Features
New research highlights ‘critical’ differences in how women experience Alzheimer’s
Addressing sex and gender differences in Alzheimer’s is ‘crucial’ for diagnosis and treatment, say experts

New research is highlighting ‘critical’ sex and gender differences in some of the most prevalent brain disorders, leading to calls for a global commitment to more inclusive healthcare and drug development.
Every three seconds, someone in the world develops dementia, with women at significantly greater risk. Statistics show that two out of three Alzheimer’s patients are women, as are four out of five of those with multiple sclerosis, while women are three times more more likely to experience migraines and to be diagnosed with mental health issues such as depression and anxiety. Yet despite being the dominant gender when it comes to brain disorders, in general we know far less about how they affect women than we do men.
A new paper, published by the Women’s Brain Foundation (WBF), highlights how evidence of ‘critical sex and gender differences’ are observed in imaging studies, postmortem analyses, and behavioural research of individuals at different stages of Alzheimer’s disease.
Established in Switzerland in 2017, the WBF brings together a global team of experts to conduct, coordinate and support research related to sex and gender differences in diseases of the brain, as well as women’s health more generally.
The new paper builds on existing research by the WBF, published in the journal Nature Medicine last year, which also found profound sex and gender differences in Parkinson’s — one of the world’s fastest growing neurological conditions, with increasing prevalence among younger women.
These differences are thought to be due to a combination of factors, both biological— such as hormones— and societal, including the type of job a woman has, their access to education and caregiving responsibilities, according to WBF president and co-founder, Dr Antonella Santuccione-Chadha.
Nearly 50 per cent of dementia cases are linked to modifiable risk factors such as physical inactivity, obesity, and cardiovascular problems, with reduced access to education, as well as psychical inactivity, both being identified as preventative factors in reducing the risk of developing the disease.
According to UK census data, women are less engaged in physical activity than men, but a recent study conducted by the WBF with the London School of Economics, showed that increasing the amount of time women cycled per day to the same as that of men, could reduce the number of dementia patients and the financial burden on the healthcare system.

Women ‘neglected’ in clinical development
WBF’s ambassador, Sofia Petersson, was herself diagnosed with dementia in her late 30s, after her father and grandmother were both diagnosed with the disease. When Sofia first started to display symptoms she had to “struggle to be believed by doctors”.
Until now, science has treated Alzheimer’s as a one-size-fits-all disease, according to Dr Santuccione-Chadha, ‘ignoring critical sex and gender differences’ and leading to ‘misdiagnosis, delayed treatment and suboptimal care’.
“Women have been neglected in clinical development,” Dr Santuccione-Chadha, an internationally recognised expert in neuroscience, neurological disorders, and psychiatric diseases, tells Femtech World.
“We know that [women] make up the majority of patients with conditions such as Alzheimer’s, Parkinson’s, multiple sclerosis, depression and anxiety, and we know that disease symptoms manifest differently. But doctors do not know how to specifically recognise these symptoms.”
The new research, the result of a collaboration of international experts, underscores the ‘significant impact of sex and gender’ on the pathogenesis, progression, diagnosis, and treatment of the condition.
The researchers found, for example, that women with Alzheimer’s disease are more likely to be depressed and to display symptoms of psychosis, while men are more apathetic. This could potentially lead to symptoms such as depression and anxiety being ‘misattributed to psychiatric causes’, the authors write, while ‘severe neuropsychiatric symptoms’ are often an exclusion criterion for clinical trials.
Knowledge gaps in prevention and treatment
Addressing these biases in clinical trials and neuropsychological assessments is crucial not only for diagnosis but for improving the accuracy and effectiveness of treatments and preventative interventions, the authors say.
Despite research highlighting the influence of sex and gender differences on disease prevention, manifestations and progression, further investigation is required to understand the role that hormone therapies, such as HRT, could play in prevention and treatment. Sex-specific variations in drug efficacy also underscore the need for tailored therapies for both men and women, yet women have been disproportionately excluded from immunotherapy trials due to factors such as older age, lower education levels, and co-morbidities.
In the Parkinson’s study, women were found to be at far greater risk (80 per cent) of the gold-standard treatment, levodopa, ‘wearing off’, or becoming less effective before the next dose, and were also at an increased risk of developing levodopa-induced dyskinesias, one of the most common side-effects of the treatment.
Meanwhile, even though multimodal prevention trials have emphasised the need for personalised intervention strategies, there are still significant knowledge gaps in terms of whether women with hormone-related risk factors for Alzheimer’s disease—such as early menopause, pregnancy complications, or delayed initiation of MHT—respond differently to lifestyle interventions compared to those without these risk factors.
