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Femtech start-up launches first virtual endometriosis centre
ELANZA Wellness aims to transform the quality of life for millions of women living with endometriosis
Chronic care start-up ELANZA Wellness has launched the first virtual endometriosis centre to help women and assigned female at birth individuals better manage their symptoms from home.
EverythingEndo aims to provide patients with a personalised symptom management plan that combines scientific research, individual data and specialist support.
Members can get medications online, learn about different treatments, meet with specialist care providers and access therapeutic interventions and education virtually.
The female-founded start-up developed the platform in collaboration with endometriosis patients, gynaecologists, advocates and holistic health providers to help people access knowledge, resources, specialised support and treatment options from the comfort of their own homes.
“People with endometriosis need better support and faster access to effective interventions,” said co-founder and CEO of ELANZA Wellness, Brittany Hawkins.
“For too long the majority of people have had their symptoms dismissed or normalised and over 70 per cent of sufferers are now left with unmanaged pain.
“It’s our aim to change that, layering data insights with specialist, compassionate care designed to take into account the mind and body.”
Hawkins’ co-founder, Catherine Hendy, said: “Endometriosis is so complex that everyone’s journey is different. We provide a supportive space for anyone looking for effective help to address their symptoms.”
In doing so, the team aims to address stark geographical disparities in care, financial barriers to treatment and health provider shortages to help patients find the right treatment.
One in ten women lives with endometriosis, a chronic condition where endometrial-like tissue grows outside the uterus.
The disease is linked to as many as 50 per cent of infertility cases, being acknowledged by public health experts as a crisis on a vast scale.
The World Health Organization (WHO) estimates that “at least” six and a half million women in the US alone have the condition, a figure that rises to as high as 190 million globally.
When accounting for hospital readmissions and repeat doctor or emergency room visits along with loss of workplace productivity, unmanaged endometriosis costs the US economy an estimated US$50bn per year.
However, symptoms can be successfully treated and disease progression can be slowed or halted with timely intervention, which translates to higher quality of life and lower costs.
To provide better management of diverse symptoms, ELANZA’s new service conducts an assessment of symptoms and provides private consultations with prescribing physicians and care navigators, as well as a dashboard of education and classes from a range of specialists, including reproductive health nurses, gynaecologists, pain and fertility specialists, nutritionists, breathwork coaches and acupuncturists.
Classes are available for at-home sessions and accessed through a Peloton-style dashboard within the platform, with members working with a dedicated care navigator to document progress.
The ELANZA team follows the biopsychosocial model of care, which takes into account the social and psychosocial determinants of health.
This approach is consistent with published research showing that a multimodal approach to managing endometriosis can improve functional and quality of life outcomes for people living with endometriosis.
“We bring the latest evidence-based virtual treatments, products and services together in one place to better connect the dots, using data to faster learn what will move the needle for each individual’s quality of life,” explained Hawkins.
“That’s the exciting part: making strides in better understanding this condition so future generations don’t need to suffer.”
The start-up, which counts a Stanford Gynecology and Obstetrics Professor Emeritus amongst its clinical advisory, emerged from Techstars New York accelerator and received funding from Human Ventures, Gaingels and the Accel Scout Fund. It has recently joined the Re/Wire development studio run by the consumer health company HALEON.
EverythingEndo is accessible from any device and works either standalone or in complementary tandem with in-office surgical and medical treatments.
For more information, visit elanzawellness.com.
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
Nighttime temperatures during pregnancy may be linked to a higher chance of an autism diagnosis in children, a recent study suggests.
The research tracked nearly 295,000 mother-child pairs in Southern California from 2001 to 2014 and linked warmer overnight temperatures with higher risk in early and late pregnancy.
Children of mothers exposed to higher than typical nighttime temperatures during weeks one to 10 of pregnancy had a 15 per cent higher risk of an autism diagnosis.
Exposure during weeks 30 to 37 was linked to a 13 per cent higher risk.
Lead author David Luglio, a post-doctoral fellow at Tulane University, said: “A key takeaway is that we identified specific windows when a mother and her developing child can be most affected by exposures to higher nighttime temperatures.
