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Hormone therapy heart-safe for under 60s with menopause symptoms

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Hormone therapy is safe for treating menopause symptoms such as hot flushes and night sweats in women aged 50–59, but should not be started after 70 due to cardiovascular risks, research shows.

The study analysed 20 years of data from over 27,000 women aged 50–79 with moderate to severe menopausal symptoms who received either treatment or placebo.

Women who began therapy between 50 and 59 showed no higher risk of heart disease compared with placebo.

In contrast, those over 70 faced substantially increased risk of atherosclerotic cardiovascular disease – a build-up of plaque in arteries that can lead to heart attacks and strokes.

Co-author JoAnn Manson is chief of the division of preventive medicine at Brigham and Women’s Hospital.

She said: “This paper has a very important message for clinicians and women considering HT use: HT is appropriate and has a favourable benefit: risk profile for treating hot flushes among women below age 60, but it’s important to avoid starting treatment after age 70 among women with hot flushes.

“Our findings support current HT guidelines but help to clarify that risk varies strongly by age.”

Researchers at Brigham and Women’s Hospital examined data from the Women’s Health Initiative trials, addressing long-standing fears about hormone therapy and heart safety.

The study is the first to look closely at links between hot flushes, hormone treatment and cardiovascular risk across different age groups.

Many women have avoided hormone therapy – used to ease hot flushes, night sweats and other symptoms – since earlier studies raised concerns about heart disease.

The new analysis showed clear age-related differences. Women starting treatment in their 50s had no added heart risks, while those beginning after 70 faced substantially higher danger.

Manson, a founding member of the Mass General Brigham healthcare system, is one of the principal investigators of the Women’s Health Initiative.

The findings offer guidance for treatment decisions during menopause, when falling oestrogen levels cause symptoms that can disrupt daily life. Hormone therapy replaces these hormones to reduce symptoms.

The heart safety profile differs sharply by age.

For women in their 50s, therapy carries no extra cardiovascular risk while easing symptoms. But beginning after 70 brings substantial risks, particularly of atherosclerotic disease.

The results support current clinical guidelines while adding clearer, age-specific evidence to help women and doctors make informed choices based on individual risk.

The distinction between age groups is key for treatment planning, offering reassurance to younger women considering therapy while warning against late initiation in older age.

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EU committee warns of women’s health ‘blind spot’

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An EU committee has backed a report warning of systemic inequalities in women’s health research, diagnosis and treatment across Europe.

The European Parliament’s Committee on Women’s Rights and Gender Equality approved the report, which was initiated by Renew Europe.

Women remain under-represented in medical research and clinical trials.

Around 72 per cent of drug trials do not provide data separated by sex and gender, while only five per cent of global research and development funding is dedicated to women’s health.

The report was led by Renew Europe rapporteur Billy Kelleher MEP of Fianna Fáil in Ireland.

It calls for greater investment in women’s health research, stronger inclusion of women in clinical trials and gender-sensitive diagnostics and treatments, particularly for endometriosis, menopause and cardiovascular disease.

Kelleher, first vice-president of Renew Europe, said: “Women’s health remains one of medicine’s biggest blind spots.

“When research, clinical trials and medical data fail to reflect women’s experiences, the result is poorer diagnosis, treatment and care.”

The report also calls for improved access to sexual and reproductive healthcare, including follow-up to the successful European Citizens’ Initiative “My Voice, My Choice”.

Its recommendations include better support for women’s physical and mental health and access to high-quality care throughout pregnancy, childbirth and the postnatal period, free from discrimination.

It also highlights additional healthcare barriers faced by LGBTQI+ people and women in marginalised communities or vulnerable situations.

Kelleher said: “This report is about closing those gaps and ensuring that women’s health is recognised as a core measure of the quality and fairness of our healthcare systems.”

By placing women’s health higher on the political agenda, the report aims to support the implementation of the EU Gender Equality Strategy and shape future European health policies.

A final vote by the European Parliament is expected in September 2026.

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W Group reveal two-stage programme for Women’s Health Week Europe 2026

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Women’s Health Week Europe 2026 has released its full programme ahead of the October event at The Emirates Stadium in London on 7–8 October, with 700+ senior decision-makers and 80+ speakers confirmed across what will be the organisation’s most ambitious edition to date.

For the first time, the event will run across two dedicated stages, each built around a distinct set of questions facing the women’s health industry.

The Global Stage takes on the macro forces shaping the sector: where capital is flowing, how AI is transforming diagnosis and treatment, the gender data gap, wearable technology, stigmatised markets, and the policy landscape across Europe.

Confirmed speakers include Merete Clausen (EIF), Frida Polli (MIT), Nichole Young-Lin (Google), Alison Cave (MHRA), Emily Darlington MP, Kerry Buckley (Boots), Tim Davis (LSEG), Henriette Hessen (Verdane), Hillary Ball (Atomico), and Christine Hockley (British Business Bank).

