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The Oxford Longevity Project: how we can make scientific breakthroughs accessible to the general public

By Leslie Kenny, Oxford Healthspan founder

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Leslie Kenny

How the Oxford Longevity Project, an initiative focusing on fasting, autophagy and ageing, aims to help women understand science and live longer, healthier

 

The Oxford Longevity Project was born out of a shared desire among my colleagues, Denis Noble, Oxford University Emeritus Professor of Physiology, Sir Christopher Ball, a former head of an Oxford college and a triple bypass survivor, and Dr Paul Ch’en, a college doctor at the University of Oxford, to empower the public with information they could use now to improve healthspan not just lifespan.

This was during the pandemic when there was a general feeling of disempowerment around health.

As an autoimmune survivor myself who managed to reverse her conditions, giving people a realistic sense of hope along with ideas on how to get started was key. Knowledge is power!

Our aim is to empower patients and practitioners with actionable information on the latest scientific lab discoveries on slowing ageing – big ideas such as autophagy, or cell renewal and recycling, which was the focus of a Nobel Prize in medicine or physiology in 2016.

What makes our process unique, besides giving access to people around the globe, is our commitment to connecting clinical pioneers and leading scientists on the same topic.

We have two aims: first, to translate the latest science into accessible information that patients and other interested non-scientists can action themselves and, second, to more quickly connect clinicians to the latest developments in treatments.

How it started

We started with virtual learning and conferences. We have held quarterly, webinars with practitioners and scientists from around the world with access for the public via Zoom, Vimeo, YouTube and Instagram.

Every expert-led webinar focuses on autophagy and a “big” disease.

Why women are different

At our most recent webinar, we looked at fasting, autophagy and ageing, in particular, at why women respond differently to fasting.

Caloric restriction activates cellular processes not usually stimulated when food is present. One such process that kicks into gear is autophagy.

A leading Oxford University scientist, Immunology Professor Katja Simon, describes autophagy a “the recycling van that delivers the rubbish to the recycling centre”, adding that “it is very important to degrade toxic waste for the survival of the cell, and a cell without autophagy cannot survive.”

The catch? Autophagic activity decreases with age. This decrease doesn’t just accompany ageing. It causes it.

Pulling the autophagic lever, by increasing the rate of autophagy, slows down ageing. This slowing down of ageing is also protective against a diverse array of age-related diseases – Alzheimer’s, cancer, cardiovascular disease, high among them.

In our webinar, Professor of Medicine, Dr. Abhinav Diwan of Washington University School of Medicine, and Dr Stephanie Estima, author of The Betty Body, highlighted that one third of all deaths in women are due to cardiovascular disease.

However, cardiometabolic risk – high lifetime risk for cardiovascular disease – skyrockets soon after menopause.

This is accompanied by other risk factors like increased risk of Alzheimer’s. In addition to differences in risk, women also present differently.

“We don’t hear the exact same story from any two women and their stories do not match what we see from men,” Professor Diwan explained.

When Estima looked at responses to fasting – touted as (perhaps) the only strategy to improve health across species – the nuance continued.

In addition to different responses to fasting between men and women, the researchers also noticed differences between women at different phases of the life cycle.

In her report, Estima made different recommendations for different groups to support that.

The future is free

Through the Oxford Longevity Project, we want people to know that there are things they can do to activate autophagy.

We are committed to offering free information and empowering people to pursue autophagy on their own terms.

Our most recent webinar, attended and viewed by hundreds of practitioners, scientists, academics and lay people around the world, highlighted that we are all united in empowering healthy ageing.

With accessible language, live seminars and free catch-up videos, the Oxford Longevity Project is one to watch.

Leslie Kenny is the founder of Oxford Healthspan, a supplement company focused on bridging the gap between Eastern wisdom and Western science in the longevity space.

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Jill Biden visits Imperial on women’s health and AMR mission

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Former US first lady Dr Jill Biden visited Imperial College Healthcare NHS Trust and Imperial College London to explore work on women’s health and antimicrobial resistance.

The visit was hosted by professor the Lord Darzi of Denham, who chairs the Fleming Initiative and directs Imperial’s Institute of Global Health Innovation.

Dr Biden, chair of the Milken Institute’s Women’s Health Network, spoke about the impact scientists, clinicians, innovators and investors can have on improving women’s healthcare.

Dr Biden stressed the importance of “collaboration, prevention and education” in improving women’s health globally.

At the museum, Dr Biden and Esther Krofah, executive vice-president of health at the Milken Institute, heard about the worldwide significance of the discovery and the contribution of women who, during wartime Britain, grew penicillin in bedpans to support early experimentation.

The discussion also explored how AMR is a key women’s health issue, with women disproportionately affected in low and middle-income countries, and in high-income settings where women are more likely than men to be prescribed antibiotics.

Dr Biden was shown an architectural model of the Fleming Centre in Paddington, which will bring together research, policy and public engagement to address AMR worldwide.

The second part of the visit brought together Imperial clinicians, researchers and innovators for a roundtable on women’s health priorities, including improving diagnosis, equity in maternity care and support during the menopause transition.

Participants highlighted wide variation in the quality of care for conditions affecting women and called for fairer access to services, with the postcode lottery named as a priority to address.

Professor Tom Bourne, consultant gynaecologist and chair in gynaecology at Imperial’s Department of Metabolism, Digestion and Reproduction, described how AI could improve diagnostic accuracy for conditions such as endometriosis.