Calls for a commitment to ‘inclusive research’
The findings underscore what the WBF has been advocating for for years. Drug developers, regulators and researchers must consider sex and gender differences in preclinical and clinical development to understand and the important implications these have for biomarker interpretation, improved clinical outcomes, and patient management.
In a new petition, which will be presented to the global leaders at the World Health Organization General Assembly 2025, the organisation is urging scientists, clinicians, regulators, policy makers, drug developers and patients to recognise the critical importance of considering sex, gender, race, and ethnicity in precision medicine.
It calls for scientists to commit to inclusive research that reflects real-world diversity, and for policymakers to ensure that sex, gender, and race-informed research is a mandatory standard in healthcare and drug development.
“To develop effective and safe solutions for both women and men, we must enhance our understanding of both biological and societal influences and ensure that clinical trials appropriately account for these factors,” adds Dr Santuccione Chadha.
“The data speaks for itself, and ignoring it is not just a scientific failure; it is negligence.”
You can donate to support the work of WBF here
Features
Gender gap in treatment persists even when men and women have same condition

Women with the same medical conditions as men were less likely to receive the same treatment across several specialties, a global research review found.
The review found differences in care for conditions including cardiovascular disease, kidney disease and Parkinson’s, with women less likely to receive some active treatments.
Of 38 studies analysed, 33 found women were less likely than men to be offered active treatment.
Researchers at the University of St Andrews found women with myocardial infarction, heart failure or an irregular heartbeat were more likely to receive medication, while men were more likely to undergo coronary bypass surgery, stenting or other surgical treatment.
Women were also less likely to be prescribed statins.
Men with Parkinson’s were more likely to be referred for deep brain stimulation.
Men with liver failure were more likely to receive a transplant, while women with kidney disease requiring dialysis were less likely to receive permanent access and spent longer using a catheter.
Women were also less likely to receive opioids for pain management.
The researchers found no significant difference between women and men in treatment for stroke or diabetes, while women were more likely to receive treatment for dementia.
None of the studies identified clinical guidelines recommending different treatment based on sex.
Researchers said this suggested the differences could not be explained by the need for different clinical approaches to women’s health.
Dr Andrew O’Malley, who co-led the study, said: “For clinicians, the findings are a prompt to check whether treatment is being offered on clinical grounds rather than assumption.”
He said studies showed doctors more often attributed women’s symptoms to anxiety and made more diagnostic errors with female patients, even when test results were positive.
Dr Miriam Veenhuizen, honorary lecturer in the School of Medicine at St Andrews, said: “While the direction of the findings was not a surprise, the consistency was. The same pattern appeared in cardiology, surgery, transplant medicine and emergency care, and it survived statistical adjustment in most studies.”
News
Far from ‘boxed in’: The innovative design transforming at-home testing

Alexander Parker is head of wellness at packaging design and manufacturing company, Burgopak.
Burgopak is a world leader in design innovation, with a 25-year-history spanning entertainment, consumer tech and now health diagnostics, including an expanding range of at-home hormone and fertility testing kits.
We speak to Alexander to discover what goes into designing robust, functional but engaging packaging and the sometimes surprising considerations that can make or break a product.
Hi Alexander. Please tell us about your role at Burgopak.
My role is about driving our growth and direction in the healthcare and wellness space, which in practice means everything from packaging to client engagement, to partnerships, to developing the team.
I also sit on the company management committee and help manage our IP portfolio.
Before stepping into this role, I spent 20 years as a designer, 15 of them as head of design – so I bring a hands-on understanding of what it takes to deliver great packaging.
At-home test kits require the user to perform a medical procedure alone, without professional support.
How does that inform your design approach?
It’s a key pillar of a project, heavily influenced by the product and its intended use.
In the case of a test kit being used to collect a sample specimen and return it to a lab, there’s often plenty of opportunity for packaging to help or hinder the process and experience.
There are layers to effective packaging.
● Structure – Physical interventions through the packaging.
● Artwork – The visual identity, messaging and instructions across the pack and instructions for use.
● Signalling – Sometimes-undervalued but what signals are communicated through the packaging – how this makes the user feel about the product, the company behind it and the task at hand.
Careful design of the instructions for use is universally appreciated and often a regulatory requirement.
However, the pack structure and artwork should also work together to communicate a clear user journey.
This could include presenting components in the order they’re used, aligning the pack layout with the IFU steps (Prepare>Test>Return), making the IFU immediately visible as a hero component.
We can also introduce physical aids, like collection tube stands, to help during the sampling process.
The packaging is often used in the return of the sample to a lab so this needs to be considered and intuitively designed.
The structure, materials and artwork are all communicating something to the user.
You want to reassure the user by signalling care, efficacy, trust and in the case of a paid product, value.
