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Sage Therapeutics appoints investor Jessica Federer to board of directors

Federer’s work focuses on addressing the gender gap in healthcare and innovation

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The US biotech company Sage Therapeutics has announced the appointment of investor Jessica Federer to the company’s board of directors.

Federer, a managing partner at Supernode Ventures, aims to address a critical gap in innovation by accelerating change through investment in early-stage femtech and health technology companies.

She was the first chief digital officer for the Bayer AG group, as well as the first woman to hold that role in the industry.

During her tenure, Federer united the company’s global digital strategy and investments to accelerate growth and held leadership positions in regulatory affairs, market access, communications, and public affairs.

“I’m honoured to join the Sage Board of Directors at such an incredibly exciting time,” the investor said in a statement.

“Sage has led the way in maternal mental health care, an area of great need and one that is particularly important to me.

“I’m looking forward to supporting the company’s goal of redefining how we think about and treat a wide range of brain health conditions. I see the vast potential for data and digital strategies in the brain health area.”

Sage Therapeutics is a Massachusetts-based biotech developing brain health medicines.

The company aims to improve brain health and change how brain disorders are thought about and treated.

Barry Greene, Sage Therapeutics CEO, said: “We are thrilled to have Jessica join our board of directors.

“She is a champion for patients and has a track record of innovation in data and digital transformation which will be a key future growth driver for the industry.

“Jessica’s innate curiosity, commitment to challenging convention, and patient-first mindset are consistent with the critical values that define our leaders.

“Her unique expertise in data and digitalisation at the intersection of policy and science will help us continue to scale our commercial growth ambitions.”

Federer began her public health career as an analyst at the Agency for Healthcare Research and Quality in the U.S. Department of Health and Human Services.

She has served on the United Nations International Telecommunications Union (UN-ITU) advisory board, as well as participated in engagements with the World Economic Forum, and is considered a thought leader in digital health.

Mental health

Women more likely than men to get health advice from influencers, study finds

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Young women are more likely than young men to get health and wellness information from social media influencers, a US survey has found.

Among adults aged 18 to 29, 57 per cent of women said they received health and wellness information from influencers, compared with 47 per cent of men.

The Pew Research Center study surveyed 5,023 US adults and examined how young people consume health and wellness content online.

Local university students said influencer content frequently appeared in their social media feeds.

Kabija Koroma, a local university student, said: “It’s more exercise stuff, more like protein and like meals and like how to get ready and like the outfits of the day of videos on TikTok or lately. My favourite ones.”

About 51 per cent of women under 30 said they often consumed influencer content focused on beauty and personal appearance, compared with 18 per cent of men.

The study also found that 21 per cent of women often saw content about therapies outside mainstream medicine, compared with 10 per cent of men.

At least one-third of both young women and young men often encountered influencer content about mental health and weight loss. Around half or more of both groups regularly saw fitness-related content.

Another local university student, Ania Davis, said: “I see a lot like how to meal prep and how to get your morning started. Affirmations stuff. But I do also ask the adults around me because sometimes the internet is not right.”

Researchers also looked at why young adults sought health and wellness information from influencers.

About 51 per cent of young women said they watched the content because they wanted to change their health or lifestyle.

Women were also more likely than men to say they enjoyed hearing from people who shared their background or beliefs, at 23 per cent compared with 14 per cent.

Nineteen per cent of young women said they used influencer content to learn about topics they did not want to ask their doctors about, compared with 10 per cent of young men.

Despite regularly using social media, some students said they did not rely solely on influencer content when making decisions about their health and wellness.

Koroma said: “I’m always on TikTok 24/7 and Instagram, but I also like to ask people older than me because I don’t know everything.”

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Menopause

Menopause hormone treatment may ease brain fog, study suggests

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Estriol treatment may ease menopause brain fog and other cognitive symptoms, according to a small observational study of 20 menopausal women.

The study involved menopausal women with an average age of 53.

They underwent an initial assessment of their cognitive symptoms before receiving a customised regimen of estriol and progesterone for 12 months.

Estriol is a natural form of oestrogen that occurs during pregnancy and has been used in Europe and Asia to treat menopausal symptoms including hot flushes and genitourinary symptoms.

It differs from estradiol, the most commonly used oestrogen hormone therapy in the US, by binding primarily to a different oestrogen receptor in the brain.

