Pregnancy
New study reveals brain changes throughout pregnancy
The firs-ever map of a human brain and the brain changes that take place over the course of pregnancy has been developed by researchers at UC Santa Barbara.
Following one first-time mother, researchers scanned her brain every few weeks, starting before pregnancy and continuing through two years postpartum.
The data, collected in collaboration with Elizabeth Chrastil’s team at UC Irvine, reveal changes in the brain’s grey and white matter across gestation, suggesting that the brain is capable of astonishing neuroplasticity well into adulthood.
Their precision imaging approach allowed them to capture dynamic brain reorganisation in the participant in exquisite detail. This approach complements early studies that compared women’s brains pre- and post-pregnancy.
The authors noted: “our goal was to fill the gap and understand the neurobiological changes that happen during pregnancy itself.”
“We wanted to look at the trajectory of brain changes specifically within the gestational window,” said Laura Pritschet, lead author of a paper just published in Nature Neuroscience.
Previous studies had taken snapshots of the brain before and after pregnancy, she said, but never have we witnessed the pregnant brain in the midst of this metamorphosis.
Decrease in grey matter, increase in white matter
The most pronounced changes the scientists found as they imaged the subject’s brain over time was a decrease in cortical grey matter volume, the wrinkly outer part of the brain. Grey matter volume decreased as hormone production ramped up during pregnancy.
However, a decrease in grey matter volume is not necessarily a bad thing, the scientists emphasised. This change could indicate a “fine-tuning” of brain circuits, not unlike what happens to all young adults as they transition through puberty and their brains become more specialised. Pregnancy likely reflects another period of cortical refinement.
“Laura Pritschet and the study team were a tour de force, conducting a rigorous suite of analyses that generated new insights into the human brain and its incredible capacity for plasticity in adulthood,” Jacobs said.
Less obvious but just as significant, the researchers found prominent increases in white matter, located deeper in the brain and generally responsible for facilitating communication between brain regions.
While the decrease in grey matter persisted long after giving birth, the increase in white matter was transient, peaking in the second trimester and returning to pre-pregnancy levels around the time of birth.
This type of effect had never been captured previously with before-and-after scans, according to the researchers, allowing for better estimation of just how dynamic the brain can be in a relatively short period of time.
“The maternal brain undergoes a choreographed change across gestation, and we are finally able to see it unfold,” Jacobs said. These changes suggest that the adult brain is capable of undergoing an extended period of neuroplasticity, brain changes that may support behavioural adaptations tied to parenting.
“85 per cent of women experience pregnancy one or more times over their lifetime, and around 140 million women are pregnant every year,” said Pritschet, who hopes to “dispel the dogma” around the fragility of women during pregnancy.
She argued that the neuroscience of pregnancy should not be viewed as a niche research topic, as the findings generated through this line of work will “deepen our overall understanding of the human brain, including its aging process.”
The open-access dataset, available online, serves as a jumping-off point for future studies to understand whether the magnitude or pace of these brain changes hold clues about a woman’s risk for postpartum depression, a neurological condition that affects roughly one in five women.
“There are now FDA-approved treatments for postpartum depression,” Pritschet said, “but early detection remains elusive. The more we learn about the maternal brain, the better chance we’ll have to provide relief.”
With support from the Ann S. Bowers Women’s Brain Health Initiative, directed by Jacobs, the team is now building on these early discoveries through the Maternal Brain Project. More women and their partners are being enrolled at UC Santa Barbara, UC Irvine, and through an international collaboration with researchers in Spain.
“Experts in neuroscience, reproductive immunology, proteomics, and AI are joining forces to learn more than ever about the maternal brain,” Jacobs said.
“Together, we have an opportunity to tackle some of the most pressing and least understood problems in women’s health.”
Insight
Higher nighttime temps linked to increased risk of autism diagnosis in children – study
Fertility
Most NHS regions in England limit IVF to single cycle, research finds
Nearly 70 per cent of NHS regions in England fund only one IVF cycle for women under 40, breaking national guidelines, new research has found.
Twenty-nine of the 42 integrated care boards, which control local NHS budgets, now offer only one round of treatment, after four reduced access in the past year.
National Institute for Health and Care Excellence (Nice) guidelines recommend three full cycles for women under 40 who have been unable to conceive for two years.
Only two of England’s 42 integrated care boards have policies consistent with these guidelines, which they are not legally obliged to follow.
The research was conducted by the Progress Educational Trust, a fertility charity.
Sarah Norcross, the director of PET, said the impact was “devastating” for couples struggling with infertility.
She said: “Infertility is already incredibly stressful for people, and it puts them under even more pressure, because there is so much riding on whether that one NHS-funded cycle is going to work.
“And for some people, that will be their only chance, because private fertility treatment is so expensive.”
The data showed regional variations, with the whole of the north-west offering just one cycle.
“It’s a postcode lottery, and we’re seeing a race to the bottom,” said Norcross.
