Fertility
Australian scientists make world-first endometriosis treatment breakthrough
The findings could help researchers determine whether a woman will need fertility treatment
A team of Australian researchers has become the first in the world to grow tissue from every known type of endometriosis, in a move that could pave the way for new research into more effective treatments and diagnoses.
Researchers from the Royal Hospital for Women, Sydney will be able to test treatments and match patients’ symptoms with specific proteins, after successfully growing 30 different lab-grown tissues taken during surgery.
The advancement will not only allow scientists to vary treatments from different types of endometriosis, but it will also help them determine whether a woman will need fertility treatment in the future.
Endometriosis is a common disease where tissue similar to the lining of the womb grows outside it in other parts of the body.
According to Endometriosis Australia, more than 830,000 of Australian girls and women live with endometriosis at some point in their life, with the disease often starting in teenagers. However, symptoms can vary dramatically between patients.
The charity estimates the illness costs the country AUS$9.7bn per year, with AUS$2.5bn coming in direct healthcare costs, and the rest in lost productivity.
Professor of obstetrics and gynaecology at Sydney Royal Hospital for Women, Jason Abbott, said collecting the cells in one place for the first time would allow researchers to accurately diagnose patients, potentially limiting the need for invasive and painful surgeries.
“Very much like we thought breast cancer, 30 years ago, was one disease and treated in one way, we now understand that [endometriosis] is much more complex than that,” he told Brisbane Times.
“All those different types of endometriosis really probably reflect different diseases … and that [can determine] their response to treatment, clinical symptoms and also things like infertility.”
The development, Abbott said, would help fast-track new treatments by enabling researchers to test new and existing drugs on the lab tissues rather than in humans.
“It’ll mean that we’ll be offering new treatments just around the corner,” he added.
Endometriosis has often been referred to as the ‘missed disease’ due to its unclear aetiology and inconsistencies in its diagnosis and management.
Unlike other long-term conditions such as diabetes and asthma, reports suggest endometriosis has remained largely ignored in government policy and research funding globally.
A 2021 study concluded that while social science and feminist research has drawn attention to the historical absences around endometriosis and the exclusion of women’s accounts, more empirical work which explores the active construction of ignorance around endometriosis in contemporary healthcare and policy contexts is urgently needed.
IVFmicro has raised £3.5m to advance its microfluidic device designed to improve IVF success rates in routine clinic use.
The Leeds-based spinout from the University of Leeds, founded in 2024, aims to increase the quality and number of embryos in an IVF cycle.
IVF, or in vitro fertilisation, combines eggs and sperm in a lab before transferring embryos to the womb. A microfluidic device is a chip with tiny channels that move very small volumes of fluid.
The company says its device could raise the number of viable embryos available for transfer and the likelihood that an embryo will implant.
Currently, IVF leads to a successful pregnancy in about 30 per cent of cases for women under 35. A single cycle typically costs around £5,000 in the UK.
“My career has focused on understanding the reproductive biology of eggs and embryos, how they develop and, crucially, why things sometimes go wrong,” said IVFmicro co-founder and scientific director Helen Picton.
“At IVFmicro, we are harnessing years of research into reproductive biology to create a practical, accessible solution that can improve outcomes for patients undergoing fertility treatment. Our goal is to make IVF more effective, more predictable, and ultimately more hopeful for those striving to start a family.”
The investment was led by Northern Gritstone, with support from Innovate UK’s Investment Partnership Programme.
“IVFMicro is a brilliant example of the world-class innovation emerging from the Northern Arc’s universities, combining scientific excellence with a clear commercial vision to tackle the societal challenge of infertility,” said Northern Gritstone chief executive Duncan Johnson.
“Millions worldwide require fertility treatment, but new solutions are needed to overcome the high costs involved and low success rates. We are especially proud that IVFMicro’s journey has been supported through our NG Studios programme and our Innovation Services, which exist to help founders like Virginia and Helen turn pioneering research into real-world impact.”
University of Leeds IVF spinout IVFmicro has raised £3.5m in pre-seed funding.
