Hormonal health
Berlin-based period tracker app bags €7m investment ahead of launching community funding round
Clue has extended an invite to its user community to become investors via Crowdcube

The female-founded period tracker app Clue has secured a €7m funding round to bridge the gender data gap.
The funds will be used to scale Clue’s digital family planning offering, expand the product portfolio, and continue research into women’s reproductive health.
Clue, a Berlin-based period and cycle tracking app, was founded in 2012 by Danish female entrepreneur, Ida Tin. The app calculates and predicts users’ periods and PMS based on users’ data, calculating fertility windows based on global averages.
More than 10 million people in 190 countries rely on the app every month to better understand their own menstrual cycle patterns and learn about their reproductive health.
Sine the app’s launch, users have tracked over 530 million cycles and contributed to “groundbreaking” research, the company says.
A dataset of over 13B de-identified data points supports studies such as investigating how the COVID-19 infection and vaccines would impact the menstrual cycle.
“So many of us still end up hacking our own solutions to health needs. Despite making up half the world’s population, the most common female health conditions still go unrecognised, under-researched, and underserved,” said Audrey Tsang, co-CEO of Clue.
“We constantly hear from our community that they feel their experiences are unheard or dismissed – except in Clue.
“We created Clue because health empowerment starts with better understanding your body. Having the language, and data, to describe your experience and advocate for yourself has a profound impact.
“The fact that it still takes an average of seven years to get an endometriosis diagnosis is just one example of how much work there still is to do in this space.”
“We believe Clue is uniquely positioned to lead the change that’s needed, at scale, by leveraging our technology, deep community insights, and research to create empathetic, effective, and accessible solutions for the most frequently experienced challenges in female health.”
Its latest funding round, hoped to drive more research into women’s menstrual health, has been led by existing investors, Balderton Capital and Union Square Ventures.
However, in a move to bring its community closer to the product development process, the company has also extended an invite to its user community to become investors via Crowdcube.
Community investors will be able to participate in and influence the app’s development through feature polls, testing, and forums directly with the Clue team.
Carrie Walter, co-CEO of Clue, said: “Clue has always been supported by some of the world’s leading investors. Today, we’re taking that one step further, by being the first menstrual and reproductive health app to invite our community to invest and become co-owners.
“After all, Clue only exists to serve this community, and because of their trust. So we see this as an exciting chance to connect with them in another way, benefitting from the depth of their engagement and diverse perspectives.
“We feel it closes an important circle to give Clue users the opportunity to participate in our success, also as investors.”
Menopause
High street bakery chain Gail’s reveals menopause plan

Gail’s has unveiled a menopause action plan offering new workplace support to thousands of staff ahead of legal reforms due in 2027.
The high street bakery chain will offer new benefits including 24/7 digital GP access and a new employee assistance programme, according to The Times.
It will also explore new online training for staff, including specific training for management.
Gail’s people director Miranda Burgum told The Times: “All we’re trying to do is talk freely and for it not to be a forbidden subject. It’s helping our managers and teams understand that this isn’t a taboo.”
“We’re going to develop the education with our managers, so it will be threaded through all our policies
“It will look at induction training, it will look at the types of people we need to make sure that we make reasonable adjustments for.
“And if somebody needs some sort of risk assessment, we’re going to be looking at [that].”
The move comes ahead of reforms due to be introduced in spring 2027 under the Employment Rights Act.
UK employers with 250 or more employees will be legally required to publish and update official menopause action plans.
The plans are intended to support employers to take effective action to improve workplace gender equality and support employees experiencing menopause.
Menopause
Menopause hormone therapy may improve cardiovascular health outcomes, study suggests