“This is critical and hopefully can help mothers prepare accordingly.”
The study is described as the first to examine how temperature may affect fetal neurodevelopment, the process by which a baby’s brain and nervous system form during pregnancy.
Extreme temperatures linked to increased risk were classified as above the 90th percentile, meaning 3.6°F hotter than average, and the 99th percentile, 5.6°F above average.
The association held even after researchers accounted for factors such as neighbourhood conditions, vegetation and fine-particle air pollution.
The study could not account for other factors such as access to air conditioning. Researchers did not find the same association with daytime temperatures, potentially because people spend more time away from home during the day.
“Heat waves are becoming more frequent, and people may only think of the dangers of daytime heat exposure,” said Mostafijur Rahman, assistant professor of environmental health sciences at Tulane University.
“These results indicate a strong association between high nighttime temperatures during pregnancy and autism risk in children and show that we need to think about exposure to heat around the clock.”
The study did not examine how higher temperatures at night might affect prenatal development, though Luglio said it is possible that warmer nights disrupt sleep for pregnant mothers.
Previous research has suggested insufficient sleep during pregnancy may be linked to a higher risk of neurocognitive delays in children.
“Extreme heat exposure during pregnancy has been linked to a range of adverse health outcomes, including prenatal neurodevelopment delays and complications with an embryo’s development of a central nervous system,” Luglio said.
“The goal of our study was to specifically explore the link between prenatal heat exposure and autism diagnoses for the first time.”
Kindbody has launched a fertility platform integrating AI with clinical care and patient support for employers and health plans.
The platform will enter a pilot with select Kindbody employer clients in 2026, covering over three million lives, ahead of wider availability in 2027.
Building on the company’s clinical model, the platform aims to improve outcomes and cost efficiency across family-building journeys. It connects Kindbody-owned clinics, partner clinics and an integrated clinical app.
The app offers virtual care across conception, pregnancy and reproductive health, extending through the menopause transition.
Launch features include updates in medication management, third-party reproduction, adoption, pregnancy, men’s health and global programme design.
David Stern, chief executive of Kindbody, said: “With our next-generation fertility platform, Kindbody is redefining what comprehensive, intelligent and affordable family-building care looks like for employers, health plans and patients.
“By unifying best-in-class clinical care, AI-driven intelligence and whole-person support, we are making it easier and more cost-effective for more people to build the families they envision.”
Kindbody has expanded access via its national network of IVF centres, including IVIRMA, Inception Fertility and Ivy Fertility.
A new Fertility Medication Portal is designed to streamline authorisations so medicines can be dispensed on time, giving patients visibility from prescription to coverage, pharmacy fulfilment and delivery tracking.
Through KindMan, men’s health education, digital resources and integrated clinical care are expanding, including hormone management programmes.
Services cover andropause (age-related testosterone decline), erectile dysfunction, low testosterone and other male reproductive conditions.
Specialist fertility care includes semen analysis, diagnostic testing, male hormone panels, genetic testing, surgical sperm extraction and sperm cryopreservation.
Launching in the second quarter, a pregnancy support app will act as a digital companion for expecting and new parents, with resources, interactive tools and clinical assessments to identify social drivers of health and mental health needs during pregnancy and beyond.
Kindbody’s physician-led menopause programme provides consultations with board-certified obstetricians and gynaecologists to diagnose, treat and manage menopausal symptoms, including hormone replacement therapy where appropriate, with support from nutritionists, mental health therapists and pelvic floor specialists.
AI and analytics will be embedded across the care journey. An AI care navigator will guide employees from benefit activation through intake, triage and scheduling.
Tools will track benefits and treatment plans, showing coverage and expected out-of-pocket costs at each step.
AI-supported scribing will assist clinicians with documentation, and a predictor tool will estimate a patient’s likelihood of having a baby across different treatment paths.
In 2027, Kindbody plans a savings model for eligible large employers that it says will guarantee lower total fertility spend while improving clinical efficiency and patient experience.
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