women who had pregnancy complications, and that several factors are likely to be involved.
Nuckols added: “Future studies should examine why women with a history of adverse pregnancy outcomes may be more susceptible to stress-driven increases in blood pressure and test whether stress reduction interventions can actually lower cardiovascular risk for these women.”
High blood pressure during pregnancy can have lasting effects on maternal health, including preeclampsia, eclampsia, stroke or kidney problems, according to the American Heart Association’s 2025 guideline for the prevention, detection, evaluation and management of high blood pressure in adults.
Monitoring blood pressure before, during and after pregnancy is crucial to help prevent and reduce the risk of long-term complications.
Laxmi Mehta is chair of the American Heart Association’s Council on Clinical Cardiology and director of preventive cardiology and women’s cardiovascular health at The Ohio State University Wexner Medical Center, and was not involved in the study.
Mehta said;’ “This study highlights the powerful connection between the mind and heart, emphasising the importance of stress management, particularly for those who have experienced adverse pregnancy outcomes.
“For the clinical care team, it reinforces the need to proactively assess and address stress as part of the comprehensive care we provide to our patients.
“Future research on whether targeted interventions to reduce or manage stress has a meaningful impact on long-term cardiovascular outcomes will be important as well.”
AI could help routine mammograms spot heart disease risk in women, as well as breast cancer, researchers have found.
A team from Emory University analysed regular screening scans from more than 123,000 women who had no prior history of cardiovascular disease.
Using an AI programme to quantify calcification and hardening in the arteries, they found women with severe cases had two to three times the risk of developing potentially fatal heart attacks, stroke and heart failure.
“This was true even in younger women under 50, a group often considered low-risk, and held up after accounting for other risk factors like diabetes and smoking,” said Hari Trivedi, Emory associate professor and co-director of the university’s Health Innovation and Translational Informatics lab, who described the research as the largest study of its kind.
“We wanted to test whether AI could use this to identify women at risk of cardiovascular disease at no extra cost or inconvenience.
“”For women, this means a mammogram you’re already having could also provide important information about your heart health, prompting a conversation with your doctor about preventive steps such as cholesterol testing or medication.”
The researchers’ work was published today in the European Heart Journal, from the European Society of Cardiology, which noted that women are largely underdiagnosed and undertreated for cardiovascular disease.
They wrote that the high resolution of routine mammograms could allow for essentially automatic, direct visualisation of the arterial beds within the breasts of nearly all adult women, with calcifications easy to detect and correlated with deposits found in other parts of the body.
The researchers said that, compared with imaging of the heart’s coronary arteries, where blockages narrow and impede the flow of oxygenated blood to the heart muscle, calcifications in breast tissue affect a separate layer of the vessel, resulting in increased artery stiffness, a measure typically linked to long-term hypertension.
They described the finding as an independent predictor of cardiovascular disease and a potentially useful addition to traditional cardiovascular risk factors.
In an accompanying editorial, Lori Daniels, a cardiologist and professor of medicine at the UC San Diego School of Medicine, said that while fewer than 40 per cent of women may know their cholesterol levels, many more are up to date with their breast cancer screening.
“Two-thirds of women aged 50-69 in the European Union reported a mammogram within the prior 2 years, and in the USA, nearly 70 per cent of women aged 45 years and older were up to date with mammography according to American Cancer Society screening guidelines,” Daniels wrote.
“Breast arterial calcification has the potential to reframe this mismatch, leveraging a widely adopted cancer-screening platform to identify cardiovascular risk in women who may not otherwise engage with prevention.”
A blood test for endometriosis showed clinical promise after detecting cases missed by standard imaging, according to a clinical validation study.
HerAnova Lifesciences has published a peer-reviewed clinical validation study of its HerResolve blood test for endometriosis in the Journal of Minimally Invasive Gynecology, the official journal of the AAGL.
The multi-centre study enrolled 298 women of reproductive age across 11 clinical sites in the US, Europe and Hong Kong.
The study population was 75.8 per cent white, 9.7 per cent Black, 9.1 per cent Asian and 5 per cent non-white Hispanic participants.
It found the test identified 61.5 per cent of histologically confirmed endometriosis cases that were missed by transvaginal ultrasound and or MRI scans.
All results were validated against the gold standard of laparoscopic findings with histopathological tissue confirmation.
The headline numbers were an AUC of 0.944, specificity of 97.5 per cent and sensitivity of 80 per cent. The high specificity was a deliberate design choice, with the model optimised to minimise false positives and reduce unnecessary invasive procedures. Performance was also consistent across menstrual phases.
The blood test, called HerResolve, is a multi-omic blood-based assay that combines three serum microRNA biomarkers, three protein biomarkers, one steroid hormone, patient age and BMI into a machine learning algorithm to detect endometriosis.
Farideh Bischoff, chief medical officer at HerAnova and corresponding author of the study, said: “Endometriosis has long been one of the most underdiagnosed and undertreated conditions in women’s health.
“HerResolve was designed to work alongside existing imaging and clinical evaluation, filling a critical gap in non-invasive disease detection.”
The test is currently available at select IVF and reproductive medicine centres across the US and is positioned as a triage tool, helping identify patients who may benefit from further evaluation or empirical treatment rather than replacing surgery entirely, but potentially reserving it for treatment rather than diagnosis.
A prospective validation study is underway in geographically and ethnically diverse populations, and HerAnova is also pursuing longitudinal analyses to evaluate whether the assay can monitor treatment response over time.
Endometriosis affects approximately one in 10 women of reproductive age, yet the average diagnostic delay remains six to 11 years.
The current gold standard, laparoscopic surgery, is invasive, dependent on surgeon skill and not without risk, making a reliable non-invasive alternative one of the most sought-after tools in women’s health diagnostics.
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