Hormone therapy started in peri- or early post-menopause was linked to a 22 per cent lower risk of cardiovascular events in women with vasomotor symptoms in a recent study.
The findings came from an observational analysis of 20 years of health data and do not show that hormone therapy caused the reduction in cardiovascular risk.
The association was strongest among Black women and women who started treatment within 10 years of menopause onset, although researchers cautioned that the findings should not guide clinical practice.
The study is the first of its kind in the US to assess the risk of future cardiovascular events among women with vasomotor symptoms who use hormone therapy during peri- and early postmenopause.
Samar R. El Khoudary, professor and chair of the Department of Epidemiology at the VCU School of Public Health and one of the study’s senior researchers, said: “The menopause transition represents a critical window for understanding how hormone therapy may relate to cardiovascular disease risk. Our findings suggest that timing of initiation may influence cardiovascular outcomes.”
The researchers stressed that the findings do not support using hormone therapy to prevent cardiovascular disease.
Potential benefits must also be weighed against risks, including the increased breast cancer risk observed with longer-term use.
The study was not a randomised controlled trial, the gold-standard method for testing biomedical treatments.
Rebecca C. Thurston, associate dean for Women’s Health Research at the University of Pittsburgh School of Medicine and one of the study’s senior researchers, said: “These findings point to women with vasomotor symptoms as those who may show cardiovascular benefit from hormone therapy initiated during the perimenopause and postmenopausal years.
“However, conclusions should be tempered by the observational nature of the study, and findings should not guide clinical practice.”
Vasomotor symptoms, meaning hot flushes and night sweats, affect up to 80 per cent of women during the menopause transition and last for an average of seven to ten years.
Their frequency and severity build through perimenopause and typically peak in early postmenopause.
Hormone therapy replaces oestrogen and progesterone that women’s bodies stop producing after menopause and is currently the most effective treatment for these symptoms.
Clinical trials led by the Women’s Health Initiative in the early 2000s raised concerns about hormone therapy’s impact on heart disease, stroke, breast cancer and other risks, leading to years of reluctance among patients and providers to use the treatment.
El Khoudary said: “Hot flashes and night sweats have a significant impact on a woman’s quality of life and ability to work productively.
“While hormone therapy is an effective treatment for these symptoms, questions have remained about its cardiovascular effects, particularly the importance of when treatment is initiated during the menopause transition.”
More recent research suggests the effects of hormone therapy on the heart and vascular system may vary by age and treatment timing, with women younger than 60 who start treatment closer to menopause onset having different levels of risk.
In 2026, the US Food and Drug Administration removed “black box” warnings from hormone therapy products, reflecting evolving evidence on the benefits and risks of treatment.
Researchers from Virginia Commonwealth University and the University of Pittsburgh analysed data from more than 2,700 women taking part in the Study of Women’s Health Across the Nation (SWAN).
The women reported vasomotor symptoms and had not previously experienced cardiovascular events.
Clinical data collected between 1997 and 2017 were used to examine whether women who started hormone therapy for vasomotor symptoms were more or less likely to experience stroke, congestive heart failure, heart attack or revascularisation procedures than women who did not start treatment.
El Khoudary said: “By using data from the SWAN study, we essentially were able to emulate a series of hypothetical clinical trials to gain a deeper understanding into how hormone therapy taken to mitigate vasomotor symptoms during peri- and early postmenopause influences cardiovascular risk over time.
“It allowed us to examine clinically meaningful cardiovascular disease events over long-term follow-up in a population and treatment window that has been challenging to study prospectively.”
Starting hormone therapy during peri- or early postmenopause was associated with an estimated 22 per cent lower risk of cardiovascular disease events.
Women who began hormone therapy within 10 years of menopause onset had an estimated 27 per cent lower risk compared with women who did not start treatment.
Among Black women, starting therapy during peri- or early postmenopause was associated with an estimated 49 per cent lower risk of cardiovascular disease events.
No clear reduction was seen among women who started therapy more than 10 years after menopause onset or among White women and other racial and ethnic groups.
El Khoudary said: “The differences in cardiovascular outcomes by race and ethnicity are notable, particularly because Black women are more likely to experience severe vasomotor symptoms.
“These findings highlight the need to better understand how hormone therapy timing may influence cardiovascular outcomes across diverse populations.”
It remains unclear why cardiovascular risk differed according to when hormone therapy was started, although researchers believe differences in blood vessel health with age may play a role.
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