Equity emerged as a central theme.

Professor Alison Holmes, professor of infectious diseases at Imperial College London and director of the Fleming Initiative, highlighted persistent gaps in women’s representation in clinical trials, including antibiotic studies, which limits the ability to optimise care and treatments.

Dr Christine Ekechi, consultant obstetrician and gynaecologist at Imperial College Healthcare NHS Trust, drew on national maternity investigations to underline the importance of valid data, meaningful engagement with affected communities and rebuilding trust.

Menopause and midlife health were also identified as priorities for clinical research.

Professor Waljit Dhillo, consultant endocrinologist and professor of endocrinology and metabolism in Imperial’s Department of Metabolism, Digestion and Reproduction, described a new treatment for hot flushes, including for women unable to take hormone replacement therapy, such as those with a history of breast cancer.

The discussion then turned to bringing innovation into health systems. Innovators shared how data and technology are being used to close gaps in women’s health, while noting challenges in accessing funding to grow and scale.

Dr Helen O’Neill and Dr Deidre O’Neill, co-founders of Hertility Health, described predictive algorithms using self-reported data to help diagnose gynaecological conditions at scale.

Embedded into clinical workflows, the technology could reduce waiting times, identify conditions earlier and improve outcomes. They noted how “we have cures for the rarest genetic conditions but don’t even have the answers to common women’s health issues.”

Dr Lydia Mapstone, Dr Tara O’Driscoll and Dr Sioned Jones, co-founders of BoobyBiome, outlined work creating products that harness beneficial bacteria found in breast milk to support infant health.

By isolating and characterising key microbial strains, BoobyBiome has created synbiotics, combinations of beneficial bacteria and the food that nourishes them, to make these benefits accessible to all babies.

Speakers throughout the visit stressed the need to reduce variation in care quality and outcomes for women, strengthen prevention and education, and address power and equity in women’s health.

Professor the Lord Ara Darzi said: “It was a privilege to welcome Dr Biden and the Milken Institute to Imperial to meet some of the outstanding researchers, clinicians and innovators advancing women’s health.

“Imperial’s unique combination of clinical excellence and world-leading research positions us at the forefront of tackling the biggest health challenges facing society and the UK’s ambition for innovation demands nothing less.

“For too long, the health needs of women and girls across their life course have not received the attention they deserve.

“By working together across borders and disciplines, we can transform equitable access to care, accelerate the detection and treatment of disease, and ultimately improve health outcomes for millions of women in the UK and around the world.”

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Wellness

AHA campaign to raise awareness of heart disease in women

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Fashion, beauty and lifestyle retailers have joined the American Heart Association to raise awareness of heart disease in women.

The Go Red. Shop with Heart. campaign launched at the New York Stock Exchange on 30 January.

Retailers will ask for donations at checkout in February or donate a percentage of proceeds from selected items.

More than four in 10 women in the US have some form of cardiovascular disease, a term for heart and blood vessel conditions such as heart disease and stroke.

Heart disease and stroke kill more women in the US each year than all forms of cancer combined.

Brands taking part include Away, Commando, Lafayette 148, Michael Kors, Reebok, ShopSimon.com, Summersalt, Torrid and White & Warren.

More than 40 other nationwide retailers are also inviting customers to support the organisation this February through its Life Is Why campaign.

Nancy Brown is chief executive officer of the American Heart Association.

She said: “Nearly 1 in 3 women die from cardiovascular disease each year, yet women are still profoundly under-represented in the clinical research, science and medicine that could save their lives.

“Retailers and consumers are uniquely positioned to turn everyday moments into meaningful change through Go Red. Shop with Heart.”

According to the American Heart Association 2026 Heart Disease and Stroke Statistics Update, heart disease is the leading cause of death in the US and stroke is the number four cause of death.

The organisation projects that at least six in 10 US adults will have cardiovascular disease within the next 30 years and related costs are expected to triple.

However, approximately 80 per cent of cardiovascular disease is preventable through lifestyle changes.

Mindy Grossman is a volunteer board member at the American Heart Association and partner and vice chair of Consello.

Grossman said: “Retail has always been a powerful connector.

“Shop with Heart gives our industry a shared platform to lead with purpose and unite consumers in support of heart health.”

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Milken launches women’s health network platform

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Milken Institute has launched the Women’s Health Network digital platform with Velir x Brooklyn Data to speed collaboration and investment across research, care and technology.

The new website creates a hub for members to share content, connect and coordinate projects, with branding and the first public Drupal build delivered by Velir x Brooklyn Data. A launch video premiered on 4 November 2025 at the inaugural steering committee and member luncheon in Washington DC, then featured at the Milken Institute Future of Health Summit.

Phase two is scheduled for February 2026, adding member log-ins for networking and content exchange. Phase three in April 2026 will add advanced collaboration tools and expanded community features.

“This launch represents the type of mission-driven, cross-sector digital work we are incredibly proud to support,” said Eliza Pare, vice-president of client services at Velir. “The Women’s Health Network is poised to transform collaboration in women’s health, and we’re honoured to help build the digital infrastructure that will make that possible.”

Chaired by former first lady Dr Jill Biden, the Women’s Health Network brings together leaders from industry, startups, investors, health systems, patient groups, academia and philanthropy. More than 100 members have joined, with a steering group that includes organisations such as the American Cancer Society, American Heart Association, Amgen, Deloitte, GE Healthcare, Merck, Microsoft, Northwell Health, Organon and others.

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