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WHO issues first pregnancy guideline for sickle cell disease

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The WHO has released its first global guideline for managing sickle cell disease (SCD) during pregnancy, aiming to reduce health risks that can be life-threatening for women and babies.

The guideline addresses a major gap in care for the 7.7 million people living with SCD globally – a number that has increased by over 40 per cent since 2000.

SCD refers to a group of inherited blood disorders where red blood cells become abnormally shaped like crescents or sickles.

These misshapen cells can block blood flow, leading to severe anaemia, painful episodes, repeated infections and medical emergencies such as strokes, sepsis or organ failure.

Dr Doris Chou is medical officer and lead author of the guideline.

Chou said: “It’s essential that women with sickle cell disease can discuss their care options early in pregnancy—or ideally before—with knowledgeable providers.

“This supports informed decisions about any treatment options to continue or adopt, as well as agree on ways of handling potential complications, so as to optimise outcomes for the woman, her pregnancy, and her baby.”

The new guideline provides evidence-based recommendations tailored for low- and middle-income countries, where the majority of cases and deaths from the disease occur.

Sub-Saharan Africa accounts for around 80 per cent of global cases, with others found in parts of the Middle East, the Caribbean and South Asia.

With greater population movement and improved life expectancy, the sickle cell gene is becoming more widespread, increasing the need for awareness among maternity care providers.

During pregnancy, health risks from SCD increase due to greater demands on the body’s oxygen and nutrient supply.

Women with the condition are four to eleven times more likely to die from pregnancy-related causes than women without SCD.

They are also more prone to complications such as pre-eclampsia – a serious blood pressure disorder – while their babies face a higher risk of stillbirth, premature birth or low birth weight.

Dr Pascale Allotey is director for sexual and reproductive health and research at WHO and the United Nations’ Special Programme for Human Reproduction.

Allotey said:”With quality health care, women with inherited blood disorders like sickle cell disease can have safe and healthy pregnancies and births.

“This new guideline aims to improve pregnancy outcomes for those affected.

“With sickle cell on the rise, more investment is urgently needed to expand access to evidence-based treatments during pregnancy as well as diagnosis and information about this neglected disease.”

The guideline includes over 20 recommendations, covering areas such as folic acid and iron supplementation (with adjustments for malaria-endemic regions), management of sickle cell crises and pain, prevention of infections and blood clots, use of prophylactic blood transfusions, and additional monitoring of both the woman and the baby’s health throughout pregnancy.

It stresses the importance of personalised and respectful care, recognising each woman’s individual needs, medical history and preferences.

The guideline also highlights the need to tackle stigma and discrimination in healthcare settings, which remains a significant barrier to care in many countries.

Mental health

New study explores why open water swimming feels so powerful for midlife women

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A team of UK researchers has published a new study examining how middle-aged, middle-class British women describe the effects of regular open water swimming on their wellbeing, including its impact on menopause symptoms and mental health.

The University of East London research uses in-depth interviews to understand women’s own accounts of swimming in outdoor water and how they feel it supports their lives.

The study looks at the patterns that emerged when women talked about what open water swimming meant to them.

Across the interviews, four themes appeared consistently.

Although menopause was never introduced by the researchers, several participants volunteered that cold water and the routine of swimming helped them feel calmer, more emotionally balanced and more in control during a major life transition.

Women felt it supported their mental wellbeing, with many describing a clear “reset” effect, a lift in mood, more energy and an increased sense of what their bodies could do, all expressed in their own terms.

They also spoke about health, strength and resilience.

Participants said the experience of swimming outdoors helped them feel more capable and better able to deal with difficult moments, including bereavement, illness and daily stress.

Finally, Interviewees emphasised the community around the lake and said that the confidence and clarity they gained often carried over into work, relationships and everyday decision-making.

This is the first qualitative study to examine open water swimming through “flourishing” a recognised psychological framework, and that participants’ accounts aligned closely with its components.

Mr James Beale is lead author and Programme Leader for the MSc Applied Sport and Exercise Sciences at the University of East London.

He said: “We are seeing a major shift in women taking up open water swimming, and many are now speaking openly about how it connects to menopause.

