News
Endometriosis rooted in genetics, say researchers
Findings could open up avenues for designing new medical treatments targeting subtypes of endometriosis, say scientists

An international team of researchers have published the largest study to date on the genetic basis of endometriosis, suggesting genetic links exist between endometriosis and conditions such as migraine and back pain.
The study, published in Nature Genetics, was conducted by the International Endometriosis Genomics Consortium (IEGC), led by the University of Oxford in collaboration with 25 teams across the world.
It studied DNA from 60,600 women diagnosed with endometriosis and 701,900 without the condition, revealing evidence of a shared genetic basis for endometriosis and other types of pain seemingly unrelated to endometriosis, including migraine, back pain and multi-site pain.
The results, scientists believe, could open up avenues for designing new medical treatments targeting subtypes of endometriosis, or even the repurposing of existing treatments for endometriosis.
Endometriosis, an inflammatory condition affecting 190 million women globally, can cause constant and intense pelvic pain, painful periods, painful bowel movements, excessive bleeding and, in some cases, infertility.
It is known that endometriosis can run in families, and therefore that genetic factors play a role in how it develops in some women but not in others.
The cause of the condition is unknown. Several theories have been suggested, including genetics and immune system problems.
Comparing the DNA code in women with and without the disease could, however, give scientists clues to the biological processes that are the basis for onset and progression.
The study conducted by IEGC identified 42 genes that were associated significantly with whether an individual had endometriosis.
By linking these variants to the profiles of molecules in endometrium and blood, researchers identified a range of genes that were differently expressed in these tissues and therefore had a likely role in disease development.
What they noted in particular is that many of the implicated genes play a role in pain perception and maintenance.
They found that there was a shared genetic basis for endometriosis and a range of other chronic pain types, such migraine, back pain, and multi-site pain, which could be related to so-called “sensitisation” of the central nervous system, which makes individuals suffering from chronic pain more prone to other types of pain.
Dr Nilufer Rahmioglu, senior research scientist at the Wellcome Centre for Human Genetics, University of Oxford, and first author of the study, said: “Using different datasets of women with and without endometriosis, some of which had unprecedented detailed data on surgical findings and pain experience collected using standardised criteria, allowed us to generate a treasure trove of new information about genetically driven endometriosis subtypes and pain experience.”
Professor Krina Zondervan, co-director of the Endometriosis CaRe Centre, and head of the Nuffield Department of Women’s & Reproductive Health, University of Oxford, senior author on the paper, added: “This study has provided a wealth of new knowledge on the genetics underlying endometriosis, which will help the research community in their efforts to come up with new treatments and possibly new ways of diagnosing the disease benefiting millions of women worldwide.”
Discussing the study, Stacey Missmer, professor of obstetrics, gynaecology and reproductive biology at the Michigan State University College of Human Medicine and US leader of IEGC for the second phase of the study, said: “We still have a lot more work to do to discover what explains the genetic heritability of endometriosis.
“But these study results are a leap forward in identifying genes associated with endometriosis and, more specifically, their function in the human body and the possible biology related to endometriosis risk.”
News
Femtech World Awards 2026: Celebrating initiatives that move women’s health forward

By Wolfgang Hackl, CEO, OncoGenomX Inc., Allschwil, Switzerland
As the FemTech World Awards 2026 winners are revealed, it is a privilege to reflect on the Research Award 2026 sponsored by OncoGenomX Inc., and on the exceptional standard set by this year’s finalists.
On behalf of OncoGenomX Inc., sincere thanks to every applicant and congratulations go to the nominees whose work continues to push women’s health innovation forward.
Research Awards matter because they do more than recognize excellence in a single moment; they help elevate the science, courage, and systems thinking needed to transform women’s health at scale.
This year’s three finalists represented three different but equally important forms of progress. Natural Cycles brought forward one of the largest studies ever conducted on menstrual and ovulatory patterns in perimenopause, analysing nearly one million cycles from more than 197,000 women across over 140 countries.
That project stood out for both its dataset scale and its ability to translate new evidence into a regulated product designed to support women navigating a historically under-researched life stage.
IVI RMA stood out for scientific rigor and clinical precision. Its multicenter, double-blinded, non-selection study on non-mosaic segmental aneuploid embryos offered high-quality evidence on implantation and live birth outcomes, helping move fertility care away from assumption and toward a more evidence-based approach to embryo management and patient counseling.
UN ESCAP’s ‘Femtech in South-East Asia: Unlocking innovation for women’s health’ stood out for a different reason.
Rather than focusing on one product area or one clinical question, it mapped an entire emerging ecosystem.
The report examined the state of femtech across key South-East Asian markets, documented barriers such as financing gaps, stigma, weak ecosystem support, and data challenges, and then translated that research into practical recommendations for governments, investors, founders, and ecosystem builders.
In many ways, all three finalists are winners.
Each project excelled on core evaluation criteria including originality, relevance, coherence, effectiveness, efficiency, impact, and sustainability.
Each also offered something genuinely valuable to the future of women’s health: stronger evidence, clearer decision-making, more informed product development, and greater visibility for unmet needs that have gone too long without sufficient attention.
The final decision was therefore a genuine head-to-head race.
The jury supported its discussion with a numerical scoring approach, but it also looked carefully at systems impact: the extent to which a project not only advances one intervention, but improves the wider conditions under which innovation can emerge, scale, and endure.
That perspective mattered in this category, because the strongest research is not always only the most technically impressive; sometimes it is the research that opens doors for many future innovations to follow.
On that basis, the OncoGenomX Jury selected UN ESCAP as the winner of the Research Award.
The decisive factor was not simply that the report was comprehensive, though it was.
It was that the project helps change the environment around innovation itself.
It provides a practical roadmap for strengthening research, improving data governance, expanding founder support, addressing gender bias in investment, scaling innovative finance, and integrating women’s health more fully into policy and development agendas.
That broader enabling effect is what distinguished the UN ESCAP project. Natural Cycles demonstrated outstanding research translation, and IVI RMA demonstrated exceptional clinical rigor.
UN ESCAP, however, showed how research can influence the structures that determine whether many other femtech solutions will ever be funded, adopted, trusted, and scaled. In that sense, its impact reaches beyond one company, one product, or one clinical pathway, and toward a healthier innovation landscape overall.
Warm congratulations again to all finalists and nominees.
And special congratulations to UN ESCAP on receiving the OncoGenomX Research Award at the Femtech World Awards 2026.
The jury’s decision reflects deep respect for all three projects and a shared belief that women’s health advances fastest when excellent science is paired with the power to reshape the systems around it.
News
WEC Chair calls out Health Minister’s delay on banning BBLs and other harmful cosmetic procedures

