Pregnancy
New study reveals brain changes throughout pregnancy

The firs-ever map of a human brain and the brain changes that take place over the course of pregnancy has been developed by researchers at UC Santa Barbara.
Following one first-time mother, researchers scanned her brain every few weeks, starting before pregnancy and continuing through two years postpartum.
The data, collected in collaboration with Elizabeth Chrastil’s team at UC Irvine, reveal changes in the brain’s grey and white matter across gestation, suggesting that the brain is capable of astonishing neuroplasticity well into adulthood.
Their precision imaging approach allowed them to capture dynamic brain reorganisation in the participant in exquisite detail. This approach complements early studies that compared women’s brains pre- and post-pregnancy.
The authors noted: “our goal was to fill the gap and understand the neurobiological changes that happen during pregnancy itself.”
“We wanted to look at the trajectory of brain changes specifically within the gestational window,” said Laura Pritschet, lead author of a paper just published in Nature Neuroscience.
Previous studies had taken snapshots of the brain before and after pregnancy, she said, but never have we witnessed the pregnant brain in the midst of this metamorphosis.
Decrease in grey matter, increase in white matter
The most pronounced changes the scientists found as they imaged the subject’s brain over time was a decrease in cortical grey matter volume, the wrinkly outer part of the brain. Grey matter volume decreased as hormone production ramped up during pregnancy.
However, a decrease in grey matter volume is not necessarily a bad thing, the scientists emphasised. This change could indicate a “fine-tuning” of brain circuits, not unlike what happens to all young adults as they transition through puberty and their brains become more specialised. Pregnancy likely reflects another period of cortical refinement.
“Laura Pritschet and the study team were a tour de force, conducting a rigorous suite of analyses that generated new insights into the human brain and its incredible capacity for plasticity in adulthood,” Jacobs said.
Less obvious but just as significant, the researchers found prominent increases in white matter, located deeper in the brain and generally responsible for facilitating communication between brain regions.
While the decrease in grey matter persisted long after giving birth, the increase in white matter was transient, peaking in the second trimester and returning to pre-pregnancy levels around the time of birth.
This type of effect had never been captured previously with before-and-after scans, according to the researchers, allowing for better estimation of just how dynamic the brain can be in a relatively short period of time.
“The maternal brain undergoes a choreographed change across gestation, and we are finally able to see it unfold,” Jacobs said. These changes suggest that the adult brain is capable of undergoing an extended period of neuroplasticity, brain changes that may support behavioural adaptations tied to parenting.
“85 per cent of women experience pregnancy one or more times over their lifetime, and around 140 million women are pregnant every year,” said Pritschet, who hopes to “dispel the dogma” around the fragility of women during pregnancy.
She argued that the neuroscience of pregnancy should not be viewed as a niche research topic, as the findings generated through this line of work will “deepen our overall understanding of the human brain, including its aging process.”
The open-access dataset, available online, serves as a jumping-off point for future studies to understand whether the magnitude or pace of these brain changes hold clues about a woman’s risk for postpartum depression, a neurological condition that affects roughly one in five women.
“There are now FDA-approved treatments for postpartum depression,” Pritschet said, “but early detection remains elusive. The more we learn about the maternal brain, the better chance we’ll have to provide relief.”
With support from the Ann S. Bowers Women’s Brain Health Initiative, directed by Jacobs, the team is now building on these early discoveries through the Maternal Brain Project. More women and their partners are being enrolled at UC Santa Barbara, UC Irvine, and through an international collaboration with researchers in Spain.
“Experts in neuroscience, reproductive immunology, proteomics, and AI are joining forces to learn more than ever about the maternal brain,” Jacobs said.
“Together, we have an opportunity to tackle some of the most pressing and least understood problems in women’s health.”
Pregnancy
Women should not be pressured into an ‘ideal birth’, says health secretary

Women should not feel pressured into an “ideal birth”, health secretary Yvette Cooper has said as she promised major maternity reform.
Cooper has returned to the Department of Health and Social Care 27 years after serving as public health minister under Tony Blair.
She said maternity and child health would be a major focus of her new role, alongside significant reforms to social care.
In an interview with the Guardian, Cooper said the changes should address any pressure on women to pursue a particular birth experience.
Families affected by maternity failures have repeatedly raised concerns that some units were reluctant to escalate medical interventions because of a preference for more natural births.
Cooper said: “I would worry about any mum feeling pressurised that there is somehow a kind of an ideal birth experience to live up to when it’s always different in every case, and you have to follow the evidence, you have to have informed choice.”
As one of her first actions as health secretary, Cooper said she intended to reintroduce binding national maternity standards.
The standards were dismantled during early Conservative NHS reforms and replaced with fragmented arrangements managed separately by individual hospital trusts.
A new maternity taskforce will draft the standards, which will have five central aims.
These include ending regional differences in levels of care and tackling racial inequalities linked to poorer outcomes in deprived areas, particularly for Black and Asian women.
