News
Peterson Center on Healthcare launches US$50m institute to assess digital health tools
The organisation aims to better monitor the evolving pipeline of emerging digital health technologies
The Peterson Center on Healthcare is to launch a nonprofit organisation to provide independent evaluations of innovative technologies in healthcare.
Launched with a commitment of US$50m, the Peterson Health Technology Institute (PHTI) aims to deliver evidence-based assessments to analyse the clinical benefits and economic impact of digital health solutions, as well as their effects on health equity, privacy and security.
Digital health technologies have vast potential to improve US health system performance by revolutionising delivery, advancing better outcomes, enhancing the patient experience, and promoting equity—all while lowering costs.
Yet, patients, providers, payers, and investors have limited information about the efficacy and performance of the many digital health tools entering the sector.
PHTI says it aims to fill this information gap with independent, publicly-available evaluations. The organisation will establish an original assessment framework developed specifically for digital health tools, in partnership with the Institute for Clinical and Economic Review (ICER).
“Technology has the power to transform healthcare, improving outcomes for millions of Americans while also reducing our rapidly growing delivery costs,” says Michael A. Peterson, CEO of the Peter G. Peterson Foundation.
“It’s clear that digital tools and artificial intelligence can provide a range of benefits to patients, but we have an inadequate understanding of what works and how much it should cost.
“By producing independent, evidence-based research on emerging technologies, the Peterson Health Technology Institute will help improve and accelerate healthcare innovation in the United States.”
The institute, Peterson says, will monitor the evolving pipeline of emerging digital health technologies to better inform the purchaser and investment community.
It will then collect and analyse evidence about the clinical performance of health technologies to ultimately identify promising digital health innovations and expose those not delivering their stated benefits.
Caroline Pearson, executive director of the Peterson Center on Healthcare, said: “As digital health tools replace and augment traditional healthcare, they should both deliver better health outcomes and improve affordability.
“In order for technology to successfully contribute to the goal of a more effective and efficient healthcare system, patients, providers, and payers need better information about what works.”
By 2030, the global digital health market is expected to reach US$1.5tn. Over the past decade, investment in digital health in the US has increased nearly tenfold, to US$15.3bn.
However, despite this significant investment, many experts argue that most digital health tools lack sufficient evidence to support their claims about clinical benefits.
“The Peterson Health Technology Institute can play an essential role in cutting through the hype surrounding new digital health technologies and the commercial interests behind them, providing independent, evidence-based evaluations of their potential for improving care and lowering costs,” said Drew Altman, president and CEO of KFF and a member of the Peterson Center on Healthcare’s advisory board.
Helen Darling, former president and CEO of the National Business Group on Health and a member of the Peterson Center on Healthcare’s advisory board, added: “The independent evaluation of digital health tools is not only a great public service and resource, but it can also help drive the industry to be more rigorous and focused on contributions that meet the most urgent needs for information, quality care, effectiveness and efficiency.”
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
Insight
Higher nighttime temps linked to increased risk of autism diagnosis in children – study
Entrepreneur
Kindbody unveils next-gen fertility platform
-
Wellness4 weeks agoDesigner perfumes recalled over banned chemical posing fertility risk
-
Insight2 weeks agoParents sue IVF clinic after delivering someone else’s baby
-
Insight3 weeks agoWomen’s health could unlock US$100bn by 2030
-
Insight4 weeks agoChina’s birth rate hits record low despite government fertility efforts
-
Menopause3 weeks agoHRT linked to greater weight loss on tirzepatide
-
Entrepreneur6 days agoUS startup builds wearable hormone tracker
-
Menopause2 weeks agoFlo Health and Mayo Clinic publish global perimenopause awareness study
-
News4 weeks agoVerdane invest in Clue to accelerate the future of women’s health






