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Mental health

Opinion: Not ‘just stress’ – How hormonal changes affect women’s brain function

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By Dr Louise Newson BSc(Hons) MBChB(Hons) MRCGP FRCGP DHealth

Over years of studying the health of women there’s one key thing that I’ve come to realise; clinicians have often been missing a crucial piece of the puzzle in understanding women’s mental health and brain function.

It all comes down to three hormones that deserve far more attention for their powerful influence on the brain — progesterone, estradiol, and testosterone.

As an example, I consulted with a 46-year-old woman last week in my clinic. She’s clever, accomplished, always been on top of things.

But recently she has been forgetting words mid-sentence, she can’t remember where she parked her car and finds herself having to read the same page three times and still nothing sticks.

Terrified that she has early-onset dementia, she visited her GP who told her it’s “just stress” or “normal ageing.”

But here’s the thing – it’s neither. It’s her brain responding to a dramatic hormonal shift, and we need to start talking about it.

Women’s mental health, and especially brain health, is deeply influenced by our hormones – progesterone, estradiol and testosterone – all three having fundamental roles in how our brains function.

However this connection is often overlooked in medicine and public conversations.

When levels of these hormones fluctuate and reduce (as they do during perimenopause and menopause) then this can have negative effects on our brain metabolism and function leading to symptoms such as memory problems, brain fog, poor sleep, low mood, anxiety, irritability and fatigue.

Menopausal women have an increased risk of developing dementia due to these hormone levels being low.

These vital hormones work to improve glucose metabolism, which provides the fuel our neurones (nerve cells) need to function and connect with each other.

They also work to reduce inflammation and improve the function of our mitochondria (the powerhouse of our cells) which all work to keep our brains healthy and working well.

Progesterone, estradiol and testosterone also increase neural growth, strengthen synaptic connections between nerves, and regulate levels of neurotransmitters such as serotonin for mood, acetylcholine for memory, melatonin for sleep and dopamine for motivation.

The presence of these hormones is linked to lower rates of memory loss and can reduce risk of Alzheimer’s disease, which affects women at nearly double the rate of men.

Importantly, “brain fog” and forgetfulness commonly reported during perimenopause and menopause are real and measurable phenomena linked to hormonal fluctuations, not just “normal ageing” or stress.

Testosterone is commonly misconstrued as “just a male hormone,” but women’s brains require it for optimal functioning.

Produced by ovaries and adrenal glands, as well as in the brain, testosterone supports cognitive sharpness, energy, and drive.

Emerging evidence links lower levels of testosterone in women to poorer performance on memory, processing speed, and even greater Alzheimer’s risk, especially among those with certain genetic risk factors.

Like estradiol, testosterone boosts dopamine activity, which is crucial for focus, motivation, and pleasure.

Many women report that restoring testosterone improves concentration, energy, and overall mental clarity.

Women’s mental health is closely associated with these changing hormone levels.

Rates of depression, psychosis and anxiety in women are more common at times of hormonal flux such as puberty, the premenstrual phase, postpartum, perimenopause and menopause.

Therefore, clinicians should certainly be assessing for hormonal factors when cognitive and mental health concerns arise in women.

Women represent nearly two-thirds of all Alzheimer’s patients, and much of this is likely driven by the neurological impact of hormone loss.

Understanding estradiol, progesterone, and testosterone as master regulators of brain metabolism and cognition should then lead to better clinical treatment.

This must take the form of more personalised approaches by clinicians, prescribing the right dose and type of hormone treatment, which when combined with a healthy lifestyle offers the best prospects for safeguarding and improving brain and mental health for women.

One of the reasons I developed the Balance app is to empower women with evidence-based information so they can make the choices that are right for them about their hormonal health.

Using technology to both monitor symptoms and learn more is so important – the response from our users has been so positive and inspiring.

Femtech has the ability to reach a global audience and transcend national borders and cultures which is really exciting for me to witness through our Balance app.

It has also enabled us to provide communities with large scale pools of information and support which are not so readily available in other ways.

Also, Balance is used to support and empower women, privately, who are too scared to communicate in the physical world.

We’ve ignored women’s brain health for too long.

Clinicians have too often dismissed symptoms, failed to account for the profound impact of these hormones on brain function, and have frequently accepted cognitive decline as inevitable.

It’s time for that to change.

Because understanding the hormone-brain connection and replacing the missing hormones isn’t just about preventing disease, it’s about helping women thrive, with their minds sharp, their memories intact, and their full cognitive potential realised.

Image Credit: Andrew Crowley

Motherhood

Natural birth pressure harming new mothers’ mental health, research finds

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Pressure to have a natural birth can cause lasting psychological harm when labour does not go to plan, new research shows.

The study found that the messages women receive during pregnancy are directly linked to the shame and self-blame many feel when those expectations are not met.

For the first time, the research provides an explanation for why unmet birth expectations contribute to psychological harm.

Several women involved in the research said they felt they had not given birth “properly”, even when medical intervention had saved their lives.

Rebecca Matthews, lead author and PhD researcher at the University of Reading, said: “These women were not failed by their bodies, they were failed by the messages they were given.

“Birth trauma does not begin with birth. It begins in the ideology sold to women throughout pregnancy.

“For the first time we can explain precisely how, by showing how birth culture creates a moral standard for women that defines what a good mother does and then leaves them to blame themselves when birth does not match that.

“Until we reform the way we prepare women for birth, we will keep seeing the same devastating consequences for mothers and their babies.”