Patient experiences will also form part of how standards are measured, while new targets will aim to identify underperformance before a major scandal develops.
Cooper, who became the first minister to take maternity leave while serving as a junior health minister in the early 2000s, said reports into maternity scandals had been “traumatic” to read and showed that systemic change was needed.
She said: “We’ve always said the NHS is about the cradle to the grave. I want to make it a personal crusade to put the cradle back at the heart of the NHS, and to have much more focus around maternity and child health, the very beginning of a family’s life, making that much more central to the priorities of the NHS, giving it the priority that it really deserves.”
Cooper said discussions about how maternity services could better listen to mothers’ needs had been taking place for the past two decades.
However, she said the emphasis on placing women and families at the centre of care appeared to have been lost.
She said: “It feels incomprehensible that we could be in this situation in the 2020s. I went back to look at some of the things that we’d done 25 years ago.
“And what did strike me was how much we were talking then about women and families being at the centre of care and about listening to women’s views.
“It is really shocking and distressing feeling that has somehow been lost in some of the maternity units where actually it should be the central issue.
“I had a direct interest. I was pregnant at the time. But I am really struck by it now, just feeling like there is this big gap in the priorities that the NHS has been focused on.”
Cooper said she was determined to provide a robust response to Donna Ockenden’s investigations into maternity failures at Shrewsbury and Telford and Nottingham, alongside Baroness Valerie Amos’s national investigation into England’s maternity system.
The investigations highlighted systemic clinical errors, understaffing and toxic institutional cultures. They found that hundreds of infant and maternal deaths were directly linked to failures to listen to mothers and defensive attempts to protect institutions.
Amos’s review faced criticism, including the resignation of an expert adviser over the lack of explicit warnings about “normal birth ideology”.
Families also questioned whether the review’s proposed statutory maternity commissioner would have sufficient independence.
Cooper said she remained committed to introducing the role.
She said: “In the end, the most important people in the maternity services are the mothers, babies, the families. But the point of having a maternity commissioner is to make sure that those issues are championed as part of an NHS.”
She also said reforms needed to address an oppositional culture between doctors and midwives in some trusts over when medical intervention during birth may be necessary.
Cooper said: “The thing that struck me most was the sense of women feeling they weren’t being listened to … And I think that probably does go back to issues around culture.”
Cooper, who served as foreign secretary until recently, said she was prepared for a difficult period in the health role as she sought to implement Andy Burnham’s social care reforms.
She said she remained committed to establishing the national care service announced by the prime minister the previous week.
A longstanding ally of former prime minister Keir Starmer and a former rival of Burnham in the 2015 Labour leadership contest, Cooper said she believed the change of prime minister had been necessary.
She said: “Of course it’s not easy. I really did not think it was possible to win the election when I came back into the shadow cabinet in 2022. It’s only because of what Keir did that we managed to win.
“But we had very difficult local election results … we have to respond to that. But I think we’ve got a sense of energy now.
“All of the things that Andy wants to focus on and drive are also just very much the things that that people are concerned about across the country.”
Pregnancy
Beetroot juice may benefit pregnant women with chronic kidney disease – study

Daily beetroot juice may help support kidney health during pregnancy in women with chronic kidney disease, early research suggests.
Pregnancy puts additional strain on the kidneys. Around half of women with moderate to severe chronic kidney disease experience a decline in kidney function while pregnant.
Despite these risks, outcomes for pregnant women with the condition have changed little over the past 30 years.
Many medicines used to manage kidney disease are also unsuitable during pregnancy, meaning women often need to stop taking them for at least nine months.
Researchers at King’s College London examined whether dietary nitrate from beetroot juice could offer a simple and safe way to support kidney function during pregnancy.
Beetroot juice is naturally rich in nitrate, which the body converts into nitric oxide. Nitric oxide widens blood vessels and improves blood flow, which could reduce the strain placed on the kidneys during pregnancy.
The study involved 108 pregnant women with stage 2 to 5 chronic kidney disease across eight UK hospitals.
Before reaching 25 weeks of pregnancy, participants were randomly assigned to receive either standard care or a daily beetroot juice supplement containing dietary nitrate.
The study was mainly designed to assess whether a larger clinical trial would be practical. However, the findings also suggested possible benefits for mothers and babies.
Kate Bramham, consultant nephrologist at King’s College Hospital, professor at King’s College London and senior author of the study, said: “For women living with chronic kidney disease, pregnancy has always meant navigating a difficult trade-off between preserving their own health and keeping their baby safe, often with few tools to do both.
“These results are an encouraging first step towards a low-cost, low-risk intervention that could genuinely make a difference for this group of women, who have been underserved by research for far too long.”
Women receiving beetroot juice experienced around 70 per cent fewer serious adverse events overall than those receiving standard care. Of the serious adverse events that occurred, around half affected newborn babies.
Among women with more advanced kidney disease, researchers also observed trends towards better kidney function after pregnancy, fewer newborn admissions to neonatal care and a reduced need for blood pressure medication during pregnancy.