“Until now, this discussion has been largely anecdotal.

“Our study shows that women repeatedly link outdoor swimming with emotional steadiness, confidence and coping during this stage of life.

“That points to an emerging area of women’s health that deserves greater attention.”

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Features

Early prenatal support cuts postpartum depression by over 80%, study finds

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Early pregnancy therapy can cut postpartum depression and anxiety by tackling prenatal anxiety, new research has revealed.

A trial of 1,200 pregnant women in Pakistan found those receiving cognitive behavioural therapy (CBT), a talking therapy that changes patterns of thought and behaviour, had 81 per cent lower odds of postpartum depression or moderate-to-severe anxiety than those receiving usual care.

Only 12 per cent of women in the intervention group developed postpartum depression, compared with 41 per cent in the control group.

The research was led by Pamela Surkan at Johns Hopkins University, in partnership with the University of Liverpool and the Human Development Research Foundation Pakistan.

Surkan said: “We hope this research doesn’t end with evidence, but with implementation.

“Every pregnant woman deserves the chance to thrive, and mental health must be recognised as a core part of maternal health everywhere.”

Among women who attended five or more sessions, the risk of low birthweight (under 2.5kg) and small-for-gestational-age births (smaller than expected for weeks of pregnancy) decreased by 39 per cent and 32 per cent respectively.

The approach was designed to be scalable: therapy was delivered by trained non-specialist counsellors in a public hospital in Rawalpindi, making it accessible and low-cost for health systems without specialist clinicians.

In Pakistan, up to 49 per cent of pregnant women experience anxiety, yet access to mental health care remains limited.

Prenatal anxiety is rarely addressed in public health systems despite long-term consequences for mothers and children.

What began at a global mental health meeting in Washington DC in 2012 evolved into a research partnership spanning 2017 to 2024. Findings from the main trial were published in March 2024.

Beyond clinical outcomes, the research linked better social support, reduced stress and fewer pregnancy-related difficulties to improved mental health outcomes.

To date, 29 peer-reviewed articles have been published from the project, which has established one of the world’s largest datasets on prenatal anxiety in low and middle-income countries and developed an intervention manual ready for wider use.

The team is now focused on scaling, with proposals submitted to test the intervention in new contexts and plans to make the manual publicly available.

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Fertility

Meta removes dozens of abortion advice and queer advocacy accounts

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Meta has removed or restricted dozens of accounts run by abortion providers, queer groups and reproductive health organisations in recent weeks.

Campaigners have called the takedowns one of the biggest waves of censorship on Meta’s platforms in years.

The actions began in October and targeted the Facebook, Instagram and WhatsApp accounts of more than 50 organisations worldwide, some serving tens of thousands of people.

Many were from Europe and the UK, with bans also affecting groups serving women in Asia, Latin America and the Middle East.

Repro Uncensored, an NGO tracking digital censorship against movements focused on gender, health and justice, said it had recorded 210 incidents of account removals and severe restrictions affecting these groups this year, compared with 81 last year.

Martha Dimitratou, executive director of Repro Uncensored, said: “Within this last year, especially since the new US presidency, we have seen a definite increase in accounts being taken down, not only in the US, but also worldwide as a ripple effect.

“This has been, to my knowledge, at least one of the biggest waves of censorship we are seeing.”

Meta denied any escalating trend of censorship and said its policies on abortion-related content had not changed.

“Every organisation and individual on our platforms is subject to the same set of rules, and any claims of enforcement based on group affiliation or advocacy are baseless,” it said in a statement.

Organisations affected include Netherlands-registered Women Help Women, a non-profit offering information about abortion to women worldwide that fields about 150,000 emails a year.

Kinga Jelinska, executive director of Women Help Women, said the ban could be “life-threatening”, pushing some women towards dangerous, less reliable information sources.

“It’s a very laconic explanation, a feeling of opacity,” Jelinska said. “They just removed it. That’s it. We don’t even know which post it was about.”

Meta said more than half of the accounts flagged by Repro Uncensored have been reinstated, including Women Help Women, which it said was taken down in error.

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