WEC chair Sarah Owen has criticised delays over a ban on high harm cosmetic procedures, including liquid BBLs.
The Women and Equalities Committee has published a letter from health minister Karin Smyth after the government missed the 18 April deadline to respond to the committee’s report on cosmetic procedures.
The report, published on 18 February, recommended that high harm procedures such as liquid Brazilian butt lifts, known as BBLs, should be banned immediately without further consultation.
MPs said the government is “not moving quickly enough” in introducing a licensing system for non-surgical cosmetic procedures and “should accelerate regulatory action”.
They also warned that “this lack of timely action is fostering complacency in self-regulation” within the industry.
In her letter, Smyth said the Department of Health and Social Care had “taken the decision to first of all focus on introducing legal safeguards for the cosmetic procedures posing the highest risks and I can confirm that we plan to consult on draft regulations in June”.
The letter added:
“Our intention is to issue a formal government response to the WEC report, once our consultation setting out our proposed approach and underpinning legislation is published.
“I acknowledge the concerns around the government’s pace of delivery in this area but, as you will appreciate, this is a complex area of policy and striking the balance between increased patient safety, placing new requirements on businesses and introducing proportionate and enforceable regulation is challenging.
“I recognise that regulation has not kept pace with the expansion of the aesthetics industry and, on that basis, I can assure you that we are committed to implementing licensing in the current parliament.”
Owen, chair of the Women and Equalities Committee and Labour MP, said:
“Further consultation and delay on clamping down on high harm procedures such as liquid BBLs is unacceptable. It allows unscrupulous people to continue to put women at risk and lets down those who have lost loved ones following these practices or who have come to serious harm themselves.
“As WEC’s report warned back in February, procedures that are deemed high risk such as liquid BBLs and liquid breast augmentations, which have already been shown to pose a serious threat to patient safety, should be banned immediately.
“While it is positive to hear a licensing system for non-surgical cosmetic procedures will be introduced within this Parliament, this issue requires faster regulatory progress, particularly in high harm areas, and the Government is not moving quickly enough.
“The Committee previously heard a powerful and shocking testimony from a woman who developed sepsis after having a liquid BBL. Her experience and those of many others provides clear evidence of the need to tackle this evolving wild west.”
A liquid BBL is a non-surgical procedure intended to alter the shape of the buttocks.
Sepsis is a potentially life-threatening response to infection that can lead to organ damage if not treated quickly.
News
Menopausal hormone therapy could prevent bone loss or lower fracture risk – study

Women who do not use menopausal hormone therapy have a greater risk of developing osteopenia or osteoporosis, conditions that weaken bones and can lead to fractures, disability and loss of independence, new research suggests.
The retrospective cohort study included 387 postmenopausal women who underwent DXA scans between 2021 and 2025. A DXA scan is an imaging test used to measure bone mineral density.
Participants were classed as menopausal hormone therapy users, who made up 33 per cent of the group, or non-users, who made up 67 per cent.
Low bone mineral density was defined as osteopenia, where bones are weaker than normal, or osteoporosis, where bones become more fragile and more likely to break.
Women taking menopausal hormone therapy had about 69 per cent lower risk of low bone mineral density in the spine and hip compared with those not using it.
The association remained after researchers accounted for age, time since menopause, vitamin D levels, smoking and other health conditions.
Diego Espinoza-Peralta, vice president of the Mexican Society of Nutrition and Endocrinology and principal investigator at Investigación Médica Sonora, said: “For years, many women have avoided menopausal hormone therapy because of safety concerns and warning labels.
“This study revisits that narrative and shows that menopausal hormone therapy may have an important added benefit: protecting bone health. That shifts the conversation from ‘avoid if possible’ to ‘reconsider in the right patient.’
“In simple terms: menopausal hormone therapy appears to independently protect bones, not just by coincidence.”
The findings suggest hormone therapy could help some women find relief from menopausal symptoms while preventing bone loss or lowering fracture risk.
Espinoza-Peralta said: “Clinicians may begin to weigh its benefits more carefully, especially in women early after menopause, potentially improving long-term health and quality of life.”
Menopause3 weeks agoPerimenopause misinformation ‘putting women at risk’
Hormonal health4 weeks agoNHS urged to update website following renaming of PCOS
News2 weeks agoWomen still being failed when they reach menopause, experts say
Entrepreneur3 weeks agoWomen’s Health Innovation Summit opens submissions for 2026 Innovation Showcase
Insight2 weeks agoBritish women among angriest in Europe, health survey reveals
News3 weeks agoThree menopause innovators shortlisted for Femtech World Award
Menopause3 weeks agoSweden eyes domestic production of oestrogen patches amid menopause treatment shortage
News4 weeks agoLow insulin diet and avoiding four food groups may prevent menopause weight gain