The Scale Stage runs in parallel, focused on execution: how to navigate regulatory approval pathways, survive the valley of death, build the evidence stack that wins payers and partners, implement AI into a women’s health business, and position for acquisition. Sessions include a reverse pitch format, in which corporates and investors pitch to founders, and a founder’s guide to getting acquired.

The programme also includes two Pitch competitions, one per day, across the Consumer & Tech and Medical Devices & Therapeutics categories, with 16 finalists competing on the mainstage in front of the full delegate audience.

Every session is case study-driven, with speakers selected on the basis of having lived the problem they are on stage to solve.

Women’s Health Week Europe 2026 takes place 7–8 October at The Emirates Stadium, London. The full programme is available now.

View the 2026 programme here

Pre-agenda pricing ends 26 June

Tickets are currently available at pre-agenda pricing, with savings of up to £600 off standard pricing. The deadline is midnight on Friday 26 June. After that, prices go up.

Secure your place: https://wplatform.co/summits/womens-health-week-europe-2026?utm_source=advocacy&utm_medium=ext_email&utm_campaign=whw-europe-26-femtech-world#tickets

Also at The Emirates: Women’s Sport Summit 2026

The day before WHW Europe, on 6 October, The Emirates Stadium will also host the inaugural Women’s Sport Summit, a dedicated one-day event bringing together 400+ attendees from across sport, business, and investment. Focused on the commercial side of women’s sport, the Summit covers the full sports cycle: money, product, and market. Where women’s sport means business.

Find out more: https://wplatform.co/summits/womens-sport-summit-europe-2026?utm_source=advocacy&utm_medium=ext_email&utm_campaign=whw-europe-26-femtech-world

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Most IVF add-ons not backed by reliable evidence, research finds

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Most IVF add-ons lack reliable evidence, with benefits either absent or inconclusive, the largest review of its kind has found.

More than 70 per cent of IVF patients in the UK, Australia and New Zealand reportedly pay for one or more additional treatments.

However, researchers found that most of the procedures, medicines and techniques had no effect on fertility or were backed by limited or low-quality evidence.

Unproven add-ons can also lead to false hope, greater financial strain and unnecessary medical procedures at an already difficult time for patients.

Dr Sarah Lensen, of the University of Melbourne, said: “In many countries, infertility care is largely provided by private clinics where IVF is highly commercialised, and some add-ons are extremely expensive.

“Our review finds a lack of evidence that most of the IVF add-ons we assessed provide any benefit to patients. Unproven add-ons can lead to false hope, greater financial strain and unnecessary medical procedures at what already can be a very difficult time for patients.”

Researchers said concerns have grown in recent years about potentially untrustworthy randomised controlled trials in reproductive medicine, including studies of IVF add-ons.

The team set out to review the effectiveness and safety of 10 commonly offered add-ons using trustworthy studies.

Researchers initially identified 157 potentially eligible randomised controlled trials but excluded 72 because of concerns about their reliability.

Randomised controlled trials compare treatments by assigning participants to different groups, helping researchers assess whether an intervention causes a particular outcome.

The team combined data from the remaining 85 trials in a meta-analysis, which brings together findings from several studies.

The review found no effect on fertility or inconclusive evidence for seven of the 10 add-ons examined.

These included acupuncture, which involves inserting thin needles into points on the body, and corticosteroids, medicines that reduce inflammation and suppress immune activity.

Endometrial receptivity testing was also not backed by reliable evidence. The procedure involves taking a sample from the lining of the womb to examine patterns of gene activity.

Another add-on was intralipid infusion, which delivers a fat-containing liquid into the bloodstream.

Researchers separately examined injections of platelet-rich plasma into the ovaries and infusions of platelet-rich plasma into the womb.

Platelet-rich plasma is made from a patient’s blood and contains a high concentration of platelets, which play a role in healing.

The seventh treatment was pre-implantation genetic testing for aneuploidy, which examines embryos to check whether they have the expected number of chromosomes.

The review found only weak evidence of a possible benefit from three other add-ons.

EmbryoGlue, an embryo transfer medium containing hyaluronic acid, may increase the probability of pregnancy and live birth. However, the evidence on live birth rates was not considered robust.

Endometrial scratching, a minor procedure that deliberately disturbs the lining of the womb, may also increase the probability of pregnancy and live birth.

Physiological intracytoplasmic sperm injection, known as PICSI, selects sperm based on their ability to bind to hyaluronic acid. Weak evidence suggested it may reduce the risk of miscarriage.

Lensen said: “There is widespread misinformation about IVF add-ons with private clinic websites and patient forums on social media – major information sources for patients – often overstating the benefits and omitting the costs and risks of add-ons.

“IVF clinics and clinicians should carefully consider whether it is appropriate to offer unproven add-ons, as their availability is often perceived by patients as implicit endorsement of benefit.”

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