Of the 29 integrated care boards that offer a single cycle, 19 provide only a partial cycle, where not all viable embryos created are transferred.
There was just one recent example of improved services, from NHS South East London, which in July 2024 went from one partial to two full cycles.
The NHS estimates that about one in seven couples may have difficulty achieving a pregnancy. One cycle of IVF can cost from £5,000 at a private clinic.
Fertility rates in England and Wales have fallen since 2010 to 1.41 children per woman in 2024, the lowest on record and below the replacement level of 2.1 at which a population is stable without immigration.
Health minister Karin Smyth said in a written parliamentary answer last month that it was “unacceptable” that access to NHS-funded fertility services varied across the country.
Revised Nice fertility guidelines are due this spring, but Norcross said changing them seemed pointless.
She said: “Fertility treatment has always been a Cinderella service. It’s always been the one they’ve chosen to cut or to ignore.
“Nice has recommended three full NHS-funded cycles, for women under 40, for more than 20 years. This has never been implemented across England, unlike in Scotland.”
Norcross advocated centralised commissioning and replicating Scotland’s approach, which included financial modelling and a phased implementation starting with two cycles to avoid long waits, moving up to three once capacity was achieved.
“It is a tried and tested plan that England could follow,” Norcross added.
A Department of Health and Social Care spokesperson said: “We recognise access to fertility treatment varies across the country and we are working with the NHS to improve consistency.
“Nice provides clear clinical guidelines, and we expect integrated care boards to commission treatment in line with these.
“Updated Nice fertility guidelines are expected this spring and we will continue to support NHS England to make sure the guidance is fully considered in local commissioning decisions.”
An NHS England spokesperson said: “These clinical services are commissioned by integrated care boards for their area based on the needs of the local population and prioritisation of resources available.
“All ICBs have a responsibility to ensure services are provided fairly and are accessible by different population groups.”
Fertility
France urges 29-year-olds to start families now
France is urging 29-year-olds to have children as part of a 16-point plan to boost fertility and raise birth rates.
Health officials say the aim is to prevent men and women facing fertility problems later in life and thinking “if only I had known”.
The strategy comes as the country, like many western nations including the UK, faces tumbling birth rates.
The trend is creating concerns about how governments can fund pensions and healthcare for ageing populations with fewer younger working people paying taxes.
But policies to raise fertility rates globally have produced limited results, and critics of the scheme suggest better housing and maternity provision could be more effective.
The government will send out “targeted, balanced, and scientifically sound information” to young people on issues including sexual health and contraception.
The material “will also reiterate that fertility is a shared responsibility between women and men,” the country’s health ministry said.
The plan includes efforts to increase the number of egg-freezing centres from 40 to 70. The process involves extracting and storing a woman’s eggs for potential future use.
The country’s health system already provides free egg-freezing for people aged 29 to 37, a service that costs about £5,000 per round in the UK.
The country’s fertility rate of 1.56 children per woman is below the 2.1 needed to maintain a stable population.
However, it is higher than rates in China, Japan and South Korea, and the UK, where the latest figures show it dropped to a record low of 1.41 in England and Wales by 2024.
Professor François Gemenne, who specialises in sustainability and migration at HEC Paris Business School, told Sky News: “This is something that demographers had known for a long time, but the fact that there were more deaths than births in France last year created a shock effect.”
He said the country’s “demographic worry” is exacerbated by the design of its pensions system and its “obsession with immigration and the fear of being ‘replaced'”.
The plan also includes a new national communication campaign, a “My Fertility” website advising on the effects of smoking, weight and lifestyle, and school lessons for children about reproductive health.
The health ministry has acknowledged its maternal and infant mortality rates are higher than neighbouring countries and is beginning a review of perinatal care to address the “concerning” situation.
Channa Jayasena, professor in reproductive endocrinology at Imperial College London, told Sky News: “On the female side, societal changes leading to older age of motherhood are certainly important.
He said obesity was also a problem as it increased women’s risk of polycystic ovary syndrome and endometriosis.
Allan Pacey, professor of andrology (male reproductive health) at Manchester University, said for most people globally, deciding to have children was “down to [non-medical] factors such as better access to education, career opportunities, taxation, housing, mortgages, finance, etc.”
“Medicine can’t help with those things,” Pacey added.
-
Insight2 weeks agoParents sue IVF clinic after delivering someone else’s baby
-
Wellness3 weeks agoWomen’s health could unlock US$100bn by 2030
-
Insight4 weeks agoChina’s birth rate hits record low despite government fertility efforts
-
Menopause3 weeks agoHRT linked to greater weight loss on tirzepatide
-
Entrepreneur7 days agoUS startup builds wearable hormone tracker
-
Menopause3 weeks agoFlo Health and Mayo Clinic publish global perimenopause awareness study
-
Menopause2 weeks agoStudy reveals gap between perimenopause expectations and experience
-
Fertility6 days agoFrance urges 29-year-olds to start families now