In your mind, compare these two pack examples.
One a simple carton with a sea of components loosely filled and rattling around inside. Poor quality print and seemingly damaged in the post.
Contrast that with a suitably robust piece of packaging, with the components arranged and labelled into steps 1, 2, 3.
They might both work, but you can imagine the second building a reassured user experience.
How often do you encounter brands that haven’t thought about the emotional and potentially anxiety-inducing moment of opening a testing kit, and what’s the first thing you fix?
Thankfully it’s not too often, in our case at least.
I think we tend to attract customers who sense there’s more to packaging than just being a container or functionally driven.
The start of a project for us is building a brief with the customer and aligning on values for the packaging – what we want people to feel when opening or using it – as well as defining the technical requirements.
So, if there’s going to be an early fix it’ll probably be here, establishing the emotional intent.
How has the rise in social media ‘unboxing’ videos and product reviews changed what you do?
Is there a tension between designing for social media shareability and designing for the privacy women often want around health testing?
I don’t think there has to be a tension, provided everyone is clear on what the goals of the packaging are, and they are aligned with the product type and its use.
We can’t influence the results of a test or the positive or negative emotional significance it has in someone’s life.
What we can do is design packaging that offers the best possible user experience.
If there’s a shareable moment at the end, packaging might be a prop within a photo or video. But equally it might be a very private experience.
If it’s a test offering a diagnosis or insights into a health condition – you can conceive of a range of emotional outcomes. As you could imagine for certain fertility products too.
The design needs to acknowledge all these possibilities in its structural design, visual identity and the signals they communicate.
For women using a fertility or hormone test, perceived quality signals trust.
How do you stop sustainable choices from reading as cheap?
Do the essentials well, look for small interventions that add value and use attention to detail to signal that the care taken over the packaging, and sustainability, extends to the user.
Material choice is incredibly important.
In the case of paperboard quality can be a spectrum so it’s important to take the time to find and qualify the right one.
One that offers the necessary performance characteristics, is verifiably from responsibly managed forests such as through FSC/PEFC, and from a mill whose activities are aligned with your sustainability targets.
Take care over the design of each touch point and detail. A fitment that holds a device should neatly cradle it. A closure should be intuitive to open and work every time.
If the pack is meant to stand up, then the proportions should be optimised to facilitate that. It’s attention to the details that’s important.
Print quality will have a big impact on perception, not just the messaging or visual identity it renders. If the print quality is poor, then it devalues the product.
Doing it well doesn’t mean using material resources – it’s careful vendor selection and quality assurance.
For some responsible premiumisation you can introduce embossing or debossing details to the artwork, a tactile three-dimensional finish.
This details-led approach is valuable across all packaging but if sustainability is driving a reduction to the essentials, then there is a heightened importance to the execution of what is left.
As at-home health testing moves into NHS and public health contexts, what does good packaging look like when the brief is scale and cost rather than aspiration?
Scale and cost often feature very heavily in the success of projects outside of these settings, so there are parallels between the public and private, but with greater imperative to strip things back.
What is important to understand is success is not a piece of packaging in isolation. It’s efficiency, kitting, quality, distribution, tracking, data management across all activities and partners. Packaging is one part of the bigger picture.
Central to all of this is the need for it to reliably and consistently encourage the correct use of the kit through structure, artwork and instructions.
It is materially efficient and from a robust agile supply chain.
Assembly and kitting might be automated so it will be designed for those production lines or in conjunction with the equipment development.
It is compliant with all transport regulations and the most cost-efficient postal streams to the patient and from them back to the lab.
So, what does good packaging look like? It’s the design that efficiently offers the best patient user experience through a robust, reliable, scalable supply chain.
How do you make the business case for investing in packaging design before the product itself is ready to market?
There’s an opportunity cost.
Packaging has the potential to be a valuable asset when someone invests time and resources into coherent design and development. By starting too late or under resourcing the process you risk having packaging that’s a commercial pain point.
At the earliest opportunity, you at least want to be selecting your packaging partners and have a clear understanding of the development timeline and milestones – structural design, prototyping, stakeholder feedback, artwork/labelling development, regulatory milestones, transit testing, stability testing, wetproofing, manufacturing, delivery.
You must complete these steps before your product can go to market.
What’s the cost to you of delaying launch because you didn’t get packaging underway sooner?
You need to spend time creating packaging that elevates your brand and is a marketing asset that works across ecommerce, retail, advertising, social media.
Engage with the other supply chain stakeholders.
One example would be involving kitting partners in the process to validate and input on packaging improvements. If it’s expensive to kit, your cost of goods go up and if it’s slow to kit you might not have a scalable solution.