The researchers interviewed 21 first-time mothers in the UK whose births did not go as planned.

From NCT and hypnobirthing classes, to social media to midwives, the researchers heard how women are surrounded by messaging that frames natural, unmedicated vaginal birth as the “gold standard”, not just medically preferable, but as a mark of being a good mother and the first test of maternal worth.

Research shows around half of women report their birth differed significantly from their expectations, and for the women in this study, all of whom experienced exactly that, the psychological consequences were profound.

Women judged themselves against the internalised moral standard that this ideology had created.

The researchers are calling for antenatal education to stop treating one kind of birth as the goal and to present all birth outcomes as equally valid routes to motherhood.

They also call for better postnatal screening for women whose births did not go as expected, specifically targeting the shame, self-blame and identity disruption that this research identifies as mechanisms underlying birth trauma.

The findings align with and extend the conclusions of the Kirkup, Ockenden and Birth Trauma Inquiry reports, all of which documented how the institutional pursuit of “normal birth” contributed to preventable harm.

This research provides the first theoretical explanation of how that ideology generates individual psychological harm and points to antenatal messaging as the primary site of such preventable harm.

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Mental health

Dr-Julian helps deliver breakthrough mental health support for Black and ethnically minoritised mothers

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A groundbreaking digital perinatal mental health pilot for Black and ethnically minoritised women has helped women access support faster, complete therapy at higher rates, and recover more successfully than national averages.

The partnership between digital tech company Dr-Julian and The Essential Baby Company Ltd within a new model of mental health care named haPPIE SHE Cares  – who offer personalised support for women sharing their healthcare experiences, showed results well above NHS benchmarks for Black and ethnically minoritised women.

The pilot was created to help women who are less likely to use traditional mental health services during pregnancy and in the first year after giving birth.

By combining trusted community referrals, culturally aware support, and fast access to therapy through Dr-Julian’s online and virtual care platform, the programme delivered standout results.

Every woman who joined the pilot started therapy, 90 per cent completed treatment, and 74 per cent recovered; well above the NHS benchmark of around 52 per cent.

Women referred through community organisations accessed support in just one day on average, compared with around 21 days through many standard services.

Even the programme’s regular referral route reduced waits to 13 days.

The findings come as NHS leaders continue to focus on maternity inequalities and unequal access to mental health care.

Black and ethnically minoritised women can face barriers including stigma, language needs, lack of trust in services, childcare pressures, and difficulty navigating complex systems.

The haPPIE SHE Cares model was designed to break down those barriers by working with trusted community groups, offering culturally informed support, and where possible matching women with therapists who understood their background or language.

Gemma Poole for The Essential Baby Company said: “Too many women who need help feel unseen, unheard or unable to get support when they need it most.

“This project shows that when services are built around trust, culture and community, women engage, recover and thrive.

“This early success could provide a blueprint for reducing inequalities in maternal mental health care across the UK. Behind every statistic is a mother who felt supported, a family that benefited and a woman who found her voice.

“Mental healthcare must work for every community. This partnership shows that when high-quality therapy is combined with culturally responsive support, outcomes improve and women get help faster.

We are proud to have provided the therapists, virtual care systems and digital pathways behind this programme. We believe this model could help NHS organisations nationwide cut waiting times and improve recovery rates.”

Women who took part described the programme as life-changing, saying it reduced isolation, gave them confidence speaking with healthcare professionals, and made them more willing to seek help.

With growing pressure on maternity and mental health services, leaders behind the project say the pilot offers a practical solution that improves care while helping cut long waiting lists.

Plans are now being explored to expand the model through training, regional partnerships, and future funding.

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Mental health

Poor sleep linked to Alzheimer’s risk in older women – study

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Poor sleep may signal higher Alzheimer’s risk in older women with greater genetic risk, a study suggests.

Older women who reported poorer sleep also showed greater memory difficulties and more Alzheimer’s-related brain changes, the study found.

That pattern appeared only in women with higher genetic risk, suggesting sleep complaints may be a stronger warning sign for some women than for others.

Researchers examined 69 women aged 65 years and older taking part in the Women Inflammation Tau Study, an ongoing project focused on ageing and Alzheimer’s disease risk.

Participants completed questionnaires about their sleep quality, underwent memory testing and received brain scans measuring tau. Tau is a protein that accumulates abnormally in Alzheimer’s disease.

The study found that poorer self-reported sleep was associated with worse visual memory performance and greater tau accumulation in brain regions affected early in Alzheimer’s disease, but only among women with higher genetic risk.

Women with lower genetic risk did not show the same relationship between sleep complaints, memory and tau build-up. The finding was specific to visual memory and was not observed for verbal memory.

Researchers said the results add to growing evidence that sleep disturbances and Alzheimer’s disease may reinforce one another over time.

Previous studies have suggested that disrupted sleep can contribute to the build-up of abnormal tau proteins, while Alzheimer’s-related brain changes may also interfere with healthy sleep patterns.

Because women account for nearly two thirds of Alzheimer’s cases and frequently report poorer sleep quality than men, the researchers said sleep may represent an important and potentially modifiable risk factor in older women.

The authors noted that self-reported sleep assessments are inexpensive and easy to administer, raising the possibility that sleep complaints could help identify people who may benefit from closer monitoring or early intervention.

They also suggested that improving sleep could become a target for future Alzheimer’s prevention strategies, particularly for women at elevated genetic risk.

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