The investment is led by Northern Gritstone, with support from Innovate UK Investor Partnerships Programme, and will be used by IVFmicro for its next verification and validation phase, leading to trials on human embryos in fertility clinics.
Helen Picton is scientific director and co-founder of IVFmicro.
She said: “My career has focused on understanding the reproductive biology of eggs and embryos, how they develop and, crucially, why things sometimes go wrong.
“At IVFmicro, we are harnessing years of research into reproductive biology to create a practical, accessible solution that can improve outcomes for patients undergoing fertility treatment.
“Our goal is to make IVF more effective, more predictable, and ultimately more hopeful for those striving to start a family.”
Globally, 1 in 6 couples will face fertility issues, yet IVF success rates are suboptimal, with only 25-30 per cent succeeding in women under 35 years of age.
This is due in part to limitations of the embryo culture process, which typically involves repetitive handling, subjective selection of the best embryo, and the expense of highly skilled operators.
IVF is an expensive process, costing on average £5,000 for a patient in the UK for one cycle, accompanied by long NHS waiting lists that have selective criteria.
IVFmicro provides the first microfluidic device (a device for safely managing embryo culture and handling with very small amounts of nutrient-rich fluid) that can be used in any IVF treatment cycle.
This precision-engineered solution improves both the number of viable embryos available for transfer and the likelihood that an embryo will implant and result in a pregnancy.
IVFmicro provides a 10-15 per cent improvement in embryo quality and quantity, a significant leap that increases the potential to fall pregnant.
IVFmicro was founded in 2018 by Virginia Pensabene, Ph.D, and Helen Picton, Bsc, Ph.D., both professors at the University of Leeds.
Pensabene has published scientific advancements in microfluidics and brings her technical and scientific expertise to the product design.
Picton is a non-clinical expert in female reproductive biology and embryology, and has generated over £8m in research grant income.
IVFmicro recently took part in the NG Studios life sciences programme, which supports pre-seed life science businesses, and is delivered by accelerator KQ Labs, the Francis Crick Institute, and Northern Gritstone.
Virginia Pensabene, CEO and co-founder, IVFmicro, said: “As a biomedical engineer, I began exploring the potential of this technology in 2017, when Helen and I first met at the University of Leeds.
“From the start, our goal was to translate our research into a real solution for patients.
“Thanks to the combination of grant funding and Northern Gritstone’s support — both through investment and its innovation programmes — we have been able to grow our team in Leeds and take a major step toward bringing this precision-engineered IVF solution to market.”
Meta has removed or restricted dozens of accounts run by abortion providers, queer groups and reproductive health organisations in recent weeks.
Campaigners have called the takedowns one of the biggest waves of censorship on Meta’s platforms in years.
The actions began in October and targeted the Facebook, Instagram and WhatsApp accounts of more than 50 organisations worldwide, some serving tens of thousands of people.
Many were from Europe and the UK, with bans also affecting groups serving women in Asia, Latin America and the Middle East.
Repro Uncensored, an NGO tracking digital censorship against movements focused on gender, health and justice, said it had recorded 210 incidents of account removals and severe restrictions affecting these groups this year, compared with 81 last year.
Martha Dimitratou, executive director of Repro Uncensored, said: “Within this last year, especially since the new US presidency, we have seen a definite increase in accounts being taken down, not only in the US, but also worldwide as a ripple effect.
“This has been, to my knowledge, at least one of the biggest waves of censorship we are seeing.”
Meta denied any escalating trend of censorship and said its policies on abortion-related content had not changed.
“Every organisation and individual on our platforms is subject to the same set of rules, and any claims of enforcement based on group affiliation or advocacy are baseless,” it said in a statement.
Organisations affected include Netherlands-registered Women Help Women, a non-profit offering information about abortion to women worldwide that fields about 150,000 emails a year.
Kinga Jelinska, executive director of Women Help Women, said the ban could be “life-threatening”, pushing some women towards dangerous, less reliable information sources.
“It’s a very laconic explanation, a feeling of opacity,” Jelinska said. “They just removed it. That’s it. We don’t even know which post it was about.”
Meta said more than half of the accounts flagged by Repro Uncensored have been reinstated, including Women Help Women, which it said was taken down in error.
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