You may also find packaging insights influence product decisions.
If you are defining components for a test kit, factor in that larger devices might in turn increase pack size and eventually incur higher shipping costs.
You might work with a device manufacturer on how a USB cable is wound so the packaging volume can be decreased – another potential packaging and shipping cost reduction.
Transit testing and design improvements ensure that products arrive in acceptable condition – reducing costs associated with replacements, damaged reputation and potentially the loss of repeat purchases.
Packaging done well is that opportunity realised – it’s value demonstrated across sales, marketing and operations.
For a founding team approaching a packaging partner for the first time, what does a genuinely useful brief contain, what do most brands leave out, and how much does coming in underprepared add to the timeline and cost?
At Burgopak we build a brief together with the customer and that usually happens in a few stages.
The initial conversation is a chance to learn more about each other, make sure we’re a good fit for one another and the project.
We like to learn more about you, your product, how it’s used and some headline information around timelines, volumes, budget, your packaging ambitions and likes/dislikes.
We explain what we do and how we typically work. This really is the kick-off point – the goal at the end of this stage is being excited to be working together on a project that looks technically and commercially feasible.
In the next stage we build-out a brief capturing the technical and brand-led requirements of the packaging.
It will cover product details, brand & experience, sales & delivery channels, fulfilment and distribution, budget and timelines, compliance and regulations.
The exact questions will vary by product and project, but they span those areas.
From this we can build the project plan – and this might involve working towards answers that aren’t yet defined.
It seems obvious, but knowing exactly what needs to be packaged is fundamental – the product, peripherals – and this can be one of the common missing puzzle pieces.
You can design a container to hold ‘something’.
But when you know exactly what the product is – its size, shape, weight, how it’s used – you can design a piece of packaging that is maximally efficient and effective in elevating the total product experience.
The risk to a successful project is not so much under preparedness at the start – we’re here to help build the brief and a realistic project plan – it’s a loss of momentum through the process.
The packager and the client must work together.
We can be very efficient and agile in doing the work but there’s also the responsibility from the client to keep momentum through rounds of feedback, coordinating product samples or technical drawings and so on.
If there’s a finite timeline and repeated delays within it there can come a crunch point – when delivery dates are pushed out or potentially avoidable compromises made.
Come prepared to collaborate on the brief – but know that the founding teams who get the best outcomes are the ones who stay engaged and keep momentum through the whole process, not just the kick-off.
Learn more about Burgopak at burgopak.com
News
Elation Health acquires EHR startup Aster

Elation Health has acquired Aster, a women’s health EHR startup created by sisters Fifi Kara and Dr Lailah Kara-Newton.
The deal, announced on 3 June 2026, will see Aster’s team join Elation Health as the company expands development of what it describes as the first agentic operating system for primary care.
An EHR, or electronic health record, is a digital system used by healthcare providers to store and manage patient information.
Aster was founded by Kara and Kara-Newton as an AI-native EHR platform for women’s health providers.
Elation Health said the acquisition would allow Aster to learn from its expertise in AI agents and support development of its agentic operating system for primary care.
Kyna Fong, co-founder and chief executive of Elation Health, said: “The Aster team impressed us with their vision and creative inventions to support independent practices.”
Fong said Elation, like Aster, was founded by siblings who wanted to change the healthcare system.
She added: “That shared north star means they understand what we’re building and why it matters. It was clear right away they would significantly add to our capabilities.”
Kara has spent 10 years creating consumer and business-to-business products across the UK, Europe and the US, and recently supported Meta’s Health & Fitness team, according to Aster’s website.
Kara-Newton previously worked as a hospital doctor in the NHS across medical and surgical specialties, including breast surgery, general surgery, emergency medicine and obstetrics and gynaecology.
Aster launched in 2023 after raising US$2.8m from Zeal Capital Partners, Cornerstone Ventures, Octopus Ventures and others.
Kara, Kara-Newton and Aster’s chief technology officer, Nacho Vazquez, will all join Elation.
Kara said: “From the moment we met Kyna Fong, Ashley Rogers, and the Elation leadership team, it was clear we were aligned on what matters most: that clinicians deserve truly incredible software that brings joy back to their practice. Together, we can now bring that vision to millions of primary care patients across the country.”
The sisters said their work was shaped by Kara-Newton’s first pregnancy, when undiagnosed pre-eclampsia led to an emergency caesarean section and neonatal intensive care admission for her son.
The founders said they wanted to build technology that could help prevent similar outcomes for other women.
The acquisition comes amid continued concern over maternal health inequalities in the US.
In the US, Black maternal mortality remains alarmingly high, with rates nearly double those of white women, and experts point to unequal access to care, implicit bias and fragmented approaches to care.
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