Previous research has shown that estriol may help protect brain cells and reduce brain atrophy in the hippocampus, the region responsible for learning and memory.

After 12 months of treatment, participants reported significant reductions in brain fog, concentration problems, working memory problems, slower processing speed, verbal memory problems and problem-solving difficulties compared with before treatment.

Senior author Dr Rhonda Voskuhl, a neurologist and member of the Comprehensive Menopause Center at UCLA Health, said: “Oestrogen plays a well-documented role in protecting the brain, yet there are still no approved type and dose of treatment that specifically targets the cognitive symptoms so many women experience during menopause.

“Women are often told to simply live with brain fog, when in fact there is a neuroscience basis for it, and potentially a way to address it. That gap in care is what motivated us to look more closely at estriol.”

Researchers also examined estriol treatment in midlife female mice to investigate how the hormone treatment might work.

Estriol reduced markers of brain pathology in the hippocampus and improved measures of working and spatial memory in the animals.

The findings are preliminary. The study was a small case series with no placebo group or randomisation, meaning the results may not apply to broader populations.

The researchers said larger placebo-controlled clinical trials using brain imaging and standardised cognitive testing are needed to confirm the findings on cognitive symptoms.

The treatment used in the study was invented by Voskuhl and is patented by UCLA. UCLA licenses the patent to CleopatraRX, which sells the treatment as PearlPAK. Voskuhl serves as a medical adviser to CleopatraRX.

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Women shouldering hidden burden of navigating healthcare system – study

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Women face a hidden burden navigating healthcare, with many repeatedly retelling their medical history, a national study suggests.

The findings indicate that Canadian women are taking on cognitive, emotional and administrative work alongside managing their health, including coordinating providers and advocating for care.

More than half of women surveyed, 53 per cent, reported a past or current chronic condition, while 64 per cent said there were health topics they struggled to raise with their doctor.

Sarah Hoffman, president and CEO of Pacific Blue Cross, said: “These findings challenge us to think differently about women’s healthcare and highlight the hidden work required to navigate the system.

“For many women, managing their health has also come to mean managing the healthcare system itself.

“They are acting as project managers of their own care, shouldering the invisible labour of coordinating between providers, retelling their medical history and advocating to be heard.

 “The gap between men and women is meaningful and raises important questions about why younger women report lower levels of confidence and support.

“It also challenges us to consider whether we are actually making progress in women’s care, and whether the next generation is being equipped with the confidence and voice to advocate for their health.”

Overall, 71 per cent of Canadians described their doctors as supportive and 88 per cent expected their appointments to go well.

Among women living with chronic conditions, 71 per cent reported having to repeat their complete health history multiple times a year.

Younger women were particularly likely to report difficulties discussing their health. The study found 81 per cent of Gen Z women aged 18 to 30 and 73 per cent of Millennial women aged 31 to 45 had health topics they struggled to raise with their doctor.

Among Gen Z women with chronic illness, 92 per cent reported having to repeat their complete health history.

The study also found differences between young women and men. While 95 per cent of Gen Z men expected a doctor’s appointment to go well, the figure was 82 per cent among Gen Z women.

Similarly, 82 per cent of Gen Z men said they felt supported by their family doctor, compared with 66 per cent of Gen Z women.

Reasons for holding back health concerns varied between generations.

Among Gen Z women, 30 per cent cited fear of dismissal and 29 per cent fear of judgement.

Embarrassment was the most common barrier among Millennial, Gen X and Boomer women, reported by 29 per cent, 27 per cent and 35 per cent respectively.

Women who felt they needed to prove themselves to be taken seriously said they adapted how they approached appointments.

Strategies included researching medical information, repeatedly describing or justifying symptoms, bringing written notes or documentation, tracking symptom timelines, making repeat visits and emphasising how symptoms affected their daily lives.

The study also found an association between feeling supported by a doctor and expecting appointments to go well.

Canadians who described their physician as supportive were nearly four times more likely to expect appointments to go well than those who felt unsupported, at 98 per cent compared with 25 per cent.

Overall, 66 per cent of Canadians said they described their symptoms accurately. This fell to 48 per cent among those who said they felt unsupported by their doctor.

The 2026 Blue Cross Women’s Health Study surveyed 2,045 adult Canadians online in March 2026 through independent research company Research + Knowledge = Insights.

The survey had a reported margin of error of plus or minus 2 per cent, 19 times out of 20.

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