The researchers found no safety concerns linked to beetroot juice supplementation during pregnancy, including no increase in hyperkalaemia, which means unusually high potassium levels in the blood.
There have been concerns that beetroot juice could increase the risk of hyperkalaemia in pregnant women with chronic kidney disease, with some online advice recommending that they avoid it. However, no increase was recorded among women receiving the supplement.
Dr Priscilla Smith, a nephrologist, King’s College London PhD student and first author of the study, said: “Pregnancy can put additional stress on the kidneys, and for women with chronic kidney disease there are currently limited options to protect kidney function during this time.
“Our findings suggest beetroot juice could offer a simple and accessible approach that is safe and worth exploring further.”
The researchers said larger clinical trials are now needed to determine whether beetroot juice can significantly reduce kidney function decline and improve long-term outcomes for mothers and babies.
If confirmed, the intervention could offer an inexpensive and widely available way to support women with chronic kidney disease during pregnancy, when safe treatment options remain limited.
The research was supported by funding from Kidney Research UK.
Dr Andrew Webb, clinical senior lecturer at King’s College London and a co-author of the study, said: “By increasing nitric oxide production, dietary nitrate from beetroot juice may help improve blood vessel function and support kidney health.
“These early findings provide an important foundation for future research into protecting women with chronic kidney disease during pregnancy and their babies.”
Pregnancy
Hospital admissions for ectopic pregnancy rising in England, study suggests

Ectopic pregnancy admissions have risen in England since 2021, according to a 20-year analysis of NHS data.
Women in the most deprived areas had more than twice the admission rate of those living in the least deprived communities.
The study was the first 20-year national analysis of NHS England data on the issue.
Dr Nicola Tempest, academic clinical lecturer in the University of Liverpool’s Department of Women’s and Children’s Health, said: “Pregnancy loss affects millions of women worldwide, yet we know surprisingly little about how its prevalence and impact has changed over time.
“Our research shows that admissions for ectopic pregnancy have continued to rise despite declining birth rates, highlighting an ongoing demand for NHS services.
“Women from the most deprived areas consistently experienced much higher admission rates for both miscarriage and ectopic pregnancy, underlining persistent health inequalities.
“Pregnancy loss should be recognised as a major women’s health research priority so we can better understand its causes and develop services that meet women’s needs and address the risk factors that are contributing to these rates.
“Importantly, research must address one of the most common and deeply personal questions women ask after pregnancy loss: ‘Why did this happen to me?’”
Ectopic pregnancy is one of the most common early pregnancy complications, with an estimated 11,000 hospital admissions each year, or around one in every 90 pregnancies.
It occurs when a fertilised egg implants outside the womb. Ectopic pregnancies result in pregnancy loss and can put the mother’s health at risk if the pregnancy continues.
Researchers at the University of Liverpool analysed hospital and maternity services data collected between 2004 and 2024.
Admissions rose significantly from 2004 to 2012, increasing by an average of around three per cent each year.
Rates remained broadly stable from 2012 to 2021 before rising significantly again.
Since 2021, admissions have increased by an average of more than four per cent a year.
The researchers said the recent rise may reflect demographic changes, including women having children later and higher rates of risk factors such as obesity.
Disruption to hospital and maternity services during the Covid-19 pandemic may also have contributed.
The study also found that miscarriage admissions fell significantly between 2018 and 2021. They rose modestly in subsequent years, although the increase was not statistically significant.
A result is statistically significant when researchers consider it unlikely to have occurred through chance alone.
For more than a decade, women in the most deprived communities had more than twice the hospital admission rate for miscarriage and ectopic pregnancy compared with those in the least deprived areas.
The researchers pointed to preventable inequalities in health, risk factors and access to care as likely contributors.
Tempest said: “These findings show that where a woman lives continues to have a profound influence on her reproductive health outcomes.
“Ultimately, reducing these inequalities will require an equity-focused approach that combines high-quality clinical care with prevention, education and services designed around the needs of the communities most at risk.
“Behind every admission for pregnancy loss, there is a woman, a family and an unanswered question, our aim and mission is not only to improve the care but also to understand and prevent it.”
News2 days agoUK femtech investment surges 194% in a decade, research finds
Entrepreneur2 weeks agoFertility startup American Baby Company secures US$4m
Insight2 weeks agoNatural Cycles receives sixth FDA clearance for fertility algorithm
Wellness6 days agoCancer patient receives ‘landmark’ treatment in world-first
Insight2 weeks agoExperimental treatment significantly slows progression of fatal brain disease in women, study finds
Sponsored Content2 weeks agoThe room is filling up at WHW Europe 2026 with super early bird pricing ending this Friday
Insight1 week agoJohnson & Johnson offers to pay US$5.5bn to settle talc cancer lawsuits
News2 weeks agoPlanetary Health Diet lowers heart risk in older women, study finds












